Clinical trials: Periodontal Defect
Furcation Defects
Rosuvastatin Gel With 1:1 Mixture of Platelet-rich Fibrin and Bone Graft in Mandibular Degree II Furcation Defects
Rosuvastatin (RSV) is a new synthetic, second-generation, sulfur-containing, hydrophilic statin, that stimulate bone formation in critical-size cortical bone defects adjacent to titanium implants, when administered locally in…
- Trial name
- NCT02369250
- Testing
- Rosuvastatin, platelet rich fibrin
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Alveolar Bone Loss, Alveolar Ridge Abnormality
Repeated Injection of I PRF and Autogenous Bone Graft for Alveolar Ridge Augmentation
The current st udy's objective was to validate the repeated effect of i PRF with autogenous bone on the of gingival thickness , width a n d volumetric bone changes durig maxillary alveolar augmentation using cone beam computer…
- Trial name
- I-PRF (NCT06711250)
- Testing
- khoury technique, khoury technique with i-PRF injections
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Intrabony Periodontal Defect
Efficacy of Insulin Like Growth Factor-1(IGF-1) on Bone Regeneration in Intrabony Defects : A Clinico-radiograph Study
The aim of this study is to clinically evaluate the efficacy of Insulin like Growth Factor (IGF-1) on bone regeneration in intrabony defects.
- Trial name
- NCT06426524
- Testing
- IGF-1 Gel, Hydroxyapatite
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Dr R Viswa Chandra
Peri-implantitis
Polynucleotide and Hyaluronic Acid-based Gel as Adjunctive Therapy to Non- Surgical Treatment of Intraosseous Peri-implant Defect. A Randomized Clinical Trial
This randomized, placebo-controlled clinical trial evaluates the efficacy of a polynucleotide and hyaluronic acid-based gel (PN-HA) as adjunctive therapy to non-surgical flapless treatment of peri-implantitis.
- Trial name
- NCT06914518
- Testing
- viscoelastic gel containing a fixed combination of natural origin PN (10 mg/ml, 1%) and HA with molecular weight > 1500 kDa (10 mg/ml, 1%), Non-Surgical Intervention
- Where
- 2 sites in Spain
- Volunteers
- 32 people
- Sponsor
- Universitat Internacional de Catalunya
Periodontal Bone Loss, Periodontal Pocket
Treatment of Intraosseous Periodontal Defects With Amelogenins
The aim of the present investigation will be evaluate the healing of periodontal intraosseous defects following Minimally Invasive Non Surgical Debridement (MINSD) and application of amelogenins, compared to MINSD alone.
- Trial name
- NCT05315804
- Testing
- MINSD and amelogenins, MINSD
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Federico II University
Tooth Loss, Peri-implant Mucosa Defect
Comparison of Two Different Surgical Approaches To Increase Peri-Implant Mucosa Thickness
The purpose of this non-inferiority trial is to determine the clinical efficacy of acellular dermal matrix (ADM) in the augmentation of the gum around dental implants as compared to an autologous gum graft (sCTG) obtained from…
- Trial name
- NCT02450383
- Testing
- Acellular Dermal Matrix, Autologous subepithelial connective tissue graft
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Intrabony Defect, Periodontal Diseases
RGD With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defect
Periodontal regeneration is a complex process that involves coordinated activities and interactions of many cell types, extracellular matrix, cytokines, and specific growth factors to restore tissue integrity.
- Conditions
- Intrabony Defect, Periodontal Diseases, Alveolar Bone Loss
- Trial name
- MINST + RGD (NCT06936605)
- Testing
- RGD Peptide
- Volunteers
- 45 people
- Sponsor
- Minia University
Intrabony Periodontal Defect
Clinical Evaluation of Injectable Alb-PRF in the Management of Intrabony Defect in Stage-III Periodontitis Patients
Clinical Evaluation of Injectable Albumin Platelet Rich Fibrin Versus Platelet Rich Fibrin in the Management of Intra-bony Defect in Stage-III Periodontitis Patients.
- Trial name
- NCT06297577
- Testing
- Albumin Platelet Rich Fibrin (Alb-PRF) combined with minimally invasive surgical technique (MIST), Minimally invasive surgical technique (MIST)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Diseases, Periodontitis
Inflammation-resolution Therapy in MINST of Periodontal Intrabony Defect: a Pilot Randomised Controlled Trial
The aim of this study is to assess whether and how a mouthwash containing an ingredient that reduces inflammation in combination with a recently developed treatment is more effective at improving advanced gum disease.
- Trial name
- AIRTIM (NCT07203872)
- Testing
- IsoDent Paro Strong (Isodent Ltd. Valtakatu 4 D, 96100 Rovaniemi, Finland) mouthwash
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Intrabony Periodontal Defect
Injectable Platelet Rich Fibrin With Demineralized Freeze-dried Bone Allograft in Treatment of Intraosseous Defects
Clinical and radiographic evaluation of injectable platelet rich fibrin (i-PRF) and demineralized freeze-dried bone allograft (DFDBA) compared to demineralized freeze-dried bone allograft (DFDBA) alone in management of…
- Trial name
- NCT03900013
- Testing
- Injectable platelet rich fibrin combined with DFDBA, Demineralized Freeze Dried Bone Allograft
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Intrabony Periodontal Defect
Novel Silk Fibroin Nanofiber Membrane Using Minimally Invasive Surgery in Treatment of Periodontal Intrabony Defects: A Randomized Clinical Trial
Clinically and radiographically by cone beam CT evaluate the regenerative potentials of silk fibroin (SF) nanofiber membrane, using minimally invasive surgery, for the regenerative treatment of intrabony periodontal defects.
- Trial name
- NCT06371027
- Testing
- Minimally Invasive Surgery Technique (MIST) + Novel Silk Fibroin (SF) nanofiber membrane, Minimally Invasive Surgery Technique (MIST) + collagen membrane, Minimally Invasive Surgery Technique (MIST)
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- October 6 University
Periodontitis, Intrabony Periodontal Defect
Effectiveness of Hyaluronic Acid (hyaDENT BG® Gel) Compared With Enamel Matrix Proteins (Emdogain®) in the Treatment of Angular Bone Defects in Combination With a Xenograft (Bio-Oss Collagen®)
The goal of this clinical trial is to learn whether hyaluronic acid (HyaDent® BG) provides similar benefits to Emdogain® when both are used with Bio-Oss® Collagen during periodontal surgery in adults with periodontal (intrabony)…
- Conditions
- Periodontitis, Intrabony Periodontal Defect, Periodontal Bone Loss
- Trial name
- NCT07230522
- Testing
- Bio-Oss Collagen + HyaDent BG, Bio-Oss Collagen + Emdogain
- Where
- Bulgaria
- Volunteers
- 17 people
- Sponsor
- Medical University of Sofia
Periodontal Intrabony Defect
Entire Papilla Preservation and Conventional Flap Surgery in Treating Intrabony Defects: A 6-Month Clinical Trial
Intraosseous defects are characterized by vertical bone loss within the borders of the alveolar bone surrounding the teeth due to periodontal disease and are considered a clinically concerning condition.
- Trial name
- NCT06687785
- Testing
- Entire Papilla Preservation Technique, Conventional Flap Surgery Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Sticky Bone, iPRF
Sticky Bone and Repeated Injectable PRF (iPRF) Application in Management of Periodontal Intrabony Defects
One of the main objectives of periodontal therapy is the regeneration of the tooth's supporting periodontal tissue to its original levels.
- Conditions
- Sticky Bone, iPRF, Periodontal Defect
- Trial name
- IPRF (NCT05211362)
- Testing
- Sticky Bone and Repeated Injectable PRF (iPRF), bone substitute
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Intrabony Periodontal Defect
Clinical Effect of APRF With DFDBA Compare to Collagen Membrane With DFDBA in Intraosseous Defect
to assess the effectiveness of advanced PRF in combination of Demineralized freeze-dried bone allograft (DFDBA) as compared to collagen membrane in combination with Demineralized freeze-dried bone allograft (DFDBA) treatment of…
- Trial name
- NCT03922503
- Testing
- Advanced- platelets rich fibrin (A-PRF) with Demineralized freeze-dried bone allograft (DFDBA), Collagen membrane with Demineralized freeze-dried bone allograft (DFDBA)
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Intrabony Defect
Regenerative Potential of Cultured Gingival Fibroblast- Mesenchymal Stem Cells in Treatment of Periodontitis
clinical trial was conducted to evaluate regenerative potentials of cultured gingival fibroblasts and GMSCs carried in beta tri calcium phosphate scaffold into intrabony periodontal defects in human by clinical and radiographic…
- Trial name
- NCT03638154
- Testing
- GF+GMSCs carried on β TCP, β TCP bone substitute only
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periodontitis, Adult, Intrabony Periodontal Defect
The Flapless Approach in Periodontal Regeneration
The present investigation is designed in order to compare the radiographic and clinical effectiveness of flapless procedure performed alone or in combination with enamel matrix derivatives in the periodontal regenerative…
- Trial name
- NCT05456555
- Testing
- Flapless with Enamel Matrix Derivatives (EMD), Flapless without Enamel Matrix Derivatives (EMD)
- Where
- Italy
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Peri-implantitis
Surgical Protocol for Peri-implantitis Treatment
Peri-implant diseases are common post-restorative complications in implant rehabilitations and they occur with an incidence of 12-43%.
- Trial name
- NCT03801187
- Testing
- chlorhexidine, Er:YAG laser, Air-Powder
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Intrabony Periodontal Defect
Evaluation of Modified Minimally Invasive Surgical Technique and Platelet Rich Fibrin With or Without Vitamin Pool A and C for Management of Periodontal Intrabony Defects
This study aims to assess clinical and radiographic outcomes after the use of vitamins A and C with PRF versus PRF alone in the treatment of periodontal intrabony defect.
- Trial name
- NCT05499598
- Testing
- Experimental: Modified minimally invasive surgical technique with PRF and vitamins A and C, Modified minimally invasive surgical technique with PRF
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Regeneration of Alveolar Tissue After Maxillary Sinus Floor Augmentation
Smart Scaffolds, Stronger Smiles Smarter Healing: AI-Boosted Multiphasic Scaffold Design for PDL Regeneration
The periodontal ligament is vital for tooth support, and its loss, frequently resulting from periodontitis, trauma, or endodontic lesions, presents a significant clinical challenge; global cases of severe periodontitis increased…
- Trial name
- NCT07845006
- Testing
- AI algorithms generated a 3D multiphasic, graded lattice structure
- Where
- Egypt
- Volunteers
- 1 people
- Sponsor
- Misr University for Science and Technology