Clinical trials: Periodontal Disease
Orthodontic Appliance Complication, Plaque, Dental
Regular Home Use of Dual-light Photodynamic Therapy on Oral Health in Adolescents Undergoing Fixed Orthodontic Treatment
This study is designed to determine the efficacy of the Lumoral method on oral health in adolescents undergoing fixed orthodontic treatment.
- Conditions
- Orthodontic Appliance Complication, Plaque, Dental, Gingival Inflammation
- Trial name
- NCT05825742
- Testing
- Lumoral Treatment, Standard oral health instructions
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Koite Health Oy
Adult Periodontitis
Periocline as an Adjunct to Scaling and Root Planing for Adult Periodontitis
Periodontal disease (commonly called gum disease) is generally treated by deep cleaning of the root surfaces of the teeth. This is also called scaling and root planing.
- Trial name
- NCT00529555
- Testing
- minocycline HCl 2.1%, Scaling and root planing
- Where
- 10 sites in United States
- Volunteers
- 602 people
- Sponsor
- Sunstar Americas
Gingivitis
Evaluation of the Addition of an Interdental Cleaning Device to Manual Brushing on Gingival Health
This study evaluates the addition of an interdental cleaning device paired with a manual toothbrush compared to using a manual toothbrush only. Plaque removal, reduction of gingival bleeding and reduction of gingival inflammation.
- Trial name
- NCT02836223
- Testing
- Interdental cleaning device, Manual Tooth brush
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Water Pik, Inc.
Gingival Diseases
Clinical Study to Examine Brushing on Dental Implants
The efficacy of two dentifrices in controlling gingivitis and plaque in adults with implants
- Trial name
- NCT00762619
- Testing
- Fluoride, Triclosan, fluoride
- Where
- 2 sites in United States, Israel
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Plaque, Gingivitis
Study to Investigate Toothpaste on Antibacterial Effects in the Different Regions of the Mouth
The clinical study will examine the effects of brushing with randomly assigned test toothpaste on the bacteria on the dental plaque, tongue, cheek, gum surface, and in saliva
- Trial name
- NCT07458464
- Testing
- stannous fluoride toothpaste, 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste
- Where
- 2 sites in Thailand
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Diabetes Mellitus, Periodontal Diseases
Development of a Molecular Diagnosing Platform for Monitoring Oral Hygiene in Diabetic Patients
More than ninety percent of adults in Taiwan are suspected to carry periodontal disease, which causes bad breath, swollen and bleeding gums, plaque and even tooth loss.
- Trial name
- NCT03351530
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- General Biologicals Corporation
Oral Health Related Quality of Life (OHRQoL)
New Functional Ingredient for Oral Care
The goal of this clinical trial is to find new ingredients for oral care products that can improve gum health. We want to learn if new botanical blends can help reduce gum inflammation, strengthen the gum's natural barrier, and…
- Trial name
- NCT07771907
- Testing
- Botanical A, Botanical B
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Access Business Group
Alveolar Bone Loss, Periodontal Bone Loss
Pilot Study on MD05 in Comparison With Open Flap Debridement in Patients Undergoing Periodontal Surgery
The purpose of the study is to gain experience of safety and efficacy with MD05 in man in alveolar bone regeneration.
- Trial name
- NCT00519155
- Testing
- MD05 and open flap debridement, Open flap debridement
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- Scil Technology GmbH
Tooth Loss, Ceramic Implant
PMCF Study of CeraRoot Ceramic Implants One-piece: 3 Years Follow up
The main objective is to evaluate the success / failure rate of CeraRoot ceramic implants (one piece) during three year follow up.
- Trial name
- NCT04598776
- Where
- Spain
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- CeraRoot SL
Gingivitis
A Study to Evaluate the Effect of a Test (Sodium Bicarbonate) Toothpaste on the Oral Microbiome
The aim of this 12-week clinical study is to evaluate the effect of a toothpaste containing sodium bicarbonate over time on the oral microbiome and to explore its effect in comparison to a regular fluoride toothpaste in…
- Trial name
- NCT07273539
- Testing
- Sodium Bicarbonate Toothpaste, Sodium Fluoride Toothpaste
- Where
- United Kingdom
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- HALEON
Tooth Loss, Soft Tissue Deficiency
A Clinical Study to Investigate Collagen Matrix 10808 for Soft Tissue Volume Augmentation Around Single Implants
The objective of this study is to investigate the safety and the function of the collagen Matrix 10808 in humans and to compare it versus the standard therapy, the transplantation of the autologous connective tissue graft.
- Trial name
- NCT02356770
- Testing
- Collagen Matrix 10808, Connective tissue graft
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Geistlich Pharma AG
Tooth Loss
An Observational Study of the T3 Pro Dental Implant System
A prospective, observational, multicenter study where 60 patients needing implants in the maxilla or mandible will be enrolled. The patients will be restored with a final prosthesis no later than 4 months following implant…
- Trial name
- Spike (NCT05498662)
- Testing
- T3 Pro dental implant system
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ZimVie
Apical Periodontitis
A Study to Compare Various Root Canal Cleaning Devices Based on Cavitation,Ultrasonic and Conventional Methods.
The goal of this clinical trial is to compare the effectiveness of various root canal cleaning devices based on the principle of cavitation, ultrasonics, and conventional methods in a normal healthy adult population aged between…
- Trial name
- NCT06005545
- Testing
- Passive Ultrasonic Irrigation (PUI) group, Endoclean (EC) group, Conventional group
- Where
- Turkey (Türkiye)
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Lumendo AG
Periodontal Diseases, Intrabony Defects
A Clinical Trial to Evaluate the Safety and Effectiveness of Resorbable Collagen Membrane - MatrixflexTM
This is a randomized, single blind, parallel-arm, multi-center, non-inferior clinical trial. 174 patients are recruited in total, and they are treated by Guided Tissue Regeneration (GTR).
- Conditions
- Periodontal Diseases, Intrabony Defects, Guided Tissue Regeneration
- Trial name
- NCT04851847
- Testing
- Guided Tissue Regeneration (GTR)
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Collagen Matrix
Dental Plaque, Gingivitis
The Study to Evaluate the Plaque Control and Anti-Gingivitis Efficacy of a Toothpaste in Chinese Population
The aim of this study is to evaluate the efficacy of the test toothpaste compared to a regular fluoride toothpaste in the reducing gingivitis and plaque accumulation in Chinese participants with plaque-induced gingivitis.
- Trial name
- NCT07816406
- Testing
- Test Toothpaste, Regular Fluoride Toothpaste
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- HALEON
Tooth Loss
An RCT Comparing Xenograft and Allograft for Ridge Preservation
To compare the effectiveness of demineralized freeze-dried bone allograft + cross-linked collagen membrane with xenograft + non-cross-linked collagen membrane for posterior extraction socket ridge preservation.
- Trial name
- NCT02330523
- Testing
- allograft + x-link collagen membrane, xenograft + non-x-link collagen
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- McGuire Institute
Periodontal Disease
Periodontal Disease Treatment of a Physically Challenged Population
Many physically handicapped patients at the dental department, Toronto Rehabilitation Institute(TRI) have considerable gingival inflammation and breath odour because of the inability to effectively handle a toothbrush.
- Trial name
- PDT (NCT01718912)
- Testing
- metronidazole-nystatin oral rinse
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Oravital Inc
Periodontitis
A Phase2 Clinical Trial of Trafermin in Patients With Marginal Periodontitis in Japan
This study is designed to evaluate the efficacy and the safety of Trafermin(recombinant human basic fibroblast growth factor: rhbFGF) in Japanese patients with marginal periodontitis, in order to verify the superiority of…
- Trial name
- NCT00199290
- Testing
- Trafermin (genetical recombination)
- Where
- 23 sites in Japan
- Volunteers
- 267 people
- Sponsor
- Kaken Pharmaceutical
Dental Plaque, Gingivitis
A Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste With a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation
The aim of this study is to assess the ability of a marketed Cetylpyridinium Chloride (CPC) mouthwash alongside a marketed Stannous Fluoride (SnF2) toothpaste in improving gingival health and reducing plaque accumulation…
- Trial name
- NCT06660069
- Testing
- Stannous Fluoride Toothpaste (Parodontax Complete Protection Toothpaste), CPC Mouthwash (Parodontax Active Gum Health Mouthwash), Regular Fluoride Toothpaste (Crest Cavity Protection)
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- HALEON
Periodontal Diseases, Peri-Implantitis
Development of a Molecular Diagnosing Platform for Relieving Periodontal Symptoms
More than ninety percent of adults in Taiwan are suspected to carry periodontal disease, which causes bad breath, swollen and bleeding gums, plaque and even tooth loss.
- Trial name
- NCT03345329
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- General Biologicals Corporation