Clinical trials: Periodontal Disease
Edentulous Mouth, Quality of Life
Changes in Oral Health-related Quality of Life (OHRQoL) During Full Arch Implant Treatment
Full-arch implant-supported fixed dental prostheses are a widely accepted treatment for edentulous patients, with high long-term implant survival rates.
- Conditions
- Edentulous Mouth, Quality of Life, Tooth Loss, Oral Health Quality of Life (OHQoL) Was Assessed
- Trial name
- NCT07568249
- Testing
- Full Arch Implant Surgery, Full arch prosthesis
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Implantology Institute
Periodontitis
Periodontitis and Inflammation: Study on Biological Samples
Periodontitis is a major public health problem because it is widespread in the adult population. It leads to the irreversible destruction of the anchoring tissues of the teeth, and represents a modifiable risk factor for systemic…
- Trial name
- CB-PARO2 (NCT06012019)
- Testing
- Biological sampling in Periodontitis Case, Biological sampling in Gingivitis Case, Biological sampling in Control Case
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gingivitis, Periodontitis
Oral Health Care in Stroke Patients in Tertiary Care Hospital
To investigate oral care provision in stroke care settings in Pakistan. Stroke can have adverse effects on oral care and health. Little is known about current oral care practices in stroke care settings.
- Conditions
- Gingivitis, Periodontitis, Dental Hygiene
- Trial name
- NCT05114681
- Testing
- Assessment of Oral care as per patient personal choice
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Alveolar Bone Loss, Alveolar Ridge Augmentation
A Novel Approach for Horizontal Augmentation: A Split Box
The goal of this clinical study is to investigate the effectiveness of the split-box technique in systemically healthy, non-smoking, over 18 years of age, participants with narrow crests (<5mm bone width) and adequate bone height…
- Conditions
- Alveolar Bone Loss, Alveolar Ridge Augmentation, Augmentation, Alveolar Ridge
- Trial name
- NCT06177899
- Testing
- Splitting of bone and fixation of bone laminae differ between the 3 groups.
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Marmara University
Apical Periodontitis, Insulin Resistance
Serum Pro-Diabetes Inflammation Biomarkers in Patients With Apical Periodontitis.
Inflammation is a common factor of chronic periodontitis and diabetes. However, to date, there is no scientific evidence supporting a causal effect of the inflammation created by apical periodontitis on the onset of insulin…
- Conditions
- Apical Periodontitis, Insulin Resistance, PreDiabetes, Diabetes; Stable
- Trial name
- NCT04824209
- Where
- 2 sites in Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Chronic Periodontitis
Effect of Disinfective Solution as an Adjunct to Maintenance Therapy of Inflamed Periodontal Pockets
This study will determine whether the supplemental use of chemical pocket disinfection with scaling and root planing is more effective than scaling and root planing alone in clinically reducing periodontal probing depth (PD)…
- Trial name
- NCT02316652
- Testing
- Scaling and root planing, Scaling and root planing with solution
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Bone Resorption, Alveolar Bone Loss
Autogenous Bone Mixed With Xenograft Versus Xenograft Alone Versus Absorbent Gelatin Sponge
Alveolar bone atrophy post-extraction has been well documented in the past years. normal healing event results in a minimal loss of vertical height (around 1 mm), but a substantial loss of width in the buccal-lingual plane (4-6…
- Conditions
- Bone Resorption, Alveolar Bone Loss, Alveolar Bone Resorption, Bone Graft Failure
- Trial name
- NCT03584984
- Testing
- Mixture of Autogenous bone & Anorganic Bovine Bone (ABB), Anorganic Bovine Bone (ABB), Absorbable gelatin sponge
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Microbiome, Cytokines
Comparison of the Effects of Oral Hygiene Regimens on Clinical, Immunomodulatory, and Microbial Outcomes and Oral Tolerance in People With Gingivitis
This study is a six-week, double-blind, randomized, parallel-group controlled clinical study. The objective of this study is to evaluate the changes to the oral microbiome, inflammatory mediators, gingival health indices and to…
- Conditions
- Microbiome, Cytokines, Plaque, Gingivitis
- Trial name
- NCT07501455
- Testing
- Distilled Water, Marketed Comparator 1, Marketed Comparator 2
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Kenvue Brands LLC
Periodontal Diseases
Analysis of Gingival Crevicular Fluid
The purpose of this study was to investigate and compare GCF interleukin-1β (IL-1β), interleukin-10 (IL-10), interleukin-36γ (IL-36γ) levels in patients with healthy (H), gingivitis (G) and chronic periodontitis (CP) status.
- Trial name
- GCF (NCT05325905)
- Testing
- Gingival crevicular fluid sampling
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Social Phobia, Periodontal Diseases
Nonsurgical Periodontal Treatment in Patients With Social Phobia
Objective: To investigate the impact of nonsurgical periodontal treatment in patients with social anxiety disorder (SAD) and controls without phobia.
- Trial name
- NSPTSP (NCT03241277)
- Testing
- Non surgical periodontal treatment
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Gingival Recession
Evaluation of Two Types of Matrix (Mucograft® and Mucoderm®) Associated With Coronally Advanced Flap
The aim of this study is to evaluate clinically the results of two types of matrix (Geistlich Mucograft® and Mucoderm®) associated with CAF technique for the treatment of gingival recessions.
- Trial name
- NCT03667105
- Testing
- CAF, MC, XDM
- Where
- Brazil
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Dental Plaque, Gingivitis
A Clinical Study Investigating the Effect of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival Health
The aim of this 4-week clinical study is to evaluate the ability of an experimental toothpaste, containing 0.454 percent (%) Stannous Fluoride (SnF2), 0.3% Zinc Chloride (ZnCl2) and 1% Alumina, to improve gingival health and…
- Trial name
- NCT06602466
- Testing
- Test toothpaste, Colgate Cavity Protection Toothpaste
- Where
- United Kingdom
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- HALEON
Periodontitis
Periodontitis Severity and Associated Factors Among Egyptian Males and Females
This cross-sectional study aims to evaluate and compare the severity of periodontitis between a group of Egyptian males and females.
- Trial name
- NCT07721337
- Testing
- Clinical Periodontal Examination and Questionnaire
- Where
- Egypt
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Periodontal Diseases, Pregnancy Gingivitis
Stress and Gingival Inflammation in Non-pregnant and Pregnant Women
Background: The purpose of the present study is to research whether stress scale scores alter with relationship to gingival inflammation and examine the impact of non-surgical periodontal therapy during pregnancy on the levels of…
- Trial name
- NCT03336957
- Testing
- periodontal treatment
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Periodontal Diseases
The Effect of Periodontal Treatment on Psoriasis
There is a relationship between psoriasis and periodontal disease. This relationship may be double-sided.
- Trial name
- NCT03939936
- Testing
- Psoriatic measurements, Non-surgical periodontal treatment, saliva samples
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people
- Sponsor
- Ozge Gokturk
Ridge Preservation, Alveolar Bone Loss
Evaluation of Autogenous Demineralized Dentin Graft for Ridge Preservation With and Without Injectable Platelet Rich Fibrin
Ridge preservation should be considered whenever possible after tooth extraction. Whether implant placement would be performed or for aesthetic consideration at pontic sites when conventional bridge is planned.
- Conditions
- Ridge Preservation, Alveolar Bone Loss, Dentin Graft
- Trial name
- NCT05437172
- Testing
- injectable platelet rich fibrin with demineralized dentin graft, demineralized dentin graft
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis
Biomarkers for Periodontitis Relapse
In this clinical study, we have collected GCF at diseased teeth and at the same time drawn blood, both before and at 3, 6 and 12 months after periodontal surgical treatment.
- Trial name
- NCT04663165
- Testing
- Periodontal surgery, Regenerative periodontal surgery
- Where
- 2 sites in Sweden
- Volunteers
- 21 people
- Sponsor
- Anders Holmlund
Periodontal Bone Loss, Periodontal Pocket
Locally Injected Vit D as a Non-surgical Modality for Periodontal Regeneration of Infrabony Defects
vitamin D has great role in bone regenration and soft tissue health. in the past periodontal regeneration was performed using bone graft and barrier membrane
- Trial name
- NCT03716765
- Testing
- locally injected vitamin D
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Attachment Loss
Oral Infections: Dietary Regulation of Local and Systemic Inflammatory Responses
The purpose of this study is to test the hypothesis that dietary n-3 PUFA will have a beneficial effect on systemic and local markers of inflammation when combined with traditional, non-surgical periodontal therapy.
- Trial name
- NCT00632957
- Testing
- Omega-3 Fatty acid (with SRP or OHI)
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Peri-Implantitis, Occlusal Trauma
All on Six Versus Parallel Implant Distribution for Maxillary Denture Opposing Mandibular All on Four
Thirty maxillary edentulous patients with previous mandibular All-on-4 screw retained prosthesis and their age ranged from 55 to 65 years were selected from the outpatient clinic, of prosthodontics Department, Faculty of…
- Conditions
- Peri-Implantitis, Occlusal Trauma, Implant Complication
- Trial name
- ASPISRMSDOMF (NCT05960500)
- Testing
- implant
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mansoura University