Clinical trials: Periodontal Disease Stage 2
Periodontitis Stage II, Periodontitis Stage III
Development and Validation of the Periodontal Map Derived From IOS and CBCT Registration for Diagnosis and Treatment Planning in Moderate-to-severe Periodontitis
This prospective diagnostic study aims to validate the clinical utility of a "Periodontal Panoramic Map" generated by the PerioAI V2.0 system, an artificial intelligence-based platform that integrates intraoral scans and…
- Conditions
- Periodontitis Stage II, Periodontitis Stage III, Periodontitis Stage IV
- Trial name
- NCT07505251
- Testing
- Perio AI V2.0 System
- Volunteers
- 80 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Uncontrolled Type 2 Diabetes Mellitus, Severe Periodontitis
A Comparison of Single-Stage Full-Mouth Disinfection With Quadrant-Based Scaling and Root Planing in Patients With Uncontrolled Type 2 Diabetes and Severe Periodontitis: An Assessment of Its Impact on Quality of Life
This study evaluated the effects of a single-stage full mouth disinfection (FMD) protocol versus a quadrant-based tooth surface cleaning and root planing (Q-SRP) protocol on changes in clinical periodontal parameters over a…
- Trial name
- NCT07598071
- Testing
- Quadrant based scaling and root planning, full mouth disinfeciton
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Pamukkale University
Stage II Grade B Periodontitis
Active Oxygen Gel vs Chlorhexidine Gel in Stage II Grade B Periodontitis
This randomized controlled clinical trial will evaluate the effectiveness of locally delivered active oxygen gel and chlorhexidine gel as adjuncts to scaling and root planing in the treatment of stage II grade B…
- Trial name
- NCT07840716
- Testing
- Active oxygen gel, Chlorhexidine gel
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Periodontal Pocket, Periodontitis
PRF Therapy for Pocket Reduction
Periodontal regenerative therapy has focused on various non-surgical and surgical treatment methods. Platelet-rich fibrin (PRF) has shown to possess multiple uses, including properties that promote healing of both soft and hard…
- Trial name
- NCT05908929
- Testing
- SRP and concomitant insertion of PRF membrane, SRP
- Where
- 2 sites in Italy
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Federico II University
Periodontitis, Diabetes
Local Delivery of Lactobacillus Reuteri Probiotic as An Adjunct to Non-surgical Periodontal Therapy in Patients With Stage II, III, and IV Periodontitis and Type 2 Diabetes Mellitus
The purpose of the study is to evaluate the effectiveness of local delivery of Lactobacillus reuteri probiotic on periodontitis patients with type 2 diabetes mellitus, as an adjunct to non-surgical periodontal treatment.
- Trial name
- NCT07598656
- Testing
- Lactobacillus reuteri DSM 17938, Distilled water
- Where
- Malaysia
- Volunteers
- 14 people
- Sponsor
- Mahsa University
Periodontitis
A Phase2 Clinical Trial of Trafermin in Patients With Marginal Periodontitis in Japan
This study is designed to evaluate the efficacy and the safety of Trafermin(recombinant human basic fibroblast growth factor: rhbFGF) in Japanese patients with marginal periodontitis, in order to verify the superiority of…
- Trial name
- NCT00199290
- Testing
- Trafermin (genetical recombination)
- Where
- 23 sites in Japan
- Volunteers
- 267 people
- Sponsor
- Kaken Pharmaceutical
Periodontitis
Impact of E-Cigarette Smoking on Healing Response to Non-Surgical Periodontal Therapy
the goal of this clinical trial is to compare the effect of vaping vs traditional smoking on non surgical periodontal therapy . the main question it aims to answer is what is the impact of traditional smoking and vaping on…
- Trial name
- NCT07668947
- Testing
- non surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 117 people
- Sponsor
- Ain Shams University
Periodontitis
''Efficacy of Locally Delivered Hyaluronic Acid Gel as an Adjunctive to Non-Surgical Management of Periodontitis
Hyaluronic Acid (HA) is an addition to the local chemotherapeutic agents. Hyaluronic acid was discovered by Meyer and Palmer. HA is widely found in the extracellular matrix and it plays an essential role in controlling cell…
- Trial name
- NCT05834517
- Testing
- Hyaluronic acid, non surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Ehab Haider Hassan El-emam
Periodontitis Stage II, Periodontitis Stage III
3-Month Clinical Trial of Liquid S-PRF in Periodontal Debridement for Periodontitis Stages II-IV
What is the purpose of this study? This study is to investigate the effect of a processed blood product in healing after treatment for gum disease.
- Conditions
- Periodontitis Stage II, Periodontitis Stage III, Periodontitis (Stage 3), Periodontitis
- Trial name
- NCT07293962
- Testing
- Normal saline irrigation, Platelet rich fibrin
- Where
- Malaysia
- Volunteers
- 14 people
- Sponsor
- Mahsa University
Periodontal Health, Periodontitis Stage III
EVALUATION OF SALIVA AND SERUM HEME OXYGENASE, ARYLESTERASE AND NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2 LEVELS IN PATIENTS WITH STAGE III PERIODONTITIS
Periodontal disease is a chronic and progressive inflammatory disease in which the hard and soft tissues that support the teeth are damaged.
- Trial name
- NCT06986044
- Testing
- Serum Total Oxidant Status, Salivary Total Oxidant Status, Serum Total Antioxidant Status
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Periodontal Disease Stage 2, Peri-Implantitis and Peri-implant Mucositis
Evaluation of Hydrogel Application in the Treatment of Periodontitis and Peri-implantitis
To date, systemic/local antibiotics, antimicrobials, laser application, and probiotics have been used as adjuncts to improve the outcome of non-surgical periodontal treatment for both periodontitis and peri-implantitis patients.
- Conditions
- Periodontal Disease Stage 2, Peri-Implantitis and Peri-implant Mucositis, Periodontal Regeneration
- Trial name
- NCT06740123
- Testing
- Nonsurgical periodontal treatment and application of H42® hydrogel to the peri-implant pocket, Nonsurgical periodontal treatment of periodontal pocket, Non-surgical periodontal treatment and application of H42® hydrogel to the periodontal pocket
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Kutahya Health Sciences University
Periodontitis, Type 2 Diabetes
Salivary C1P and PGE2 Levels in Periodontitis Patients With T2DM and Effect of Non-Surgical Periodontal Treatment
Diabetes and periodontal disease are the most common chronic multifactorial and inflammatory diseases in humans, and there is a bidirectional relationship between type 2 diabetes and periodontitis.
- Trial name
- NCT05454059
- Testing
- Non-surgical periodontal treatment, ELISA Test, Periodontal Examination
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Type 2 Diabetes Mellitus
Prolactin Levels in Type 2 Diabetic Patients With Stage III Periodontitis
evaluate the role of prolactin hormone in the pathogenesis of periodontitis by assessing its local gingival levels and assess clinical parameters in patients who have type two diabetes
- Trial name
- prolactin (NCT06941246)
- Testing
- Non Surgical Periodontal Treatment, paper points, ELISA Kits
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Periodontitis
Evaluation of iPRF With Vitamin C in StageII Grade A Periodontitis
Comparing the effect of using vitamin C with injectable PRF as a locally delivered adjunct to scaling and root planing versus scaling and root planing with local delivery of injectable PRF and scaling and root planing alone on…
- Trial name
- NCT05129267
- Testing
- Group B, Group C
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Cairo University
Periodontitis, Hypertension
Effect of Non-surgical Periodontal Therapy in Hypertensive Patients With Assessment of Endocan and TNF-α Levels in GCF
There is a strong crossway relationship between periodontitis and hypertension. Hypertension is the most prevalent of cardiovascular diseases and its prevalence is increased by the presence of periodontitis.
- Conditions
- Periodontitis, Hypertension, TNF Alpha, Endocan
- Trial name
- NCT06627192
- Testing
- NSPT, clinical and biochemical assesment
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Periodontal Diseases
Clinical and Microbiological Evaluation of Laser Assisted New Attachment Procedure (LANAP) Using Nd:Yag vs. Diode Laser in the Management Of Stage II Periodontitis
The aim of the present study is to compare the efficacy of LANAP to conventional scaling and root planing in the management of stage II periodontitis.
- Trial name
- NCT06358937
- Testing
- Laser Assisted New Attachment Procedure using ND:YAG laser, Laser Assisted New Attachment Procedure using diode laser, Scaling and Root Planing using ultrasonic and curettes
- Where
- Egypt
- Volunteers
- 27 people
- Sponsor
- Mahmoud Salem
Periodontal Disease, Periodontitis
Assessment of Ozonated Sunflower Seed Oil Gel as an Adjunctive Therapy to Mechanical Debridement in the Treatment of Stage II Grade B Periodontitis
I) Patients: The present study will be carried on periodontitis patients. The patients will be informed about the treatment steps.
- Conditions
- Periodontal Disease, Periodontitis, Periodontitis Stage II
- Trial name
- NCT07636993
- Testing
- Mechanical debridement ., sun flower, ozonated sun flower
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Periodontitis
Novel Bone Substitute (ALBO-OS) in Patients With Periodontal Disease or Who Need Alveolar Preservation
The recent Global Burden of Disease Study indicates that severe periodontitis is the 6th most prevalent disease worldwide, with an overall prevalence of 11.2% and around 743 million people affected, and the global burden of…
- Trial name
- NCT07500961
- Testing
- Albo Os
- Where
- Bosnia and Herzegovina
- Volunteers
- 20 people
- Sponsor
- Albos d.o.o. Beograd
Periodontal Diseases
Oral and Systemic Levels of TFF-1 and TTF-3 in Periodontal Diseases
Trefoil factor family (TFF) consists of a group of small peptides that have key roles in host immune response and repair of tissue damage. Interleukin (IL)-1β is a regulatory proinflammatory cytokine in periodontal inflammation.
- Trial name
- NCT04407026
- Testing
- biofluids
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Aydin Adnan Menderes University
Periodontitis, Periodontal Diseases
Accuracy of an AI-clinical Knowledge-based Hybrid System for Detecting Periodontitis in OPG Images
Periodontitis is highly prevalent and rarely detected and treated in the earlier stages of the disease. Orthopantomography (OPG) is the most frequently taken dental radiograph around the world, and its systematic screening may…
- Trial name
- NCT06306677
- Testing
- AI-clincial-based hybrid system for radiographic image analysis
- Where
- 3 sites in China, Hong Kong and 1 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University