Clinical trials: Periodontal Diseases Inflammation
Gingival Inflammation
Evaluation Of Zirconia Crowns Restoring Endodontically Treated Posterior Teeth With Two Finish Line Designs And Occlusal Reduction Schemes
The aim of this study is to evaluate the clinical performance of two finish line designs (feather edge and rounded shoulder) in relation with two occlusal designs (flat and planar) in endodontically treated teeth restored with…
- Trial name
- NCT04052490
- Testing
- Abutment with flat occlusal reduction with feather edge finish
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis, Bruxism
Impact of Subgingival Instrumentation on Jaw Symptoms of Probable Bruxers Among Patients With Periodontitis
This study aims to explore the mechanisms by which periodontal disease affects the bruxers and to assess the impact of subgingival instrumentation on jaw symptoms of probable bruxers among patients with periodontitis .
- Trial name
- NCT06429917
- Testing
- Subgingival instrumentation
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis, Endodontic Inflammation
Endo-perio Lesion's Treatment With Using Diode Laser 940nm
Periodontal marginal and periapical diseases cause a huge destruction of tissues surrounding the tooth with periodontal patients.
- Trial name
- NCT04628845
- Testing
- Endo-perio therapy with laser 940nm, Endo-perio therapy without laser 940nm
- Where
- 3 sites in Poland
- Volunteers
- 20 people
- Sponsor
- Pomeranian Medical University Szczecin
Peri-Implantitis
SPiT-frequency; the Effect of Increased Frequency of Intervention on Post-surgical Peri-implant Inflammation
This pilot study is an interventional clinical study on the supportive peri-implant treatment (SPiT) necessary to maintain/ improve the clinical conditions surrounding a dental implant following surgical treatment of…
- Trial name
- SPiT-freqvzy (NCT04705012)
- Testing
- Submucosal supportive therapy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Gingival Inflammation
Lactobacillus Reuteri Strains for Gingivitis Reduction
The aim of the present study was to investigate the potential beneficial effects in volunteer young adults of orally administered L. reuteri (DSM 17938 and ATCC PTA 5289) on gingival inflammation.
- Trial name
- NCT06234839
- Testing
- L. reuteri (DSM 17938 and ATCC PTA 5289) in form of oral tablets
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Periodontitis, Obesity (Body Mass Index >30 kg/m2)
Obesity and Clinical and Cytokine Responses to Periodontal Therapy
This prospective controlled clinical study included 80 participants allocated into four groups according to body mass index (BMI) and periodontal status: obese periodontitis, normal-weight periodontitis, obese periodontally…
- Trial name
- NCT07869277
- Testing
- Scaling and Root Planing (SRP)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emine Çifcibaşı
COPD Exacerbation, Periodontal Health
Efficacy of Periodontal Treatment on Systemic Inflammation and for Prevention of Exacerbations in Patients With COPD
Current data are showing a potential link between inflammatory biomarkers in chronic periodontitis and COPD. However the impact of periodontal treatment on systemic inflammation as measured by biomarkers and time to occurrence of…
- Trial name
- Expertention (NCT03279718)
- Testing
- Periodontal Treatment
- Where
- 3 sites in Germany
- Volunteers
- 4 people
- Sponsor
- Heidelberg University
Peri-Implantitis and Systemic Inflammation
Peri-implantitis and Systemic Inflammation
To investigate the effects of peri-implantitis (a disease around dental implants) and its treatment at both local and systemic levels using clinical and biological parameters.
- Trial name
- LASSO (NCT05964127)
- Testing
- Air flow device, Hand instruments, Access flap surgery
- Where
- United Kingdom
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Eastman Dental Insitute and Hospital
Gingival Inflammation, Dental Plaque Accumulation
Evaluation of the Anti-plaque Effect of a Bioflavonoid-based Antiseptic Mouthwash
This study evaluates the antiplaque efficacy of a bioflavonoid-based mouthwash compared to a positive control (0.12% chlorhexidine mouthwash).
- Trial name
- NCT07824388
- Testing
- Bioflavonoid mouthwash, Chlorhexidine 0.12% mouthwash
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Gingival Inflammation and Loss the Orthodontic Mini-screws
Strontium-Hydroxyapatite Coated Mini-Screws: Antibacterial Effect and Stability
This randomized controlled clinical trial aims to evaluate the antibacterial efficacy and stability of strontium-incorporated hydroxyapatite (Sr-HA) coated orthodontic mini-screws (OMSs) used for maxillary canine retraction.
- Trial name
- NCT07105969
- Testing
- Strontium Incorporated Hydroxyapatite [Sr-HA] coated mini-screws purchased from Dentarum company
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Periodontitis, Adult, Inflammation Gum
Effect of Local Cannabidiol on Clinical and Inflammatory Outcomes in Periodontal Maintenance Patients.
This study will determine if cannabidiol (CBD) has any effect on local inflammation in periodontal maintenance patients. Many successful therapies exist for the active, untreated periodontal patient.
- Trial name
- NCT05646459
- Testing
- cannabidiol, floss, proxabrush
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Gingivitis, Dental Plaque
MicroRepair® ABX vs Chlorhexidine 0.12% in Gingivitis Patients
This randomized controlled clinical trial is designed to compare the adjunctive effects of two mouthwashes used after professional biofilm removal in patients with generalized plaque-induced gingivitis, a reversible inflammatory…
- Conditions
- Gingivitis, Dental Plaque, Gingival Inflammation
- Trial name
- GEM-CHX012 (NCT07088653)
- Testing
- MicroRepair ABX mouthwash, Chlorhexidine 0.12% mouthwash
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Periodontal Inflammation
Saliva Levels of S100A12, CRP, Fetuin-A in Periodontal Disease Patients
Hs-CRP, Fetuin-A and S100A12 are acute phase proteins associated with many systemic diseases and conditions. The aim of this study was to determine the clinical parameters and salivary Hs-CRP, Fetuin-A and S100A12 levels before…
- Trial name
- NCT03345745
- Testing
- salivary samples
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ordu University
Good Health, Gingival Inflammation and Bleeding
Oil Pulling Reduction
The goal of this study is to scientifically evaluate the efficacy of this oil pulling oral rinse in reducing dental plaque, gingival inflammation, gingival bleeding, and selectively reducing caries- and periodontal…
- Conditions
- Good Health, Gingival Inflammation and Bleeding, Dental Plaque
- Trial name
- NCT07706647
- Testing
- GuruNanda natural Oil Pulling oral rinse, TheraBreath Plaque Control Oral Rinse, GuruNanda water-based non-whitening mouthwash
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Allostatic Load, Periodontitis, Chronic
Impact of Periodontal Inflammation on Allostatic Load
Periodontitis is a prevalent global health issue that contributes to systemic inflammation and is closely linked to stress as a risk factor. Both conditions have been investigated for bidirectional relationship.
- Trial name
- NCT06978712
- Testing
- Sub-gingival instrumentation
- Where
- India
- Volunteers
- 112 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Gingivitis
Effectiveness of the Use of Dental Floss
Bacterial plaque-induced gingivitis is considered the most common oral disease in dentate individuals and the most frequent type of periodontal disease.
- Trial name
- NCT04909840
- Testing
- Instructions oral hygiene with toothbrush plus dental floss, Instructions oral hygiene with toothbrush only
- Where
- Brazil
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Maria
Periodontal Diseases, Periodontitis
Interaction Between Immune Cells and Bacteria Associated With Periodontitis
This study evaluates the interaction between host immune cells and bacteria associated with periodontitis. It comprises biological material from donors with and without periodontal disease.
- Conditions
- Periodontal Diseases, Periodontitis, Aggressive Periodontitis, Immunologic Disease
- Trial name
- NCT03225950
- Testing
- In vitro stimulation of blood with periodontitis-associated- and control bacteria, Anti-CCP- and anti-P.g.-antibodies titers, Analysis of selected single nucleotide polymorphisms (SNPs)
- Where
- 2 sites in Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Cleft Lip and Palate, Periodontal Pocket
Periodontal Changes Following Mid Maxillary Distraction
To evaluate the health status of the periodontium and dentition at the distraction osteogenesis site in CLP subjects using mid maxillary distraction (MMD).
- Conditions
- Cleft Lip and Palate, Periodontal Pocket, Attachment Loss, Periodontal
- Trial name
- NCT03686761
- Testing
- A Involvement with the osteotomy site of the surgery
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alexandria
Periodontal Diseases, Inflammation
Annexin Levels of Periodontal Inflammatory Regulation
ANXA1, a member of the annexin family, plays a role in the resolution of inflammation and the regulation of anti-inflammatory responses, while ANXA2 is involved in the initiation of the inflammatory responses.
- Trial name
- NCT06554756
- Testing
- Saliva, serum and GCF sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medipol University
Tooth Abrasion, Gingival Recessions
The Effect of Retraction Cord on the Surrounding Periodontal Tissues in Restorative Treatment
The goal of this clinical trial is to learn whether a retraction cord affects gum health when used during tooth restoration procedures.
- Conditions
- Tooth Abrasion, Gingival Recessions, Non-Carious Cervical Lesions (NCCLs), Periodontal Health
- Trial name
- NCT07734935
- Testing
- Gingival Retraction Cord, Composite Resin Restorative, Universal Adhesive - G-Premio Bond
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Istanbul University