Clinical trials: Periodontal Diseases Inflammation
Inflammation Gum, Cardiac Surgery
Impact of Teeth Extraction on Inflammation Marker's Levels in Patients Who Undergoing Cardiac Surgery
The aim of this study is to examine effects of dental treatments, surgical (extractions) and non-surgical procedures (non-surgical periodontal therapy), on serum levels for PCR, WBCs and PCT in patients needing a dental…
- Trial name
- NCT04626011
- Testing
- Tooth extractions
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- University of Trieste
Gingivitis and Periodontal Diseases, Gingivitis; Chronic
Guided Biofilm Therapy Compared to Traditional Cleaning for Treating Gingival Inflammation in Orthodontic Patients
Why is this study being done? This study is for people with braces who have gum inflammation (gingivitis), which is when gums are swollen and bleed easily.
- Conditions
- Gingivitis and Periodontal Diseases, Gingivitis; Chronic, Gingivitis, Gingival Bleeding
- Trial name
- NCT07355517
- Testing
- Guided Biofilm Therapy, Traditional Ultrasonic Scaling + Polishing
- Where
- Jordan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Peri-Implantitis
HIF-1 Alpha, VEGF and MMP-8 Levels in PICF of Smokers Versus Non Smokers
Smoking is a major risk factor for developing peri-implantitis so the current study is comparing inflammatory markers in smokers versus non smokers to know if they have a potential role in pathogenesis of peri-implantitis
- Trial name
- NCT05325918
- Where
- Egypt
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Bacteremia, Periodontal Diseases
Bacteremia From Periodontal Treatment to Elucidate the Underpinnings of Sepsis
Approximately 40,000 Swedes suffer from sepsiseach year, about 20% die. Biomarkers that are sensitive to current or previous bacteremia are needed in the treatment of sepsis.
- Conditions
- Bacteremia, Periodontal Diseases, Sepsis, Heart Diseases
- Trial name
- NCT04565691
- Testing
- Non-surgical periodontal treatment
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Malmö University
HIV, Periodontal Diseases
The Impact of Oral Health in HIV Patients on Antiretroviral Therapy
This is a prospective cohort study designed to investigate the range of metabolic abnormalities observed in patients living with HIV on antiretroviral therapy.
- Conditions
- HIV, Periodontal Diseases, Caries, Non-communicable Disease
- Trial name
- OHART (NCT04645693)
- Where
- United States
- Volunteers
- 227 people
- Sponsor
- University of Pennsylvania
Gingivitis, Periodontitis
Is Professional Tooth Cleaning Necessary for Managing Gingivitis (Gingival Inflammation) if Subjects Use Intelligent Toothbrushes?
Periodontitis is highly prevalent and develops from plaque-induced gingivitis. Managing gingivitis is key to preventing periodontitis and its complications.
- Trial name
- NCT07549347
- Testing
- Optimal oral care regimen, Periodontal Treatment
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Polycystic Ovary Syndrome, Inflammation Gum
Endocan Levels at Polycystic Ovary Syndrome and Periodontal Inflammation
Periodontal diseases are chronic inflammatory disease occurred by the interaction between pathogenic microorganism and the host defense.
- Conditions
- Polycystic Ovary Syndrome, Inflammation Gum, Cytokines
- Trial name
- NCT03264846
- Testing
- Collection of Serum and Saliva Samples
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Ebru Saglam
HİDRADENİTİS SUPPURATİVA
Periodontal Status and Disease Severity in Hidradenitis Suppurativa Patients
This cross-sectional study aims to evaluate the periodontal status of individuals diagnosed with hidradenitis suppurativa (HS) and to compare them with systemically healthy controls.
- Trial name
- NCT07294456
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Gingivitis
Nitrate Consumption and Gingival Inflammation
The aim of this investigation is to evaluate the impact of the 14- day consumption of a nitrate-rich diet on the the extent of gingival inflammation in a cohort of periodontal aftercare patients.
- Trial name
- NITGIN14 (NCT05866341)
- Testing
- nitrate-rich lettuce juice, nitrate-depleted lettuce juice
- Volunteers
- 44 people
- Sponsor
- Wuerzburg University Hospital
Periodontitis, Periodontal Inflammation
DNI Values After Periodontal Treatment
The study included 70 systemically healthy individuals, as a test group of 35 patients with Stage 3, Grade A periodontitis and a control group of 35 individuals with no periodontal disease.
- Conditions
- Periodontitis, Periodontal Inflammation, Inflammatory Response
- Trial name
- NCT05666622
- Testing
- Only routine non-surgical periodontal treatment was applied to the patients.
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Gingivitis
Efficacy of a Naturally-derived Mouthrinse for Gingival Inflammation
Gingivitis, defined as inflammation of the gingival tissues, has long been associated with bacterial accumulation [plaque] on the tooth surface adjacent to the gingiva, causing an inflammatory reaction.
- Trial name
- NCT00885599
- Testing
- Herbal API, Cepacol, Listerine Antiseptic Mouth Rinse
- Where
- Israel
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Gingival Recession, Gingival Diseases
Biofiller and Gingival Phenotype Thickening
The periodontal phenotype is defined as the combination of the gingival phenotype and the thickness of the buccal bone plate (bone morphotype).
- Conditions
- Gingival Recession, Gingival Diseases, Gingival Inflammation
- Trial name
- NCT07104019
- Testing
- Biofiller Injection, connective tissue graft
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Inonu University
Gingival Inflammation
Efficacy of Eco-Friendly Toothpaste Tablets Versus Conventional Toothpaste Using PI and GI Index
Objectives: To assess the change in gingival index (GI) and plaque index (PI) when comparing the use of toothpaste tablets to conventional toothpaste.
- Trial name
- NCT05805865
- Testing
- Toothpaste Tablet, Conventional Toothpaste
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Periodontitis
Biomarkers for Periodontitis Relapse
In this clinical study, we have collected GCF at diseased teeth and at the same time drawn blood, both before and at 3, 6 and 12 months after periodontal surgical treatment.
- Trial name
- NCT04663165
- Testing
- Periodontal surgery, Regenerative periodontal surgery
- Where
- 2 sites in Sweden
- Volunteers
- 21 people
- Sponsor
- Anders Holmlund
Gingivitis, Periodontitis
Circadian Clock Gene Expression in Periodontal Disease
This observational study aims to investigate whether periodontal inflammation is associated with alterations in the expression of circadian clock-related genes and proteins in gingival tissues.
- Trial name
- PERIOCLOCK (NCT07452783)
- Testing
- Gingival Tissue Biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Inonu University
Periodontitis, Inflammation
Evaluation of Trimethylamine N-oxide (TMAO) Levels in Periodontal Disease
Salivary and serum levels of TMAO and TNF-α can distinguish between individuals with periodontitis and periodontally healthy individuals.
- Conditions
- Periodontitis, Inflammation, Trimethylamine N-oxide (TMAO), TNF-alfa
- Trial name
- TMAO (NCT06906510)
- Testing
- Salivary and Serum TMAO Mesurement, Salivary and Serum TNF-α Mesurement
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ankara Medipol University
Periodontal Diseases, Periodontal Pocket
Thyme Honey Mouthwash in Management of Periodontitis in Renal Patients
There is a known correlation between oral health and systemic disease. Particularly significant evidences associate periodontal bacteria and tooth loss to systemic disorders and specifically to cardiovascular disease, such as…
- Conditions
- Periodontal Diseases, Periodontal Pocket, Periodontal Attachment Loss, Periodontal Inflammation
- Trial name
- NCT06129097
- Testing
- Thyme honey mouthwash
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- British University In Egypt
Gingivitis and Periodontal Diseases
Evaluation of Toothbrush Bristles
The goal of this randomized clinical trial is to investigate two different types of toothbrush bristles. The main questions it aims to answer are the effects of two different bristle types on: how much plaque is on the teeth how…
- Trial name
- NCT07306026
- Testing
- Toothbrush with tapered bristles, Toothbrush with end-rounded bristles
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Periodontal Inflammation, Periodontal Diseases
The Role of Diet in Periodontal Inflammation: A Controlled Clinical Study
Diet can influence the body's healing and repair mechanisms. A dietary imbalance obviously cannot trigger periodontal disease in the absence of a primum movens, which is bacterial plaque.
- Trial name
- NCT05864768
- Testing
- Vegan/vegetarian diet, Omnivorous diet
- Where
- Italy
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Periodontal Diseases, IBD
Periodontal Therapy on the Gut Microbiome of Inflammatory Bowel Disease
Periodontitis and inflammatory bowel disease have been associated by meta-epidemiologic evidence, although their mechanistic connection needs to be further explored.
- Conditions
- Periodontal Diseases, IBD, Dysbiosis, Inflammation
- Trial name
- NCT04790825
- Testing
- Full mouth scaling and root planing (FMSRP)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Turin, Italy