Clinical trials: Periodontal Intrabony Defects
Periodontitis, Intrabony Periodontal Defect
MIST Versus M-MIST for the Treatment of Intrabony Defects
This is a 12-month longitudinal, double-blind, parallel-design randomized controlled clinical trial involving surgical therapeutic intervention (Phase 4).
- Conditions
- Periodontitis, Intrabony Periodontal Defect, Periodontitis, Chronic
- Trial name
- NCT06058923
- Testing
- M-MIST, MIST
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Periodontal Diseases
Treatment of Periodontal Intrabony Defects With A-PRF or OFD
The aim of this randomized clinical trial was to clinically evaluate and compare the healing of intrabony defects after treatment with advanced platelet-rich fibrin (A-PRF+) toped flap debridement (OFD) in periodontitis patients.
- Trial name
- NCT04823572
- Testing
- A-PRF/OFD
- Where
- Hungary
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Bony Defects, Periodontal Disease
Minimally Invasive Non-Surgical Periodontal Therapy Alone vs. Minimally Invasive Non-Surgical Periodontal Therapy With I-PRF With or Without Chlorhexidine on Stage III Periodontitis Patients
This study aims to assess the effect of chlorhexidine augmented I-PRF together with MINST and I-PRF alone with MINST versus MINST alone in the treatment of stage III periodontitis patients.
- Trial name
- MINST (NCT07791238)
- Testing
- Minimally Invasive Nonsurgical Therapy, Injectable Platelet-Rich Fibrin, Chlorhexidine 2%
- Volunteers
- 63 people
- Sponsor
- Cairo University
Periodontitis
Minimally-invasive Non-surgical and Surgical Periodontitis Treatment
To compare the efficacy of a modified minimally-invasive non-surgical periodontal therapy (MINST) approach with a surgical approach (M-MIST) in determining bone and clinical attachment changes in intrabony defects
- Trial name
- NCT03797807
- Testing
- MINST, MIST, GTI subgroup (Geometrical/Thermal Imaging)
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Chronic Periodontitis
Comparison of Autologous PRF, 1% Alendronate and 1.2% Atorvastatin Gel in Chronic Periodontitis Treatment
The present study is designed as a single-centre, randomized, controlled clinical trial to evaluate and compare the clinical efficacy of autologous PRF, 1% alendronate (ALN) and 1.2% atorvastatin (ATV) gel placement with open…
- Trial name
- NCT02516111
- Testing
- Open flap debridement (OFD), OFD with PRF, OFD with ALN
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Periodontal Intrabony Defects, Stage III Grade B Periodontitis
Sub-junctional Pinhole Technique
Pinhole Regenerative Therapy (PRT) following minimally invasive non-surgical periodontal therapy (MINST) in the treatment of intrabony defects associated with Stage III Grade B periodontitis.
- Trial name
- PRT (NCT07763223)
- Testing
- Sub-junctional Pinhole Technique (S-PHT)
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Chronic Periodontitis
Nanocrystalline Hydroxyapatite Bone Substitute for Treating Periodontal Intrabony Defects
The present clinical trial included 20 patients (11 females and 9 males, aged 36 to 56 years) suffering from moderate or advanced chronic periodontitis.
- Trial name
- NCT04643288
- Testing
- open flap debridement, n-HA bone graft
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Weam Ahmed Elbattawy
Periodontal Diseases
Autologous Platelet Concentrate (APC) in Intrabony Defects
The aim of this 12-month clinical study is to treat patients affected by gum disease (periodontitis) by a minor gum surgery that aims to reduce the depth of the gum pockets.
- Trial name
- NCT04254861
- Testing
- Simplified Papilla Preservation Flap (SPPF) and PRGF ENDORET (PRGF ENDORET®-KMU16), Simplified Papilla Preservation Flap (SPPF) and GTR
- Where
- United Kingdom
- Volunteers
- 74 people
- Sponsor
- Queen Mary University of London
Intrabony Periodontal Defect
Efficacy of Titanium Granules in the Treatment of Periodontal Intrabony Defects
The ideal goal of the periodontal treatment is not only to prevent the progression of the disease, but also the regeneration and reconstruction of lost tissues.
- Trial name
- NCT04932161
- Testing
- Titanium Granules, Hydroxyapatite
- Where
- India
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- SVS Institute of Dental Sciences
Periodontitis, Intrabony Periodontal Defect
C-PRF With Minimally Invasive Non-Surgical Periodontal Therapy
This randomized controlled clinical study evaluated whether concentrated platelet-rich fibrin (C-PRF) provides additional clinical and radiographic benefits when used together with minimally invasive non-surgical periodontal…
- Conditions
- Periodontitis, Intrabony Periodontal Defect, Non Surgical Periodontal Treatment
- Trial name
- NCT07696845
- Testing
- Minimally Invasive Non-Surgical Treatment, Concentrated Platelet-Rich Fibrin
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Altinbas University
Periodontal Bone Loss
Erythropoietin Gel as an Adjunct to Xenograft in the Surgical Management of Intrabony Periodontal Defects
The aim of the study is to evaluate the use of erythropoietin gel as an adjunct to xenograft in the surgical management of intrabony periodontal defects.
- Trial name
- NCT05360511
- Testing
- particulate xenograft + erythropoietin gel., particulate xenograft
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Simvastatin, Photodynamic Therapy
Treatment of Intrabony Defects With Simvastatin and Antimicrobial Photodynamic Therapy
Antimicrobial photodynamic therapy (aPDT) is characterized by the association of photosensitizing agents, promoting the generation of reactive oxygen species like free radicals and singlet oxygen, which are cytotoxic to certain…
- Conditions
- Simvastatin, Photodynamic Therapy, Periodontal Diseases
- Trial name
- NCT05031923
- Testing
- SMV and antimicrobial photodynamic therapy, SMV application
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Periodontitis
Curcumin Paste as an Adjunctive Therapy in Periodontitis
The turmeric (Curcuma longa) plant, a herb belonging to the ginger family. The most active component of turmeric is curcumin, which makes up 2 to 5% of the spice.
- Trial name
- NCT04032132
- Testing
- curcumin paste, curettage
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Intrabony Periodontal Defect, Periodontal Disease
Evaluation of NIPSA Using Alloplastic Bone Graft and Cross-Linked Hyaluronic Acid in theTreatment of Intrabony Defects
Sixty patients will be selected from the outpatient clinic in the Oral Medicine and Periodontology Department, Faculty of Dentistry, Mansoura University, Egypt, according to preoperative clinical and radiographic data that will…
- Trial name
- RCT (NCT07737678)
- Testing
- allopastic bone graft, cross-linked hyaluronic acid, Non-Incised Papillae Surgical Approach
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Periodontal Regeneration
Minimally Invasive Flap With Platelet Rich Fibrin or Growth Factor Enhanced Matrix in Treatment of Intrabony Defect
Twenty-one intra-bony defects in fifteen systemically healthy patients with moderate to severe chronic periodontitis were randomly classified into 3 groups, 7 sites each.
- Trial name
- RCT (NCT04786327)
- Testing
- Minimal invasive flap technique, Minimally invasive flap with root conditioning (EDTA) and platelet rich fibrin, minimally invasive flap with root contioning by EDTA and growth factor enhanced matrix GEM21S
- Where
- Egypt
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Tanta University
Periodontal Diseases
Treatment of Periodontal Intrabony Defects With A-PRF+ or EMD
The aim of this randomized clinical trial was to clinically evaluate and compare the healing of intrabony defects after treatment with advanced platelet-rich fibrin (A-PRF+) to enamel matrix derivatives (EMD) in periodontitis…
- Trial name
- NCT04404374
- Testing
- A-PRF/EMD
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Semmelweis University
Intrabony Periodontal Defect
Efficacy of Insulin Like Growth Factor-1(IGF-1) on Bone Regeneration in Intrabony Defects : A Clinico-radiograph Study
The aim of this study is to clinically evaluate the efficacy of Insulin like Growth Factor (IGF-1) on bone regeneration in intrabony defects.
- Trial name
- NCT06426524
- Testing
- IGF-1 Gel, Hydroxyapatite
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Dr R Viswa Chandra
Chronic Periodontitis
Comparison of Autogenous Periosteal Pedicle Graft and Collagen Membrane in Management of Periodontal Intrabony Defects
A clinical and radiographic evaluation of autogenous periosteal pedicle graft in comparison with collagen membrane for management of periodontal intrabony defects.
- Trial name
- NCT02248103
- Testing
- Periosteal pedicle graft, Bioresorbable collagen membrane
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Intrabony Defects
DFDBA and Amniotic Membrane in the Treatment of Periodontal Osseous Defects
Amniotic membrane may be considered as a biologically active scaffold, which in combination with Bone Replacement Grafts (BRG) can be widely used to reconstruct periodontal Intrabony Defects (IBDs), due to the presence of stem…
- Trial name
- NCT02635529
- Testing
- OFD+ DFDBA, OFD+ DFDBA+ AM
- Where
- India
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Periodontitis
Growth Factors Release of PRF and PRGF
Background: platelet concentrate could enhance growth factors (GF) crevicular fluid levels which might be crucial to proper tissue repair and wound healing.
- Trial name
- NCT02447510
- Testing
- group 1 bio-oss bone xenograft, group 2 platelet rich in growth factor (autogenous platelet rich in growth factor), group 3 platelet rich fibrin (autogenous platelet rich fibrin)
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University