Clinical trials: Periodontitis, Adult
Moderate to Advanced Chronic Periodontitis
Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients
The purpose of this study is to determine the effect of local application of minocycline microspheres on the periodontal inflammation and bone loss prevention in patients diagnosed with moderate-severe chronic periodontitis…
- Trial name
- NCT01647282
- Testing
- locally-applied minocycline HCl (1 mg), scaling and root planing (Sc/RP)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Nebraska
Chronic Periodontitis
Study to Compare Laser Assisted New Attachment Procedure (LANAP) to Traditional Treatments of Chronic Periodontitis
The purpose of this study is to compare the Laser Assisted New Attachment Procedure (LANAP protocol) using the Free-running (FR) Pulsed Neodimium: Yttrium aluminium garnet (Nd:YAG) laser to Scaling and Root Planing (SRP) alone…
- Trial name
- LANAP (NCT01282229)
- Testing
- LANAP
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Institute for Advanced Laser Dentistry
Chronic Periodontitis
Role of Infected Blood Dendritic Cells in Heart Disease Risk
The investigators hypothesize that blood dendritic cells harbor pathogens from the oral cavity in chronic periodontitis and disseminate these pathogens to atherosclerotic plaques.
- Trial name
- NCT01568944
- Testing
- Oral Antibiotic and Oral Rinse, Standard Treatment
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Augusta University
Periodontitis Chronic Generalized Moderate, Periodontitis Chronic Generalized Severe
Clinical Evaluation of Laser Therapy Used as an Adjunct to Non-Surgical Treatment of Gum Disease
The use of lasers to treat various problems in dentistry is growing as it has in medicine. One application is the use of lasers to treat periodontal disease.
- Trial name
- NCT04027686
- Testing
- Laser Therapy, Non-surgical Scaling and Root Planing
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Periodontitis, Chronic
Adjunctive Hydrogen Peroxide for Periodontal Therapy
There have been many adjunctive treatments for the additional clinical benefits to scaling and root planing (SRP) in the treatment of chronic periodontitis.
- Trial name
- AHP (NCT03262701)
- Testing
- Hydrogen Peroxide Gel, 13 weeks, Hydrogen Peroxide Gel, 26 weeks, Scaling and Root planing group
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Periapical Periodontitis
Encapsulated Mesenchymal Stem Cells for Dental Pulp Regeneration.
To compare the dental survival in a period of one year of mature permanent teeth with apical lesion following the administration of encapsulated Mesenchymal Stem Cells under a regenerative endodontic procedure and a conventional…
- Trial name
- RanoKure (NCT03102879)
- Testing
- Regenerative Endodontic Procedure, Conventional Root Canal Treatment
- Where
- Chile
- Volunteers
- 36 people
- Sponsor
- Universidad de los Andes, Chile
Chronic Periodontitis
The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis
To evaluate the respective or combinatory efficacy of locally delivered 2% Minocycline (MO) and surface and root planning (SRP) by assessing both clinical parameters and the loads of four main periodontal pathogens in treating…
- Trial name
- NCT02355977
- Testing
- minocycline, surface and root planning
- Volunteers
- 70 people
- Sponsor
- Zhejiang University
Periodontitis
Effect of Injectable Platelet-Rich Fibrin (i-PRF) in Initial Treatment of Chronic Periodontitis
Current treatments of periodontitis have limited efficacy since they fail to suppress microorganisms satisfactorily over time. The aim of present study was to investigate whether there are differences between initial treatment of…
- Trial name
- EIPRFITCP (NCT04178590)
- Testing
- SRP + Injectable Platelet-Rich Fibrin
- Where
- Serbia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Chronic Periodontitis
Comparison of Autogenous Periosteal Pedicle Graft and Collagen Membrane in Management of Periodontal Intrabony Defects
A clinical and radiographic evaluation of autogenous periosteal pedicle graft in comparison with collagen membrane for management of periodontal intrabony defects.
- Trial name
- NCT02248103
- Testing
- Periosteal pedicle graft, Bioresorbable collagen membrane
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Generalized Chronic Periodontitis
Activated MMP-8 as Diagnostic Test for Periodontitis
Background: Untreated periodontal disease may influence general health. However, how may a physician who is not trained in periodontal probing detect untreated periodontitis? Activated matrix metalloproteinase-8 (aMMP-8) in…
- Trial name
- MMP-8 (NCT02280122)
- Testing
- no intervention provided
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Goethe University
Periodontal Diseases, Chronic Periodontitis
Effect of Switching From Cigarette Smoking to the Use of IQOS on Periodontitis Treatment Outcome
The purpose of this study was to demonstrate in patients with generalized chronic periodontitis that switching from cigarette smoking to using IQOS improves the response to periodontal therapy and the overall oral health status…
- Conditions
- Periodontal Diseases, Chronic Periodontitis, Periodontal Pocket, Tooth Mobility
- Trial name
- NCT03364751
- Testing
- IQOS, Cigarette
- Where
- 26 sites in Japan
- Volunteers
- 179 people
- Sponsor
- Philip Morris Products S.A.
Adult Periodontitis
Periocline as an Adjunct to Scaling and Root Planing for Adult Periodontitis
Periodontal disease (commonly called gum disease) is generally treated by deep cleaning of the root surfaces of the teeth. This is also called scaling and root planing.
- Trial name
- NCT00529555
- Testing
- minocycline HCl 2.1%, Scaling and root planing
- Where
- 10 sites in United States
- Volunteers
- 602 people
- Sponsor
- Sunstar Americas
Periodontitis
Long-term Safety of Minocycline in Patients With Gum Disease
This study will look at the safety of using the study medicine for a long time. It will see if the germs get used to the medicine, making it not work as well, if it's used by people with gum disease for a long time.
- Trial name
- NCT00668746
- Testing
- Minocycline HCl microspheres
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- OraPharma
Chronic Peritonitis
Effects of Vitamin D on Moderate to Severe Periodontitis
The object of the study was to evaluate the direct effect of high dose vitamin D supplementation on chronic periodontitis, and suggest the recommended dose for clinic use.
- Trial name
- NCT03044886
- Testing
- vitamin D
- Volunteers
- 360 people
- Sponsor
- Beijing Chao Yang Hospital
Periodontitis, Gingivitis
The Effects of DHA on Periodontitis
The purpose of this study is to determine whether docosahexaenoic acid (DHA) is effective in the treatment of periodontitis in adults.
- Conditions
- Periodontitis, Gingivitis, Inflammation
- Trial name
- DAP (NCT01976806)
- Testing
- Aspirin, Docosahexaenoic acid
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Generalized Moderate Chronic Periodontitis, Generalized Severe Chronic Periodontitis
Treatment of Periodontitis With Er:YAG Laser
The purpose of this research project is to gain information on the best and most comfortable way to treat the periodontal disease.
- Conditions
- Generalized Moderate Chronic Periodontitis, Generalized Severe Chronic Periodontitis, Periodontal Diseases
- Trial name
- NCT03628872
- Testing
- Scaling and root planing, Er:YAG Laser, Hand instruments
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Columbia University
Chronic Periodontitis
Combined Use of Er:YAG and Nd:YAG Laser
The aim of the present study was to compare the effectiveness of combined Er:YAG and Nd:YAG laser therapy to that of scaling and root planning with hand instruments in nonsurgical treatment of chronic periodontitis.
- Trial name
- NCT02851823
- Testing
- Periodontal curettes, Er-YAG+Nd-YAG lasers
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Chronic Periodontitis
Short-term Effect of 2% Atorvastatin Dentifrice in Periodontal Status.
Periodontal disease (PD) is an inflammatory, infectious and destructive condition of the tissues surrounding the teeth. However, even if bacteria are required to initiate periodontal disease, the immune response is responsible…
- Trial name
- NCT01929135
- Testing
- Medicated 2% atorvastatin dentifrice, Non-medicated dentifrice
- Where
- 2 sites in Chile
- Volunteers
- 38 people
- Sponsor
- Universidad de los Andes, Chile