Clinical trials: Periodontitis
Periodontal Pocket, Periodontitis
Multicenter Study on the Use of a Collagen-based Hydrogel for the Treatment of 153 Periodontal Pockets in 38 Adults With Generalized Stage III Periodontitis
This is a prospective, observational, multicenter study designed to evaluate the real-world efficacy and safety of H42®, a collagen hydrogel, in the treatment of periodontal pockets.
- Trial name
- NCT07592377
- Testing
- H42® Collagen Hydrogel for the non-surgical treatment of periodontal pockets
- Where
- 2 sites in Italy
- Volunteers
- 38 people
- Sponsor
- Bioteck S.p.A.
Periodontitis
A Study to Assess the Safety of Using Fibroblast Growth Factor-2 With Periodontal Surgery in Japan (Phase 3)
This study aims to investigate the safety in using Trafermin (recombinant human basic fibroblast growth factor) with periodontal surgery.
- Trial name
- NCT01015404
- Testing
- Trafermin
- Where
- 6 sites in Japan
- Volunteers
- 25 people
- Sponsor
- Kaken Pharmaceutical
Periodontal Diseases
Evaluation of PerioMonitor for Detection of Oral Inflammatory Load (OIL) in Human Subjects
The purpose of this multicenter, prospective, single arm Study is to evaluate the efficacy and safety of PerioMonitor as an aid to the presumptive detection of oral inflammation associated with periodontal diseases.
- Trial name
- NCT05153798
- Where
- 3 sites in United States, Canada
- Volunteers
- 117 people
- Sponsor
- Oral Science International Inc.
Periodontitis
Emdogain and Straumann Bone Ceramic in Infrabony Defects
Randomised, controlled, clinical study to compare the effect of the combination of bone ceramic and enamel matrix proteins (test) versus autogenous bone graft alone (control) in the treatment of deep-wide intrabony defects
- Trial name
- NCT00906776
- Testing
- Emdogain PLUS, Autogenous bone
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Institut Straumann AG
Periodontitis
Effect of Adjunctive Treatment With Arestin on the Subgingival Microflora in Patients With Moderate to Advanced Periodontitis
The purpose of this study is to measure the antimicrobial effects of Arestin in subjects with moderate to advanced periodontal disease
- Trial name
- NCT00371332
- Testing
- Minocycline HCL Microspheres
- Where
- 5 sites in United States
- Volunteers
- 128 people
- Sponsor
- OraPharma
Periodontitis
Regular Home Use of Dual-light Photodynamic Therapy in the Management of Chronic Periodontitis
The study is a single site, randomized clinical trial designed to determine the efficacy of the Lumoral treatment in periodontitis patients.
- Trial name
- HOPE-CP (NCT05278416)
- Testing
- Lumoral treatment -device and Lumorinse tablets
- Where
- Finland
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Koite Health Oy
Periodontitis
PerioWave Re-Treatment Protocol Compared to Scaling and Root Planing (SRP) and a Single Treatment With PerioWave
This is a pivotal, prospective, randomized, blinded, multicenter study to evaluate two treatments of photodynamic disinfection in adults with chronic periodontal disease.
- Trial name
- NCT00336661
- Testing
- PerioWave
- Where
- 2 sites in China
- Volunteers
- 105 people
- Sponsor
- Ondine Research Laboratories
Periodontitis
Study of Scaling and Root Planing With PerioWave Versus Scaling and Root Planing Alone in Chronic Periodontitis
This study is to determine whether scaling and root planing (SRP) followed by photodynamic disinfection results in improved outcomes that persist over time in adults with chronic periodontitis when compared with subjects with SRP…
- Trial name
- NCT00297531
- Testing
- PerioWave, Scaling and Root Planing
- Where
- 4 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Ondine Research Laboratories
Periodontitis
Emdogain Minimally Invasive Surgical Technique
The aim of this controlled study is to assess the clinical outcomes and patient reported outcomes of using minimally invasive surgical procedure with Straumann Emdogain as an adjunct (test treatment) or without Straumann Emdogain…
- Trial name
- NCT02551770
- Testing
- Scaling and root planing, Scaling and root planing without Emdogain, Emdogain application
- Where
- 4 sites in United States, Canada and 1 more
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Institut Straumann AG
Periodontitis
Trial in Periodontal Tissue Regeneration Using Fibroblast Growth Factor-2
The present clinical trial clarified that basic fibroblast growth factor-2 (FGF-2) can induce regeneration of periodontal tissue lost by progression of periodontitis and evaluated the safety of such induction.
- Trial name
- NCT00514657
- Testing
- Trafermin (genetical recombinant of human basic Fibroblast Growth Factor)
- Volunteers
- 91 people
- Sponsor
- Kaken Pharmaceutical
Periodontal Disease, Gingival Inflammation and Bleeding
Efficacy of Oral Hygiene Regimens in Patients Undergoing Non-Surgical Periodontal Treatment
The objective of this clinical study is to evaluate the efficacy of multi-component oral hygiene regimens as adjunctive to non-surgical periodontal treatment in patients with stage II periodontitis.
- Trial name
- PEREG (NCT07803484)
- Testing
- Active Oral Hygiene Regimen
- Where
- 2 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- Colgate Palmolive
Chronic Periodontitis
A Phase II Clinical Trial of YH23537 in Patients With Chronic Periodontal Disease.
This study is designed to evaluate the efficacy and the safety of YH23537 in Korea patients with chronic periodontitis, in order to investigate the recommended therapeutic dose.
- Trial name
- NCT02585596
- Testing
- YH23537 1000mg/day, YH23537 2000mg/day, YH23537 3000mg/day
- Where
- South Korea
- Volunteers
- 275 people
- Sponsor
- Yuhan Corporation
Chronic Periodontitis
Effect of Probiotic Inersan and Doxycycline in Chronic Periodontitis
Periodontitis is a multifactorial disease that can lead to the destruction of supporting tissues of the teeth resulting in pocket formation, recession or both.
- Trial name
- NCT02174757
- Testing
- Inersan, Doxycycline
- Where
- India
- Volunteers
- 30 people
- Sponsor
- CD Pharma India Pvt. Ltd.
Periodontitis
The Efficacy and Safety of Flurbiprofen Chip Versus Chlorhexidine Chip (Periochip®) in Therapy of Adult Chronic Periodontitis
The purpose of the study is to assess efficacy and safety of Flurbiprofen Chip versus Chlorhexidine chip (Periochip®) in therapy of adult chronic periodontitis.
- Trial name
- NCT01040286
- Testing
- Flurbiprofen, Chlorhexidine
- Where
- Israel
- Sponsor
- Dexcel Pharma Technologies Ltd.
Periodontal Diseases
Treatment of Advanced Periodontitis Using an Oscillating Chitosan Device Versus Regular Curettes Alone
40 patients diagnosed with localised periodontitis will be included at each center, 20 patients will be treated with the control treatment, 20 patients will be treated by test treatment.
- Trial name
- NCT04173156
- Testing
- Labrida Bioclean, Gracey Periodontal curettes
- Where
- 3 sites in Norway, Turkey (Türkiye)
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Labrida AS
Parodontitis
Evaluation of the Efficacy of STERIFY GEL in the Treatment of Periodontitis Following Scaling and Root Planing
The purpose of this clinical study is to evaluate the safety and efficacy of treating periodontal disease with the STERIFY GEL medical device in combination with SRP procedure, in terms of periodontal pocket healing.
- Trial name
- SFYCT (NCT05975177)
- Testing
- Sterify Gel, Scaling and root planing
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- Sterify S.r.l.
Apical Periodontitis
A Study to Compare Various Root Canal Cleaning Devices Based on Cavitation,Ultrasonic and Conventional Methods.
The goal of this clinical trial is to compare the effectiveness of various root canal cleaning devices based on the principle of cavitation, ultrasonics, and conventional methods in a normal healthy adult population aged between…
- Trial name
- NCT06005545
- Testing
- Passive Ultrasonic Irrigation (PUI) group, Endoclean (EC) group, Conventional group
- Where
- Turkey (Türkiye)
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Lumendo AG
Chronic Periodontitis
Effect of Probiotics on Chronic Periodontitis in Smoker and Non- Smokers
Periodontitis is one of the most common chronic inflammatory disease with the etiology of bacterial plaque and is associated with a number of putative bacterial species.
- Trial name
- NCT02329353
- Testing
- Lactobacillus brevis CD2 Lozenges
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Next Gen Pharma India Pvt. Ltd.
Moderate to Severe Chronic Periodontitis
Evaluation of the KLOX BioPhotonic OraLum Gel With a LED Curing Lamp in Moderate to Severe Chronic Periodontitis
Multicenter, prospective, interventional open case series study using a randomized split-mouth design in moderate to severe chronic periodontitis patients having half-mouth treated with the KLOX BioPhotonic OraLum gel with a LED…
- Trial name
- NCT02325570
- Testing
- KLOX BioPhotonic OraLum Gel, Scaling and Root Planing (SRP)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- KLOX Technologies Inc.
Periodontal Diseases
A Randomized, Double-blind, Controlled Study to Evaluate the Safety and Feasibility of a Intraoral Electrotherapy Device
A parallel-armed, sham-controlled, and participant-blind pilot study will be conducted to determine the safety and effectiveness of use of a noninvasive intraoral electrotherapy device to treat periodontal disease.
- Trial name
- NCT04793048
- Testing
- a noninvasive intraoral electrotherapy device
- Volunteers
- 30 people
- Sponsor
- Shanghai Keku Medical Technology Co., Ltd.