Clinical trials: Periodontitis, completed
Chronic Periodontitis
Locally Delivered Metformin and Aloe Vera for Treatment of Intrabody Defects in Chronic Periodontitis
Metformin (MF), a biguanide group of anti-diabetic drug has been shown to enhance osteoblasts differentiation and inhibit osteoclast differentiation in vitro, thus may exhibit a favorable effect on alveolar bone.
- Trial name
- NCT03204071
- Testing
- Aloevera, Metformin
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Chronic Periodontitis
Comparison Between Two Non-surgical Periodontal Treatment Procedures With and Without Interdental Hygiene Devices in Periodontitis Patients: a Longitudinal Prospective Controlled Clinical Trial
Periodontitis is treated by regularly clearance of the disease-causing biofilm through domestic care and dental measures (Petersilka et al., 2002, Herrera et al., 2008).
- Trial name
- NCT04339309
- Testing
- Non-surgical periodontal treatment with interdental hygiene devices, Non-surgical periodontal treatment without interdental hygiene devices
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis, Adult
To Evaluate the Effects of Systemic Probiotics & Antibiotics and Local Application of Antibiotics As an Adjuvant to NSPT
Background: Periodontitis is defined as "an inflammatory disease of the supporting tissues of the teeth caused by specific microorganisms or groups of specific microorganisms, resulting in progressive destruction of the…
- Trial name
- NCT06570863
- Testing
- Antibiotics(doxycycline), Probiotics, Metronidazole gel 25%
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Dr fizza khalid
Periodontitis (Stage 3), Smoking ( Cigarette)
Salivary TNF-α, FoxO-1, and SIRT-1 Levels in Periodontitis and Smoking
This study examines whether smoking and gum disease (periodontitis) are linked to changes in three biological markers found in saliva: TNF-α, FoxO-1, and SIRT-1.
- Trial name
- NCT07764549
- Testing
- Salivary Biomarker Analysis (ELISA)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Zehra Hasgül
Chronic Periodontitis
Clinical Efficacy Of 810 Nanometer Diode Laser As An Adjunct To Mechanical Periodontal Treatment Of Residual Periodontal Pockets
Background: Aim of this randomized controlled parallel-designed study was to evaluate the effects of diode laser as an adjunct to mechanical periodontal treatment on clinical parameters and gingival crevicular fluid (GCF) volume…
- Trial name
- NCT02531555
- Testing
- 810 Nanometer Wavelenght GaAlAs Diode Laser, Gracey curettes
- Where
- Turkey (Türkiye)
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Marmara University
Diabetes Mellitus, Periodontal Disease
Periodontal Treatment With Diode Laser in the Patients With Diabetes Melitus
This study aimed to investigate the effects of diode laser (DL) in addition to non-surgical periodontal treatment on periodontal parameters, systemic inflammatory response, and serum hemoglobin A1c (HbA1c) level in patients with…
- Trial name
- NCT03444363
- Testing
- Laser group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Aggressive Periodontitis, Generalized
Periodontal Debridement Associated With Systemic Antibiotics and Single/Repeated PDT to Treat Aggressive Periodontitis
The aim of this project is to compare the efficacy and the local effect of the association of single or repeated application of photodynamic therapy (PDT) with antibiotic agents using Amoxicillin + Metronidazole or Clarithromycin…
- Trial name
- NCT03132714
- Testing
- Full-mouth ultrasonic debridement, Amoxicillin 500mg, Metronidazole 400mg
- Where
- Brazil
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Smoking, Cigarette
Smoking and Peptidoglycan Recognition Protein-1 and Initial Periodontal Therapy
A total of 40 patients with CP (20 smokers (S+CP) and 20 nonsmokers (S-CP)) and 40 periodontally healthy subjects (20 smokers (S+PH) and 20 nonsmokers (S-PH)), comprising 80 subjects, were included in this study.
- Trial name
- NCT03915730
- Testing
- Initial periodontal therapy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Periodontitis, Gingivitis
Regulatory T Cell With Related Interleukins in Periodontal Disease Progression
T Regulatory cells which suppressor subset of T cells and related cytokines remain in blood and infiltrates into the tissue under need.
- Trial name
- NCT06135116
- Testing
- Flow Cytometric Detection of Regulatory T Cells and Cytokines analysis by ELISA
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Apical Periodontitis
Retreatment and Diabetes
ABSTRACT This prospective, controlled, single-center clinical study aims to compare postoperative pain levels and analgesic consumption after nonsurgical endodontic retreatment in individuals with diabetes mellitus and…
- Trial name
- NCT07679880
- Testing
- root canal retreatment
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Periodontitis
Probiotic Use in Chronic Periodontitis Patients
Aim: to evaluate the additional effects of the 12 weeks usage of a Streptococcus containing probiotic tablet after scaling and rootplaning compared to a placebo tablet.
- Trial name
- NCT02403960
- Testing
- probiotic
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Irreversible Pulpitis With Apical Periodontitis
The Effect of Eddy Sonic Versus AF Max Activation of Bio-ceramic Sealer on Post-operative Pain in Teeth With Symptomatic Irreversible Pulpitis With Apical Periodontitis
The aim of endodontic therapy for an inflamed tooth is to eliminate the source of inflammation. Relieving pain depends on the effectiveness of root canal therapy.3 Postoperative pain in endodontic treatments, affecting 3-58% of…
- Trial name
- NCT06640218
- Testing
- sealer activation with Eddy sonic and AF max, without AF max or Eddy sonic sealer activation
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Polycystic Ovary Syndrome, Chronic Periodontitis
Chronic Periodontitis and Polycystic Ovary Syndrome
Background: The aim of this study was to investigate the levels of malondialdehyde (MDA), total antioxidant status (TAS), 8-hydroxy-2´- deoxyguanosine (8-OHdG) in blood serum and saliva samples in female patients with chronic…
- Trial name
- NCT02954120
- Testing
- no intervention provided
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Chronic Periodontitis
Comparison of Alendronate With Atorvastatin in Chronic Periodontitis
The present study is designed as a single-centre, randomized, controlled clinical trial to evaluate and compare the clinical efficacy of two local drug delivery systems containing 1% ALN gel and 1.2% ATV gel in treatment of…
- Trial name
- NCT02455869
- Testing
- SRP and Atorvastatin, SRP and Alendronate
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Government Dental College and Research Institute, Bangalore
Tobacco Use, Periodontitis
Snuff Use, Smoking, Periodontitis and Mortality: 30-year Cohort Study From Sweden
Smoking and dual using associated with poor periodontal health.
- Trial name
- NCT03918902
- Testing
- Qestinnaires
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Periodontitis, Treatment Adherence
I-Smads in Periodontitis
Recently, it has been stated that Smads play an active role in all conditions where transforming growth factor-beta (TGF-β) is involved, including periodontal inflammation.
- Trial name
- NCT04846166
- Testing
- Periodontally healthy group, Periodontitis
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Periodontal Health, Periodontitis
Effect of Periodontal Treatment on Salivary and Serum Biomarkers in Periodontitis
The present study aimed to determine the effect of non-surgical periodontal treatment on serum and salivary SIRT-1, MMP-9, and T-SOD levels in periodontitis stage III grade B (P-III-B) and C (P-III-C) patients.
- Trial name
- NCT06255470
- Testing
- Non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Marmara University
Periodontitis
Impact of Periodontal Treatment on NT-proBNP Levels
In light of the controversy that are already approved but that however still exists regarding the efficacy and influence the management of Periodontitis, the aim of this study was to evaluates, at 6-months follow-up, the…
- Trial name
- NCT05174494
- Testing
- Evaluation of serum CRP and NT-proBNP
- Where
- Italy
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Catania
Periodontal Diseases, Epigenetics
DNA Methylation Profile of the SOCS-1 Gene Promoter in Smokers Patients With Chronic Periodontitis.
Periodontitis is related to host genetics, constitution of the dental biofilm and environmental factors such as smoking. DNA methylation is a mechanism of genetic expression that can inhibit or silence gene expression.
- Trial name
- NCT03371446
- Testing
- oral epithelial cells obtained by rinsing with 3% sucrose
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Periodontal Disease, Periodontal Disease Stage 2
Probiotics And Ozonated Olive Oil To Maintain Oral Eubiosis In Stage I And II Periodontitis Patients
The goal of this clinical trial is to investigate the clinical benefits of the combined use of ozonized olive oil products (mouthwash and toothpaste) and probiotics on the health status of patients with Stage I and II…
- Trial name
- NCT06955546
- Testing
- Toothpaste Product, Mouthwash Product, Probiotic
- Where
- Italy
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Massimo Corsalini