Clinical trials: Periodontitis, completed
Pulp Necrosis, Immature Permanent Teeth
PRF and CGF Scaffolds With EDTA in Regeneration
This study evaluated the regenerative outcomes of immature permanent teeth with necrotic pulps treated using three scaffold types-blood clot, platelet-rich fibrin (PRF), and concentrated growth factor (CGF)-combined with either…
- Conditions
- Pulp Necrosis, Immature Permanent Teeth, Open Apex, Periapical Periodontitis
- Trial name
- RET-EDTA-CGF (NCT07265804)
- Testing
- Blood Clot + 5% EDTA, Blood Clot + 17% EDTA, PRF + 5% EDTA
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Chronic Periodontitis
Efficacy of INERSAN in Patients With Chronic Periodontitis as Adjunctive to Full Mouth Disinfection
The purpose of this study is to evaluate beneficial effects of probiotic Lactobacillus brevis CD2 tablets in addition to the primary treatment for patients with chronic periodontitis (Full Mouth Disinfection), at local level and…
- Trial name
- NCT01438333
- Testing
- lactobacillus brevis tablets
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of L'Aquila
Chronic Periodontitis, Type 2 Diabetes
Diabetes and Periodontal Therapy Trial
The primary aim of the study is to determine if non-surgical periodontal therapy (scaling and root planing and supportive periodontal therapy) is efficacious compared to delayed therapy in reducing elevated glycosylated…
- Trial name
- DPTT (NCT00997178)
- Testing
- Non-surgical periodontal therapy, Delayed non-surgical periodontal therapy
- Where
- 8 sites in United States
- Volunteers
- 514 people
- Sponsor
- Stony Brook University
Chronic Periodontitis, Periodontal Pocket
Autologous Fibrin Glue Application as an Adjunct to Nonsurgical Periodontal Treatment of Chronic Periodontitis
Chronic periodontitis is an inflammatory and polymicrobic disease characterized by the irreversible loss of alveolar bone and connective tissue attachment of the teeth.
- Conditions
- Chronic Periodontitis, Periodontal Pocket, Periodontal Attachment Loss, Periodontal Diseases
- Trial name
- NCT04082949
- Testing
- autologous fibrin glue application as an adjunct to nonsurgical periodontal treatment of chronic periodontitis
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people
- Sponsor
- Inonu University
Periodontitis, Diabetes
Effect of Non Surgical Treatment of Periodontitis on Diabetes Control
The aim of this study is to investigate the effects of non-surgical periodontal treatment on the metabolic control of type2 diabetes patients.
- Trial name
- PARODIA1 (NCT02745015)
- Testing
- non-surgical periodontal treatment
- Where
- Cameroon
- Volunteers
- 45 people
- Sponsor
- Yaounde Central Hospital
Pain Postoperative
Apical Patency and Postoperative Pain.
The purpose of this study is to determine whether maintaining an apical patency causes postoperative pain in posterior teeth with necrotic pulp and apical periodontitis.
- Trial name
- NCT02768285
- Testing
- APICAL PATENCY
- Where
- Turkey (Türkiye)
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Isparta Military Hospital
Periodontitis
Bactericidal Permeability Protein Inhibitor and Interleukin-1beta Levels After Non-surgical Periodontal Treatment
The aim of this study was to examine the relationship between healing response after non-surgical periodontal treatment and baseline gingival crevicular fluid (GCF) levels of bactericidal/permeability-increasing protein (BPI) and…
- Trial name
- NCT06354504
- Testing
- Non-surgical periodontal treatment
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Periodontitis, Metabolic Syndrome
Effects of Periodontal Therapy in Patients With Metabolic Syndrome
A 6-month, parallel-arm, investigator-masked, randomized clinical trial was conducted in patients with MetS and severe periodontitis.
- Trial name
- MetS (NCT03960216)
- Testing
- Scaling and root planning, Supragingival Prophylaxis
- Volunteers
- 60 people
- Sponsor
- Universidad Complutense de Madrid
Asymptomatic Apical Periodontitis
Postoperative Pain and Quality of Life Following Root Canal Treatment With Two Different Sealers
This study compares two different root canal sealers, AH Plus and BioRoot Flow, to determine whether the type of sealer used during root canal treatment affects pain after treatment and oral health-related quality of life.
- Trial name
- NCT07884799
- Testing
- AH Plus, BioRoot Flow
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people
- Sponsor
- Karadeniz Technical University
Post-operative Pain, Apical Periodontitis
The Effect of Different Irrigation and Disinfection Methods on Post-operative Pain (PP)
Aim: The aim of this study was to examine post-operative pain (PP) severity after conventional irrigation and sonic activation methods, with and without laser disinfection in mandibular molar teeth diagnosed with symptomatic…
- Trial name
- PP (NCT05195021)
- Testing
- EDDY, Diode Laser device, Conventional irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Biruni University
Periodontal Disease, Periodontitis
Assessment of Ozonated Sunflower Seed Oil Gel as an Adjunctive Therapy to Mechanical Debridement in the Treatment of Stage II Grade B Periodontitis
I) Patients: The present study will be carried on periodontitis patients. The patients will be informed about the treatment steps.
- Conditions
- Periodontal Disease, Periodontitis, Periodontitis Stage II
- Trial name
- NCT07636993
- Testing
- Mechanical debridement ., sun flower, ozonated sun flower
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Periodontitis, Chronic Prostatitis (CP)
Periodontal Therapy and Genitourinary Inflammation in Patients With Prostatitis and Recurrent Urinary Tract Infections
This randomized controlled clinical trial evaluates the impact of non-surgical periodontal therapy on systemic inflammatory markers in patients with chronic prostatitis or recurrent urinary tract infections.
- Conditions
- Periodontitis, Chronic Prostatitis (CP), Urinary Tract Infections
- Trial name
- PERIO-PSA (NCT07438184)
- Testing
- Non-surgical periodontal therapy, Oral hygiene instruction
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Salamanca
Intrabony Periodontal Defect
Clinical and Radiographic Evaluation of the Entire Papilla Preservation (EPP) Technique Versus Modified Minimally Invasive Surgical Technique (M-MIST) in Treatment of Intraosseous Defects in Patients With Stage III Periodontitis: A Randomized Clinical Trial
Periodontitis is defined as loss of periodontal attachment due to microbial associated host mediated inflammation. This would lead to the apical migration of the junctional epithelium allowing the bacterial biofilm to undergo…
- Trial name
- NCT04100798
- Testing
- Entire Papilla Preservation technique, Modified Minimally invasive Surgical Technique
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Cairo University
Healing Wound, Periodontitis
Imaging Analysis Following Periodontal Surgery
This is a single centre, randomised, single-blind, parallel-group clinical trial that aims at evaluating the use of imaging (2D and 3D) in obtaining geometric and thermometric changes of postoperative healing patterns and…
- Trial name
- NCT03631693
- Testing
- Simplified papilla preservation flap, Resective periodontal flap with osseous recontouring
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Queen Mary University of London
Chronic Periodontitis
Clinical Efficacy Of 810 Nanometer Diode Laser As An Adjunct To Mechanical Periodontal Treatment Of Residual Periodontal Pockets
Background: Aim of this randomized controlled parallel-designed study was to evaluate the effects of diode laser as an adjunct to mechanical periodontal treatment on clinical parameters and gingival crevicular fluid (GCF) volume…
- Trial name
- NCT02531555
- Testing
- 810 Nanometer Wavelenght GaAlAs Diode Laser, Gracey curettes
- Where
- Turkey (Türkiye)
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Marmara University
Periodontitis, Obesity (Body Mass Index >30 kg/m2)
Obesity and Clinical and Cytokine Responses to Periodontal Therapy
This prospective controlled clinical study included 80 participants allocated into four groups according to body mass index (BMI) and periodontal status: obese periodontitis, normal-weight periodontitis, obese periodontally…
- Trial name
- NCT07869277
- Testing
- Scaling and Root Planing (SRP)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emine Çifcibaşı
Periodontitis
Salivary Proteome in Response to Non-surgical Periodontal Treatment
This study aims to investigate salivary proteome changes in periodontitis patients before and after non-surgical treatment. Ten systemically healthy and non-smoker individuals with stage III, grade C periodontitis underwent…
- Trial name
- NCT05952895
- Testing
- Conventional quadrant-wise scaling and root planing (SRP)
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Periodontal Diseases, Chronic Periodontitis
Photodynamic Therapy During Supportive Periodontal Therapy
27 subjects on SPT, each with at least two residual pockets ≥5mm, were recruited for this randomised, split-mouth controlled trial, providing a total of 72 sites.
- Conditions
- Periodontal Diseases, Chronic Periodontitis, Periodontal Attachment Loss
- Trial name
- NCT02666573
- Testing
- Fotosan 630, CMS Dental, Copenhagen, Denmark, Scaling and root planing
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Irreversible Pulpitis With Apical Periodontitis
Effect of Common Analgesia on Pulp Sensibility
his study will investigate whether commonly used analgesics - 400 mg ibuprofen and 500 mg paracetamol - influence the accuracy of pulpal sensibility tests (cold test and electric pulp test) in patients with symptomatic…
- Trial name
- NCT07125911
- Testing
- Ibuprofen 400 mg (if necessary), Paracetamol 500 mg
- Where
- Pakistan
- Volunteers
- 122 people
- Sponsor
- HITEC-Institute of Medical Sciences
Carotid Artery Calcification, Periodontal Diseases
Assessment of Carotid Artery Calcifications
The aim of the study was to determine retrospectively the presence of carotid artery calcification (CAC) detected on digital panoramic radiographs (DPRs) and correlate the finding of such calcifications with gender, smoking…
- Trial name
- NCT04017078
- Testing
- diagnosis of carotid artery calcification on digital panoramic radiograph
- Where
- Turkey (Türkiye)
- Volunteers
- 1,101 people
- Sponsor
- Baskent University