Clinical trials: Periodontitis
Aggressive Periodontitis
Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis
The aim of this study is to assess the clinical outcomes of full-mouth ultrasonic debridement combined with clarithromycin or amoxicillin + metronidazole association for the treatment of generalized aggressive periodontitis…
- Trial name
- NCT02969928
- Testing
- Full-mouth ultrasonic debridement, Clarithromycin, Amoxicillin
- Where
- Brazil
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Periapical Periodontitis
Encapsulated Mesenchymal Stem Cells for Dental Pulp Regeneration.
To compare the dental survival in a period of one year of mature permanent teeth with apical lesion following the administration of encapsulated Mesenchymal Stem Cells under a regenerative endodontic procedure and a conventional…
- Trial name
- RanoKure (NCT03102879)
- Testing
- Regenerative Endodontic Procedure, Conventional Root Canal Treatment
- Where
- Chile
- Volunteers
- 36 people
- Sponsor
- Universidad de los Andes, Chile
Chronic Periodontitis
Short-term Effect of 2% Atorvastatin Dentifrice in Periodontal Status.
Periodontal disease (PD) is an inflammatory, infectious and destructive condition of the tissues surrounding the teeth. However, even if bacteria are required to initiate periodontal disease, the immune response is responsible…
- Trial name
- NCT01929135
- Testing
- Medicated 2% atorvastatin dentifrice, Non-medicated dentifrice
- Where
- 2 sites in Chile
- Volunteers
- 38 people
- Sponsor
- Universidad de los Andes, Chile
Periodontitis
Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis
Chronic periodontitis is an infectious disease of periodontal support tissues caused by bacterial biofilm, which leads to inflammation and destruction of periodontal support tissues ultimately resulting in tooth loss.In the…
- Trial name
- NCT05530252
- Testing
- Oral biological antimicrobial gel, minocycline hydrochloride ointment, SRP
- Where
- China
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Beijing Stomatological Hospital, Capital Medical University
Chronic Peritonitis
Effects of Vitamin D on Moderate to Severe Periodontitis
The object of the study was to evaluate the direct effect of high dose vitamin D supplementation on chronic periodontitis, and suggest the recommended dose for clinic use.
- Trial name
- NCT03044886
- Testing
- vitamin D
- Volunteers
- 360 people
- Sponsor
- Beijing Chao Yang Hospital
Periodontitis, Periodontal Diseases
Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers
The purpose of this study is to determine in current and non-smokers the clinical and microbiological effects of 3 therapies: scaling and root planing (SRP) alone; SRP in combination with the orally administered antibiotic…
- Trial name
- NCT00066066
- Testing
- Scaling and root planing, Metronidazole, Amoxicillin
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- The Forsyth Institute
Periodontitis Chronic Generalized Moderate, Periodontitis Chronic Generalized Severe
Clinical Evaluation of Laser Therapy Used as an Adjunct to Non-Surgical Treatment of Gum Disease
The use of lasers to treat various problems in dentistry is growing as it has in medicine. One application is the use of lasers to treat periodontal disease.
- Trial name
- NCT04027686
- Testing
- Laser Therapy, Non-surgical Scaling and Root Planing
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Rheumatoid Arthritis, Psoriatic Arthritis
Role of Oral and Intestinal Microbiota in Rheumatoid Arthritis (RA)
Rheumatoid arthritis (RA) is an inflammatory form of arthritis that causes joint pain and damage. RA attacks the lining of the joints (synovium), causing swelling that can result in aching and throbbing, and eventually deformity.
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Periodontal Disease
- Trial name
- NCT01198509
- Testing
- doxycycline, vancomycin
- Where
- 2 sites in United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Aggressive Periodontitis
Clarithromycin as Adjuvant to Periodontal Debridement
To assess the periodontal clinical response and the possible adverse effects of the clarithromycin combined to periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis.
- Trial name
- NCT02829983
- Testing
- Clarithromycin, One-stage full-mouth ultrasonic debridement (FMUD)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Gingival Diseases
Collection of Gingival Crevicular Fluid From Periodontitis Patients
To collect GCF (gingival crevicular fluid) samples from diseased patients suffering only from gingivitis and/or periodontitis.
- Trial name
- NCT00763048
- Testing
- Fluoride, Fluoride, triclosan
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Chronic Periodontitis
Combined Use of Er:YAG and Nd:YAG Laser
The aim of the present study was to compare the effectiveness of combined Er:YAG and Nd:YAG laser therapy to that of scaling and root planning with hand instruments in nonsurgical treatment of chronic periodontitis.
- Trial name
- NCT02851823
- Testing
- Periodontal curettes, Er-YAG+Nd-YAG lasers
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Apical Periodontitis, Pulp Disease, Dental
A New Clinical Use of Ferumoxytol Nanoparticles: An Antibiofilm Treatment
The goal of this observational is study is to develop a protocol for root canal biofilms disinfection using a clinically approved and commercially available iron oxide nanoparticle formulation Ferumoxytol/H2O2 treatments.
- Trial name
- NCT06110494
- Testing
- Iron oxide nanoparticles treatment Ferumoxytol/H2O2, NaOCl, NaCl
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Periodontitis
Effect of Injectable Platelet-Rich Fibrin (i-PRF) in Initial Treatment of Chronic Periodontitis
Current treatments of periodontitis have limited efficacy since they fail to suppress microorganisms satisfactorily over time. The aim of present study was to investigate whether there are differences between initial treatment of…
- Trial name
- EIPRFITCP (NCT04178590)
- Testing
- SRP + Injectable Platelet-Rich Fibrin
- Where
- Serbia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Postoperative Pain
Effects of Photobiomodulation on Postoperative Pain After Primary Endodontic Therapy in Molars With Symptomatic Apical Periodontitis
The purpose of this study is to evaluate the effects of photobiomodulation (PBM) on postoperative pain after endodontic treatment in mandibular molar teeth diagnosed with symptomatic apical periodontitis.
- Trial name
- NCT05032612
- Testing
- PBM Therapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- The University of Texas Health Science Center, Houston
Periodontitis
Effect of Postsurgical Systemic Doxycycline After Regenerative Periodontal Therapy
Study Hypothesis: The administration of 200 mg doxycycline once a day for 7 days after regenerative periodontal therapy of infrabony defects improves the results of therapy (clinical vertical attachment gains [CAL-V], bony fill)…
- Trial name
- GTRDOXY (NCT01030666)
- Testing
- Doxycycline, modified/simplified papilla preservation flap; scaling, Prefgel/Emdogain
- Where
- 2 sites in Germany
- Volunteers
- 61 people
- Sponsor
- Peter Eickholz
Generalized Aggressive Periodontitis, Aggressive Periodontitis
Alternative Antibiotic Regime in the Treatment of GAgP
The objective of this randomized clinical study was to evaluate the effect of systemic administration of moxifloxacin compared to amoxicillin plus metronidazole combined with non-surgical treatment in patients with generalized…
- Trial name
- NCT02223702
- Testing
- Amoxicillin, Metronidazole, Moxifloxacin
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Chronic Periodontitis
Comparison of Autogenous Periosteal Pedicle Graft and Collagen Membrane in Management of Periodontal Intrabony Defects
A clinical and radiographic evaluation of autogenous periosteal pedicle graft in comparison with collagen membrane for management of periodontal intrabony defects.
- Trial name
- NCT02248103
- Testing
- Periosteal pedicle graft, Bioresorbable collagen membrane
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Furcation Defects, Periodontitis
Effect of Laser Use on Guided Tissue Regeneration in Treatment of Molar Teeth With Class 2 Furcation Affected by Periodontitis
Purpose: The proposed study will evaluate and compare the clinical response of using bioresorbable collagen membrane alone or defect debridement with erbium Laser irradiation in conjunction with bioresorbable collagen membrane in…
- Conditions
- Furcation Defects, Periodontitis, Alveolar Bone Loss Beyond Furcation
- Trial name
- NCT01522131
- Testing
- bioresorbable membrane alonewill be used for regeneration of the periodontium(control)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Endodontic Disease, Periapical Diseases
Comparison of Clinical Outcomes Between GentleWave® and Biolase®
Introduction: In the US, 15 million root canal treatments (RCTs) are carried out annually. Success rates decrease with conventional chemo-mechanical root canal preparation techniques used on teeth with periapical radiolucencies…
- Conditions
- Endodontic Disease, Periapical Diseases, Periapical Periodontitis, Root Canal Infection
- Trial name
- NCT05555043
- Testing
- Irrisafe ip, GentleWave System, Waterlase iPlus
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Periodontitis
Local and Systemic Antimicrobials in Non-surgical Periodontal Therapy
The main treatment of every patient with periodontitis is non-surgical periodontal treatment (NSPT) with the ultimate goal to arrest inflammation.
- Trial name
- NCT05608564
- Testing
- Piperacillin and Tazobactam in gel form, Amoxicillin and Metronidazole
- Where
- Serbia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Belgrade