Clinical trials: Periodontitis (Stage 3)
Periodontitis (Stage 3), Smoking ( Cigarette)
Salivary TNF-α, FoxO-1, and SIRT-1 Levels in Periodontitis and Smoking
This study examines whether smoking and gum disease (periodontitis) are linked to changes in three biological markers found in saliva: TNF-α, FoxO-1, and SIRT-1.
- Trial name
- NCT07764549
- Testing
- Salivary Biomarker Analysis (ELISA)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Zehra Hasgül
Head and Neck Cancer, Chronic Periodontitis
suPAR is a Potential Biomarker of in Chronic Periodontitis Through the Impact of Post-radiotherapy on HNCs Patients
This study aims to improve a soluble urokinase plasminogen activator receptor suPAR is a reliable biomarker of chronic periodontitis and may be replaced in patients with head and neck cancer post-radiotherapy (HNC post-RT).
- Conditions
- Head and Neck Cancer, Chronic Periodontitis, Radiotherapy; Complications
- Trial name
- HNCs (NCT06481059)
- Testing
- Head and Neck cancer post-radiotherapy
- Where
- Iraq
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Al-Maarif University College
Periodontitis (Stage 3), Periodontitis Stage III
Three-Session Non-Surgical Periodontal Therapy Improves Biochemical and Microbiological Profiles in Patients With Severe Grade C Periodontitis
This clinical study investigates two different non-surgical periodontal therapy approaches in patients with advanced periodontitis and compares them with periodontally healthy individuals.
- Trial name
- TSTG (NCT07272980)
- Testing
- Scaling and Root Planing (SRP)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Gülnur Emingil
Periodontitis
Electrolysed Saline Rinse as an Adjunct for Treatment of Chronic Periodontitis
The study will be conducted as a prospective, double-blind, parallel, randomized, placebo-controlled study at the Dental Clinic of University Medical Centre Ljubljana.
- Trial name
- EOSPERIO (NCT06692582)
- Testing
- Electrolysed saline rinse, Distilled water group, Chlorhexidine 0,12%
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University of Ljubljana
Periodontitis, Diabete Mellitus
Omega-3 Pufa and Aspirin as Adjunctive Therapy in Treatment of Smoker Patients With Stage Iii Periodontitis
Background: Smoking reduces the effect of non-surgical periodontal therapy, a host modulation regimen consisting of omega-3 polyunsaturated fatty acids (ω-3 PUFA) supplementation with low-dose aspirin (ASA) with or without…
- Trial name
- NCT07385300
- Testing
- Omega-3 PUFA and Aspirin as adjunctive therapy to (SRP), Omega-3 PUFA and Aspirin and doxycycline as adjunctive therapy to (SRP), scaling and root planning (SRP)
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Alexandria University
Treatment of Stage III Periodontitis, Local Application of Insulin in Pockets
Local Application of Insulin Versus Hyaluronic Acid in Stage III Periodontitis
The present study will be performed on fourty-five patients suffering from periodontitis according to the criteria of American academy of periodontology to evaluate clinically effect of topical application of insulin versus…
- Trial name
- NCT07746206
- Testing
- Insulin, Hyaluronic acid gel, mechanical debridement
- Where
- 2 sites in Egypt
- Volunteers
- 45 people
- Sponsor
- Doaa Atta Aid
Periodontitis, Periodontitis (Stage 3)
Periodontal Dressings in Non-Surgical Therapy
This study aims to evaluate and compare the efficacy of two different eugenol-free periodontal dressing materials-Ora-Aid (a hydrophilic polymer) and Coe-Pak (a zinc oxide-based paste)-following non-surgical periodontal treatment…
- Conditions
- Periodontitis, Periodontitis (Stage 3), Periodontal Pocket
- Trial name
- NCT07472218
- Testing
- Ora Aid application, Coe-Pack application
- Volunteers
- 25 people
- Sponsor
- Saglik Bilimleri Universitesi
Periodontal Disease, AVDC Stage 3, Periodontal Disease, AVDC Stage 4
Fasting-mimicking Diet and Periodontitis (FMD)
Periodontitis (gum disease) leads to the formation of gum pockets. Its treatment involves deep cleaning of the teeth, to remove soft and hard tooth deposits under the gum line.
- Conditions
- Periodontal Disease, AVDC Stage 3, Periodontal Disease, AVDC Stage 4, Periodontitis
- Trial name
- FMD (NCT06074861)
- Testing
- Fasting-mimicking diet + non-surgical periodontal therapy
- Where
- 5 sites in Spain
- Volunteers
- 28 people
- Sponsor
- Universitat Internacional de Catalunya
Periodontitis (Stage 3), Periodontal Health
Evaluation of the Effect of Smoking on Apelin, Periostin, and High-Sensitivity CRP Levels in Gingival Crevicular Fluid and Serum
Periodontal health is influenced by various local and systemic factors, with smoking being one of the major environmental risk factors.
- Conditions
- Periodontitis (Stage 3), Periodontal Health, Smoking Cigarette
- Trial name
- NCT07870473
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Periodontitis (Stage 3), Minimally Invasive Surgical Procedures
Bone Substitutes and NIPSA in Intrabony Periodontal Defects: A Randomized Controlled Trial
This multicenter randomized controlled clinical trial aims to compare the clinical, radiographic, microbiological and molecular outcomes of two collagenated xenogeneic bone substitutes (GTO® and GenOs®) used in combination with…
- Conditions
- Periodontitis (Stage 3), Minimally Invasive Surgical Procedures, Bone Substitutes
- Trial name
- NCT07671963
- Testing
- GTO® with NIPSA surgical approach, GenOs® + NIPSA
- Where
- 2 sites in Italy, Serbia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Periodontitis Stage II, Periodontitis Stage III
3-Month Clinical Trial of Liquid S-PRF in Periodontal Debridement for Periodontitis Stages II-IV
What is the purpose of this study? This study is to investigate the effect of a processed blood product in healing after treatment for gum disease.
- Conditions
- Periodontitis Stage II, Periodontitis Stage III, Periodontitis (Stage 3), Periodontitis
- Trial name
- NCT07293962
- Testing
- Normal saline irrigation, Platelet rich fibrin
- Where
- Malaysia
- Volunteers
- 14 people
- Sponsor
- Mahsa University
Chronic Periodontitis
The Effect of Zinc on the Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients
To evaluate the effect of systemic administration of zinc on the gingival crevicular fluid level of total oxidant capacity in controlled Type-2 diabetic patients with stage-II and III periodontitis after non-surgical periodontal…
- Trial name
- NCT03923829
- Testing
- Zinc Sulfate, scaling and root planing
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis
Impact of Nonsurgical Periodontal Therapy on Oral Health Related Quality of Life
Periodontitis is a destructive inflammatory disease of tooth supporting tissues and it adversely affects oral and general health as well as lowering the quality of life.
- Trial name
- NCT06143085
- Testing
- Root surface debridement
- Where
- Iraq
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Vitamin D Deficiency, Periodontitis
25-Hydroxyvitamin D Levels in Patients With Periodontitis (Stage III)
Periodontitis; is an inflammatory disease of tissues characterized by bone destruction around the teeth. Vitamin D plays an important role in several inflammatory diseases by promoting the expression of inflammatory cytokines…
- Trial name
- NCT05343273
- Testing
- taking a blood sample
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Bony Defects, Periodontal Disease
Minimally Invasive Non-Surgical Periodontal Therapy Alone vs. Minimally Invasive Non-Surgical Periodontal Therapy With I-PRF With or Without Chlorhexidine on Stage III Periodontitis Patients
This study aims to assess the effect of chlorhexidine augmented I-PRF together with MINST and I-PRF alone with MINST versus MINST alone in the treatment of stage III periodontitis patients.
- Trial name
- MINST (NCT07791238)
- Testing
- Minimally Invasive Nonsurgical Therapy, Injectable Platelet-Rich Fibrin, Chlorhexidine 2%
- Volunteers
- 63 people
- Sponsor
- Cairo University
Peridontal Disease
Assessment of Pro-Resolution Mediator Levels in Periodontitis Stage III and IV Before and After Periodontal Therapy
This study aims to assess Pro-Resolution Mediator levels during non-surgical periodontal therapy in individuals with Stage III and IV periodontitis, comparing them to healthy subjects.
- Trial name
- NCT06789458
- Testing
- Professional mechanical plaque control
- Where
- 2 sites in Egypt
- Volunteers
- 22 people
- Sponsor
- Cairo University
Periodontitis, Dental Caries
Using Combination of Synthetic Bone Substitutes During Extractions
The study was designed to assess the effectiveness of conservation ridge preservation (horizontal and vertical dimension) after tooth extraction with and without combination of bone substitutes based on synthetic (calcium sulfate…
- Conditions
- Periodontitis, Dental Caries, Alveolar Bone Losses
- Trial name
- NCT01503593
- Testing
- Calcium Phosphate, Calcium Sulphate
- Volunteers
- 40 people
- Sponsor
- Rambam Health Care Campus
Periodontitis
Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis
Chronic periodontitis is an infectious disease of periodontal support tissues caused by bacterial biofilm, which leads to inflammation and destruction of periodontal support tissues ultimately resulting in tooth loss.In the…
- Trial name
- NCT05530252
- Testing
- Oral biological antimicrobial gel, minocycline hydrochloride ointment, SRP
- Where
- China
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Beijing Stomatological Hospital, Capital Medical University
Periodontitis
Periodontitis Stage III and IV and Oral Health Related Quality of Life
Patients diagnosed with stage III or IV periodontitis during routine visits at the department of periodontology will undergo a validated questionnaire to understand the impact of the disease on their quality of life.
- Trial name
- NCT05481567
- Testing
- Questionnaire
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Cagliari
Periodontitis, Diabetes Mellitus
Levels of Neuregulin-4 and Its Receptor ErbB4 in Periodontitis Patients With and Without Diabetes Type 2
The aim of this study is to assess the levels of neuregulin-4 and its receptor ErbB4 in the GCF and saliva in stage III and IV periodontitis patients with and without type 2 diabetes mellitus.
- Trial name
- NCT04930588
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cairo University