Clinical trials: Periodontitis (Stage 3)
Smoking Reduction
Cathelicidin LL-37 Levels in the GCF and the Saliva of Smokers and Non-smokers With Stage III,IV Periodontitis
Periodontitis is considered an inflammatory disease that results in the disruption of oral hemeostasis and is associated with the presence of dental plaque influenced by genetic and environmental factors.
- Trial name
- NCT04861493
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Periodontal Disease, Periodontitis (Stage 3)
Evaluation of the Potential Effects of LRP5 and Tph1 in the Pathogenesis of Periodontal Disease Individuals With Stage III Grade B Periodontitis
Objectives: The aim of this study was to determine the changes in LRP5 and TPH1 levels in serum and saliva samples due to periodontal inflammation and to evaluate the relationship between these values and clinical periodontal…
- Conditions
- Periodontal Disease, Periodontitis (Stage 3), Periodontitis Stage III
- Trial name
- NCT06933797
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ankara University
Periodontitis (Stage 3)
Effects of Non-Surgical Periodontal Treatment on Inflammatory and Bone Markers in Periodontitis Patients
The goal of this study is to learn how a standard treatment called Scaling and Root Planing (SRP) affects specific biochemical markers in people with advanced gum disease (periodontitis).
- Trial name
- GPNMB-PERIO St (NCT07475013)
- Testing
- Scaling and Root Planing (SRP)
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Periodontal Disease, Periodontitis (Stage 3)
Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis
This randomized double-blind placebo-controlled clinical trial aims to evaluate the clinical and biochemical effects of omega-3 fatty acids combined with low-dose aspirin as an adjunct to scaling and root planing (SRP) in smoker…
- Conditions
- Periodontal Disease, Periodontitis (Stage 3), Smoking Behaviors
- Trial name
- OASP (NCT07673185)
- Testing
- Omega-3 Fatty Acids (EPA plus DHA) plus low dose aspirin
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Periodontitis, Periodontitis (Stage 3)
Effect of Guided Biofilm Therapy in Patients With Stage 3 Periodontitis
This randomized interventional study aims to compare the clinical and biochemical effects of conventional non-surgical periodontal therapy (NSPT), adjunctive diode laser therapy, and guided biofilm therapy (GBT) in patients with…
- Trial name
- NCT07788937
- Testing
- Non-Surgical Periodontal Therapy, Diode Laser Therapy, Guided Biofilm Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ataturk University
Periodontitis, Periodontitis Stage I
Relationship Between NLRP3 Inflammasome Activation and Stages of Periodontitis: An Association With Inflammaging
This study aims to investigate the relationship between NLRP3 inflammasome activation and different stages of periodontitis, with a focus on its association with inflammaging.
- Conditions
- Periodontitis, Periodontitis Stage I, Periodontitis Stage II, Periodontitis Stage III
- Trial name
- NCT07590089
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Periodontitis (Stage 3)
Hydrolyzed Collagen As A Host Modulation Agent in Non-Surgical Periodontal Treatment
This study was planned on the basis of the hypothesis that 'food supplements containing collagen will support the clinical effectiveness of non-surgical periodontal therapy'.
- Trial name
- NCT07683741
- Testing
- Collagen hydrolyzed peptides
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Hatice Yemenoglu
Intrabony Periodontal Defect
The Effect of A-PRF+ Versus Open Flap Debridement in the Treatment of Patients With Stage III Periodontitis
To assess the effectiveness of advanced PRF+ as compared to open flap debridement in treatment of periodontal intraosseous defects in stage III periodontitis patients.
- Trial name
- NCT03924336
- Testing
- Advanced- platelets rich fibrin (A-PRF+) + Open flap debridement (OFD), Open flap debridement (OFD) alone
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontal Diseases, Periodontal Pocket
Effectiveness of SRP+ Lipo-curcumin Gel for the Treatment of Stage III Periodontitis.
The aim of the present study is to clinically and radiographically compare the effectivness of Scaling and Root Plannig (SRP) in association with lipo-curcumin gel (LC) respect SRP+ lipo-gel (L), SRP+ discharged (D) gel and SRP…
- Conditions
- Periodontal Diseases, Periodontal Pocket, Periodontal Attachment Loss
- Trial name
- NCT06624241
- Testing
- Lipo-Curcumin gel + SRP, Lipo gel + SRP, Discharged Gel + SRP
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Periodontitis, Acute-Phase Response
Relationship Between LRG and Periodontal Disease
This study aimed to investigate gingival crevicular fluid (GCF) and serum levels of LRG, interleukin (IL)-6 and tumor necrosis factor (TNF)-α in patients with periodontitis before and after non-surgical periodontal treatment.
- Conditions
- Periodontitis, Acute-Phase Response, Inflammation
- Trial name
- NCT04383561
- Testing
- Non-surgical periodontal treatment, Oral hygiene instructions
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University