Clinical trials: Perioperative
Perioperative Care, Surgery--Complications
Perioperative Hypothermia and Myocardial Injury After Non-cardiac Surgery
We propose to test the hypothesis that aggressive warming reduces the incidence of major cardiovascular complications, compared to routine care.
- Conditions
- Perioperative Care, Surgery--Complications, Hypothermia; Anesthesia, Myocardial Injury
- Trial name
- PROTECT (NCT03111875)
- Testing
- aggressive warming, routine thermal management
- Where
- 11 sites in United States, China
- Volunteers
- 5,056 people
- Sponsor
- The Cleveland Clinic
Blood Pressure
Perioperative Blood Pressure Screening to Improve Long-term Cardiovascular Health
To explore in a pilot randomized clinical trial, the impact of Home Blood Pressure Monitoring with patient directed information as compared to usual care on the postoperative management of blood pressure.
- Trial name
- NCT03634813
- Testing
- High Blood Pressure Monitor, Usual Care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Post Operative Analgesia, Bariatric Surgery
Oral Acetaminophen for Post-Op Pain Management in Bariatric Surgery Patients
Adult patients with morbid obesity who have had Roux-en-Y gastric bypass (RYGB) or laparoscopic sleeve gastrectomy (LSG) surgery have impaired drug metabolism.
- Conditions
- Post Operative Analgesia, Bariatric Surgery, Bariatric Surgery (Gastric Bypass), Bariatric Surgery Patients
- Trial name
- NCT06658574
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Rutgers, The State University of New Jersey
Nephrectomy, Partial Nephrectomy
Erector Spinae Plane Block (ESPB): in Patients Undergoing Surgery Through a Flank or Anterior Subcostal Incision.
Using a randomized double-blinded study design, the study goal is to evaluate the superiority of Erector Spinae Plane block (ESPB) in the peri-operative pain management of patients undergoing surgery through a flank or anterior…
- Conditions
- Nephrectomy, Partial Nephrectomy, Incision Site Discomfort
- Trial name
- NCT03691935
- Testing
- Ropivacaine, Normal saline
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Milton S. Hershey Medical Center
Outcome Assessment, Patient Satisfaction
Evaluation of Factors Associated With Patient Satisfaction and Mood-State in Regional Anesthesia
Patient satisfaction is an important subjective measure of healthcare quality which contributes to evaluation of the structure, process and outcome of services.
- Trial name
- NCT03476278
- Testing
- Questionnaire
- Volunteers
- 300 people
- Sponsor
- Derince Training and Research Hospital
Anxiety
Audiovisual Interactive Games to Alleviate Pediatric Perioperative Anxiety
Pediatric anxiety upon induction of anesthesia is widely prevalent and can lead to negative patient psychological impact and hindrance to induction of anesthesia.
- Trial name
- NCT06111742
- Testing
- Bedside Entertainment and Relaxation Theater (BERT)
- Where
- United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Yale University
Gender Dysphoria, Opioid Use
The Effect of Pectoral Blocks on Perioperative Pain in Gender Affirmation Top Surgery
Despite recent advancements with regional and local anesthesia, postoperative pain continues to be a major concern for patients undergoing breast surgery.
- Conditions
- Gender Dysphoria, Opioid Use, Pain, Postoperative
- Trial name
- NCT04474366
- Testing
- Ropivacaine 0.2% Injectable Solution, Saline (0.9%)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Cancer of Head and Neck, Narcotic Use
Perioperative Analgesia Using Gabapentin in Head and Neck Cancer Surgery
Patients undergoing head and neck cancer surgery often have a lot of pain after surgery, which can lead to a need for a lot of narcotic pain medication.
- Trial name
- NCT03682367
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of California, Davis
Valvular Heart Surgery
Efficacy of Prothrombin Complex Concentrate Reducing Perioperative Blood Loss in Cardiac Surgery
This non-inferiority, randomized controlled trial aims to evaluate whether coagulation-guided low-dose four-factor prothrombin complex concentrate (PCC) is non-inferior to fresh frozen plasma (FFP) in reducing cumulative chest…
- Trial name
- NCT04244981
- Testing
- Prothrombin Complex Concentrate, Human, Fresh Frozen Plasma
- Where
- 2 sites in China
- Volunteers
- 476 people
- Sponsor
- SHI Jia
Liver Cancer
Clinical Trial of Standard Versus Goal-Directed Perioperative Fluid Management (GDT) for Patients Undergoing Liver Resection
The purpose of this study is to help us learn what is the best amount of fluid to administer to patients during liver surgery. Patients will receive either an amount for this surgery based on weight, blood pressure, heart rate…
- Trial name
- NCT01596283
- Testing
- Standard fluid management, Goal directed fluid therapy with the Edwards EV1000 system
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Obesity, Laparoscopic Gastric Bypass Surgery
CURES: The Effect of Deep Curarisation and Reversal With Sugammadex on Surgical Conditions and Perioperative Morbidity
The purpose of this study is to investigate if a deep neuromuscular block with a continuous infusion of rocuronium titrated to a post-tetanic count (PTC) of 1-2 responses combined with reversal of neuromuscular blockade with…
- Conditions
- Obesity, Laparoscopic Gastric Bypass Surgery, Surgical Conditions, Respiratory Function
- Trial name
- CURES (NCT01748643)
- Testing
- deep neuromuscular blockade with rocuronium, reversal with sugammadex, normal neuromuscular blockade reversal with rocuronium, reversal with neostigmine
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Ziekenhuis Oost-Limburg
Kidney Cancer, Prostate Cancer
Effect of Perioperative Intravenous Lidocaine Infusion in Robotic-Assisted Urologic Surgery
Controlling pain is fundamental during and after surgical procedures. This study examines pain associated with robotic assisted surgery on prostate cancer or a kidney mass.
- Trial name
- NCT03824808
- Testing
- Lidocaine Hydrochloride 0.8% in Dextrose 5% Solution, 0.9% Sodium Chloride Injection
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Missouri-Columbia
Laparoscopic Gastric Bypass Surgery, Ketamine
Perioperative Ketamine for Pain With Gastric Bypass
Opioid medications such as morphine, hydrocodone and oxycodone are standard for treating pain after surgery, however there are disadvantages.
- Trial name
- NCT03448068
- Testing
- Ketamine, Standard therapy
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Dysfunctional Voiding, Postoperative Pain
The Effect of Oral PhenazopyrIdine on Perioperative Voiding After Mid-urethral sliNg (EPIPhANy Study)
Randomized clinical trial using phenazopyridine to decrease voiding dysfunction after a retropubic midurethral sling operation.
- Trial name
- EPIPhANy (NCT02806713)
- Testing
- Phenazopyridine, no Phenazopyridine
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Massachusetts, Worcester
Pain, Postoperative
Perioperative Administration of Pregabalin for Pain After Mastectomy
The investigators hypothesize that pregabalin will decrease post-operative pain scores and analgesic use following total mastectomy compared to placebo.
- Trial name
- NCT00938548
- Testing
- Pregabalin
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Severance Hospital
Penicillin Allergy
Perioperative Antibiotic Choices for Surgical Prophylaxis in Penicillin-allergic Pediatric Patients
The proposed research project will retrospectively review the anesthetic records over the past 5 years and identify patients who present with a history of penicillin allergy or allergy to an antibiotic in the penicillin family.
- Trial name
- NCT02036840
- Testing
- Antibiotic
- Where
- United States
- Volunteers
- 513 people
- Sponsor
- Joseph D. Tobias
Gastrointestinal Cancer
Perioperative Palliative Care Surrounding Cancer Surgery for Patients & Their Family Members
The study goal is to compare surgeon-palliative care team co-management, versus surgeon alone management, of patients and family members preparing for major upper gastrointestinal cancer surgery.
- Trial name
- PERIOP-PC (NCT03611309)
- Testing
- Surgeon-palliative care team co management, Surgeon team alone management
- Where
- 5 sites in United States
- Volunteers
- 379 people
- Sponsor
- Stanford University
Pancreatic Adenocarcinoma, Resectable Pancreatic Carcinoma
S1505: Combination Chemotherapy or Gemcitabine Hydrochloride and Paclitaxel Albumin-Stabilized Nanoparticle Formulation Before Surgery in Treating Patients With Pancreatic Cancer That Can Be Removed by Surgery
This randomized phase II trial studies how well fluorouracil, irinotecan hydrochloride, and oxaliplatin (combination chemotherapy) works and compares to gemcitabine hydrochloride and paclitaxel albumin-stabilized nanoparticle…
- Trial name
- NCT02562716
- Testing
- Fluorouracil, Gemcitabine Hydrochloride, Irinotecan Hydrochloride
- Where
- 807 sites in United States
- Volunteers
- 147 people
- Sponsor
- SWOG Cancer Research Network
Curvature of Spine
The Use of Tranexamic Acid to Reduce Perioperative Blood Loss During High Risk Spine Fusion Surgery
The purpose of this study is to determine if tranexamic acid reduces perioperative blood loss and red blood cell transfusion during high risk spine surgery.
- Trial name
- TXA (NCT01728636)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Northwestern University
Post-traumatic Stress Disorder
Perioperative Propranolol in Patients With Post Traumatic Stress Disorder (PTSD)
Understanding what treatments may facilitate perioperative care of Veterans with posttraumatic stress disorder (PTSD) is of great importance to the U.S. health care system.
- Trial name
- NCT01555554
- Testing
- Propranolol Hydrochloride
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of California, San Francisco