Clinical trials: Perioperative
Pain, Perioperative
Study To Investigate The Effectiveness Of Pregabalin For Management Of Patients Undergoing Total Hip Replacement
The purpose of this study is the investigate if pregabalin started a day before surgery and continued for 14 days post-operatively can reduce post-operative pain, relieve pre- and post-operative anxiety and sleep disturbances.
- Trial name
- NCT00905437
- Testing
- Pregabalin
- Where
- 7 sites in India
- Volunteers
- 72 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Distal Radius Fracture
Perioperative Glucocorticoid Administration in the Treatment of Adult Distal Radius Fractures
The purpose of this investigation is to compare functional outcome measures and range of motion for patients receiving glucocorticoid (GC) injections versus those not receiving GCs for the treatment of distal radius fractures.
- Trial name
- NCT03898154
- Testing
- Dexamethasone, Methylprednisolone
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- C. Liam Dwyer
Anxiety State, Satisfaction
Immersive Virtual Reality Exposure for Reducing Preoperative Anxiety in Children
Perioperative anxiety management for children undergoing surgery poses a major challenge to anaesthesiologists as high anxiety, reported in numerous studies, leads to detrimental effects physiologically, mentally and on pain…
- Conditions
- Anxiety State, Satisfaction, Compliance
- Trial name
- NCT07018999
- Testing
- Immersive virtual reality operating theatre tour
- Where
- Hong Kong
- Volunteers
- 114 people
- Sponsor
- Hong Kong Children's Hospital
Chronic Sinus Infection
Use of Perioperative Antibiotics in Endoscopic Sinus Surgery
The objective of this study is to determine whether the use of postoperative antibiotics following endoscopic sinus surgery (ESS) decreases postoperative infection rates.
- Trial name
- NCT03369717
- Testing
- Amoxi Clavulanate
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Obesity, Laparoscopic Gastric Bypass Surgery
CURES: The Effect of Deep Curarisation and Reversal With Sugammadex on Surgical Conditions and Perioperative Morbidity
The purpose of this study is to investigate if a deep neuromuscular block with a continuous infusion of rocuronium titrated to a post-tetanic count (PTC) of 1-2 responses combined with reversal of neuromuscular blockade with…
- Conditions
- Obesity, Laparoscopic Gastric Bypass Surgery, Surgical Conditions, Respiratory Function
- Trial name
- CURES (NCT01748643)
- Testing
- deep neuromuscular blockade with rocuronium, reversal with sugammadex, normal neuromuscular blockade reversal with rocuronium, reversal with neostigmine
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Ziekenhuis Oost-Limburg
Dysphagia
Dysphagia Following Anterior Cervical Spine Surgery; Single Dose Steroid vs Saline (DysDexVSSal)
This prospective, randomized, double blind, controlled study evaluates the effect of a single dose of perioperative IV steroid versus saline on swallowing after anterior cervical spine surgery
- Trial name
- NCT03711474
- Testing
- Dexamethasone, Saline
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Colorectal Surgery
Efficacy Comparison of Two Preoperative Skin Antisepsis Preparations in Colorectal Surgery
Surgical site infections (SSI) are one of the most common complications in the post-operative patient, and the second most common health care associated infection overall.
- Trial name
- NCT01233050
- Testing
- 2% Chlorhexidine Gluconate/70% Isopropyl Alcohol, Iodine Povacrylex/74% Isopropyl Alcohol
- Where
- 3 sites in United States
- Volunteers
- 802 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Temperature Change, Body
The Effect of Convective Pre-warming on Intra-operative Thermoregulatory Capabilities
This prospective randomized clinical trial will assess the effect of pre-operative convective warming on intra-operative thermoregulation in patients undergoing gastrointestinal or genitourinary surgical procedures with the Tiger…
- Trial name
- NCT03876808
- Testing
- Bair Hugger™ Temperature Management Unit Model 750, 3M™ Bair Paws™ Flex Gown
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Missouri-Columbia
Atelectasis, Postoperative Pulmonary
Evaluation of the Effects of Intraoperative Ventilation Modes on Perioperative Atelectasis
In hysterectomy surgeries, due to factors such as the abdominal nature of the procedure, prolonged operative duration, and the use of the head-down (Trendelenburg) position during surgery, a lobe or a specific region of the lungs…
- Trial name
- NCT07413575
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Post-operative Hemorrhage
Evaluating Perioperative Dexamethasone and the Risk of Bleeding in Tonsillectomy
Tonsillectomy (removal of the tonsils) is a very common surgery in children. Bleeding after tonsillectomy is one of the risks of this surgery and can be more dangerous in children since they have less blood volume than adults.
- Trial name
- NCT01415583
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 314 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Pelvic Floor Disorders
Pelvic Floor Physical Therapy vs Standard Care in Transgender Women Undergoing Vaginoplasty for Gender Affirmation
Currently, perioperative pelvic floor physical therapy (PFPT) is not standard of care for all patients who undergo vaginoplasty surgery.
- Trial name
- FLOWER (NCT05690555)
- Testing
- Preoperative and Postoperative Pelvic Floor Physical Therapy (PFPT), No Pelvic Floor Physical Therapy (PFPT), Postoperative PFPT
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- The Cleveland Clinic
Perioperative Hypothermia
Prospective Trial of the Effect of Preoperative Forced-air Warming on Perioperative Body Temperature Following Neuraxial Anesthesia in Total Hip Arthroplasty Patients
The purpose of this study is to determine if placement of a forced-air warming device prior to institution of regional anesthesia improves perioperative temperature control in patients undergoing total hip arthroplasty.
- Trial name
- NCT01626690
- Testing
- Bair-Paws Warming Device, Bair-Hugger Warming Device
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Wisconsin, Madison
Esophageal Cancer
Does Perioperative Goal Directed Therapy Using Flotrac Improve Outcomes in Esophagectomy Patients
The objective of this prospective, randomized controlled study is to ascertain whether the perioperative use of the FloTrac device to guide fluid and vasopressor management during esophagectomy improves patient outcomes.
- Trial name
- NCT02864355
- Testing
- Goal Directed Therapy
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Medical University of South Carolina
Staphylococcus Aureus, Health Care Associated Infection
Reducing Perioperative S. Aureus Transmission
The purpose of this study is to prevent the spread of S. aureus, a dangerous bacterium, within the operating room and between patients undergoing surgery.
- Conditions
- Staphylococcus Aureus, Health Care Associated Infection, Health Care Worker Patient Transmission
- Trial name
- NCT03638947
- Testing
- Swab and decolonization using povidone-iodine cleansing
- Where
- United States
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Randy Loftus
Bleeding, Hemorrhage
Protamine in Cardiac Surgery and Haemostasis
Protamine is used after Cardiopulmonary Bypass (CPB) to reverse the anticoagulant effects of heparin and restore coagulation. Convincing evidence from in-vitro and in-vivo studies suggest that an overdose of protamine has…
- Trial name
- PROTT (NCT01608971)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Prostate Hypertrophy, Renal Disease
Effect of Deep BLock on Intraoperative Surgical Conditions
Rationale: A deep neuromuscular block is often associated with improved surgical conditions especially in laparoscopic surgery. However, a deep block comes at the expense of a variety of items that may conflict with the use of a…
- Trial name
- BLISS (NCT01631149)
- Testing
- Surgical block (rocuronium; atracurium/mivacurium)
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Leiden University Medical Center
Thermal Burns
Continuous Lidocaine Infusion for Management of Perioperative Burn Pain
Thermal injury results in one of the most intense and prolonged forms of pain the body can experience. Opioid narcotics are the most powerful drugs for acute and chronic pain, and their use in the perioperative period has been…
- Trial name
- NCT02059902
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- HealthPartners Institute
Pain
Effects of Perioperative B&O Suppositories on Post-op Pain and Morphine Use After Laparoscopic Prostatectomy
This study is evaluating the effect of a Belladonna and Opium suppository administered intraoperatively on post operative pain after laparoscopic radical prostatectomy for prostate cancer. This is a blinded randomized study.
- Trial name
- NCT00863928
- Testing
- belladonna 16.2 mg and opium 60 mg suppository
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Benaroya Research Institute
Bladder Cancer, Low Testosterone Levels
Perioperative Hypogonadism in Men Undergoing Radical Cystoprostatectomy for Bladder Cancer
The purpose of this study is to examine the relationship between testosterone level changes around the time of radical cystectomy.
- Trial name
- NCT03063125
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Kansas Medical Center
Orthostatic Hypotension, Hemodynamic Instability
Trial Comparing Low Dose and High Dose Steroids in Patients Undergoing Colorectal Surgery
The purpose of this study is to evaluate the effect of low dose versus high dose steroids vital signs of patients currently on steroids or recently treated with steroids undergoing major colorectal surgery.
- Conditions
- Orthostatic Hypotension, Hemodynamic Instability, Fever, Hypothermia
- Trial name
- NCT01559675
- Testing
- Hydrocortisone High Dose, Hydrocortisone Low Dose
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Cedars-Sinai Medical Center