Clinical trials: Perioperative
Pain, Postoperative Depression
Study on the Use of Low Dose Ketamine After Gastric Bypass and Gastrectomy
This is a randomized, double-blind, placebo-controlled, two-arm parallel, single-center study. One hundred subjects (50 in each arm) will be enrolled.
- Trial name
- NCT02452060
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- NYU Langone Health
Malignant Gastrointestinal Neoplasm, Malignant Peritoneal Neoplasm
Consumer-Based Activity Monitor in Evaluating and Measuring Activity of Older Patients With Abdominal Cancer Undergoing Surgery
This pilot clinical trial studies how well consumer-based activity monitor works in evaluating and measuring activity of older patients with abdominal cancer undergoing surgery.
- Trial name
- NCT02356471
- Testing
- Management of Therapy Complications Fitbit Zip (portable pedometer device), Questionnaire Administration, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Wake Forest University Health Sciences
Diabetes Mellitus
Perioperative Continuous Glucose Monitoring
To evaluate use of continuous glucose monitoring (CGM) technology in the preoperative setting: evaluate feasibility of placement of CGM during preoperative clinic visit with intent to utilize CGM throughout perioperative period.
- Trial name
- CGM (NCT05937373)
- Testing
- Continuous Glucose monitor, Standard of Care
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Wake Forest University Health Sciences
Cancer Colon
Perioperative Iron for Colorectal Cancer (PICoC Study)
The PICoC study aims to investigate whether oral ferric maltol given postoperatively offers an improvement in patient and clinician reported outcomes compared to standard care.
- Trial name
- PICoC (NCT05177484)
- Testing
- oral ferric maltol
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Acute Kidney Injury
Aortix Therapy for Perioperative Reduction of Kidney Injury
The study is a prospective, non-randomized feasibility study to evaluate the safety and performance of providing support with the Aortix System to patients at heightened risk of acute kidney injury (AKI) undergoing cardiovascular…
- Trial name
- A Priori (NCT04999163)
- Testing
- Aortix System
- Where
- 5 sites in Australia
- Volunteers
- 20 people
- Sponsor
- Procyrion
Penicillin Allergy
Perioperative Antibiotic Choices for Surgical Prophylaxis in Penicillin-allergic Pediatric Patients
The proposed research project will retrospectively review the anesthetic records over the past 5 years and identify patients who present with a history of penicillin allergy or allergy to an antibiotic in the penicillin family.
- Trial name
- NCT02036840
- Testing
- Antibiotic
- Where
- United States
- Volunteers
- 513 people
- Sponsor
- Joseph D. Tobias
Anaesthesia
General Anesthesia With Xenon in Inspiratory Concentrations of 50% and 70% and Total I.V. Anaesthesia.
The purpose of this study is to evaluate the quantity of propofol administered with Xenon in two inspiratory concentrations, to maintain comparable depth of anaesthesia during the maintenance period of general anaesthesia.
- Trial name
- NCT00919126
- Testing
- Xenon, Medical Air in Oxygen
- Where
- 6 sites in France, Germany and 1 more
- Volunteers
- 102 people
- Sponsor
- Air Liquide SA
Pediatric Perioperative Blood Pressure Management
Assessment of Efficacy, Safety and Dosing of Clevidipine in Pediatric Participants Undergoing Surgery (PIONEER)
Evaluate the efficacy, safety, and dosing of clevidipine as an intravenous (IV) infusion for blood pressure (BP) management in paediatric participants in the perioperative setting.
- Trial name
- PIONEER (NCT01938547)
- Testing
- clevidipine
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Cardiac Output
Impedance Cardiography: Clinical Evaluation of Endotracheal Cardiac Output Monitor (ECOM)
1. Compare measurements of cardiac output derived from electrical measurements from electrodes on an endotracheal tube (ECOM or Endotracheal Cardiac Output Monitor) to those made from a pulmonary artery thermodilution catheter.
- Trial name
- ECOM (NCT00924482)
- Testing
- Placed ECOM endotracheal cardiac output monitor in patients undergoing cardiac surgery
- Volunteers
- 261 people
- Sponsor
- University of California, San Francisco
Pancreatectomy
Perioperative Intravenous Lidocaine Infusion for Patients Undergoing Laparoscopic and Open Pancreatectomies
The purpose of this study is to evaluate if a lidocaine infusion will provide benefit to pancreatectomy patients in regards to analgesia and return of bowel function.
- Trial name
- NCT02623803
- Testing
- Lidocaine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Mayo Clinic
Opioid Dependence, Chronic Pain
Perioperative Ketamine in Opioid-Tolerant Patients Undergoing Lumbar Spine Surgery
The goal of this study is to determine whether comprehensive perioperative administration of the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine can increase postoperative pain tolerance and reduce opiate consumption in…
- Trial name
- NCT04220489
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Jacques E. Chelly
Head and Neck Cancer, Analgesia
Multimodal Pain Study in Free Flap Patients
This study will be a randomized, prospective study comparing Pain Management Arm A and Pain Management Arm B. Arm A will have scheduled Tylenol with opioids available as needed (PRN) in the peri-operative period.
- Trial name
- NCT04246697
- Testing
- Tylenol, Oxycodone, Morphine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kansas Medical Center
Infertility, Female, Pain, Postoperative
Assessing Efficacy of Intravenous Acetaminophen for Perioperative Pain Control for Oocyte Retrieval
In this research study we want to learn more about how effective certain medications are at reducing pain after oocyte (egg) retrieval surgery and how effective they are at reducing the time between the retrieval and discharge…
- Trial name
- NCT03073980
- Testing
- IV Acetaminophen, PO Acetaminophen
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Coronary Disease, Heart Diseases
Effects of Magnesium on Individuals Undergoing Coronary Artery Bypass Graft Surgery
The purpose of this study is to examine the effects of supplemental magnesium on the neurocognitive function of individuals undergoing coronary artery bypass graft (CABG) surgery.
- Conditions
- Coronary Disease, Heart Diseases, Cardiovascular Diseases, Neurologic Manifestations
- Trial name
- POINT (NCT00041392)
- Testing
- Magnesium, 0.9% saline
- Where
- United States
- Volunteers
- 389 people
- Sponsor
- Duke University
Osteoarthritis
Tranexamic Acid in Knee Joint Surgery
Total knee joint replacement surgery can lead to significant blood loss, which can affect recovery after surgery. Tranexamic acid (TXA) is a medication which stops the breakdown of blood clots and therefore prevents blood loss.
- Trial name
- TRACKS (NCT02278263)
- Testing
- Tranexamic Acid, Normal saline (0.9% NaCl)
- Where
- 5 sites in New Zealand
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Andrew G Hill, MBChB, MD (Thesis), EdD, FACS, FRACS
Diabetes, Surgery
Perioperative Insulin Glargine Dosing Study
The main objective of this study is to compare three strategies of evening insulin glargine dosing to preoperative glucose values in patients with diabetes undergoing surgery to determine which dosing strategies most often…
- Trial name
- NCT00309465
- Testing
- Lantus, Insulin
- Where
- 2 sites in United States
- Volunteers
- 402 people
- Sponsor
- Tamra Dukatz
Postoperative Pain, Delirium
Study of Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery
Pain, confusion, and breaks in normal sleep cycles have been challenges commonly faced by patients after undergoing joint surgeries.
- Conditions
- Postoperative Pain, Delirium, Confusion, Sleep
- Trial name
- NCT01505465
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hospital for Special Surgery, New York
Older Adults, Anxiety
Behavioral Activation and Medication Optimization For Improving Perioperative Mental Health In Older Adults Undergoing Oncologic Surgery
Using a Hybrid Type 1 Effectiveness-Implementation randomized control trial (RCT) design, the investigators will test the effectiveness of a bundled behavioral activation and medication optimization in reducing symptoms of…
- Conditions
- Older Adults, Anxiety, Depression, Major Surgical Resection of a Thoracic Malignancy
- Trial name
- NCT05685511
- Testing
- Behavioral Activation, Medication Optimization, Usual care resources
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Washington University School of Medicine
Heart Diseases
Metoprolol to Reduce Perioperative Myocardial Injury
The purpose of this research study is to test if a commonly used, FDA-approved medication, called metoprolol, given at the conclusion of anesthesia following surgery, and during postoperative admission, reduces the possibility of…
- Trial name
- ORION (NCT03138603)
- Testing
- Metoprolol Tartrate
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- University of Chicago
Pain, Postoperative
Perioperative Administration of Pregabalin for Pain After Robot-assisted Endoscopic Thyroidectomy
The investigators hypothesize that pregabalin will decrease post-operative pain scores and analgesic use following robot-assisted endoscopic thyroidectomy compared to placebo.
- Trial name
- NCT00905580
- Testing
- Pregabalin
- Where
- South Korea
- Volunteers
- 99 people
- Sponsor
- Severance Hospital