Clinical trials: Perioperative Biomarkers
Abdominal Surgery, Thoracic Surgery
Perioperative Kinetics of Reactive Hyperemia Using Noninvasive Digital Thermal Monitoring
Primary Objective: The primary objective of the study is to characterize and measure the impact of major surgery on the kinetics of endothelial function during the perioperative period.
- Trial name
- NCT00683150
- Testing
- Endothelial Function Test
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- M.D. Anderson Cancer Center
NSCLC Stage IIIA/B, NSCLC Stage II
Construction of a Prognostic and Prediction Model for Perioperative Immunotherapy in NSCLC: A Multi - Omics Perspective
This research focuses on exploring biomarkers for the application of PD - 1/PD - L1 immune checkpoint inhibitors in the perioperative immunotherapy of lung cancer.
- Trial name
- NCT06856798
- Volunteers
- 120 people
- Sponsor
- Ziming Li
Thyroidectomy, Oxidative Stress
Opioid-Free Versus Opioid-Based Anesthesia in Thyroid Surgery
This study will compare opioid-free anesthesia and opioid-based anesthesia in adult euthyroid patients undergoing elective thyroidectomy.
- Conditions
- Thyroidectomy, Oxidative Stress, Anesthesia
- Trial name
- OFA-OBA (NCT07864155)
- Testing
- Fentanyl (IV), Dexmedetomidine and lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Malatya Egitim Ve Arastirma Hastanesi
Congenital Heart Disease
Copeptin- Relevance as a Perioperative Marker in Pediatric Cardiac Surgery
This study evaluates the relevance of Copeptin in children with congenital heart disease undergoing cardiac surgery with the need of cardiopulmonary bypass. Three blood samples are taken of each patient.
- Trial name
- NCT03316508
- Where
- Austria
- Volunteers
- 81 people
- Sponsor
- Claudia Herbst
Impacted Third Molar, Postoperative Pain
Kynurenic Acid and Serotonin as Perioperative Neuroinflammatory Biomarkers in Sequential Third Molar Surgery
A prospective cohort of 40 consecutive patients with bilateral impacted mandibular third molars underwent two sequential surgical extractions separated by a two-week interval.
- Conditions
- Impacted Third Molar, Postoperative Pain, Neuroinflammation, Anxiety
- Trial name
- KYNA-3M (NCT07644065)
- Testing
- Ibuprofen, Ibuprofen + Gabapentin
- Where
- Bulgaria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Esophagectomy, HALP Score
Perioperative HALP and Surgical Outcomes
Esophagectomy is associated with substantial postoperative morbidity despite advances in perioperative care. The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score has been proposed as a composite biomarker reflecting…
- Conditions
- Esophagectomy, HALP Score, Perioperative Biomarkers, Postoperative Complications
- Trial name
- NCT07761975
- Testing
- Perioperative HALP Score Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 131 people
- Sponsor
- Istanbul Saglik Bilimleri University
Perioperative Stress
Temporal Profile of Biomarkers Associated to Perioperative Stress Due to Carotid Endarterectomy Under Regional Anesthesia
Carotid endarterectomy (CEA) is a high risk surgical and anesthesiological procedure. It is an essential part of stroke-prevention strategies, however the incidence of CEA related peri-operative stroke is between 5% and 10%.
- Trial name
- NCT03957018
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- University of Pecs
Pancreatic Ductal Adenocarcinoma (PDAC)
Perioperative Fostamatinib With Gemcitabine and Nab-paclitaxel in Resectable Pancreatic Cancer
This is a Phase 1b trial evaluating the combination of Fostamatinib, a Syk kinase inhibitor currently FDA-approved for chronic idiopathic thrombocytopenia purpura (ITP), with the standard of care chemotherapy agents gemcitabine…
- Trial name
- NCT06639724
- Testing
- Fostamatinib in combination with chemotherapy (gemcitabine and nab-paclitaxel)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of California, San Diego
Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma (Siewert II-III)
Molecular Characterization of Tumor-Microenvironment Interactions to Predict Drug Resistance in Gastric and GEJ Adenocarcinoma
Surgical resection remains the only curative option for resectable gastric cancer, but perioperative FLOT chemotherapy is associated with substantial rates of chemoresistance and recurrence, largely driven by marked tumor…
- Trial name
- GASTROIMMUNE (NCT07692477)
- Volunteers
- 250 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Coronary Artery Disease, Anesthesia
Influence of Oxygen on Perioperative Outcome in Patients Undergoing General Anaesthesia for Elective Non-cardiac Surgery
The purpose of this study is to investigate the impact of supraphysiologic oxygen (hyperoxia) on myocardial function in anaesthetized patients undergoing non-cardiac vascular surgery.
- Trial name
- Promise-O2 (NCT04808401)
- Testing
- Oxygen
- Where
- Switzerland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern