Clinical trials: Perioperative Hyperglycaemia
Hyperglycaemia (Diabetic), Bariatric Surgery Candidate
Perioperative Evaluation of Glucose Profile Using Continuous Glucose Monitoring System in Glucose Intolerant Patients
The recent use of a pre-operative carbohydrate loading compared to fasting has been shown to improve the early recovery after surgical procedures by reducing the profound stress response following surgery and allowing a better…
- Trial name
- PERISURG-CGM (NCT04343040)
- Testing
- carbohydrate supplement (Preload™), 6 hours of preoperative fasting
- Sponsor
- University Hospital, Lille
Osteoarthritis, Knee, Osteoarthritis, Hip
Continuous Glycemia Monitoring in Perioperative Period in Patients Undergoing Total Knee or Hip Arthroplasty
All across surgery specialties, wound or implant infections constitute rare, yet potentially severe complications of surgical procedure. It is considered, that glucose metabolism disorders, e.g.
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Hyperglycemia, Diabetes Mellitus, Type 2
- Trial name
- NCT04444570
- Testing
- Continuous glycemia measuring device (Dexcom) implantation into the subcutaneous tissue
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Perioperative Hyperglycaemia, Insulin Therapy
Perioperative Closed-loop Glucose Control
The prevalence of diabetes and hyperglycaemia in surgical patients is rising and associated with grater complication rates, length of stay and mortality rates.
- Conditions
- Perioperative Hyperglycaemia, Insulin Therapy, Elective Surgery, Closed-Loop Glucose Control
- Trial name
- POP-LOOP (NCT04361799)
- Testing
- CamAPS, Standard insulin therapy
- Where
- Switzerland
- Volunteers
- 45 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Anesthesia, Sedation
The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes
Perioperative fasting has historically been viewed as a low-risk intervention. However, preliminary data indicate that perioperative loss of nutrition and fluids is likely harmful.
- Conditions
- Anesthesia, Sedation, Monitored Anesthesia Care, Procedure
- Trial name
- MACS (NCT07022951)
- Testing
- Preoperative fasting
- Where
- United States
- Volunteers
- 1,200,000 people
- Sponsor
- Massachusetts General Hospital
Hyperglycemia, Diabetes
Diabetes in the Perioperative Period
High blood glucose levels in surgical patients with and without diabetes are associated with increased risk of medical complications and death.
- Trial name
- NCT00738114
- Where
- United States
- Volunteers
- 3,184 people
- Sponsor
- Emory University
Knee Replacement, Hip Replacement
Perioperative Hyperglycaemia in Primary Total Hip and Knee Replacement
The purpose of this study is to analyze how common stress hyperglycaemia (abnormally high blood glucose) is in primary hip and knee replacement surgeries and which factors predispose to hyperglycaemia.
- Conditions
- Knee Replacement, Hip Replacement, Hyperglycemia
- Trial name
- HyTe-1 (NCT01021826)
- Where
- Finland
- Volunteers
- 193 people
- Sponsor
- Coxa, Hospital for Joint Replacement
T2DM Patients With Traumatic Brain Injury
Hybrid Closed-Loop System in Neurosurgical Perioperative Hyperglycemia: An Open RCT
In this study, we plan to use an open-source hybrid closed-loop artificial pancreas system and a combination of a traditional insulin pump and continuous glucose monitoring (CGM) respectively to conduct short-term intensive…
- Trial name
- NCT06909071
- Testing
- Hybrid Closed-Loop Artificial Pancreas System
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanxi Bethune Hospital
Hyperglycemia
Metformin Use in Patients Undergoing Total Joint Replacement Surgery
The goal of this pilot, randomized, single-blind, placebo-controlled trial is to evaluate the feasibility of and provide preliminary information for a multi-center randomized controlled trial that will assess the effects of…
- Trial name
- NCT06280274
- Testing
- Metformin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Anemia, Iron Deficiency, Hyperglycemia
Prevalence of Hyperglycemia and Anaemia in Elective Surgical Patients
The study is a prospective, observational study of adult, non-cardiac, non-obstetric, elective surgical patients conducted over a period of one week.
- Trial name
- EPIC-1 (NCT03318055)
- Where
- 6 sites in South Africa
- Volunteers
- 343 people
- Sponsor
- University of Cape Town
Diabetes Mellitus, Type 2, Hyperglycemia
Oral Peri-operative TIming of Metformin (or) Salsalate to Improve Non-cardiac Surgery Glucose Control
Hypothesis: In surgical patients with type 2 diabetes, taking either metformin or salsalate on the morning of surgery will reduce the incidence of hyperglycemia, inflammation and even surgical site infections, without any obvious…
- Conditions
- Diabetes Mellitus, Type 2, Hyperglycemia, Perioperative/Postoperative Complications, Salsalate to Improve Non-cardiac Surgery Glucose Control
- Trial name
- OPTIM(i)SING (NCT03816488)
- Testing
- Metformin, Salsalate
- Sponsor
- McMaster University
Anesthesia, Continuous Glucose Monitoring
Metabolic Control in Anesthesia and Surgery
The goal of this observational study is to investigate how a standard dose of the drug dexamethasone affects blood sugar levels during and after non-cardiac surgery in adult patients.
- Conditions
- Anesthesia, Continuous Glucose Monitoring, Hyperglycemia Steroid-induced, Hyperglycemia Stress
- Trial name
- MACS (NCT07573930)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Zealand University Hospital