Clinical trials: Perioperative Inflammatory Response
Systemic Inflammatory Response Syndrome
Perioperative Sitagliptin Medication for Reduction of the Inflammatory Response Associated With Cardiopulmonary Bypass
Sitagliptin is an inhibitor of the enzyme dipeptidylpeptidase-4 (DPP-4) and represents an established drug in type 2 diabetes mellitus treatment. However, Sitagliptin may also have several antiinflammatory properties.
- Trial name
- SiCa-Flam (NCT05725798)
- Testing
- Sitagliptin
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Muenster
Postoperative Complications, Cardiovascular Complication
Perioperative Inflammatory Response Assessment in High-risk Patients Undergoing Noncardiac Surgery
Postoperative cardiovascular complications are common after noncardiac surgery. The association between perioperative inflammation and the occurrence of cardiovascular complications after surgery is still unknown.
- Conditions
- Postoperative Complications, Cardiovascular Complication, Myocardial Ischemia, Inflammation
- Trial name
- INSIGHT (NCT04753307)
- Testing
- Laboratory measurements
- Where
- Austria
- Volunteers
- 1,400 people
- Sponsor
- Medical University of Vienna
Heart Valve Diseases, Systemic Inflammatory Response Syndrome
Corticosteroid Prophylaxis on the Cardiopulmonary Bypass-Induced Systemic Inflammatory Response
To observe the effect of glucocorticoid on the dynamic changes of monocyte subsets in the peripheral blood of valve disease patients undergoing cardiopulmonary bypass perioperatively.
- Trial name
- NCT01296074
- Testing
- Corticosteroid
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Anzhen Hospital
Craniotomy Surgery
Effects of Ultrasound-Guided Scalp Block on Opioid Use, Hemodynamics, and Postoperative Inflammation in Craniotomy
This study shows that in craniotomy patients using a skull pin head holder, an ultrasound-guided scalp block reduces perioperative opioid consumption, improves hemodynamic stability, and decreases the inflammatory response.
- Trial name
- NCT07545655
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Colorectal Cancer, Colon Cancer
Effect of Celecoxib on Perioperative Inflammatory Response in Colon Cancer
The proposed study aims to investigate how the administration of a drug known to reduce inflammation in humans, Celecoxib, will effect the peri-operative inflammatory response of a patient undergoing primary tumor resection…
- Trial name
- NCT01284504
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stanford University
Colon Cancer
Effect of Omega-3 Fatty Acids on the Perioperative Immune Response and Erythrocyte Function
Ideally, the postoperative inflammatory response is part of a well-orchestrated mechanism that contributes to tissue healing and rapid recovery.
- Trial name
- EMPIRE (NCT02231203)
- Testing
- Omegaven
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- Medical Center Alkmaar
Inflammatory Response, Cardiac Disease
Effect of Colchicine on Perioperative Anti-inflammatory Organ Injury in Cardiac Surgery
All patients will be completed collection of demographic data, clinical data, and be observed for inflammatory organ damage, oxygenation index or SpO2/ FIO2, WBC, NEU, interleukin-1β, interleukin-6, interleukin-8 (IL-1β/6/8)…
- Trial name
- NCT06118034
- Testing
- Colchicine 0.5 MG
- Where
- China
- Volunteers
- 768 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Nephrolithiasis, Postoperative Inflammation
Inflammatory Response Under Spinal vs General Anesthesia in PCNL: NLR, RDW, LAR.
This observational study compares the effects of spinal versus general anesthesia on the perioperative systemic inflammatory response in adults undergoing PCNL.
- Trial name
- SAGEPCNL (NCT07205224)
- Testing
- Anesthesia Type
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Sevim Şenol Karataş
To Evaluate Clinical Results, Insulin Resistance and Inflammatory Response to Trauma in Morbidly Obese Patients
Clinical Evaluation, Organic Response in Obesity Patients Subjected to Vertical Videolaparoscopy Gastroplasty With or Without Perioperative Cares Recommended by the Acerto Project. Randomized Study.
Background To evaluate clinical results, insulin resistance and inflammatory response to trauma in morbidly obese patients undergoing laparoscopic Sleeve gastrectomy who received either traditional preoperative care or treatment…
- Trial name
- NCT02113995
- Testing
- ACERTO protocol vs Traditional care
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Cuiaba University
Perioperative Inflammatory Response
Assessing the Role of "Statin" Therapy and Perioperative Inflammatory Response in Patients Undergoing Major Orthopedic Surgery
The purpose of the present study is to quantify the degree of modulation, if any, in the perioperative inflammatory response associated with statins use.
- Trial name
- NCT00656292
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Mayo Clinic
Postoperative Infections, Jaundice
Effectiveness Of Symbiotic Therapy In Jaundiced Patients
The aim of the present study was therefore to evaluate if the perioperative administration of symbiotics reduces postoperative infectious morbidity in jaundiced patients scheduled for hepato-biliary and pancreatic surgery.
- Trial name
- NCT01683708
- Testing
- Symbiotic therapy
- Volunteers
- 20 people
- Sponsor
- Azienda Ospedaliera Ordine Mauriziano di Torino
Anemia, Coronary Disease
PBM as Strategy to CABG Anemic Patients Bypass Graft (CABG)
Anemia poses risks during coronary artery bypass grafting (CABG), increasing complications and mortality rates. Blood transfusions in cardiac surgery have negative outcomes, prompting the use of erythropoietin in Patient Blood…
- Conditions
- Anemia, Coronary Disease, Coronary Artery Disease, Coronary Stenosis
- Trial name
- NCT06542393
- Testing
- Erythropoietin, blood transfusion
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Thoracic Surgery, Prehabilitation
Preoperative Inspiratory Muscle Training Effects on the Perioperative Inflammatory Reaction in Cardiac Surgery.
This study evaluates the impact of preoperative high-intensity inspiratory muscle training (IMThi) before cardiac surgery on perioperative inflammatory response.
- Conditions
- Thoracic Surgery, Prehabilitation, Respiratory Therapy
- Trial name
- EMI HiPo (NCT03158402)
- Testing
- Prehabilitation with inspiratory muscle training
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Angers
Infection, Bacterial Infection
Leukocyte Depletion of Autologous Whole Blood
Leukocyte depletion of autologous whole blood prior to storage does not reduce infection rate (wound, urinary tract, other), use of antibiotic treatment and length of hospital stay but may increase retransfusion perioperatively…
- Conditions
- Infection, Bacterial Infection, Sepsis
- Trial name
- LDAWB-2001 (NCT00176124)
- Testing
- leukocyte depletion of whole blood, Leukocyte filtration/Depletion
- Where
- 3 sites in Germany
- Volunteers
- 1,089 people
- Sponsor
- Heidelberg University
Sepsis, Thiamine Deficiency
Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species (ROS)
This research is a clinical trial with a Randomized Controlled Trial (RCT) design. The purpose is to identify the effect of intravenous thiamine administration compared to normal saline placebo on glucagon levels and ROS levels…
- Trial name
- NCT05663164
- Testing
- Vitamin B
- Where
- Indonesia
- Volunteers
- 30 people
- Sponsor
- Universitas Sumatera Utara
General Anesthesia, Cervical Plexus Block
EFFECTS OF TWO ANESTHESİA TECHNİQUES ON INFLAMMATORY RESPONSE AND AMİNO ACİD METABOLİSM İN THYROİD SURGERY
The main aim of this study is to compare the effects of two different anesthesia methods-(1) general anesthesia alone and (2) combination of general anesthesia with cervical plexus block-on postoperative inflammatory process and…
- Conditions
- General Anesthesia, Cervical Plexus Block, Thyroid Surgery
- Trial name
- NCT07592832
- Testing
- General Anesthesia, cervical plexus block
- Volunteers
- 60 people
- Sponsor
- Harran University
Systemic Inflammatory Response Syndrome, Myocardial Ischemia
Inflammatory Response During Anesthesia and Surgery
The purpose of this study is to investigate the effects of total intravenous anesthesia versus volatile anesthesia on the perioperative inflammatory response during and after major surgery.
- Trial name
- IRAS (NCT00356746)
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- UMC Utrecht
Laparotomy, Laparotomy Surgery
Saudi Emergency Laparotomy Audit
The Saudi Emergency Laparotomy Audit (SELA) is a national, multicenter observational clinical audit designed to evaluate outcomes and quality of care for patients undergoing emergency laparotomy in Saudi Arabia.
- Conditions
- Laparotomy, Laparotomy Surgery, Emergency Treatment, Abdominal Diseases
- Trial name
- SELA (NCT07429929)
- Testing
- Emergency Laparotomy
- Where
- Saudi Arabia
- Volunteers
- 10,000 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Prostate Cancer, Prostate Biopsy
Administration of Antibiotic Prophylaxis for Transperineal Prostate Biopsy in Cipto Mangunkusumo Hospital
This randomized controlled trial aims to compare the rate of perioperative infection complications in transperineal prostate biopsy between the group that receives prophylactic antibiotic and the group that receives placebo.
- Conditions
- Prostate Cancer, Prostate Biopsy, Perioperative Complication, Bacteriuria
- Trial name
- NCT04985110
- Testing
- Cotrimoxazole
- Where
- Indonesia
- Volunteers
- 78 people
- Sponsor
- Universitas Indonesia
Inflammation, Systemic Inflammatory Response Syndrome
Inflammatory Response in Aortic Valve Replacement
The study investigates inflammatory and antiinflammatory response in patients with severe aortic valve stenosis needing either surgical treatment (surgical aortic valve replacement) or interventional cardiology treatment…
- Conditions
- Inflammation, Systemic Inflammatory Response Syndrome, Thoracic Surgery, Aortic Valve Stenosis
- Trial name
- NCT02324140
- Testing
- Whole blood analysis
- Where
- Switzerland
- Volunteers
- 101 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern