Clinical trials: Perioperative Medicine
Cardiac Surgery, Older Adults
Behavioral Activation and Medication Optimization In Older Adults Undergoing Cardiac Procedures
This Hybrid 1 Study will test the effectiveness of a bundled intervention comprised of behavioral activation and medication optimization in reducing symptoms of depression and anxiety in older adults undergoing cardiac surgery…
- Conditions
- Cardiac Surgery, Older Adults, Depression, Anxiety
- Trial name
- NCT05575128
- Testing
- Behavioral activation, Medication optimzation, Care as usual
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Washington University School of Medicine
Perioperative Complication, Perioperative/Postoperative Complications
Registry of Anesthesia and Perioperative Medicine
To assess mortality and morbidity associated to anesthesia interventions
- Conditions
- Perioperative Complication, Perioperative/Postoperative Complications, Anesthesia Morbidity, Anesthesia; Adverse Effect
- Trial name
- RAMP (NCT05869578)
- Testing
- Anesthesia Intervention
- Where
- Chile
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Clinica Alemana de Santiago
Allergic Reaction, Hypersensitivity
Standardised Drug Provocation Testing in Perioperative Hypersensitivity
The goal of this clinical trial is to evaluate the safety and outcome of systematic drug provocation testing with anaesthetics at therapeutic doses in adult patients undergoing diagnostic work-up for perioperative…
- Conditions
- Allergic Reaction, Hypersensitivity, Perioperative Complication, Anaphylaxis
- Trial name
- NCT06065137
- Testing
- Full dose DPT with propofol, Full dose DPT with ketamine, Full dose DPT with etomidate
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Morbid Obesity, Postoperative Pain
Patients-Controlled Epidural Analgesia After Gastric Bypass for Morbid Obesity Using Morphine-Levobupivacaine Regimens
Adequate postoperative analgesia can facilitate recovery following gastric bypass surgery for morbid obesity. The efficacy and safety of intravenous patient - controlled analgesia has been studied, but up to date no data are…
- Conditions
- Morbid Obesity, Postoperative Pain, Postoperative Bowel Function, Postoperative Ambulation
- Trial name
- NCT01249872
- Testing
- GROUP A : 0 mg MORPHINE-0.1% LEVOBUPIVACAINE, GROUP B : 1 mg MORPHINE- 0.1% LEVOBUPIVACAINE, GROUP C : 2 mg MORPHINE-0.1% LEVOBUPIVACAINE
- Where
- Greece
- Volunteers
- 96 people
- Sponsor
- University of Patras
Cataract, Cataract (Post-operative Cataract Surgery Follow-up)
Randomized Controlled Trial of the STEIN Protocol: A Neuroplastic Pain Education and Guided Breathing Intervention During Awake Cataract Surgery
This randomized controlled trial evaluates whether a standardized perioperative neuroplastic intervention: the STEIN Protocol (Strategies and Techniques for Enhancing Integration and Neuroplasticity), consisting of pain…
- Trial name
- SLin (NCT07715591)
- Testing
- Music and Guided Imagery, Control, Music Only
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of California, Los Angeles
Brugada Syndrome (BrS), Ventricular Arrhythmia
Prospective Multicentre Observational Registry of Peri-procedural Anaesthesia, Sedation and Related Medication Exposure in Patients With Brugada Syndrome
The goal of this observational study is to evaluate the perioperative risk of malignant ventricular arrhythmias in adult patients diagnosed with Brugada Syndrome undergoing anaesthetic procedures.
- Conditions
- Brugada Syndrome (BrS), Ventricular Arrhythmia, Anesthesia, Sedation
- Trial name
- PROSP_BRUGANAE (NCT07655102)
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Clinic of Barcelona
Neuromuscular Blockade, Residual Curarisation, Postoperative
Provider Variability in the Use of Neuromuscular Blocking Drugs and Reversal
The use of neuromuscular blocking agents during surgery is associated with postoperative respiratory complications and increased risk of readmission to the hospital following ambulatory surgery.
- Conditions
- Neuromuscular Blockade, Residual Curarisation, Postoperative, Surgery Under General Anaesthesia
- Trial name
- NCT03585348
- Testing
- Neuromuscular blocking agents
- Where
- 2 sites in United States
- Volunteers
- 265,537 people
- Sponsor
- Beth Israel Deaconess Medical Center
Hypersensitivity, Drug
GERAP's Epidemiological Survey on Perioperative Hypersensitivity Reactions
Perioperative hypersensitivity reactions are still associated with significant morbidity and mortality despite early recognition and use of epinephrine.
- Trial name
- SERAP (NCT04654923)
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- University Hospital, Strasbourg, France
Perioperatoire Medicine, Surgery
Evaluation of a Structured Hospital-Community Care Follow-up Based on Perceived Quality of Care After Surgery, Aimed at Reducing Persistent Opioid Use in Primary Care: a Pragmatic Randomized Controlled Trial
The OPTIMISTE program is based on a structured postoperative follow-up centered on patients' subjective perception of recovery using validated Patient Reported Outcome Measures (PROMs), including the mQoR-15f score.
- Trial name
- OPIOID CITY FR (NCT07659730)
- Testing
- Patient-Reported Outcomes-based perioperative follow-up (QoR-15 focus)
- Volunteers
- 772 people
- Sponsor
- University Hospital, Strasbourg, France
Knee Arthritis
The Efficacy of Collaborative Patient Education on Total Knee Arthroplasty
This project is about the integrated rehabilitation program for the patients receiving total knee arthroplasty. The investigators are monitoring the WOMAC(Western Ontario and Mcmaster University Arthritis Index)/ Pain…
- Trial name
- NCT05346822
- Testing
- integrated rehabilitation (the collaborative patient education)
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Melanoma
Perioperative Treatment With Tranexamic Acid in Melanoma
Surgery is a key element in the treatment of melanoma, and naturally linked with an inflammatory response and recruitment of innate immune cells.
- Trial name
- PRIME (NCT05899465)
- Testing
- Tranexamic acid, Saline
- Where
- 5 sites in Denmark
- Volunteers
- 1,204 people
- Sponsor
- University of Aarhus
Obesity, Overweight
Perioperative Pharmacokinetics of Anesthetic Drugs and Complications in Overweight and Obese Patients
This observational study aims to investigate the impact of body composition on the absorption, distribution, and metabolism of anesthetic drugs, as well as on the incidence of complications in overweight and obese patients.
- Trial name
- NCT07530848
- Where
- China
- Volunteers
- 2,100 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Inflammation, Myocardial Infarction
Statin Drugs to Prevent Complications During Surgery
Patients undergoing non-cardiac surgery frequently experience perioperative cardiac complications that may be due to excess inflammatory reactions.
- Conditions
- Inflammation, Myocardial Infarction, Myocardial Ischemia
- Trial name
- STAR-VaS (NCT00967434)
- Testing
- Atorvastatin
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute
Breast Cancer, Cardiac Toxicity
Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Nonmetastatic Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel, fluorouracil, epirubicin hydrochloride, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them…
- Conditions
- Breast Cancer, Cardiac Toxicity, Perioperative/Postoperative Complications
- Trial name
- NCT01093235
- Testing
- bevacizumab, cyclophosphamide, docetaxel
- Where
- United Kingdom
- Volunteers
- 800 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Drug Allergy
Perioperative Hypersensitivity in Children
There are limited studies on perioperative hypersensitivity (POH) reactions in children. The diagnosis of POH might be underestimated due to the difficulty of recognizing the reactions.
- Trial name
- NCT05706246
- Testing
- diagnostics
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Istanbul University - Cerrahpasa
Gastroesophageal Adenocarcinoma
A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma
GEMINI-PeriOp GC study will assess the safety, tolerability, pharmacokinetics (PK) and preliminary anti-tumor activity of novel agents or novel combinations as perioperative treatment in participants with locally advanced…
- Trial name
- NCT07069712
- Testing
- Sonesitatug Vedotin, Rilvegostomig, Trastuzumab Deruxtecan (T-DXd)
- Where
- 70 sites in United States, Canada and 9 more
- Volunteers
- 100 people
- Sponsor
- AstraZeneca
Obesity; Drug
Adequacy of Perioperative Cefuroxime Dosage According to the BMI
This study evaluates the dosage of perioperative cefuroxime for obese patients. Dosage was increased if the BMI was over 30kg/m*m and as well over 50kg/m*m. Drug levels were measured in blood and tissue.
- Trial name
- NCT03141476
- Testing
- Cefuroxime 1,5g, Cefuroxime 3g, Cefuroxime 4,5g
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Postoperative Complications
Prospective Validation of ExCARE Model for 30-Day Postoperative Mortality
This prospective observational cohort study aims to validate the ExCARE risk model, derived from four preoperative variables (age, ASA-PS classification, procedure urgency, and surgical magnitude), for predicting in-hospital…
- Trial name
- ExCARE-HNSC (NCT07293377)
- Where
- Brazil
- Volunteers
- 3,000 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Surgery
The Effect of Bowel Preparation on Perioperative Bleeding
Now a days, due to the change in lifestyle, the extended lifespan and the increase in the rate of the road accidents, the need for surgical operation of spinal instrumentation has been increased.
- Trial name
- NCT02493894
- Testing
- PEG, Cefazolin
- Where
- Iran
- Volunteers
- 105 people
- Sponsor
- Isfahan University of Medical Sciences
Cataract
Sharp Health Companion App for Cataract Surgery Preparation and Recovery
This randomized controlled trial evaluated the effectiveness of the Sharp Health Companion App, a smartphone-based digital health tool, compared to standard printed instructions for supporting older adults undergoing cataract…
- Trial name
- NCT07028359
- Testing
- Printed Instructions with Phone Reminders, Sharp Health Companion App (CareKit)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Sharp HealthCare