Clinical trials: Perioperative Neurocognitive Disorder
Aortic Valve Replacement, Aortic Stenosis
TAVI Protocol - Paravertebral Block Study
Trans-apical aortic valve replacement is a new treatment for severe aortic stenosis. It is offered to elderly patients with medical problems that would markedly increase the risk of conventional cardiac surgery.
- Trial name
- TAVI PVB (NCT01404975)
- Testing
- Thoracic paravertebral block (PVB)
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University Health Network, Toronto
Postoperative Complications, Elderly
Elderly Patients Undergoing Surgery During Perioperative Period
The elderly patients have poorer overall conditions and have lower tolerance to trauma, anesthesia, and surgery. Therefore, the incidence of postoperative complications is relatively higher.
- Conditions
- Postoperative Complications, Elderly, Postoperative Delirium (POD), Risk Prediction Model
- Trial name
- NCT07314762
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Cardiac Surgery With Cardiopulmonary Bypass, Postoperative Delirium
Mechanisms and Intervention Strategies of Perioperative Glycemic Variability on Postoperative Delirium
Delirium is a sudden change in attention, thinking, and awareness that can occur after heart surgery. It may slow recovery and is associated with longer hospital stays and poorer health outcomes.
- Trial name
- NCT07893353
- Testing
- Intranasal insulin-20U, Intranasal insulin-40U, Intranasal Saline
- Where
- China
- Volunteers
- 225 people
- Sponsor
- Fujian Medical University Union Hospital
Delirium, Postoperative
Liraglutide in Preventing Delirium in Diabetic Elderly After Cardiac Surgery
This study aims to clarify the preventive effect of perioperative liraglutide application on postoperative delirium in elderly patients with Type 2 diabetes undergoing cardiac surgery.
- Trial name
- NCT06361238
- Testing
- Liraglutide injection
- Where
- China
- Volunteers
- 260 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Postoperative Delirium
Perioperative Dexmedetomidine on Postoperative Delirium in Patients With Brain Tumors
Neurosurgery is a risk factor for delirium. Dexmedetomidine might reduce delirium by reducing neuroinflammation, improving postoperative analgesia and sleep quality.
- Trial name
- NCT06164314
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Beijing Tiantan Hospital
PND
The Effects of Different Anesthesia Methods on Perioperative Neurocognitive Disorders in the Elderly
Perioperative Neurocognitive Disorders(PND) is a common perioperative complication among the elderly, especially in the plastic surgery.
- Trial name
- NCT04488952
- Testing
- nerve block combined with general anesthesia, spinal anesthesia
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Shenzhen Second People's Hospital
Cognitive Change, Total Knee Anthroplasty
Early Cognitive Changes After General Versus Spinal Anesthesia in Older Adults Undergoing Total Knee Arthroplasty
This prospective observational study investigated early postoperative cognitive changes in older adults undergoing elective total knee arthroplasty under general or spinal anesthesia.
- Trial name
- NCT07860593
- Testing
- General Anesthesia, Spinal Anesthesia with Bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Haseki Training and Research Hospital
Postoperative Cognitive Dysfunction, Postoperative Delirium
Perioperative GDNF as a Predictive Factor for Postoperative Delirium and Adverse Neurological Outcomes in Pediatric Surgery
To observe the dynamic changes in serum levels of inflammatory cytokines (e.g., IL-6, TNF-α), Brain-Derived Neurotrophic Factor (BDNF), and Glial Cell Line-Derived Neurotrophic Factor (GDNF) during the perioperative period in…
- Trial name
- NCT07192549
- Testing
- Sevoflurane group, Propofol group
- Volunteers
- 200 people
- Sponsor
- General Hospital of Ningxia Medical University
Older Adults, Surgery
Perioperative Transcranial Photobiomodulation and Delayed Neurocognitive Recovery in Older Patients
Delayed neurocognitive recovery is a common neurocognitive complication in older patients after surgery, especially those with preoperative neurocognitive decline.
- Conditions
- Older Adults, Surgery, Transcranial Photobiomodulation, Delayed Neurocognitive Recovery
- Trial name
- NCT07736092
- Testing
- Transcranial photobiomodulation therapy, Transcranial pseudo-photobiomodulation
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Delirium, Dementia, Amnestic, Cognitive Disorders, Postoperative Complications
Postoperative Cognitive Dysfunction in Geriatric Patients
Geriatric patients have a high risk of developing postoperative cognitive deficits. Hypothetical causes are insufficient intraoperative cerebral perfusion or drugs that are administered in the perioperative setting.
- Conditions
- Delirium, Dementia, Amnestic, Cognitive Disorders, Postoperative Complications, Memory Disorders
- Trial name
- NCT00512200
- Where
- Switzerland
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Postoperative Delirium (POD), Abdominal Neoplasms
Perioperative Biomarkers and Postoperative Delirium in Older Adults Undergoing Abdominal Cancer Surgery
This prospective observational cohort study aims to investigate the relationship between perioperative endogenous melatonin levels and postoperative delirium in patients aged 65 years or older undergoing elective abdominal cancer…
- Trial name
- NCT07859488
- Testing
- Perioperative Biomarker Assessment, Confusion Assessment Method (CAM)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Fatma Cigdem Ozakin
Confusion
Hypnosis Versus SIVOC by Remifentanil During TAVI Procedures : Iloact on Peripoperative Confusion
TAVI has become a credible alternative to conventional cardiac surgery in aged high-risk patients with aortic valve stenosis. A large part of these procedures are performed with sedation using remifentanil target-controlled…
- Trial name
- HYPSED (NCT03974269)
- Testing
- TAVI : Transcatether Aortic Valve Implantation
- Where
- France
- Volunteers
- 186 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Cognition Disorders, Impaired Cognition
Digital Game: A Scale to Evaluate the Perioperative Cognitive Function
INTRODUCTION: Cognitive dysfunction is a frequent adverse event in the postoperative period, especially in elderly patients. The tests commonly used for the detection of postoperative cognitive dysfunction are time-consuming and…
- Conditions
- Cognition Disorders, Impaired Cognition, Self-Assessment
- Trial name
- MentalPlus® (NCT02551952)
- Testing
- MentalPlus®
- Where
- Brazil
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Neurocognitive Disorders
Study for Perioperative Neurocognitive Disorders After Deep Brain Stimulation Surgery for Parkinson's Disease
Perioperative neurocognitive disorders(PND) is common to see in elderly patients. Although PND increases patient mortality as well as hospitalization time, apparent inflammatory factors, and related mechanisms are still unknown.
- Trial name
- NCT04696978
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- wenbinlu
Perioperative Neurocognitive Disorders
The Reliability and Validity of Perioperative Cognitive Test Network Platform for Monitoring Neurocognitive Changes
This study aimed to analyze the reliability and validity of the results of the new designed perioperative cognitive test network platform, and to judge the reliability and scientific nature of the perioperative cognitive test.
- Trial name
- NCT06028568
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital