Clinical trials: Perioperative Neurocognitive Disorders, open to volunteers
Perioperative Care, EEG Power Spectra
Extended Emergence Strategy on Post-Anesthesia Care Unit Events After Outpatient Orthopedic Surgery
The goal of this clinical trial is to learn if an extended emergence from anesthesia can improve recovery room (Post-Anesthesia Care Unit or PACU) outcomes in lower-leg or foot surgery with nerve blocks.
- Conditions
- Perioperative Care, EEG Power Spectra, Delirium - Postoperative
- Trial name
- PACU-EMERGE (NCT07533370)
- Testing
- Standard of Care EEG-Guided Emergence, Extended EEG Emergence Trajectory
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Harrison Shong-Wen Chow
Cardiac Surgery With Cardiopulmonary Bypass, Postoperative Delirium
Mechanisms and Intervention Strategies of Perioperative Glycemic Variability on Postoperative Delirium
Delirium is a sudden change in attention, thinking, and awareness that can occur after heart surgery. It may slow recovery and is associated with longer hospital stays and poorer health outcomes.
- Trial name
- NCT07893353
- Testing
- Intranasal insulin-20U, Intranasal insulin-40U, Intranasal Saline
- Where
- China
- Volunteers
- 225 people
- Sponsor
- Fujian Medical University Union Hospital
Dementia, Postoperative Delirium (POD)
Prediction and Prevention of Postoperative Mortality and Morbidity
This study will contribute to creating a prospective and automated preoperative risk assessment algorithm for predicting 30-day mortality, major adverse cardiac and cerebrovascular events (MACCE), and postoperative neurocognitive…
- Conditions
- Dementia, Postoperative Delirium (POD), Postoperative Neurocognitive Disorder, Major Adverse Cardiac and Cerebrovascular Events
- Trial name
- NCT06042413
- Testing
- Personalized CPC Prehabilitation, Cognitive Training, Meditation
- Where
- 5 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- University of Pittsburgh
Postoperative Delirium (POD), Abdominal Neoplasms
Perioperative Biomarkers and Postoperative Delirium in Older Adults Undergoing Abdominal Cancer Surgery
This prospective observational cohort study aims to investigate the relationship between perioperative endogenous melatonin levels and postoperative delirium in patients aged 65 years or older undergoing elective abdominal cancer…
- Trial name
- NCT07859488
- Testing
- Perioperative Biomarker Assessment, Confusion Assessment Method (CAM)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Fatma Cigdem Ozakin
Aortic Diseases, Cardiac Surgical Procedures
Selective Antegrade Cerebral Perfusion and Perioperative Optic Nerve Sheath Diameter in Ascending Aortic Surgery
In ascending aortic surgery the distal anastomosis may be constructed with the aortic cross-clamp maintained, or, where the extent of the aortic pathology and the geometry of the graft require it, after release of the cross-clamp…
- Conditions
- Aortic Diseases, Cardiac Surgical Procedures, Aortic Aneurysm, Thoracic, Delirium - Postoperative
- Trial name
- SACP-ONSD (NCT07800806)
- Testing
- Optic nerve sheath and optic nerve diameter ultrasonography, Transcranial Doppler ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people
- Sponsor
- Koşuyolu Kartal Heart Training and Research Hospital
Postoperative Delirium (POD)
Perioperative Dezocine Administration and Postoperative Delirium in Elderly Cardiac Surgery Patients
Postoperative delirium (POD) is a common complication in elderly patients undergoing cardiac surgery and is associated with prolonged hospitalization, increased morbidity, and poor recovery.
- Trial name
- NCT07768150
- Testing
- Dezocine, Normal Saline (NS)
- Where
- 2 sites in China
- Volunteers
- 640 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Delirium - Postoperative
Correlation Between Perioperative EEG Variability and Postoperative Delirium Incidence.
This clinical study aims to investigate whether multiscale entropy analysis of electroencephalogram data can distinguish between ordinary elderly surgical patients and elderly patients with postoperative delirium.This study may…
- Trial name
- NCT07323940
- Testing
- Collect preoperative and intraoperative electroencephalogram data
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Xin Chen
Delirium, Cognitive Impairment
Redesigning the Surgical Pathway (PROMoTE)
Cognitive complications, that is problems with thinking and memory, are incredibly common after surgery, occurring in 10-50% of all older surgical patients.
- Conditions
- Delirium, Cognitive Impairment, Perioperative/Postoperative Complications, Cognitive Dysfunction
- Trial name
- PROMoTE (NCT05114876)
- Testing
- Multicomponent delirium-risk prevention bundle
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Sunnybrook Health Sciences Centre
Frailty
Preoperative Frailty and Postoperative Neurocognitive Disorders in Geriatric Patients in Georgia
The number of elderly people in the global population is growing, presenting an increasing challenge. Technological advances in medicine have made it possible to perform complex surgeries on geriatric patients, improving the…
- Trial name
- FRAILCOG-GE (NCT06700291)
- Testing
- Surgery
- Where
- Georgia
- Volunteers
- 230 people
- Sponsor
- New Hospitals Georgia
Adolescent Idiopathic Scoliosis, Neuromuscular Scoliosis
Kids With Iron Deficiency and Scoliosis
This study is a randomized controlled trial of preoperative oral iron supplementation, to identify whether iron deficiency is a modifiable risk factor for adverse surgical outcomes such as red blood cell transfusion and…
- Conditions
- Adolescent Idiopathic Scoliosis, Neuromuscular Scoliosis, Perioperative/Postoperative Complications, Iron Deficiencies
- Trial name
- KIDS (NCT06042699)
- Testing
- Oral ferrous sulfate
- Where
- United States
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Columbia University
Postoperative Cognitive Complications, Delirium
Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery
This is a prospective observational cohort study of adult patients undergoing high-risk surgery at UT Southwestern Medical Center.
- Conditions
- Postoperative Cognitive Complications, Delirium, Perioperative/Postoperative Complications, Brain Injuries
- Trial name
- NCT07577726
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Perioperative Neurocognitive Disorder
Treatment of Perioperative Neurocognitive Disorders With Olfactory Enrichment
Perioperative neurocognitive disorder (PND) is one of the most common postoperative complications among elderly patients. However, the mechanism and targeted intervention of PND remains unclear.
- Trial name
- NCT06488807
- Testing
- Olfactory Enrichment
- Where
- China
- Volunteers
- 686 people
- Sponsor
- Shanghai 10th People's Hospital
Older Adults, Surgery
Perioperative Transcranial Photobiomodulation and Delayed Neurocognitive Recovery in Older Patients
Delayed neurocognitive recovery is a common neurocognitive complication in older patients after surgery, especially those with preoperative neurocognitive decline.
- Conditions
- Older Adults, Surgery, Transcranial Photobiomodulation, Delayed Neurocognitive Recovery
- Trial name
- NCT07736092
- Testing
- Transcranial photobiomodulation therapy, Transcranial pseudo-photobiomodulation
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Perioperative Neurocognitive Disorders
The Effect of Esketamine on Postoperative Cognitive Function in Elderly Patients Undergoing Oral and Maxillofacial Surgery
Esketamine is a common anesthetic adjuvant. Previous studies have shown that it may have protective effects on the brain. This study aims to investigate whether esketamine can improve cognitive function recovery in elderly…
- Trial name
- NCT07665099
- Testing
- esketamine, Normal Saline
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Xijing Hospital
Pediatric, Adenotonsillectomy
AI-Generated Maternal Voice Storytelling During Pediatric Adenotonsillectomy
This prospective, three-arm randomized controlled trial aims to evaluate the effects of AI-generated maternal voice storytelling on the perioperative stress response, emergence delirium, anesthetic requirements, and perioperative…
- Trial name
- NCT07706725
- Testing
- AI-Generated Maternal Voice Storytelling, Relaxing Instrumental Music, midazolam premedication
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Adiyaman University Research Hospital
Delirium
Perioperative EEG-Monitoring and Postoperative Delirium in Patients Undergoing Cardiovascular Surgery
Postoperative delirium is common in patients undergoing cardiovascular surgery and associated with poor outcomes. However the pathogenesis of postoperative delirium is poorly understood.
- Trial name
- NCT04832568
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Huazhong University of Science and Technology
Postoperative Cognitive Dysfunction, Perioperative Neurocognitive Disorder
POCD After Major Gynecologic Surgery
This prospective observational cohort study aims to determine the incidence of early postoperative cognitive dysfunction (POCD) in patients undergoing major gynecological surgery.
- Trial name
- POCD-GYN (NCT07589348)
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Fatihhan Zeytun
Delirium in Old Age, Delirium, Postoperative
Effect of Low-dose EsketaMine on dElirium in High-risk Elderly Patients uNdergoing elecTive Surgery (ELEMENT)
Delirium is an acutely occurred neurocognitive disorder characterized by fluctuating symptoms of inattention, altered consciousness and cognitive dysfunction.
- Conditions
- Delirium in Old Age, Delirium, Postoperative, Anesthesia, Cognitive Dysfunction
- Trial name
- NCT06817239
- Testing
- Esketamine, Normal saline
- Where
- 6 sites in China
- Volunteers
- 1,670 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Anesthesia, Hip Fractures
Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)
The ANDES Platform Trial is a pragmatic, multicenter, adaptive randomized controlled platform trial in patients aged 65 years or older undergoing surgery for hip fracture.
- Conditions
- Anesthesia, Hip Fractures, Dementia, Cognitive Impairment
- Trial name
- ANDES platform (NCT06452147)
- Testing
- Nerve block, Standard anesthesia care, Bupivacaine liposome
- Where
- 13 sites in China
- Volunteers
- 1,860 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Postoperative Delirium
Perioperative Dexmedetomidine on Postoperative Delirium in Patients With Brain Tumors
Neurosurgery is a risk factor for delirium. Dexmedetomidine might reduce delirium by reducing neuroinflammation, improving postoperative analgesia and sleep quality.
- Trial name
- NCT06164314
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Beijing Tiantan Hospital