Clinical trials: Perioperative Neurocognitive Disorders, active
Fraily, Abdominal Surgery
Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.
This is a bicentric, prospective, non-pharmacological, randomized study designed to compare the efficacy and safety of awake neuraxial anesthesia with sedation versus general anesthesia in frail patients undergoing elective major…
- Conditions
- Fraily, Abdominal Surgery, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- SAFE-AWARENESS (NCT07486336)
- Testing
- Neuraxial anesthesia, General Anesthesia, avoidance of GABAergic-drugs strategy
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Ente Ospedaliero Ospedali Galliera
Cardiac Surgery
Perioperative Cerebral Function Assessment for Cardiac Surgery
Perioperative neurological complications in cardiovascular surgical procedures are associated with a significant risk of mortality and disability.
- Trial name
- PEACE (NCT06660602)
- Testing
- cardiac surgery
- Where
- China
- Volunteers
- 1,845 people
- Sponsor
- China National Center for Cardiovascular Diseases
Perioperative Care, EEG Power Spectra
Extended Emergence Strategy on Post-Anesthesia Care Unit Events After Outpatient Orthopedic Surgery
The goal of this clinical trial is to learn if an extended emergence from anesthesia can improve recovery room (Post-Anesthesia Care Unit or PACU) outcomes in lower-leg or foot surgery with nerve blocks.
- Conditions
- Perioperative Care, EEG Power Spectra, Delirium - Postoperative
- Trial name
- PACU-EMERGE (NCT07533370)
- Testing
- Standard of Care EEG-Guided Emergence, Extended EEG Emergence Trajectory
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Harrison Shong-Wen Chow
Cognitive Decline, Urinary Bladder Cancer
Association of POCD With Circulating Biomarkers in Patients Undergoing TUR of Bladder Tumor
Bladder tumor is one of the most widespread tumors in the world, with increasing prevalence at the global level. One of the procedures in patients with bladder tumors is transurethral resection of the bladder (TURM) most often…
- Conditions
- Cognitive Decline, Urinary Bladder Cancer, Frail, Biomarker
- Trial name
- NCT07165236
- Where
- Croatia
- Volunteers
- 42 people
- Sponsor
- Osijek University Hospital
Emergence Delirium
Frontal Alpha Asymmetry and Pediatric Emergence Delirium
This study aimed to investigate whether the association between the preoperative anxiety level and emergence delirium involves EEG frontal alpha asymmetry in pediatric patients undergoing ophthalmic surgery under general…
- Trial name
- NCT05800639
- Testing
- Ophthalmic surgery, General anesthesia
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Gangnam Severance Hospital
PND, POCD - Postoperative Cognitive Dysfunction
Effects of Ciprofol on Perioperative Neurocognitive Function in Elderly Patients Undergoing Daytime Surgery
As life expectancy increases, the rate of disability among elderly individuals is also rising. Elderly patients undergoing home-based rehabilitation after surgery without medical supervision may experience complications and…
- Trial name
- NCT07895407
- Testing
- Ciprofol, propofol
- Where
- China
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Postoperative Neurocognitive Dysfunction, Cognitive Dysfunction
Perioperative IL-33 is Associated with the Early Stage of Postoperative Neurocognitive Dysfunction After Major Abdominal Surgery
Perioperative neurocognitive dysfunction(PND) are common complications of major surgery among patients, could be a long-term disease, which sometimes lasts for several years, and it is meaningful to find a biomarker of PND at the…
- Conditions
- Postoperative Neurocognitive Dysfunction, Cognitive Dysfunction, Postoperative Complications, Neuropsychological Tests
- Trial name
- NCT06704451
- Where
- China
- Volunteers
- 150 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Emergence Delirium, Perioperative Neurocognitive Disorder
Quantitative Neurofeedback Techniques for Treating Perioperative Cognitive Disorders in Elderly Patients
The goal of this clinical trial is to learn if quantitative measurement of brain and neurofeedback intervention techniques works to prevent perioperative neurocognitive deficits in elderly oncology patients who are to undergo…
- Trial name
- NCT06752148
- Testing
- neurofeedback intervention training game
- Volunteers
- 390 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
General Surgery
The GUARDIAN Pilot Trial
The treatments will be: 1) norepinephrine or phenylephrine infusion to maintain intraoperative MAP ≥85 mmHg, delayed resumption of chronic antihypertensive medications, and a target ward MAP ≥80 mmHg (tight pressure management)…
- Trial name
- GUARDIAN (NCT04789733)
- Testing
- Tight pressure management, Routine pressure management
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Cleveland Clinic
Emergence Delirium, Postoperative Delirium
Verification of a New Predictive Delirium Score in Adults With Elective Cardiac Valve or Bypass Surgery With Perioperative Use of a Heart-lung Machine; a Monocentric Pilot Observational Study
Basics (state of scientific knowledge): Delirium is an acute disturbance of consciousness and attention that develops over a short period of time and fluctuates in severity.
- Trial name
- MO-FA2-(TB) (NCT07276503)
- Volunteers
- 100 people
- Sponsor
- University Hospital Tuebingen
Postoperative Delirium (POD)
Perioperative Dezocine Administration and Postoperative Delirium in Elderly Cardiac Surgery Patients
Postoperative delirium (POD) is a common complication in elderly patients undergoing cardiac surgery and is associated with prolonged hospitalization, increased morbidity, and poor recovery.
- Trial name
- NCT07768150
- Testing
- Dezocine, Normal Saline (NS)
- Where
- 2 sites in China
- Volunteers
- 640 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Post-Operative Cognitive Decline in Older Adults, Post-operative Cognitive Decline
Post-operative Cognitive Decline After Ambulatory Cataract Surgery in the Elderly Population
Postoperative cognitive decline is a recognized complication following anesthesia and surgery in older adults; however, its incidence after ambulatory cataract surgery performed under sedation is not well understood.
- Conditions
- Post-Operative Cognitive Decline in Older Adults, Post-operative Cognitive Decline, Perioperative Neurocognitive Disorders, Cataract Surgery Anesthesia
- Trial name
- NCT07714174
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Dementia, Postoperative Delirium (POD)
Prediction and Prevention of Postoperative Mortality and Morbidity
This study will contribute to creating a prospective and automated preoperative risk assessment algorithm for predicting 30-day mortality, major adverse cardiac and cerebrovascular events (MACCE), and postoperative neurocognitive…
- Conditions
- Dementia, Postoperative Delirium (POD), Postoperative Neurocognitive Disorder, Major Adverse Cardiac and Cerebrovascular Events
- Trial name
- NCT06042413
- Testing
- Personalized CPC Prehabilitation, Cognitive Training, Meditation
- Where
- 5 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- University of Pittsburgh
Cardiovascular Surgery, Perioperative Neurocognitive Disorders
Exploring the Predictive Value of Electroencephalography Features in Perioperative Neurocognitive Disorders Following Cardiovascular Surgery
To explore the predictive value of Electroencephalography features in Perioperative Neurocognitive Disorders in patients undergoing cardiovascular surgery under general anesthesia
- Trial name
- NCT06692309
- Testing
- cardiovascular surgery
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
Perioperative Neurocognitive Disorder
Treatment of Perioperative Neurocognitive Disorders With Olfactory Enrichment
Perioperative neurocognitive disorder (PND) is one of the most common postoperative complications among elderly patients. However, the mechanism and targeted intervention of PND remains unclear.
- Trial name
- NCT06488807
- Testing
- Olfactory Enrichment
- Where
- China
- Volunteers
- 686 people
- Sponsor
- Shanghai 10th People's Hospital
Perioperative Complication, Infections
Perioperative Longitudinal Study of Complications and Long-term Outcomes
Purpose: with an increased risk of complications. Improved preoperative risk stratification and earlier diagnosis of these complications may ameliorate postoperative recovery and improve long-term outcomes.
- Conditions
- Perioperative Complication, Infections, Myocardium; Injury, Kidney Injury
- Trial name
- PLUTO (NCT05331118)
- Where
- Netherlands
- Volunteers
- 9,000 people
- Sponsor
- UMC Utrecht
Anesthesia, Hip Fractures
Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)
The ANDES Platform Trial is a pragmatic, multicenter, adaptive randomized controlled platform trial in patients aged 65 years or older undergoing surgery for hip fracture.
- Conditions
- Anesthesia, Hip Fractures, Dementia, Cognitive Impairment
- Trial name
- ANDES platform (NCT06452147)
- Testing
- Nerve block, Standard anesthesia care, Bupivacaine liposome
- Where
- 13 sites in China
- Volunteers
- 1,860 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Aortic Diseases, Cardiac Surgical Procedures
Selective Antegrade Cerebral Perfusion and Perioperative Optic Nerve Sheath Diameter in Ascending Aortic Surgery
In ascending aortic surgery the distal anastomosis may be constructed with the aortic cross-clamp maintained, or, where the extent of the aortic pathology and the geometry of the graft require it, after release of the cross-clamp…
- Conditions
- Aortic Diseases, Cardiac Surgical Procedures, Aortic Aneurysm, Thoracic, Delirium - Postoperative
- Trial name
- SACP-ONSD (NCT07800806)
- Testing
- Optic nerve sheath and optic nerve diameter ultrasonography, Transcranial Doppler ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people
- Sponsor
- Koşuyolu Kartal Heart Training and Research Hospital
Delirium, Postoperative Cognitive Dysfunction
Biomarkers Associated With Postoperative Cognitive Dysfunction
Loss of cognitive function after major surgery is a significant risk in older people. It can occur acutely in the days after surgery as delirium or in months to years later as a persistent reduction in brain function termed…
- Conditions
- Delirium, Postoperative Cognitive Dysfunction, Cognitive Decline, Cognitive Impairment
- Trial name
- NCT05464355
- Testing
- Intraoperative electroencephalography recording, Neurofilament light chain measurement, Tau protein measurement
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Oxford
Carotid Artery Disease, Carotid Artery Stenoses
Perioperative Argon Inhalation to Improve Neurocognitive Recovery After Carotid Surgery
Currently, over 400,000 reconstructive surgeries on carotid arteries are performed annually worldwide, including carotid endarterectomy (CEA) and carotid stenting.
- Trial name
- NCT07200180
- Testing
- Аrgon-oxygen breathing mixture, Nitrogen-oxygen breathing mixture
- Where
- 2 sites in Russia
- Volunteers
- 100 people
- Sponsor
- Negovsky Reanimatology Research Institute