Clinical trials: Perioperative Pain
Hepatectomy
Intravenous Lidocaine for Hepatectomy
Liver resection is increasingly performed for hepatic tumors, mainly primary liver cancers and resectable metastases, but also for some benign lesions.
- Trial name
- ILHEP (NCT07590830)
- Testing
- Standardized General Anesthesia Induction and Maintenance Protocol incorporating Intravenous Lidocaine
- Where
- 9 sites in France
- Volunteers
- 312 people
- Sponsor
- Rennes University Hospital
Hemorrhoids, Perioperative Anxiety
Dexmedetomidine vs Tramadol for Anxiety, Pain, and Hemodynamics in Hemorrhoidectomy
This prospective, randomized, double-blind, placebo-controlled trial evaluates whether preoperative intravenous dexmedetomidine or tramadol reduces perioperative anxiety compared with placebo in patients undergoing elective…
- Conditions
- Hemorrhoids, Perioperative Anxiety, Postoperative Pain
- Trial name
- DEXTRA-H (NCT06860100)
- Testing
- Dexmedetomidine, Tramadol, 0.9 % Normal Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Yuzuncu Yil University
Femoral Neck Fractures, Blood Loss, Surgical
Effect of Regional Anesthesia Techniques on Perioperative Blood Loss in Femoral Neck Fracture Surgery
This retrospective observational study evaluates the effect of different regional anesthesia techniques on perioperative blood loss in patients undergoing femoral neck fracture surgery.
- Conditions
- Femoral Neck Fractures, Blood Loss, Surgical, Postoperative Pain
- Trial name
- NCT07702084
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Knee Osteoarthritis
Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty (RELIFE)
Knee replacement surgery for osteoarthritis is a commonly performed procedure in Canada with 75,000 of these surgeries performed each year.
- Trial name
- RELIFE (NCT06423716)
- Testing
- Duloxetine
- Where
- 2 sites in Canada
- Volunteers
- 150 people
- Sponsor
- Sunnybrook Health Sciences Centre
Opioid Cessation
Perioperative Recovery of Moods, Opioids, and Pain Trial (PROMPT)
The investigators aim to characterize the relationship between changes in emotional distress, opioid use, and pain throughout surgery and recovery.
- Trial name
- PROMPT (NCT02070003)
- Testing
- Motivational Interviewing and Physician Guided Opioid Weaning
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Stanford University
Colorectal Cancer
Effect of Lidocaine on Postoperative Pain in Elderlypatients Undergoing Colorectal Cancer Surgery
Patients who meet the enrollment criteria will be randomized 1:1 to the lidocaine group or placebo group.
- Trial name
- NCT05920980
- Testing
- lidocaine
- Where
- China
- Volunteers
- 276 people
- Sponsor
- West China Hospital
Musculoskeletal Pain
TENS and Perioperative Fracture Patients
This is a pilot study designed to evaluate the effectiveness of TENS as part of post-operative pain management. Subjects receiving a TENS unit as part of clinical practice will be approached for consent and followed for 12 months.
- Trial name
- TENS (NCT04209673)
- Testing
- Multimodal Pain management including TENS unit, Multimodal Pain management not including TENS unit
- Where
- United States
- Volunteers
- 205 people
- Sponsor
- Wake Forest University Health Sciences
Pain Management, Postoperative Pain
Effects of S-ketamine on Perioperative Opioid Consumption
This study is a triple-blind randomized controlled trial conducted at a tertiary care hospital in Brussels. It investigates whether a single dose of S-ketamine can reduce opioid (morphine) consumption in the first 24 hours after…
- Conditions
- Pain Management, Postoperative Pain, Opioid Consumption, Postoperative, Opioid Analgesia
- Trial name
- NCT07528651
- Testing
- Esketamine at low dose, Saline (0.9% NaCl)
- Where
- Belgium
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Pain, Postoperative
Effect of Perioperative Intravenous Lidocaine on Opioid Consumption and Pain After Laparoscopic Totally Extraperitoneal Inguinal Hernioplasty
The primary objectives of this study is to access the effect of perioperative lidocaine infusion on total morphine requirement during the first 24 h postoperatively in patients who underwent laparoscopic totally extraperitoneal…
- Trial name
- NCT02601651
- Testing
- Lidocaine, Normal saline
- Where
- Nepal
- Volunteers
- 64 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
the Effect of TEAS on the Children' Pain and Agitation
Effects of Perioperative TEAS on Postoperative Pain and Agitation in Pediatric Adenoidectomy and Tonsillectomy
Adenoidectomy and tonsillectomy are generally performed during childhood to help reduce snoring and improve sleep or caused by recurrent infection.And insufficient analgesia may result in postoperative sore throat, difficulty…
- Trial name
- NCT05330494
- Testing
- transcutaneous electrical acupoint stimulation(TEAS)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xian Children's Hospital
HİP FRACTURE, Hip Surgery (Lateral Incision)
Perioperative Analgesic Effects of PENG Versus PENG Plus LFCN Block in Hip Surgeries
This study is designed to find the best way to control pain after hip surgery performed through a side (lateral) incision. Two different types of nerve blocks used before the operation will be compared.
- Conditions
- HİP FRACTURE, Hip Surgery (Lateral Incision), Postoperative Pain Management, Analgesia, Postoperative
- Trial name
- NCT07329829
- Testing
- Pericapsular nerve group (PENG) block, Lateral Femoral Cutaneous Nerve (LFCN) Block
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Methadone, Pain, Post Operative
Perioperative Methadone in Hip Fracture Patients
Postoperative analgesic treatment needs to be improved. Numerous studies suggest that a single dose of Methadone given during surgery significantly ameliorates postoperative pain and reduces postoperative opioid consumption.
- Conditions
- Methadone, Pain, Post Operative, Pain, Postoperative, Analgesics, Opioid
- Trial name
- NCT05581901
- Testing
- Methadone (Dose1), Methadone (Dose 2), Methadone (Dose 3)
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- University of Southern Denmark
Pudendal Neuralgia, Neuralgia
Perioperative Medical Program to Optimize Nerve Regeneration After Robot-assisted Laparoscopic Neurolyses of Pudendal and/or Inferior Cluneal Nerves for Chronic Neuralgias: Results After 1-year Follow-up
Pudendal and inferior cluneal neuralgias are responsible for chronic pelvicperineal pain. These two neuralgias are associated in approximately 25% of cases.
- Trial name
- REGEN (NCT06796595)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- UBOSGA
Osteoarthritis, Pain
Celebrex Total Knee Arthroplasty Study
This study will investigate the benefits of administering celecoxib (Celebrex), a selective cyclooxygenase -2 (COX-2) inhibitor, in treating osteoarthritis (OA) subjects undergoing elective unilateral primary total knee…
- Trial name
- NCT00359151
- Testing
- Celecoxib
- Where
- 7 sites in United States
- Volunteers
- 22 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Juvenile; Scoliosis, Scoliosis Idiopathic
Studying Melatonin and Recovery in Teens
The goal of this feasibility clinical trial is to learn if melatonin can help teens having major musculoskeletal surgery by promoting healthy sleep.
- Conditions
- Juvenile; Scoliosis, Scoliosis Idiopathic, Scoliosis; Adolescence, Scoliosis;Congenital
- Trial name
- SurgerySMART (NCT06093477)
- Testing
- Fast-Dissolve Melatonin Pill
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Stanford University
Patients Major Laminectomy Surgery
Evaluations of Optimizing Perioperative Fluid Management on Postoperative Pain Outcomes
Patient characteristics, duration of surgery, and infusion volumes will be compared between the groups. Oxygen transport and organ function will be compared Length of hospital stay, morbidity, postoperative pain intensity were…
- Trial name
- NCT02245581
- Testing
- SVV-guided fluid management, CVP-guided fluid management
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Vitreoretinal Surgeries, Postoperative Nausea and Vomiting
SPI-directed Analgesia for Vitreoretinal Surgeries
The aim of this randomized trial is to assess the efficacy of SPI-directed analgesia for vitreoretinal surgeries (VRS), presence of PONV and oculocardiac reflex (OCR) and compare Numerical Rating Scale (NRS) with Surgical Pleth…
- Conditions
- Vitreoretinal Surgeries, Postoperative Nausea and Vomiting, Postoperative Pain
- Trial name
- SPIVS (NCT02973581)
- Testing
- Metamizol, Acetaminophen, 0,5 % bupivacaine with of 2% lidocaine
- Where
- Poland
- Volunteers
- 176 people
- Sponsor
- Medical University of Silesia
Total Knee Replacement
A Study to Compare Different Ways of Steroid Administration After Total Knee Implantation
We are going to evaluate the difference between perioperative intravenous steroid supplementation, perioperative periarticular steroid supplementation, and standard anaesthesia protocols.
- Trial name
- NCT04432012
- Testing
- Dexamethasone Sodium Phosphate 4 mg/ml intravenous, Dexamethasone Sodium Phosphate 4 mg/ml intra-articular
- Where
- Switzerland
- Volunteers
- 159 people
- Sponsor
- Christian Candrian
Delirium, Delirium in Old Age
Perioperative Pain and Delirium in Geriatric Patients With Hip Fracture
The objective of this trial will be to establish whether the ultrasound-guided suprainguinal fascia iliaca compartment block is capable of protecting geriatric patients with hip fracture from delirium as compared to placebo
- Conditions
- Delirium, Delirium in Old Age, Hip Fractures, Dementia
- Trial name
- Delirium-Hip (NCT04404959)
- Testing
- fascia iliaca compartment block with ropivacaine
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- Aretaieion University Hospital
Pain
Study of the Effect of Regional Nerve Blocks on Pain and Inflammation After Video Assisted Thorascopic Lung Surgery
The purpose of this study is to compare: 1. The degree of systemic postoperative inflammation (cytokine measurement) with the degree of post-operative pain 2. The degree of pain and nausea and 3.
- Trial name
- VATS_IM (NCT00639795)
- Testing
- Thoracic Paravertebral Nerve Block
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Memorial Medical Center