Clinical trials: Perioperative Pain Control
Supratentorial Tumors
Comparison of Systemic Opioid (Morphine) and Pre-Incision Bilateral Scalp Nerve Block for Pain Management in Craniotomy Patients
The goal of this randomized controlled clinical trial is to compare the effectiveness of systemic opioids versus pre-incision bilateral scalp nerve block in managing intraoperative noxious stimuli and postoperative pain in adult…
- Trial name
- NCT07425678
- Testing
- Scalp nerve block, Morphine, Lidocaine
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- Aga Khan University
Anxiety
Perioperative Pregabalin Use, Rehabilitation, Pain Outcomes and Anxiety Following Hip Surgery
Pain prior to surgery is of particular concern in patients undergoing total hip arthroplasty (THA) since it is the most important predictor of pain and poor function 2-3 years after surgery.
- Trial name
- RCT (NCT00762099)
- Testing
- Pregabalin
- Where
- Canada
- Volunteers
- 184 people
- Sponsor
- Sunnybrook Health Sciences Centre
Hyperalgesia, Pain, Postoperative
DNA Methylation and Perioperative Pain Treatment
In the last few years much attention has been paid to hyperalgesia induced by opioids, which represents a clinically significant condition following acute and chronic exposure to opioids.
- Trial name
- MEDAPO (NCT02938455)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Bologna
Analgesia
Perioperative Analgesic Modalities for Breast Cancer Surgeries
The incidence of breast cancer is among women world wide, detection increased with introduction of mammography as a screening tool.
- Trial name
- NCT04248608
- Testing
- serratus plane block, erector spinae block, Morphine Sulfate
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- National Cancer Institute, Egypt
Persistent Postoperative Pain
Avoid With Locoregional Analgesia Persistant Postoperative Pain In Children
Persistent postoperative pain is a substantial pain (scores 4-10 using a 0-10 numeric scale) that develops 3 months after surgery. Persistent postoperative pain can be a problem even in ambulatory surgery.
- Trial name
- AWA3PASIC (NCT06271174)
- Testing
- Carbocaine, Profofol and/or Suxaméthonium and/or Sévoflurane
- Where
- France
- Volunteers
- 208 people
- Sponsor
- Nantes University Hospital
Complex Obstetric Surgery, Perioperative Pain Management
COMFORT Trial: Complex Obstetric Management With Focused Regional Transversus Abdominis Plane Block
To assess the effect of intraoperative transversus abdominis plane (TAP) blocks on the amount of opioid pain medications expressed as morphine milliequivalents (MME) used postoperatively in patients who have undergone cesarean…
- Conditions
- Complex Obstetric Surgery, Perioperative Pain Management, Cesarean Delivery, Postoperative Pain Control
- Trial name
- COMFORT (NCT06925152)
- Testing
- Bupivicaine intervention arm
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Tennessee
Vasectomy, Pain
Perioperative Virtual Reality Intervention for Pain and Anxiety During Vasectomies
The goal of this clinical trial is to learn if a virtual reality (VR) program (TRIPP) can reduce pain, anxiety, and distress in adult men (aged 18+) undergoing a vasectomy under local anesthesia.
- Conditions
- Vasectomy, Pain, Anxiety, Virtual Reality
- Trial name
- NCT07055178
- Testing
- Virtual reality (VR) guided meditation therapy, Treatment as usual
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Pancreatic Neoplasms
Analgesia and Pancreatic Cancer Surgery
Long-term survival for patients with pancreatic carcinoma is low, even following resection, the 5-year survival rate of patients ranges from 10 to 25%1.
- Trial name
- NCT01929915
- Testing
- Epidural patient controlled analgesia, Intravenous patient controlled analgesia
- Where
- Taiwan
- Volunteers
- 135 people
- Sponsor
- National Taiwan University Hospital
Experience, Life
Our Anesthesia Experiences in Hepatopancreatobiliary Surgery Practices: a Retrospective Study
Has the evolving anesthetic management in major abdominal surgeries had a positive impact on patients' one-year postoperative mortality and length of hospital stay? Which of the anesthetic management parameters have influenced…
- Trial name
- NCT06002776
- Testing
- a retrospective study
- Where
- Turkey (Türkiye)
- Volunteers
- 6 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Post-Surgical Pain
Perioperative ACT-Based Clinical Hypnosis for Opioid Weaning
This randomized-controlled trial (RCT) will evaluate the effectiveness of a pain psychology intervention -- consisting of a hybrid of acceptance and commitment therapy (ACT) and clinical hypnosis intervention -- in reducing…
- Trial name
- NCT03730350
- Testing
- Clinical Hypnosis
- Where
- Canada
- Volunteers
- 92 people
- Sponsor
- University Health Network, Toronto
Colorectal Cancer
Effect of Lidocaine on Postoperative Pain in Elderlypatients Undergoing Colorectal Cancer Surgery
Patients who meet the enrollment criteria will be randomized 1:1 to the lidocaine group or placebo group.
- Trial name
- NCT05920980
- Testing
- lidocaine
- Where
- China
- Volunteers
- 276 people
- Sponsor
- West China Hospital
Pain, Postoperative, SPINAL Fracture
Bilateral Erector Spinae Plane Block Versus Local Anesthetic Infiltration for Perioperative Analgesia in Spine Surgery.
Postoperative pain still represents an important perioperative issue, affecting more than 80% of patients undergoing surgery. A suboptimal pain management doesn't just affects quality of life, but can compromise rehabilitation…
- Conditions
- Pain, Postoperative, SPINAL Fracture, Spondylolisthesis
- Trial name
- NCT04123106
- Testing
- ESP block, Wound infiltration
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Colorectal Disorders, Regional Anesthesia Morbidity
Transversus Abdominis Plane Blocks With and Without Dexamethasone
Dexamethasone will be used as an adjunct to local anesthetics (bupivacaine) to prolong the duration of laparoscopically-placed transversus-abdominis plane blocks in elective colorectal resection.
- Conditions
- Colorectal Disorders, Regional Anesthesia Morbidity, Analgesia, Local Anesthetic Complication
- Trial name
- TAP-DEX (NCT05432934)
- Testing
- Dexamethasone
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Post-mastectomy Pain Syndrome
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery.
Breast cancer is the most common malignancy among females. Nearly 40% of breast surgery patients experience moderate to severe acute postoperative pain, with severe pain persisting for more than 6 months in almost 20-50% of…
- Trial name
- NCT05935059
- Testing
- Pregabalin, Tianeptine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- National Cancer Institute, Egypt
Delirium, Pain
Pregabalin in the Prevention of Postoperative Delirium and Pain
The purpose of this study is to determine whether administration of pregabalin by mouth immediately preoperatively and three times daily for 3 days after surgery reduces the incidence of delirium postoperatively and improves…
- Trial name
- NCT00819988
- Testing
- Pregabalin, Sugar pill
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- Ottawa Hospital Research Institute
Perioperative Analgesia
Adding Dexmedetomidine Versus Ketamine to Bupivacaine in Fluoroscopy Guided Caudal Analgesia for Lumbosacral Surgeries
This study will evaluate the effect of adding dexmedetomidine to bupivacaine compared to ketamine in the caudal block on perioperative analgesia in patients undergoing lumbosacral surgeries under general anesthesia.
- Trial name
- NCT07573969
- Testing
- Group C (plain bupivacaine (0.125%)), Group D (plain bupivacaine (0.125%) + 2μg/kg dexmedetomidine), Group K (plain bupivacaine (0.125%) + 1mg/kg ketamine)
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Ain Shams University
Breastcancer, Perioperative Pain
Efficacy of Serratus Posterior Intercostal Plane Block for Analgesia and Inflammatory Marker in Breast Surgery
To study the efficiacy of serratus posterior superior block in controlling perioperative breast cancer surgery pain and its effect on inflamatory markers.
- Conditions
- Breastcancer, Perioperative Pain, Inflammation
- Trial name
- NCT06502067
- Testing
- Analgesia mangement group A,B
- Volunteers
- 80 people
- Sponsor
- Ain Shams University
PENG Block, Hip Fracture Surgeries
Comparison of Femoral Nerve Block and Combined PENG Plus Femoral Nerve Block in Geriatric Hip Surgery
Hip fracture surgery in geriatric patients is frequently associated with severe perioperative pain, which may complicate positioning for spinal anesthesia and increase perioperative opioid requirements.
- Trial name
- PENG-FEM (NCT07350044)
- Testing
- Pericapsular nerve group (PENG) block plus femoral nerve block, Femoral Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Ankara City Hospital Bilkent
Postoperative Pain
Thoracic Paravertebral Block Versus IV Fentanyl Infusion
High-quality analgesia during and following cardiac surgery is infrequently obtained, Sternotomy and thoracotomy is associated with significant pain that resulte in hypoventilation, atelectasis, and hypoxemia,Pain management is…
- Trial name
- NCT03903367
- Testing
- Fentanyl Citrate
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Beni-Suef University
Pain, Postoperative, Pain, Acute
Parecoxib in Total Knee Arthroplasty
Early mobilization and rehabilitation can be difficult after total knee arthroplasty (TKA) due to a high incidence of moderate to severe postoperative pain.
- Conditions
- Pain, Postoperative, Pain, Acute, Analgesia, Analgesic Nephropathy
- Trial name
- NCT05924412
- Testing
- Intravenous study drug, Intravenous saline solution
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- University of Chile