Clinical trials: Perioperative Pain Control
Post-Mastectomy Chronic Pain Syndrome
Dex & Mastectomy Pain
Chronic post-surgical pain is a common complication following mastectomy and represents a significant source of long-term morbidity.
- Trial name
- NCT07556952
- Testing
- Dexamethasone (intravenous), Normal Saline (0.9% NaCl)
- Where
- Canada
- Volunteers
- 170 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Laparoscopic Surgery
Labetalol and Esmolol: Vital Signs and Post Operative Pain Management
This study proposes to investigate the effects of labetalol or esmolol on managing the vital signs (like blood pressure and heart rate) during surgery, on pain management, and on the later recovery after surgery.
- Trial name
- NCT01114971
- Testing
- Fentanyl, Labetalol, Esmolol
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Cedars-Sinai Medical Center
Anesthesia Depth Monitoring, Analgesia Assessment
Target-Controlled Infusion (TCI) Effectiveness in Hysteroscopy
This prospective, randomized, observational study aims to evaluate the perioperative anesthetic efficacy of different Target-Controlled Infusion (TCI) models-specifically Minto, Schnider, and Eleveld pharmacokinetic models-in…
- Conditions
- Anesthesia Depth Monitoring, Analgesia Assessment, Perioperative Safety and Recovery, Target Controlled İnfusion
- Trial name
- NCT07023263
- Testing
- Schnider+ Mİnto, Eleveld
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Gazi University
Toxicology, Bariatric Surgery Analgesia
Preoperative Toxicological Screening on Perioperative Anesthetic Management
Background: Preoperative substance use is a growing concern in patients undergoing metabolic bariatric surgery (MBS), but its impact on short-term outcomes remains debated.
- Conditions
- Toxicology, Bariatric Surgery Analgesia, Bariatric Surgery, Substance Use
- Trial name
- NCT07100314
- Testing
- Multi-Drug One Step Screen Test Panel (Urine)
- Where
- Egypt
- Volunteers
- 1,260 people
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Perioperative Analgesia in Major Upper Abdominal Surgery
Regional Block for Upper Abdominal Surgeries
Pain control after major upper abdominal surgeries is an essential step to guard against postoperative complications such as lung atelectasis. This major step can be achieved by opioids or regional blocks.
- Trial name
- NCT05691933
- Testing
- Block group, Morphine infusion
- Volunteers
- 120 people
- Sponsor
- Alexandria University
Laparoscopic Hysterectomy, Postoperative Recovery
Perioperative Duloxetine for Pain Management After Laparoscopic Hysterectomy
The aim of the investigators of the study is to evaluate the effect of peri-operative duloxetine on post-operative recovery in patients undergoing laparoscopic hysterectomy.
- Conditions
- Laparoscopic Hysterectomy, Postoperative Recovery, Postoperative Pain
- Trial name
- NCT03350334
- Testing
- Duloxetine
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Acibadem University
Pain, Postoperative, Acute Pain
EFFECT - EFFectiveness of ESPB (Erector Spinae Plane Block) in Laparoscopic Cοlectomies Trial
The aim of the trial is to study the efficacy of continuous bilateral Erector Spinae Plane Block (ESPB) in managing perioperative pain in patients who undergo elective laparoscopic colectomy.
- Conditions
- Pain, Postoperative, Acute Pain, Postoperative Complications, Pain
- Trial name
- EFFECT (NCT04879004)
- Testing
- Ropivacaine injection
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Democritus University of Thrace
Chronic Pain, Knee Pain Chronic
Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty
Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total…
- Conditions
- Chronic Pain, Knee Pain Chronic, Post Operative Pain
- Trial name
- PROVISION (NCT06123715)
- Testing
- Vitamin C
- Where
- 3 sites in Canada
- Volunteers
- 400 people
- Sponsor
- University Health Network, Toronto
Analgesia
Perioperative Thoracotomy Analgesia; Different Analgesic Modalities
the study aim is to compare the analgesic effect of thoracic epidural versus serratus plane block versus erector spinae block in thoracic surgeries
- Trial name
- NCT04264689
- Testing
- serratus anterior block, thoracic epidural, erector spinae block
- Where
- Egypt
- Volunteers
- 51 people
- Sponsor
- National Cancer Institute, Egypt
Arthroscopy, Analgesia
Ultrasound-Guided Extrafascial Versus Intrafascial Interscalene Brachial Plexus Block in Shoulder Arthroscopy
The aim of the study is to compare the diaphragmatic excursion and postoperative analgesia in the extrafascial versus intrafascial Interscalene brachial plexus block in patients undergoing shoulder arthroscopy.
- Conditions
- Arthroscopy, Analgesia, Intrafascial Interscalene Brachial Plexus Block
- Trial name
- NCT05222334
- Testing
- Intrafascial interscalene brachial plexus block, Extrafascial interscalene brachial plexus block group, Bupivacaine
- Volunteers
- 50 people
- Sponsor
- Tanta University
Lung Cancer (Diagnosis), Pain Management
Impact of Perioperative Body Temperature on Postoperative Complications and Pain in Video-assisted Thoracoscopic Surgery Patients Utilizing Continuous Temperature Monitoring
A report from the National Cancer Center (published in JNCC) shows that lung cancer has the highest rates of both new cases and deaths in China.
- Conditions
- Lung Cancer (Diagnosis), Pain Management, Postoperative Complications, Body Temperature Measurement
- Trial name
- NCT07251439
- Testing
- Continuous body temperature monitoring
- Volunteers
- 144 people
- Sponsor
- Peking University People's Hospital
THA
Duloxetine for Perioperative Pain in Hip Arthroplasty: A RCT
The primary objective of this study is to compare total narcotic intake standardized via milligram morphine equivalents between duloxetine and placebo cohorts after a total hip arthroplasty.
- Trial name
- NCT06807866
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Miami
Plane Block, Regional Anaesthesia
Comparison of the Analgesic Efficacy of Subcostal TAP and M-TAPA Blocks in Laparoscopic Sleeve Gastrectomy Surgery
Objective The aim of this study is to compare the analgesic efficacy of bilateral subcostal transversus abdominis plane (TAP) and modified thoracoabdominal (M-TAPA) blocks in reducing intraoperative opioid consumption and…
- Conditions
- Plane Block, Regional Anaesthesia, Transversus Abdominis Plane (TAP) Block, Bariatric Surgery
- Trial name
- NCT06934772
- Testing
- M-TAPA, Subcostal TAP
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Haseki Training and Research Hospital
Pain Management, Regional Anesthesia
Revision of Deep Brain Stimulator in Patients With Parkinson's Disease
Parkinson's disease is a chronic and progressive neurodegenerative disease that affects the central nervous system, particularly impairing movement control.
- Conditions
- Pain Management, Regional Anesthesia, Deep Brain Stimulation, Parkinsons Disease
- Trial name
- NCT07176494
- Testing
- Patients who underwent surgery under general anesthesia, Patients who underwent surgery under regional anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ankara Etlik City Hospital
Postoperative Pain, Cardiac Surgery
ASPB-PIPB Combination in Cardiac Surgery
Cardiopulmonary bypass surgery is associated with significant postoperative pain, which may adversely affect respiratory function, delay mobilization, prolong hospital stay, and increase postoperative complications.
- Conditions
- Postoperative Pain, Cardiac Surgery, Cardiopulmonary Bypass, Median Sternotomy
- Trial name
- NCT07716943
- Testing
- Combined ASPB and PIPB, Anterior Serratus Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Condition: Abdominal Bone Flap Cranioplasty; Focus of Study: Perioperative Analgesia
Efficacy Of Scalp Block And Ultrasound Guided TAP Block With Clonidine As Adjuvant To Ropivacaine Versus Intravenous Fentanyl On Intraoperative Hemodynamics And Perioperative Analgesia In Abdominal Bone Flap Cranioplasties
This study assesses efficacy of scalp block and Ultrasound guided transverse abdominis plane (TAP) block with 1µg/kg clonidine as adjuvant to 0.2% ropivacaine versus intravenous fentanyl (0.1µg/kg/hr) on intraoperative…
- Trial name
- NCT03667352
- Testing
- Unilateral Scalp Block, Transversus abdominis plane block, Intravenous Fentanyl
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Dhritiman Chakrabarti