Clinical trials: Perioperative Risk Assessment
Vascular Death, Myocardial Infarction
Vascular Events In Noncardiac Surgery Patients Cohort Evaluation Study (VISION)
The investigators' study has 4 primary objectives. Among patients undergoing noncardiac surgery the investigators will determine: (1) the incidence of major perioperative vascular events; (2) the optimal clinical model to predict…
- Conditions
- Vascular Death, Myocardial Infarction, Cardiac Arrest, Stroke
- Trial name
- VISION (NCT00512109)
- Where
- 8 sites in Brazil, Canada and 5 more
- Volunteers
- 40,060 people
- Sponsor
- McMaster University
Postoperative Delirium (POD), Perioperative Neurocognitive Disorders
Ortopod CZ Pilot Study
ORTOPOD PILOT STUDY is a non-randomized, non-interventional clinical study that addresses the issue of perioperative neurocognitive disorder (deterioration of cognitive functions in the preoperative and perioperative period) and…
- Trial name
- ORTOPODCZ (NCT06869876)
- Where
- Czechia
- Volunteers
- 75 people
- Sponsor
- Tomas Bata Hospital, Czech Republic
Postoperative Complications, Cardiovascular Complication
Perioperative Inflammatory Response Assessment in High-risk Patients Undergoing Noncardiac Surgery
Postoperative cardiovascular complications are common after noncardiac surgery. The association between perioperative inflammation and the occurrence of cardiovascular complications after surgery is still unknown.
- Conditions
- Postoperative Complications, Cardiovascular Complication, Myocardial Ischemia, Inflammation
- Trial name
- INSIGHT (NCT04753307)
- Testing
- Laboratory measurements
- Where
- Austria
- Volunteers
- 1,400 people
- Sponsor
- Medical University of Vienna
Anesthesiological Risk Reduction, Intensive Care Risk Reduction
Identification of Outcome Relevant Indicators in Routine Data
The availability of electronic documentation systems in patient care means that large amounts of clinical routine data are available from which conclusions can be drawn for improving patient care.
- Trial name
- NCT04670744
- Where
- Germany
- Volunteers
- 1,000,000 people
- Sponsor
- Charite University, Berlin, Germany
Surgery, Cardiovascular
BNP Evaluation Before Surgery Study: an Observational Study of Natriuretic Peptide Levels Prior to Surgery.
A prospective, multi-centre, observational study of preoperative natriuretic peptide testing for patients undergoing non-cardiac surgery conducted over four weeks.
- Trial name
- EPIC-2 (NCT04114032)
- Where
- South Africa
- Volunteers
- 174 people
- Sponsor
- University of Cape Town
Anxiety State, Anxiety Postoperative
Perioperative Anxiety Risk Factors in Parents of Children Undergoing Thoracic Surgery
Risk factors associated with perioperative anxiety in parents of pediatric patients undergoing thoracic surgery are unknown. It is therefore necessary to identify them in order to better understand, above all, modifiable factors.
- Conditions
- Anxiety State, Anxiety Postoperative, Parents, Surgery
- Trial name
- NCT05752708
- Testing
- Diagnostic Test
- Where
- Poland
- Volunteers
- 123 people
- Sponsor
- National Institute for Tuberculosis and Lung Diseases, Poland
Perioperative Risk Assessment
Frailty Assessment Reveals Cognitive Differences in ASA Classification: Anesthesiologists vs Large Language Models
The American Society of Anesthesiologists (ASA) Physical Status Classification System is widely used to assess perioperative risk, but it does not explicitly include frailty as a standardized variable.
- Trial name
- ASA-AI (NCT07399938)
- Testing
- Observational Assessment Only
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Perioperative Bleeding
Platelet Function Testing Help and Intraoperative Bleeding Risk for Patients Who Are on Plavix Prior to Surgery
A large number of patients are currently on Antiplatelet inhibition using aspirin or Plavix therapy (A Thieno pyridine - ADP mediated platelet inhibitor).
- Trial name
- NCT00653900
- Where
- United States
- Sponsor
- Cedars-Sinai Medical Center
Perioperative Care
Validation of B-type Natriuretic Peptide With N-terminal Pro B-type Natriuretic Peptide in Perioperative Risk Assessment
This is a single-centre, prospective study to determine the correlation and comparative thresholds between N-terminal pro-brain natriuretic peptide (NT ProBNP, Roche) and brain natriuretic peptide (BNP, Abbott) tests.
- Trial name
- NCT05352698
- Testing
- NT ProBNP (Roche)
- Where
- Canada
- Volunteers
- 466 people
- Sponsor
- Jordan Leitch
Esophagectomy, HALP Score
Perioperative HALP and Surgical Outcomes
Esophagectomy is associated with substantial postoperative morbidity despite advances in perioperative care. The Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) score has been proposed as a composite biomarker reflecting…
- Conditions
- Esophagectomy, HALP Score, Perioperative Biomarkers, Postoperative Complications
- Trial name
- NCT07761975
- Testing
- Perioperative HALP Score Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 131 people
- Sponsor
- Istanbul Saglik Bilimleri University
Patent Foramen Ovale
Patent Foramen Ovale (PFO) and Risk of Perioperative Stroke
This is a multi-centre, prospective cohort study to determine if asymptomatic PFO is a risk factor for developing perioperative overt and covert stroke in patients undergoing non-cardiac surgery.
- Trial name
- CAPPRES (NCT05592301)
- Testing
- Diffusion-weighted Magnetic Resonance Imaging (DW-MRI), Transcranial Doppler (TCD), Transthoracic Echocardiogram (TTE)
- Where
- Canada
- Volunteers
- 408 people
- Sponsor
- University Health Network, Toronto
Postoperative Complications (Cardiopulmonary)
Preoperative Exercise Testing and Perioperative Outcomes
The goal of this observational study is to learn whether results from a brief exercise test done before surgery can help identify adults who may be more likely to have problems after moderate- to high-risk noncardiac surgery.
- Trial name
- SAMPO (NCT07519733)
- Testing
- Recruited participants receive preoperative rapid submaximal cardiopulmonary exercise testing within the current risk assessment framework of the pre-surgical evaluation clinic
- Where
- United States
- Volunteers
- 992 people, healthy volunteers welcome
- Sponsor
- Yale University
Surgical Procedures, Telemedicine
The Risk of Surgical Cancellation in Adult Patients Assessed by Telephone Versus In-person for Scheduled Non-cardiac Elective Surgery.
Telemedicine has been regulated in Colombia since 2006, with applications in anesthesia being explored since 2004 to improve accessibility and reduce costs.
- Conditions
- Surgical Procedures, Telemedicine, Preanesthetic Medication, Preoperative Care
- Trial name
- NCT06693869
- Where
- Colombia
- Volunteers
- 1,176 people
- Sponsor
- Universidad de Antioquia
ASA Class III/IV Patients, Surgery
Artificial Intelligence-augmented Perioperative Clinical Decision Support
The study investigates a novel anaesthesiological clinical decision support (CDS) application, that integrates risk evaluation tools and updated clinical guidelines guided by artificial intelligence in the setting of preoperative…
- Conditions
- ASA Class III/IV Patients, Surgery, Clinical Decision Support Systems
- Trial name
- KIPeriOP (NCT05284227)
- Testing
- Electronic Clinical Decision Support Application
- Where
- Germany
- Volunteers
- 210 people
- Sponsor
- Wuerzburg University Hospital
Colorectal Cancer Postoperative Complications
KIA-Korekt: Staged Unimodal-to-Multimodal AI Evaluation for Perioperative Risk Prediction in Colorectal Cancer
Perioperative complications following surgery for colorectal cancer (CRC) represent a major cause of postoperative morbidity and mortality.
- Trial name
- KIA-Korekt (NCT07537491)
- Where
- Germany
- Volunteers
- 910 people
- Sponsor
- Rene Mantke
Placenta Previa, Placenta Accreta
ROTEM in Patients With Placenta Previa
The rotational thromboelastogram (ROTEM) test can be performed on patients with placenta previa/accreta/increta/percreta who have a high likelihood of massive bleeding, and the predictors can be identified by comparing the…
- Conditions
- Placenta Previa, Placenta Accreta, Placenta Increta, Placenta Percreta
- Trial name
- NCT04213755
- Testing
- ROTEM
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Bundang Hospital
Breast Neoplasms, Surgery Scheduled
Proof of Concept of the Aiinane Preoperative Risk Assessment Tool.
BACKGROUND: Each year, over 13,000 patients in Catalonia and more than 4 million worldwide experience last-minute surgery cancellations (LMC) due to preoperative inefficiencies.
- Conditions
- Breast Neoplasms, Surgery Scheduled, Surgery Related Complications Rate, Preanesthetic Medication
- Trial name
- aiinane-24-1 (NCT07021235)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Ancor Serrano
Pulmonary Aspiration During Anaesthetic Induction, Gastric Emptying Time
Gastric Emptying With Metoclopramide in GLP-1 Agonist Patients Undergoing Elective Surgery
This is a multicentre, investigator-blinded, randomised controlled trial evaluating whether the use of oral metoclopramide before surgery can reduce the amount of residual gastric content in patients who are taking glucagon-like…
- Conditions
- Pulmonary Aspiration During Anaesthetic Induction, Gastric Emptying Time, Preoperative Risk Assessment, Obesity (Disorder)
- Trial name
- GEM-GLP1RA (NCT07100691)
- Testing
- Metoclopramide
- Where
- 2 sites in Ireland
- Volunteers
- 80 people
- Sponsor
- Mater Misericordiae University Hospital
Telemedicine, Anesthesia
Anesthetic and Perioperative Risk Assessment Before Programmed Surgery: Anesthetic Teleconsultation Versus Face-to-face Anesthesia Consultation.
The anesthesia safety decree made it compulsory in 1994 to carry out a pre-anesthesia consultation before any operative or interventional act.
- Conditions
- Telemedicine, Anesthesia, Consultation, Remote
- Trial name
- TELANESTH (NCT04920604)
- Testing
- Face-to-face anesthesia consultation, Remote anesthesia consultation
- Where
- France
- Volunteers
- 172 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Cleft Palate, Cleft Lip
Perioperative Respiratory Adverse Events in Cleft Lip and Palate Surgery: Incidence, Risk Factors, and Clinical Scoring
Cleft lip and palate surgeries present unique anesthetic challenges due to shared airway access with the surgical field, frequent anatomical abnormalities, and a predominantly infant and toddler population.
- Conditions
- Cleft Palate, Cleft Lip, Laryngospasm, Bronchospasm
- Trial name
- NCT07651904
- Testing
- Standard General Anesthesia per Institutional Protocol
- Volunteers
- 150 people
- Sponsor
- Marmara University Pendik Training and Research Hospital