Clinical trials: Peripheral Arterial
Peripheral Arterial Disease, Atherosclerosis of Extremities
Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk
The Low dose ColchicinE in pAtients with peripheral Artery DiseasE to address residual vascular Risk (LEADER-PAD) trial will evaluate if anti-inflammatory therapy with colchicine will reduce vascular events in patients with…
- Conditions
- Peripheral Arterial Disease, Atherosclerosis of Extremities, Inflammation
- Trial name
- LEADER-PAD (NCT04774159)
- Testing
- Colchicine 0.5 MG Oral Tablet
- Where
- 86 sites in United States, Australia and 8 more
- Volunteers
- 6,150 people
- Sponsor
- Population Health Research Institute
Peripheral Arterial Disease, Subarachnoid Block
Effect of Subarachnoid Block and Femoropopliteal Block to Limb Perfusion in PAD Patients
This pilot study investigates the effects of femoropopliteal and subarachnoid nerve blocks on tissue oxygen saturation (StO2) in patients with Peripheral Arterial Disease (PAD) during lower limb surgeries.
- Conditions
- Peripheral Arterial Disease, Subarachnoid Block, Femoropopliteal Block, Tissue Oxygen Saturation
- Trial name
- NCT06702202
- Testing
- Mixture of local anesthetics, 0.5% hyperbaric bupivacaine
- Where
- Indonesia
- Volunteers
- 16 people
- Sponsor
- Universitas Indonesia
Vascular Disease, Peripheral, Physical Inactivity
Inter-individual Physiological Response to a Training and Detraining Period in Cardiometabolic Risk Factors Subjects
Background: Although exercise training is a well described therapy for some cardiometabolic diseases such as obesity, type 2 diabetes, arterial hypertension, and metabolic syndrome, there is scarcity of knowledge about the…
- Conditions
- Vascular Disease, Peripheral, Physical Inactivity, Arterial Hypertension, Endothelial Dysfunction
- Trial name
- VASCU-HEALTH (NCT05710653)
- Testing
- Exercise training intervention
- Where
- Chile
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cristian Alvarez
Bypass Complications, Disorder of Blood Gas
Difference Between Central and Peripheral Arterial Blood Oxygen Saturation With Different CPB Strategy
Femoro-femoral cardiopulmonary bypass with retrograde perfusion is needed for totally thoracoscopic cardiac surgery. one of the major complication of retrograde perfusion is organ hypoperfusion.
- Trial name
- NCT01698853
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Diabetic Foot, Peripheral Arterial Disease
Diagnostic Tools to Establish the Presence and Severity of Peripheral Arterial Disease in People With Diabetes
In the UK there are over 7,000 leg amputations each year because of diabetes. The most important cause of this is poor circulation. The detection of poor circulation in patients with diabetes is difficult.
- Conditions
- Diabetic Foot, Peripheral Arterial Disease, Diabetic Foot Ulcer, Peripheral Vascular Diseases
- Trial name
- DM PAD (NCT05009602)
- Testing
- Toe Brachial Pressure Index (TBPI), Ankle Brachial Pressure Index (ABPI), Exercise Ankle Brachial Pressure Index (ABPI)
- Where
- 17 sites in United Kingdom
- Volunteers
- 604 people
- Sponsor
- Imperial College London
Peripheral Artery Disease
Safety and Performance of the Zeus CC Stent for the Treatment of Iliac Occlusive Disease
The purpose of this study is to evaluate safety and performance of the balloon-expandable Zeus CC (Rontis AG) stent for the treatment of Trans-Atlantic Inter-Society Consensus (TASC) A, B, C and D iliac lesions.
- Trial name
- EAZY (NCT01499329)
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- be Medical
Peripheral Arterial Disease
Peripheral Arterial Disease Biomarkers
The study aims to determine how expression levels of biomarkers for peripheral arterial disease change over time in response to exercise therapy, surgical or endovascular intervention, and whether they can be used to predict…
- Trial name
- PADBIRD (NCT06373302)
- Volunteers
- 100 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Peripheral Artery Disease, PAD
A Study to Evaluate the Effect of Sarpogrelate on Blood Hyperviscosity
This study is to evaluate the effect of sarpogrelate on blood viscosity after 24 weeks in patients with high blood viscosity.
- Trial name
- NCT03509922
- Testing
- Anplag Tab. 100mg bid, Anplag Tab. 100mg tid
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yuhan Corporation
Peripheral Vascular Disease
JET-RANGER Trial - JETStream Atherectomy With Adjunctive Paclitaxel-Coated Balloon Angioplasty vs Plain Old Balloon Angioplasty Followed by Paclitaxel-Coated Balloon
A prospective, multicenter, randomized study evaluating the use of Jetstream Atherectomy (JS) followed by DCB in comparison to the use of plain old balloon angioplasty (POBA) followed by DCB alone in the treatment of complex…
- Trial name
- NCT03206762
- Testing
- Jetstream Atherectomy with randomization to the Ranger or IN.PACT DCB Arm or the POBA+DCB (Ranger or IN.PACT) Arm
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Midwest Cardiovascular Research Foundation
Peripheral Arterial Occlusive Disease, Critical Limb Ischemia
Safety, Tolerability, and Biodistribution of [89Zr]Zr-DFO-APAC in Subjects With PAOD/CLI and Healthy Volunteers (Acronyms: 89Zr = Zirconium-89, DFO = Desferrioxamine, APAC = AntiPlatelet AntiCoagulant, PET/CT = Positron Emission Tomography/Computed Tomography)
The goal of this Phase 0 clinical trial is to evaluate safety and biodistribution of [89Zr]Zr-DFO-APAC in patients with peripheral arterial occlusive disease / critical limb ischemia (PAOD/CLI) and healthy volunteers.
- Trial name
- CHASE (NCT06204237)
- Testing
- [89Zr]Zr-DFO-APAC, PET/CT scan
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Aplagon Oy
Subclinical Cardiovascular Impairments, Obstructive Sleep Apnea Syndrome
Cardiovascular Impairments and Obstructive Sleep Apnea Syndrome
Which are the anthropometric parameters and/or of severity of the syndrome of apnea of sleep (SAS) which make it possible to anticipate occurred of vascular anomalies, anatomical and/or functional precociously found among…
- Trial name
- INFRASAS (NCT01089257)
- Where
- 3 sites in France
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Peripheral Vascular Disease
A Multi-center Clinical Trial of the Misago™ Self-Expanding Stent System for Superficial Femoral Artery
OSPREY is a multi-center, single arm, non-randomized, prospective clinical trial. Subjects will undergo a superficial femoral artery (SFA) stent procedure using the Misago™ Peripheral Self Expanding stent once all of the…
- Trial name
- OSPREY (NCT01118117)
- Testing
- Misago™ Self-Expanding Stent System
- Where
- 31 sites in United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Terumo Medical Corporation
Artery Disease
Investigating the Safety and Clinical Performance of Eight iVascular Devices for Endovascular Intervention in Renal, Iliac or Femoral Arteries
The rationale of this study is to confirm and support the clinical safety and performance of any of these products in a real-world population of 209 patients who underwent an endovascular intervention within standard-of-care of…
- Trial name
- NCT05902923
- Testing
- endovascular intervention
- Where
- 6 sites in France
- Volunteers
- 209 people
- Sponsor
- iVascular S.L.U.
Peripheral Arterial Disease
Nitrites, Exercise, and Peripheral Arterial Disease
The hypothesis of this proposal is that in subjects with PAD, regular consumption of a high nitrate supplement which raises plasma nitrite, in conjunction with 12 weeks of supervised exercise training at the limb ischemic…
- Trial name
- NO-PAD (NCT01684930)
- Testing
- Beetroot Juice (Beet-It Stamina Shot) & Supervised Exercise Training
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Duke University
Peripheral Arterial Disease
Cost-utility Analysis, Cost-effectiveness Analysis, Budget Impact Analysis
Cardiovascular pathologies (CV), the second leading cause of death just behind tumors, are particularly frequent in France and strongly mobilize the resources of the healthcare system (ambulatory and health facility).
- Trial name
- DAMAGE (NCT04283565)
- Testing
- Systematic screening of AOMI by BPI measurement., Management of CVRF by a motivationnal interviewing.
- Where
- France
- Volunteers
- 614 people
- Sponsor
- University Hospital, Tours
PAD - Peripheral Arterial Disease, PAD
Tack Optimized Balloon Angioplasty Post-Market Study
The objective of this study is to obtain outcomes following dissection repair with the Tack Endovascular System in a broad population of patients undergoing endovascular treatment of lesions within the superficial femoral…
- Conditions
- PAD - Peripheral Arterial Disease, PAD, Dissection, Arterial Dissection
- Trial name
- TOBA PMS (NCT05361967)
- Testing
- The Tack Endovascular System
- Where
- 10 sites in United States
- Volunteers
- 6 people
- Sponsor
- Spectranetics Corporation
Peripheral Arterial Disease
PAD Screening Study
Peripheral arterial disease (PAD) due to atherosclerotic narrowing of arteries of the lower limb is common and associated with increased cardiovascular mortality and morbidity.
- Trial name
- NCT05584072
- Testing
- Active pedal plantarflexion (APP) test
- Where
- Hong Kong
- Volunteers
- 500 people
- Sponsor
- Chinese University of Hong Kong
Healthy
Effects of the Short-Chain Fatty Acids-Targeted Dietary Interventions on the Selected Autonomic Functions in Humans
Recent data feature short-chain fatty acids (SCFAs), products of gut microbial fermentation, as modulators of the blood pressure of the host.
- Trial name
- NCT06851039
- Testing
- Potato starch supplementation, Sodium butyrate supplementation, Accessible starch supplementation
- Where
- Poland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Peripheral Arterial Disease
BRAVO: Biomarker Risk Assessment in Vulnerable Outpatients
The investigators hypothesize that among people with lower extremity peripheral artery disease (PAD), biomarker levels are higher during time periods immediately preceding an acute coronary event compared to time periods not…
- Trial name
- BRAVO (NCT02276781)
- Where
- 6 sites in United States
- Volunteers
- 595 people
- Sponsor
- Northwestern University
Vascular Access Complications, Cardiac Catheterization
Femoral Arterial Access With Ultrasound Trial
This study is designed to evaluate the routine use of vascular ultrasound as an aid for proper placement of a femoral arterial sheath during cardiac catheterization and peripheral arterial angiography.
- Conditions
- Vascular Access Complications, Cardiac Catheterization, Peripheral Vascular Disease
- Trial name
- FAUST (NCT00667381)
- Testing
- Real-time Ultrasound Guidance (Site-Rite 5 or 6 machine)
- Where
- 4 sites in United States
- Volunteers
- 1,014 people
- Sponsor
- University of California, Irvine
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