Clinical trials: Peripheral Arterial
Critical Limb Ischemia
Autologous Endothelial Progenitor Cells (EPCs) From Peripheral Blood in the Treatment of Critical Limb Ischemia
Aim: to value the safety and efficacy of local intramuscular administration of immunoselected autologous endothelial progenitor cells in the treatment of critical limb ischemia in patients without revascularization options.
- Trial name
- NCT01595776
- Testing
- Endothelial progenitor cells intramuscular implant
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Surgery, Arterial Catheterization, Peripheral
Feasibility of Obtaining Pulse Oximetry Readings From the Oropharynx
This is a prospective study to evaluate the feasibility of obtaining a pulse oximetry ready from the oropharynx with a standard oximeter probe that has been attached to an oral airway or a tongue blade.
- Trial name
- NCT05690633
- Testing
- Pulse oximetry
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Joseph D. Tobias
Peripheral Artery Disease, Coronary Artery Disease
Diagnosis and Treatment of CAD in Severe PAD After Lower Extremity Revascularization
Peripheral artery disease, lack or blood flow to the legs, has a high prevalence in the Veteran population. In patients with severe peripheral artery disease that requires an endovascular or surgical intervention for lower leg…
- Trial name
- CAD in sPAD (NCT06387355)
- Testing
- Coronary computed topography (CT) angiography with FFR-CT
- Where
- 7 sites in United States
- Sponsor
- VA Office of Research and Development
Peripheral Vascular Diseases
Comparison Study of Vasovist® Magnetic Resonance Angiography (MRA) and an MRA With a Conventional Extracellular Contrast Agent With X-ray Angiography in Patients With Peripheral Artery Disease
The particular aim of this study is the comparison of the diagnostic results of MRA images upon application of Vasovist (gadofosveset), a contrast agent not yet available on the market, with the MRA images upon application of a…
- Trial name
- NCT00296855
- Testing
- Vasovist (BAY86-5283, MS-325)
- Where
- 26 sites in Argentina, Austria and 4 more
- Volunteers
- 261 people
- Sponsor
- Bayer
Peripheral Artery Disease, In-stent Restenosis
LDD in Treatment of Femoropopliteal ISR
This study will evaluate the effectiveness and safety of local drug delivery using TAPAS balloon catheter system in the treatment of femoropopliteal in-stent restenosis.
- Trial name
- NCT03521843
- Testing
- balloon dilation only, balloon dilation+local drug delivery
- Where
- China
- Volunteers
- 40 people
- Sponsor
- RenJi Hospital
Ischemia Reperfusion Injury, Peripheral Artery Disease
Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion
In this study, we are trying to see if vitamin B6 can minimize the amplified blood pressure response to exercise following ischemia-reperfusion injury.
- Trial name
- NCT06369350
- Testing
- Vitamin B6 25 MG, Vitamin B6 50 MG, Vitamin B6 100 MG
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Peripheral Arterial Disease
PQ Bypass Guide Wire Delivery System for Femoropopliteal Bypass
To assess the safety of performing a percutaneous fem-pop bypass using the PQ Bypass Guidewire Delivery System and commercially available stent grafts.
- Trial name
- PQB4FP1 (NCT01930071)
- Testing
- PQ Bypass Guide Wire Delivery System
- Where
- New Zealand
- Volunteers
- 4 people
- Sponsor
- Endologix
Atherosclerosis, Coronary Artery Disease
Innate Human Collateral Supply to Different Vascular Regions
Both clinical and experimental studies demonstrate the importance of the pre-existing, ie innate collateral supply in different vascular regions.
- Trial name
- NCT02063347
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Peripheral Arterial Disease(PAD)
Real-World Registry of the Rotarex(TM) Rotational Excisional Atherectomy System (XTRACT Registry)
The XTRACT Registry is a prospective, single arm multicenter study on the use of on the Rotarex(TM) Rotational Excisional Atherectomy System.
- Trial name
- NCT07016698
- Testing
- Rotarex(TM) Rotational Excisional Atherectomy System
- Where
- 2 sites in United States
- Volunteers
- 600 people
- Sponsor
- C. R. Bard
Peripheral Arterial Disease
A Trial of Alirocumab and Plaque Regression in Peripheral Arterial Disease
Peripheral arterial disease (PAD) is characterized by lower limb arterial obstruction due to atherosclerosis. Magnetic resonance imaging (MRI) methods can accurately quantify atherosclerotic plaque in the superficial femoral…
- Trial name
- NCT02959047
- Testing
- Alirocumab
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Peripheral Artery Disease, Overweight or Obesity
Promote Weight Loss in Obese Peripheral Artery Disease (PAD) Patients to Prevent Mobility Loss
The PROVE Trial is a randomized clinical trial that will determine whether a weight loss intervention combined with walking exercise achieves greater improvement or less decline in six-minute walk distance at 12 month follow-up…
- Trial name
- PROVE (NCT04228978)
- Testing
- Weight loss, Exercise
- Where
- 7 sites in United States
- Volunteers
- 212 people
- Sponsor
- Northwestern University
Peripheral Arterial Disease, Peripheral Artery Disease
Impacts of Mitochondrial-targeted Antioxidant on Peripheral Artery Disease Patients
Peripheral artery disease (PAD) is a common cardiovascular disease, in which narrowed arteries reduce blood flow to the limbs, causing pain, immobility and in some cases amputation or death.
- Trial name
- NCT03506633
- Testing
- MitoQ
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Nebraska
Peripheral Artery Disease
Functional Evaluation With Questionnaire in Patients Investigated for Suspected Peripheral Artery Disease
The purpose of this study is to test the routine faisibility of a questionnaire to estimate walking impairment(The WELCH questionnaire) in patients investigated for suspected PAD.
- Trial name
- WELCH-bis (NCT01632033)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Angers
Peripheral Artery Disease, Quality of Life
VADOplex Critical Limb Ischemia Study
In patients with critical limb ischemia (CLI) and foot ulcers wound healing is an important goal which can normally only be achieved after sufficient treatment of the underlying ischemia (revascularization either by an operation…
- Conditions
- Peripheral Artery Disease, Quality of Life, Wound Healing
- Trial name
- NCT02034539
- Testing
- VADOplex system
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Asklepios Kliniken Hamburg GmbH
Chronic Limb Threatening Ischemia
Efficacy of the Ranger Drug-Coated Balloon in Treating BTK Lesions in Patients With CLTI
This is a prospective, multicenter, observational study designed to evaluate the clinical outcomes of the Ranger™ SL paclitaxel-coated balloon, a type of drug-coated balloon (DCB), in the treatment of below-the-knee (BTK) lesions…
- Trial name
- NCT07014475
- Testing
- drug-coated balloon
- Where
- China
- Volunteers
- 700 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Cardiovascular Diseases, Coronary Artery Disease
The Effect Of An Expanded Long Term Periodization Exercise Training In Patients With Cardiovascular Disease
Benefits from cardiac rehabilitation (CR) programs are evidence based and widely recognized. Less than 50% of people who participate in hospital-based CR programs maintain an exercise regimen for as long as six months after…
- Trial name
- NCT03335319
- Testing
- Periodized Exercise Training Regime, Non Periodized Exercise Training Regime
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- University of Lisbon
Peripheral Arterial Disease
Ankle Arterial Doppler Waveform Assessment For Surveillance Following Lower Limb Revascularisation
The goal of this observational study is to determine the diagnostic performance of serial ankle arterial Doppler waveform assessments in detecting significant arterial restenosis in patients with Peripheral Arterial Disease (PAD)…
- Trial name
- WAVE (NCT06619223)
- Testing
- Duplex Ultrasound
- Volunteers
- 121 people
- Sponsor
- Imperial College London
Carotid Artery Diseases, Aortic Diseases
Intervascular Post-Market Clinical Follow-Up (PMCF) Registry
The purpose of this registry is to evaluate the long-term safety and performance of Intervascular Vascular Grafts and Patches (Intergard Standard, Hemashield, Intergard Silver, Intergard Synergy) for bypass, repair or replacement…
- Conditions
- Carotid Artery Diseases, Aortic Diseases, Peripheral Arterial Diseases
- Trial name
- NCT07322913
- Testing
- Intergard Standard - Collagen Coated Vascular Grafts and Patches, Hemashield - Collagen Coated Vascular Grafts and Patches, Intergard Silver - Antimicrobial Collagen Coated Vascular Grafts and Patches
- Where
- 5 sites in United States, Belgium and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Intervascular
Heart Failure, Systolic, Heart Failure, Diastolic
Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status
The purpose of the study is to determine associations between fitness status, bacteria in the mouth, and the blood flow to muscle.
- Conditions
- Heart Failure, Systolic, Heart Failure, Diastolic, Peripheral Arterial Disease, Overweight and Obesity
- Trial name
- NCT06009276
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Virginia
Critical Limb Ischemia, Arterial Occlusive Disease
Randomized Study of Pregabalin for Pain Reduction in Patients With Rest Pain and Lower Limb Ischemia
The hypothesis behind the trial is the concept that Pregabalin is effective in reducing pain at rest in lower limb ischemia, and the study evaluates active treatment or placebo added to the regular pain regimens for these…
- Conditions
- Critical Limb Ischemia, Arterial Occlusive Disease, Pain, Ischemia
- Trial name
- NCT00403780
- Testing
- pregabalin
- Where
- 3 sites in Sweden
- Volunteers
- 18 people
- Sponsor
- Karolinska Institutet
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