Clinical trials: Peripheral Arterial
Health Behavior
Feasibility of a Multi Site RCT to Establish the Effectiveness of a Health Behaviour Change Intervention for Patients With Peripheral Arterial Disease (PAD).
The purpose of this study was to evaluate the feasibility of conducting a randomised controlled trial (RCT) comparing brief psychological intervention to help patients with Peripheral Arterial Disease (PAD), reduce cardiovascular…
- Trial name
- NCT04753281
- Testing
- Lifestyle counselling
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- NHS Grampian
Peripheral Artery Disease
Utility of Sortilin as a Biomarker of Restenosis After Lower Extremity Endovascular Revascularization
Sortilin is a 95-kDa protein related to circulating cholesterol. It is found inside different cell types and circulating in blood and it has been associated with the risk of atherosclerosis development and cardiovascular…
- Trial name
- NCT05759130
- Where
- Italy
- Volunteers
- 207 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Chronic Critical Limb Ischemia, Peripheral Vascular Diseases
Study to Evaluate the Safety & Performance of the Xpert(TM) Stent in Treating Below-the-knee Lesions in Patients Undergoing Percutaneous Intervention for Chronic CLI.
The purpose of this study is to evaluate the safety and performance of the Xpert(TM) self-expanding stent in infrapopliteal lesions as part of an overall treatment strategy in patients undergoing percutaneous intervention for the…
- Trial name
- XCELL (NCT00515346)
- Testing
- Xpert(TM) Self-expanding Transhepatic Biliary Stent System feasibility in treating chronic critical limb ischemia
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- VIVA Physicians
Peripheral Arterial Disease
Paclitaxel Balloon Versus Standard Balloon in In-stent Restenoses of the Superficial Femoral Artery (PACUBA I Trial)
Prospective monocenter single-blind randomized (1:1) investigator sponsored clinical trial, in which consecutive patients candidates for percutaneous intervention of angioplasty to treat symptomatic in-stent restenosis of the SFA…
- Trial name
- PACUBA 1 (NCT01247402)
- Testing
- drug eluting balloon angioplasty, standard balloon angioplasty
- Where
- 2 sites in Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Peripheral Artery Disease, De Novo Stenosis
Compare the Effectiveness and Safety of Genoss® DCB and IN.PACT Admiral® DCB in Patients With Peripheral Artery Disease
The purpose of this clinical trial is to demonstrate the non-inferiority of GENOSS DCB versus IN.PACT Admiral DCB on late lumen loss 6 months after the procedure in patients with de novo or non-stented restenotic lesions of the…
- Trial name
- NCT05134545
- Testing
- Genoss® DCB, IN.PACT Admiral® DCB
- Where
- South Korea
- Volunteers
- 119 people
- Sponsor
- Genoss Co., Ltd.
Peripheral Artery Disease
Directional Versus Orbital Atherectomy Plaque Modification and Luminal Area Assessment of the Femoro-popliteal Artery Via Intravascular Ultrasound
This single center prospective, randomized study will be conducted to investigate plaque removal and luminal gain using CSI's DIAMONDBACK 360® Peripheral Orbital Atherectomy System (OAS) (St.Paul, MN) versus Medtronic's Hawkone…
- Trial name
- NCT03495453
- Testing
- Percutaneous Revascularization of the Femoropopliteal Arteries using a DAS, Percutaneous Revascularization of the Femoropopliteal Arteries using a OAS device
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- NYU Langone Health
Peripheral Arterial Disease, Atherosclerosis
Sonodynamic Therapy Manipulates Atherosclerosis Regression Trial on Patients With PAD and Claudication
The purpose of this trial is to evaluate the safety and efficacy of sonodynamic therapy (SDT) on reducing atherosclerotic plaques inflammation among patients with symptomatic femoropopliteal peripheral artery disease.
- Conditions
- Peripheral Arterial Disease, Atherosclerosis, Cardiovascular Diseases
- Trial name
- SMART-PAD (NCT03457662)
- Testing
- OMC and pseudo-SDT, OMC and SDT
- Where
- China
- Volunteers
- 32 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Intermittent Claudication
(Cost) Effectiveness Study of Exercise Therapy in Patients With Peripheral Arterial Disease
The purpose of this study is to determine if supervised exercise therapy in a physiotherapeutic setting, with or without therapy feedback, is more (cost-)effective than exercise therapy based on a 'go home and walk' advice…
- Trial name
- EXITPAD (NCT00279994)
- Testing
- Exercise therapy, Accelerometer (PAM; Personal Activity Monitor), Oral Exercise Therapy advise
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Atrium Medical Center
Peripheral Artery Occlusive Disease, Peripheral Artery Restenosis
Drug-eluting Balloon vs. Conventional Balloon in the Treatment of (re)Stenosis - a Randomized Prospective Study
The purpose of this study is to determine whether the use of drug-eluting balloons is effective in the treatment of (re)stenosis in bypass vein grafts.
- Conditions
- Peripheral Artery Occlusive Disease, Peripheral Artery Restenosis, Peripheral Artery Stenosis
- Trial name
- DRECOREST1 (NCT03023098)
- Testing
- Conventional PTA, Drug-eluting balloon
- Where
- Finland
- Volunteers
- 57 people
- Sponsor
- Helsinki University Central Hospital
Peripheral Arterial Disease (PAD), Intermittent Claudication
Home-based Exercise Therapy for Patients With PAD
Cardiovascular disease represents a considerable economic burden to society and effective preventive measures are necessary. Patients with peripheral arterial disease (PAD) have a severe impairment of functional ability, namely…
- Trial name
- WalkingPAD (NCT04749732)
- Testing
- WalkingPad plus Psychological Intervention - PsyWPad Group, WalkingPad plus Virtual Assistant - CyberWPad Group, WalkingPad group - Paper WPad Group
- Where
- Portugal
- Volunteers
- 200 people
- Sponsor
- Centro Hospitalar do Porto
Chronic Limb-Threatening Ischemia
AcoArt Litos PCB Below-the-knee Global Trial
The objective of this study is to assess whether efficacy of the AcoArt Litos PCB is superior and whether safety of AcoArt Litos PCB is noninferior to the control device (FDA cleared PTA Balloon Catheter) regarding treatment of…
- Trial name
- NCT06330493
- Testing
- PCB, PTA
- Where
- 18 sites in United States, Austria and 1 more
- Volunteers
- 75 people
- Sponsor
- Acotec Scientific Co., Ltd
Peripheral Vascular Disease
The DESappear Study: Drug Eluting Scaffold
The aim of this study is to prospectively collect information to evaluate the safety and performance of the Akesys Prava Sirolimus Eluting Bioresorbable Peripheral scaffold system for the treatment of symptomatic primary…
- Trial name
- DESappear (NCT02869087)
- Testing
- Akesys Prava Scaffold
- Where
- 11 sites in Austria, Belgium and 2 more
- Volunteers
- 21 people
- Sponsor
- Elixir Medical Corporation
Peripheral Arterial Disease, Diagnosis
DIAbetes Maximal ACCeleration
Prevalence of diabetes mellitus (DM) is increasing rapidly, with patient numbers projected to rise to 643 million by 2030. As a consequence of diabetes-related atherosclerosis, peripheral arterial disease (PAD) and in particular…
- Conditions
- Peripheral Arterial Disease, Diagnosis, Diabetic Foot
- Trial name
- DIAMACC (NCT05646147)
- Testing
- Maximal Systolic Acceleration
- Volunteers
- 238 people
- Sponsor
- Leiden University Medical Center
Atherosclerosis, LDL-hypercholesterolemia
Effect of Mipomersen on LDL-Cholesterol Levels in Patients Treated by Regular Apheresis
Elevated LDL-cholesterol is a major risk factor for heart disease. In patients with heart disease LDL-cholesterol should be lowered to levels below 70 mg/dl to prevent progression of disease.
- Trial name
- MICA (NCT01598948)
- Testing
- mipomersen
- Where
- Germany
- Volunteers
- 17 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Infrainguinal Peripheral Artery Disease, Peripheral Arterial Disease
Post-Market Registry of AURYON Atherectomy Device in Subjects Affected With Infrainguinal Peripheral Artery Disease
The PATHFINDER Registry is a prospective, non-randomized, single arm, multicenter observational study. This pilot registry is aimed to evaluate the performance (peri-procedural) and clinical outcomes (intermediate and long-term)…
- Conditions
- Infrainguinal Peripheral Artery Disease, Peripheral Arterial Disease, PAD
- Trial name
- PATHFINDER (NCT04229563)
- Testing
- AURYON Atherectomy System
- Where
- 10 sites in United States
- Volunteers
- 102 people
- Sponsor
- Angiodynamics, Inc.
Critical Limb Ischemia, Severe Leg Ischemia
Phase II Combination Stem Cell Therapy for the Treatment of Severe Leg Ischemia
The purpose of this research study is to compare in patients with double-sided claudication if the transplant of a combination of stem cells obtained from the bone marrow of the same patient will contribute to the formation of…
- Conditions
- Critical Limb Ischemia, Severe Leg Ischemia, Peripheral Artery Disease, Peripheral Vascular Disease
- Trial name
- MESENDO (NCT00721006)
- Testing
- MESENDO
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- TCA Cellular Therapy
Critical Illness, Low Peripheral Perfusion
Local Warming to Improve Pulse Oximetry Accuracy in Critically Ill Patients
Pulse oximeters are widely used in intensive care to continuously estimate the oxygen level in the blood. However, pulse oximeter measurements may be less accurate when blood flow to the fingers is poor, which is common in…
- Conditions
- Critical Illness, Low Peripheral Perfusion, Pulse Oximetry Accuracy
- Trial name
- PULSEWARM (NCT07792304)
- Testing
- Protocolized Local Warming
- Where
- 4 sites in Sweden
- Volunteers
- 240 people
- Sponsor
- Vastra Gotaland Region
Peripheral Arterial Disease
Using SnapshotNIR With Provocative Leg Maneuver for PAD Assessment
The objective of this trial is to determine if Near-infrared spectroscopy (NIRS) can accurately evaluate the degree of Peripheral Arterial Disease (PAD) during a Provocative Elevation Maneuver of the Lower Extremity (PEMLE) test…
- Trial name
- NCT06237621
- Testing
- SnapshotNIR imaging
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kent Imaging Inc
Peripheral Arterial Disease
STELLAREX: ILLUMENATE Global and In-Stent Restenosis (ISR)
Cohort 1: Single-Arm, multicenter study to continue to assess the safety and performance of the Stellarex 035 Drug Coated Balloon (formerly known as the Cardiovascular Ingenuity (CVI) Paclitaxel-Coated PTA Balloon Catheter) in…
- Trial name
- ILLUMENATE (NCT01927068)
- Testing
- Stellarex 0.035" Over-the-Wire (OTW) drug-coated angioplasty balloon (Stellarex DCB)
- Where
- 44 sites in Australia, Austria and 8 more
- Volunteers
- 499 people
- Sponsor
- Spectranetics Corporation
Intermittent Claudication, Peripheral Vascular Disease
Extract of Ginkgo Biloba (EGB 761) and Vascular Function
This study will determine if a highly standardized herbal extract of the leaves of the Ginkgo Biloba tree will benefit patients who have pain on walking due to narrowing of the arteries of the legs.
- Trial name
- NCT00029991
- Testing
- Gingko Biloba (Herb)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
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