Clinical trials: Peripheral Arterial
Peripheral Arterial Disease, Intermittent Claudication
Heat Therapy for Peripheral Arterial Disease (HEATPAD)
Peripheral arterial disease (PAD) is a disabling condition, with symptoms of muscle cramping or pain on exertion, which can substantially reduce quality of life.
- Conditions
- Peripheral Arterial Disease, Intermittent Claudication, Critical Limb Ischemia
- Trial name
- HEATPAD (NCT06186505)
- Testing
- AirGlove
- Volunteers
- healthy volunteers welcome
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Peripheral Artery Disease
Clinical Study of Focal Implant Used for Lower Extremity Post-angioplasty Dissection
This is a prospective, multicenter, randomized controlled trail using spot stenting to treat lower extremity post-angioplasty dissection.
- Trial name
- PINTO (NCT05562076)
- Testing
- the spot stent(ZENFLEX ® Pinto) system, the bare stent( Everflex) system
- Where
- 12 sites in China
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Zhejiang Zylox Medical Device Co., Ltd.
Peripheral Arterial Disease
Constrained Balloon Combined With Drug-coated Balloon Angioplasty for Femoropopliteal Lesion
This study will assess the safety and efficacy of Chocolate balloons as a combination with drug-coated balloons in the treatment of popliteal artery lesions in lower limb atherosclerotic occlusive disease and will compare them…
- Trial name
- NCT05894460
- Testing
- Chocolate balloon
- Where
- China
- Volunteers
- 254 people
- Sponsor
- Xuanwu Hospital, Beijing
Peripheral Vascular Diseases, Peripheral Arterial Disease
Calf Muscle Perfusion in Patients With Intermittent Claudication by Non-invasive MSOT
The objective of the proposed study is to define independent parameters for the diagnostic assessment of the perfusion situation of the calf muscle based on multispectral optoacoustic tomography (MSOT) in a cross-sectional…
- Conditions
- Peripheral Vascular Diseases, Peripheral Arterial Disease, Intermittent Claudication
- Trial name
- MSOT_IC (NCT05373927)
- Testing
- Multispectral Optoacoustic Tomography (MSOT)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ulrich Rother
Ischemia
Study of Autologous Bone Marrow Concentrate for the Treatment of Critical Limb Ischemia (CLI)
Injections of concentrated bone marrow mononuclear cells into ischemic tissues will result in vasculogenesis
- Trial name
- NCT00498069
- Testing
- Harvest Smartprep2 BMAC System, SmartPReP2 BMAC System
- Where
- 6 sites in United States
- Volunteers
- 48 people
- Sponsor
- Harvest Technologies
Coronary Artery Disease, Peripheral Vascular Disease
Study of the SafeSeal(TM) Hemostasis Patch Following Percutaneous Coronary Artery and Peripheral Vascular Interventions
We seek to determine if the use of the SafeSeal(TM) topical hemostasis patch is associated with reductions in time to hemostasis and time to ambulation compared to standard manual compression after arterial sheath removal…
- Trial name
- NCT00481741
- Testing
- SafeSeal(TM) Hemostasis Patch
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Rochester
Atherosclerosis, Intermittent Claudication
Does the Reduction of Total Body Iron Storage (TBIS) Alter Mortality in a Population of Patients With Advanced PVD?
Veterans Affairs Cooperative Study #410, The Iron and Atherosclerosis Trial, FeAST, a 24-hospital prospective randomized single-blinded clinical trial of graded iron reduction was conducted between May 1, 1999 and April 30, 2005…
- Conditions
- Atherosclerosis, Intermittent Claudication, Peripheral Vascular Diseases
- Trial name
- FeAST (NCT00032357)
- Testing
- Ferritin reduction to 25 ng/ml by phlebotomy
- Where
- 24 sites in United States, Puerto Rico
- Volunteers
- 1,277 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Peripheral Artery Disease
Evaluation of Patients With Suspected Endofibrosis
Define responses to exercise on both arterial bruits and oxymetry in patients referred for suspected endofibrosis.
- Trial name
- Stethosport (NCT02501694)
- Testing
- Auscultation
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Arterial Occlusive Diseases
Feasability Study of Autologous Bone Marrow Aspirate Concentrate for Treatment of CLI
The purpose of this study is to determine if concentrated nucleated cells from your own bone marrow, injected or infused into an ischemic limb, will restore sufficient blood flow to avoid amputation.
- Trial name
- NCT00595257
- Testing
- centrifuge, laboratory, tabletop (SmartPReP2 BMAC System)
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Harvest Technologies
Peripheral Vascular Diseases
Efficacy and Safety of XRP0038/NV1FGF in Critical Limb Ischemia Patients With Skin Lesions
Primary objective is to demonstrate the superiority of riferminogene pecaplasmid (XRP0038/NV1FGF) over placebo in the prevention of major amputation above the ankle of the treated leg or of death from any cause, whichever comes…
- Trial name
- TAMARIS (NCT00566657)
- Testing
- riferminogene pecaplasmid
- Where
- 32 sites in United States, Argentina and 30 more
- Volunteers
- 525 people
- Sponsor
- Sanofi
Critical Limb Ischemia, Ischemia
VEGF Gene Transfer for Critical Limb Ischemia
The purpose of this gene therapy study is to evaluate the safety and efficacy of intramuscular gene transfer using Vascular Endothelial Growth Factor (VEGF) or placebo in patients with moderate to high-risk Critical Limb Ischemia…
- Conditions
- Critical Limb Ischemia, Ischemia, Leg Ulcer
- Trial name
- NCT00304837
- Testing
- pVGI.1 (VEGF-2)
- Where
- 3 sites in United States
- Sponsor
- Losordo, Douglas, M.D.
Critical Limb Ischemia, Peripheral Arterial Disease
Pilot Safety Study of Injectable SIS for Critical Limb Ischemia
This study is intended to collect safety and effectiveness data on the Cook Injectable Small Intestinal Submucosa (SIS)
- Conditions
- Critical Limb Ischemia, Peripheral Arterial Disease, Peripheral Vascular Disease
- Trial name
- CLIC (NCT02145845)
- Testing
- Injectable SIS
- Where
- Czechia
- Volunteers
- 13 people
- Sponsor
- Cook Group Incorporated
Intermittent Claudication
Safety and Efficacy of K-134 for the Treatment of Intermittent Claudication
The purpose of this study is to evaluate the safety and efficacy of K-134 for the treatment of intermittent claudication.
- Trial name
- NCT00783081
- Testing
- K-134, Cilostazol 100 mg BID
- Where
- 42 sites in United States, Russia
- Volunteers
- 387 people
- Sponsor
- Kowa Research Institute, Inc.
Peripheral Artery Disease, Type 2 Diabetes
Comparative Efficacy of Ticagrelor Versus Aspirin on Blood Viscosity in Peripheral Artery Disease Patients With Type 2 Diabetes
The hypothesis being that both aspirin-ticagrelor and ticagrelor monotherapy will be superior to aspirin monotherapy in the reduction of whole blood viscosity at the end of each 4 week treatment period.
- Trial name
- NCT02325466
- Testing
- Aspirin, Ticagrelor
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Intermittent Claudication, Peripheral Vascular Disease
The Dose Response of Niacin ER/Lovastatin on Peak Walking Time (PWT) in Patients With Intermittent Claudication - TROPIC
The purpose of this study is to compare the dose response and safety of Niacin ER/Lovastatin, Niaspan® and Lovastatin with each other, in subjects with leg pain caused by a narrowing of their leg arteries.
- Trial name
- NCT00071266
- Testing
- Niacin Extended Release and Lovastatin Tablets
- Where
- 26 sites in United States
- Volunteers
- 870 people
- Sponsor
- Kos Pharmaceuticals
Arteriosclerosis Obliterans
Sufficient Treatment of Peripheral Intervention by Cilostazol
Recently, Nanto et al. reported that cilostazol effectively prevented restenosis in a retrospective analysis of 121 femoropopliteal artery lesions in percutaneous transluminal angioplasty (PTA) patients who had undergone PTA.
- Trial name
- STOP-IC (NCT00912756)
- Testing
- cilostazol
- Where
- 13 sites in Japan
- Volunteers
- 200 people
- Sponsor
- Kansai Rosai Hospital
Peripheral Arterial Disease, Common Femoral Artery Stenosis
Endovascular Treatment of Primary Common FEmoral Artery atheroSclerotic Disease wiTh IntraVAscular Litothripsy
Prospective, nonrandomized, multicenter, national, multidisciplinary, real-world data collection with the aim to evaluate the short-term safety and efficacy of intravascular lithotripsy in the treatment of steno-obstructive…
- Conditions
- Peripheral Arterial Disease, Common Femoral Artery Stenosis, Common Femoral Artery Occlusion, Critical Limb-Threatening Ischemia
- Trial name
- FESTIVAL (NCT05821829)
- Testing
- Intravascular litothripsy (IVL)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Pisa
Intermittent Claudication
The Initial Effect of Training on Mitochondrial Function in Patients With Intermittent Claudication
The hypothesis of this study is that one bout of leg exercise gives acute qualitative changes in mitochondrial function in claudication. Final purpose is to determine the optimal exercise frequency in treatment of claudication.
- Trial name
- NCT01842412
- Testing
- exercise
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Peripheral Artery Disease
Exercise Training Versus Best Medical Treatment Only in Peripheral Artery Disease
The aim of the investigators' study is to analyze the value of supervised exercise training combined with medical therapy versus best medical treatment only with respect to quality of life.
- Trial name
- NCT00926081
- Testing
- Supervised exercise training
- Where
- Austria
- Volunteers
- 120 people
- Sponsor
- Medical University of Vienna
Peripheral Artery Disease, Peripheral Vascular Disease
Study to Determine the Performance of the Astron and Pulsar-18 Stents in Europe
BIOFLEX-I EU is the European arm of the BIOFLEX-I IDE study (NCT01319812). Data from BIOFLEX-I EU will be pooled with data in the IDE.
- Trial name
- BIOFLEX-I EU (NCT01661231)
- Testing
- Astron/Pulsar-18 stent
- Where
- 7 sites in Austria, Belgium and 2 more
- Volunteers
- 456 people
- Sponsor
- Biotronik AG
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