Clinical trials: Peripheral Arterial Obstructive Disease
Peripheral Arterial Disease, Angioplasty
Analysis of the Different Strategies for Revascularization of the Lower Limbs by Peripheral Angioplasty
Peripheral arterial disease (PAD) caused by atherosclerosis causes damage to the arteries originating in the aorta (descending) from the iliacs to the extremities of the lower limbs. It causes significant morbidity and mortality.
- Trial name
- NCT05155462
- Testing
- One or two phone call
- Where
- France
- Volunteers
- 330 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Critical Limb Ischemia
Safety Study of Gene Therapy in Treating Critical Leg Ischemia
The purpose of this study is to determine the safety, tolerability and preliminary efficacy of intramuscular injections of VM202 for subjects with critical limb ischemia.
- Trial name
- NCT00696124
- Testing
- VM202 2 mg, VM202 4 mg, VM202 8 mg
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Helixmith Co., Ltd.
Peripheral Arterial Disease
Blood Flow Quantification Near Stented SFA Lesions Using Ultrasound Velocimetry
Peripheral arterial disease (PAD) in the lower extremity is the third leading cause of atherosclerotic cardiovascular morbidity. Endovascular treatment has become the principal surgical strategy in femoro-popliteal lesions.
- Trial name
- EchoPIV in SFA (NCT04934501)
- Testing
- High-frame-rate contrast-enhanced ultrasound measurements (echoPIV), Computed tomography angiography (CTA) scan
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Rijnstate Hospital
Peripheral Artery Disease, Polyvascular Disease
Randomized Comparison of Efficacy and Safety of High-intensity Rosuvastatin/Ezetimibe Combination Versus Treat-to-target Rosuvastatin Monotherapy for Patients With Peripheral Artery or Polyvascular Disease (CARE-PVD Trial)
Patients with atherosclerotic peripheral artery disease often have combined coronary artery disease or cerebral artery disease and show high rates of cardiovascular mortality and morbidities.
- Trial name
- NCT06231966
- Testing
- Combination therapy of high-intensity dose rosuvastatin and ezetimibe, Rosuvastatin monotherapy for treat-to-target
- Where
- South Korea
- Volunteers
- 2,462 people
- Sponsor
- Yonsei University
Diabetes Mellitus Type 2, Cardiovascular Diseases
PRimary IndividualiZed Evaluation of Cardiovascular Events in Patients With Diabetes Mellitus Using hemoTAG
To evaluate the proportion of diabetic mellitus patients with CV events as measured by HEMOTAG.
- Conditions
- Diabetes Mellitus Type 2, Cardiovascular Diseases, Coronary Artery Disease, Cerebrovascular Disease
- Trial name
- PRIZETAG (NCT06567795)
- Testing
- Hemotag
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- Aventusoft, LLC.
Atherosclerosis, Intermittent Claudication
Patient Acceptance of Whole Body Magnetic Resonance Angiography
Investigation of how the patients experience whole body MRA. After the WB-MRA the patients will fill in a questionnaire, that contains questions about the WB-MRA procedure and how the patient felt during the examination.
- Conditions
- Atherosclerosis, Intermittent Claudication, MRI
- Trial name
- NCT00556101
- Testing
- Whole body magnetic resonance angiography
- Where
- Denmark
- Volunteers
- 81 people
- Sponsor
- Copenhagen University Hospital at Herlev
Limb Salvage Rates With Endovascular Therapy
Endovascular Limb Salvage in Trinidad and Tobago
The purpose of this study was to investigate limb salvage rates in patients with critical limb ischemia after endovascular revascularization.
- Trial name
- NCT05547022
- Testing
- Endovascular revascularisation
- Where
- Trinidad and Tobago
- Volunteers
- 157 people
- Sponsor
- Naveen Seecheran
Chronic Lower Limb Ischemia, Peripheral Athero Obstructive Disease
Paclitaxel Eluting Stent in Long SFA Obstruction: A Prospective, Randomized Comparison With Bypass Surgery
Chronic lower limb ischemia due to atherosclerosis causes significant morbidity especially in elderly: the prevalence of asymptomatic obstructive peripheral atherosclerosis among 40-74 old is 4-22%.
- Conditions
- Chronic Lower Limb Ischemia, Peripheral Athero Obstructive Disease, Critical Ischemia, Claudication
- Trial name
- finnptx (NCT01450722)
- Testing
- bypass surgery, stent placement, stent placement
- Where
- Finland
- Volunteers
- 400 people
- Sponsor
- Kuopio University Hospital
Peripheral Arterial Disease
Investigation of Safety, Pharmacokinetics and Pharmacodynamics of Different Doses of BIWH 3 in Patients With Chronic Critical Limb Ischaemia
The primary aim of this trial was to investigate the safety of a 6 hour intraarterial infusion of BIWH 3 (pyro-Glu-rhMCP-1) in patients with severe peripheral arterial occlusive disease (PAOD) and chronic Critical Limb Ischaemia…
- Trial name
- COINART-1 (NCT02215824)
- Testing
- BIWH 3
- Volunteers
- 7 people
- Sponsor
- Boehringer Ingelheim
Peripheral Arterial Disease
Auryon Atherectomy System With Standard Balloon Angioplasty Versus Standard Balloon Angioplasty Alone in Europe
The goal of this clinical trial is to learn if the Auryon Atherectomy System with balloon angioplasty safe and effective in treating lower limb blockages.
- Trial name
- AMBITION BTK (NCT07472439)
- Testing
- Auryon Atherectomy System, Balloon Angioplasty
- Volunteers
- 50 people
- Sponsor
- Angiodynamics, Inc.
Peripheral Arterial Disease
Exploring the Exercise Fear Experiences of Patients With Peripheral Arterial Disease: A Qualitative Study
This study explored the exercise fear experience of patients with lower extremity arteriosclerosis obliterans. We conducted qualitative interviews and identified four core themes contributing to patients' fear of physical…
- Trial name
- NCT07877129
- Testing
- a descriptive qualitative design
- Where
- China
- Volunteers
- 18 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Atherosclerosis, Coronary Disease
Natural History of Peripheral Arterial Disease
The Veterans Administration Patient Study examined the progression of peripheral arterial disease (PAD) in patients with large vessel PAD or isolated small vessel PAD.
- Conditions
- Atherosclerosis, Coronary Disease, Arterial Occlusive Diseases, Peripheral Vascular Diseases
- Trial name
- NCT00005254
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Peripheral Arterial Disease
Feasibility Clinical Trial of the Cardio Flow Orbital Atherectomy System to Treat Peripheral Artery Disease (PAD)
This trial is a First in Human early feasibility study of a novel atherectomy device to treat peripheral artery disease. The trial is a prospective, single arm design that will enroll 10 patients at 1 - 2 sites.
- Trial name
- FAST (NCT03365154)
- Testing
- Cardio Flow FreedomFlow™ Orbital Atherectomy System treatment, Balloon Angioplasty
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Cardio Flow, Inc.
Critical Lower Limb Ischemia, Peripheral Artery Disease
Prospective Registry to Investigate the Safety and Efficacy of the Treatment With the Selution Sirolimus Drug Coated Balloon in TASC C and D Atheroma-occlusive Infra-Inguinal Disease in Patients With Chronic Limb Threatening Ischemia From Singapore
Extensive arterial occlusion significantly reduces arterial perfusion, and may eventually lead to Critical Limb Ischemia (CLI). The pathology gives rise to symptoms such as ischemic pain, slow healing wounds at lower extremity…
- Trial name
- PRISTINE (NCT04534257)
- Testing
- SELUTION Sirolimus DCB
- Where
- Singapore
- Volunteers
- 75 people
- Sponsor
- Singapore General Hospital
Peripheral Arterial Disease
REVASC-PAD: REstricted VASCular Exercise for Peripheral Arterial Disease - A Feasibility Study at University of Tennessee Medical Center
The purpose of this study is to evaluate the effects of Blood Flow Restriction (BFR) training on walking function, health-related quality of life, and safety among adults with Peripheral Arterial Disease (PAD).
- Trial name
- REVASC-PAD (NCT07223437)
- Testing
- Blood Flow Restriction Cuff System, Low-load Resistance Training, High-load Resistance Training
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Atherosclerosis, Arteriosclerosis
BIOLUX P-II First-in-Man Study to Compare the Passeo-18 Lux DRB Against POBA in Infrapopliteal Arteries
A prospective, multicentric, randomized controlled trial to assess the safety and performance of the Passeo-18 Lux Paclitaxel releasing PTA balloon catheter versus the uncoated Passeo 18 PTA balloon catheter for the treatment of…
- Conditions
- Atherosclerosis, Arteriosclerosis, Vascular Disease, Peripheral Artery Disease
- Trial name
- BIOLUX P-II (NCT01867736)
- Testing
- Passeo-18 Lux DRB, Standard PTA (POBA)
- Where
- 6 sites in Austria, Belgium and 1 more
- Volunteers
- 72 people
- Sponsor
- Biotronik AG
Peripheral Artery Disease
Effect of Transcutaneous Electrical Nerve Stimulation in Peripheral Artery Disease TENS-PAD Study / TENS-AOMI
Purpose: The investigators team recently carried out a proof of concept study testing the efficacy of one single 45-minute session of 10 Hz TENS prior to walking, versus placebo.
- Trial name
- TENS-PAD (NCT02678403)
- Testing
- Transcutaneous electrical nerve stimulation (TENS)
- Where
- 4 sites in France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Toulouse
Peripheral Arterial Disease
IN.PACT Global Clinical Study
The purpose of this study is to collect safety and efficacy data on the IN.PACT Admiral™ Drug Eluting Balloon (DEB) in treatment of atherosclerotic disease in the superficial femoral and/or popliteal arteries in a "real world"…
- Trial name
- NCT01609296
- Testing
- IN.PACT Admiral™ Drug Eluting Balloon
- Where
- 65 sites in Argentina, Australia and 25 more
- Volunteers
- 1,535 people
- Sponsor
- Medtronic Endovascular
Peripheral Artery Disease
BIOTRONIK Dynetic-35 Stent for the Treatment of Peripheral Iliac Lesions
BIOTRONIK cobalt chromium balloon-expandable Dynetic-35 stent in association with Passeo-35 Xeo peripheral dilation catheter for the treatment of peripheral iliac lesions
- Trial name
- BIONETIC-I (NCT04830228)
- Testing
- Ballon expandable stent and PTA
- Where
- 15 sites in Austria, Belgium and 4 more
- Volunteers
- 160 people
- Sponsor
- Biotronik AG
Peripheral Artery Disease
Hepatocyte Growth Factor to Improve Functioning in PAD
HI-PAD is a placebo controlled double-blind randomized pilot clinical trial to determine whether VM202 may improve walking ability in people with lower extremity peripheral artery disease (PAD).
- Trial name
- HI-PAD (NCT03363165)
- Testing
- VM202
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Northwestern University
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