Clinical trials: Peripheral Arterial Obstructive Disease
Peripheral Arterial Disease
A Study Evaluating the Endovascular Treatment of Subjects With Stenotic or Restenotic Lesions of the Common Femoral Artery With the Supera Vascular Mimetic Implant Compared to Surgical Common Femoral Artery Endarterectomy
The SUPERSURG RCT trial investigates the efficacy and safety of the endovascular treatment of stenosis or restenosis in the common femoral artery (CFA) of patients presenting with Rutherford classification 2,3 or 4 with a Supera…
- Trial name
- SUPERSURG-RCT (NCT04349657)
- Testing
- Supera Peripheral Stent System treatment group, Endarterectomy treatment group
- Where
- 13 sites in Belgium, Netherlands and 1 more
- Volunteers
- 286 people
- Sponsor
- KANDO Research
Critical Limb Ischemia
Drug-Eluting Balloon Angioplasty Versus Bypass Surgery as First-Line Strategies in Infrageniculate Arterial Disease for Critical Limb Ischemia in Type 2 Diabetic Pacients: a Randomised Controlled Clinical Trial
The aim of this study is to evaluate the outcomes of drug-eluting balloon angioplasty and vein bypass surgery in diabetic patients with critical limb ischemia due to infrapopliteal arterial disease.
- Trial name
- NCT04760119
- Testing
- Vein bypass surgery first strategy, Endovascular treatment first (drug coated balloon angioplasty) strategy
- Where
- Lithuania
- Volunteers
- 40 people
- Sponsor
- Lithuanian University of Health Sciences
Peripheral Artery Disease, Vascular Disease
In-Stent Restenosis Post-Approval Study
The objective of the ISR 14-04 study is to evaluate post-market safety and effectiveness of GORE® VIABAHN® Endoprosthesis for treatment of In-Stent Restenosis of the Superficial Femoral Artery.
- Trial name
- NCT02542267
- Testing
- Gore VIABAHN Endoprosthesis
- Where
- 23 sites in United States, Germany and 2 more
- Volunteers
- 108 people
- Sponsor
- W.L.Gore & Associates
Arteriosclerosis
Association Between Peripheral Artery Stiffness and Cardiovascular Disease
Arterial pulse wave velocity (PWV) is strongly correlated with atherosclerosis, and the PWV of carotid or femoral artery could predict the severity of arterial atherosclerosis.
- Trial name
- NCT00201565
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Peripheral Artery Disease
Iliac Artery Treatment With The Invatec Scuba™ Cobalt Chromium Stent (INTENSE)
The purpose of this study is to determine the safety and effectiveness of the Scuba™ stent in subjects with symptomatic claudication or rest pain and angiographic confirmation of de novo or restenotic lesions in the common and/or…
- Trial name
- INTENSE (NCT00880230)
- Testing
- Scuba Iliac Stent System
- Where
- 3 sites in United States, Germany
- Volunteers
- 141 people
- Sponsor
- Medtronic Endovascular
Peripheral Arterial Disease
Antiplatelet Effects of Evolocumab in Patients With Peripheral Arterial Disease
This investigation will be conducted in subjects >18 years of age with PAD. Platelet activation and aggregation, and biomarkers associated with platelet activation, oxidative stress, and inflammation will be assessed prior to…
- Trial name
- NCT03247972
- Testing
- Evolocumab
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Inova Health Care Services
Peripheral Arterial Disease
Serum Levels of Klotho as a Possible Biomarker of Peripheral Artery Disease
Klotho, a membrane-bound protein co-receptor for fibroblast growth factor 23 (FGF23), is involved in atherosclerotic process and cardiovascular diseases. It regulates blood glucose and cholesterol levels.
- Trial name
- NCT05757271
- Where
- Italy
- Volunteers
- 207 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Diabetic Foot Ulcers
Registry HBOT in DFU
Overview of available data to assess the benefits of HBOT to DFU patients
- Trial name
- NCT06693180
- Testing
- HBOT
- Where
- Netherlands
- Volunteers
- 600 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Peripheral Arterial Disease, Acute Limb Ischemia
Pounce™ Thrombectomy System Retrospective Registry
The PROWL registry is an open-label retrospective, multi-center, US study of the Surmodics™ Pounce™ Thrombectomy System for the non-surgical removal of emboli and thrombi in the peripheral arterial vasculature.
- Trial name
- PROWL (NCT05868161)
- Testing
- Pounce Thrombectomy System
- Where
- 9 sites in United States
- Volunteers
- 500 people
- Sponsor
- SurModics, Inc.
Peripheral Arterial Disease (PAD)
A Multiple Ascending Dose Study of RO4905417 in Healthy Volunteers and Patients With Peripheral Arterial Disease (PAD).
This single center, multiple ascending dose study will assess the safety, tolerability, pharmacokinetics and pharmacodynamics of RO4905417 at different doses in healthy volunteers and patients with peripheral arterial disease.
- Trial name
- NCT00760565
- Testing
- RO4905417
- Where
- 7 sites in United States, Australia and 1 more
- Volunteers
- 72 people
- Sponsor
- Hoffmann-La Roche
Peripheral Arterial Disease
A Superiority Trial of the SUPERA Peripheral Stent System in Patients With Femoro-popliteal Artery Disease
The purpose of this study (superiority trial) is to compare the Supera® Peripheral Stent System with a standard nitinol self-expanding stent for treatment of femoro-popliteal arterial occlusive disease.
- Trial name
- NCT03941314
- Testing
- Supera® Peripheral Stent System, EverFlex™ Self-Expanding Peripheral Stent System
- Where
- 3 sites in Spain, Switzerland
- Volunteers
- 300 people
- Sponsor
- Kantonsspital Winterthur KSW
Peripheral Artery Disease (PAD)
The NICE-PAD II Trial
Among people with peripheral artery disease (PAD) age 50 and older, the investigators will test the hypothesis that PAD participants randomized to nicotinamide riboside (NR) will have greater improvement or less decline in…
- Trial name
- NICE (NCT07782671)
- Testing
- Nicotinamide Riboside (NR)
- Volunteers
- 250 people
- Sponsor
- Northwestern University
Peripheral Arterial Disease
Impact of Virtual Reality on Patient Pain During Lower Limb Revascularization Via Endovascular Surgery Under Local Anesthesia With Sedation
The prevalence of peripheral arterial disease (PAD) increases with age In addition to medical treatment, endovascular procedures can be performed, depending on the stage of the disease, to prevent complications and/or sequelae…
- Trial name
- REVDOU (NCT07181434)
- Testing
- The patient will be equipped with VR headsets
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Poitiers University Hospital
Peripheral Artery Disease, Intermittent Claudication
Motivating Physical Activity With Behavioural interVention and Electrical Stimulation Remotely in Intermittent Claudication
Peripheral Arterial Disease (PAD) is a common vascular disease which commonly causes limb pain and reduced exercise tolerance termed Intermittent Claudication (IC).
- Trial name
- MAvERIC (NCT06114732)
- Testing
- Walking exercise behaviour change intervention + TENS
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Glasgow Caledonian University
Peripheral Arterial Disease
Tele-assessment and Face-to-face Assessment of the 30-second Sit-stand Test in Peripheral Artery Disease
Peripheral artery disease (PAD) is a chronic and progressive condition caused by narrowing or blockage of arteries in the lower limbs due to atherosclerosis.
- Trial name
- NCT07497360
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Izmir Democracy University
Intermittent Claudication, Peripheral Artery Disease
A Study of CK-2017357 in Patients With Peripheral Artery Disease and Symptomatic Claudication
The primary objective of this early-stage clinical study is to demonstrate an effect of single doses of CK-2017357 on measures of skeletal muscle function and fatigability in patients with peripheral artery disease and…
- Trial name
- NCT01131013
- Testing
- 375 mg CK-2017357, 500 mg CK-2017357
- Where
- 14 sites in United States
- Volunteers
- 61 people
- Sponsor
- Cytokinetics
Peripheral Arterial Disease
To Investigate the Effect of Far-infrared Radiation on Lower Extremity Acupoints on the Blood Circulation of Lower Extremities in Patients With Hemodialysis
This study intends to irradiate the acupoints of both lower extremities of hemodialysis patients with far-infrared therapeutic apparatus to explore its effect on foot blood circulation, peripheral artery occlusion disease (PAOD)…
- Trial name
- NCT05822960
- Testing
- far-infrared radiation
- Where
- 2 sites in Taiwan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Peripheral Arterial Disease, Peripheral Artery Disease
Dietary Nitrate Supplementation and Thermoregulation
This is a double-blinded, randomized, crossover design study to assess the effects of dietary nitrate supplementation (beetroot juice) on peripheral artery disease (PAD) patients (ages 50-85) diagnosed with Fontaine stage I or II…
- Trial name
- NCT03506646
- Testing
- Beet root juice
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Nebraska
Symptomatic Peripheral Artery Disease With Femoropopliteal Lesions, Moderate or Severe Claudication (Rutherford Category 2 or 3)
Korean Multicenter Registry of ELUVIA Stent for Femoropopliteal Artery Disease (K-ELUVIA Registry)
Prospective, multi-center single-arm observational study A total of 100 subjects with femoropopliteal artery disease who meet all inclusion and exclusion criteria will be included.
- Conditions
- Symptomatic Peripheral Artery Disease With Femoropopliteal Lesions, Moderate or Severe Claudication (Rutherford Category 2 or 3), Critical Limb Ischemia (Rutherford Category 4 or 5)
- Trial name
- NCT03505931
- Testing
- Implantation of Eluvia stent
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Peripheral Artery Disease, Vascular Disease
Adenosine-induced Myocardial Blood Flow in Peripheral Artery Disease Patients
The purpose of the study is to assess the effect of blood flow to the heart when subjects are treated with ticagrelor (Brilinta) or clopidogrel (antiplatelet drugs that stop the blood from clumping together) in patients with…
- Conditions
- Peripheral Artery Disease, Vascular Disease, Arterial Occlusion Disease, Intermittent Claudication
- Trial name
- PAD (NCT02121288)
- Testing
- Ticagrelor, clopidogrel
- Sponsor
- AstraZeneca
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