Clinical trials: Peripheral Arterial Vascular Occlusion
Intermittent Claudication
BE Study of Once Daily PMR Compared to Twice Daily Cilostazol Tablets in Healthy Volunteers
The study is designed to evaluate the bioequivalence and the within-subject variability between the test formulation of extended-release tablet of cilostazol (PMR) administered once daily and the reference formulation of…
- Trial name
- NCT06167265
- Testing
- Cilostazol Tablet 100 mg, PMR Tablet 145 mg
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Genovate Biotechnology Co., Ltd.,
Peripheral Arterial Disease, Superficial Femoral Artery Stenosis
SELUTION4SFA Trial
This study aims to demonstrate the safety and efficacy of the SELUTION SLR™ 018 DEB compared to plain (uncoated) balloon angioplasty in the treatment of peripheral arterial disease (PAD) in the superficial femoral artery (SFA)…
- Trial name
- NCT05132361
- Testing
- SELUTION SLR™ 018 DEB, Plain (Uncoated) Balloon Angioplasty (PTA)
- Where
- 34 sites in United States, Austria and 2 more
- Volunteers
- 300 people
- Sponsor
- M.A. Med Alliance S.A.
Peripheral Arterial Disease
Short Spot Versus Long Lesion Stenting as Best Treatment for Extensive Occlusive SFA Disease
Since the length of lesion seems to be negatively associated with stent patency due to restenosis, it is thought that the efficacy of treatment in patients with multiple (> 1) short (focal; > 1 and < 5 cm) SFA lesions can be…
- Trial name
- STRONG (NCT03227822)
- Testing
- Short spot stenting, Long lesion stenting
- Volunteers
- 3 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Peripheral Arterial Disease
Effects of Canola Oil on Blood Vessel Function in Peripheral Arterial Disease
The fatty acid composition of canola oil will have beneficial acute and chronic effects on vascular function in individuals with peripheral arterial disease.
- Trial name
- NCT01250275
- Testing
- traditional canola oil, high oleic canola oil, soybean oil
- Where
- Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Peripheral Arterial Disease, Intermittent Claudication
The Effects of Metformin on Functional Capacity in Individuals With Peripheral Artery Disease-Related Intermittent Claudication
The purpose of this study is to determine the effects of metformin on functional capacity (pain-free and maximum walking times) in individuals with peripheral artery disease (PAD)-related intermittent claudication.
- Trial name
- NCT01799057
- Testing
- Metformin
- Where
- Australia
- Volunteers
- 2 people
- Sponsor
- Baker Heart and Diabetes Institute
Peripheral Arterial Disease, Diabetic Angiopathies
Evaluating Bu Yang Huanwu Decoction For Early Diabetic Vascular Disease
The goal of this clinical trial is to learn if adding a Traditional Chinese Medicine formula, Bu Yang Huanwu Decoction (specifically the capsule form called Hua Yu Wan Capsule), to standard treatment can help prevent leg pain at…
- Conditions
- Peripheral Arterial Disease, Diabetic Angiopathies, Arterial Occlusive Diseases
- Trial name
- NCT07658807
- Testing
- Hua Yu Wan Capsule, Aspirin
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xuanwu Hospital, Beijing
Peripheral Arterial Disease
Influence of Rivaroxaban for Intermittent Claudication and Exercise Tolerance in Patients With Symptomatic PAD
The aim of the conducted research is to evaluate the protective effect of rivaroxaban (trade name of the Xarelto medicinal product), administered together with acetylsalicylic acid (ASA), in comparison with the effectiveness of…
- Trial name
- PAD_RIV_CLI (NCT04305028)
- Testing
- Rivaroxaban, Aspirin
- Volunteers
- 100 people
- Sponsor
- Poznan University of Medical Sciences
Chronic Limb-threatening Ischemia, Endovascular Therapy
Prospective Multicenter Registry on the Endovascular Treatment in Critical Limb Threatening Ischemia With Below the Knee Lesions With Wound, Ischemia, and Foot Infection (WIFI) Assessment
This is a prospective multicenter clinical study that used WIFI grading scores at different periods to evaluate the therapeutic value of endovascular therapy and this grading system for Chronic limb-threatening ischemia.
- Trial name
- NCT04710420
- Testing
- Endovascular therapy
- Where
- China
- Volunteers
- 842 people
- Sponsor
- Xuanwu Hospital, Beijing
Peripheral Arterial Disease, Quality of Life
Patient-centered Outcomes Related to TReatment Practices in Peripheral Arterial Disease: Investigating Trajectories (PORTRAIT)
An estimated 8 million individuals in America are affected by peripheral arterial disease (PAD), blockages of the leg arteries that can cause excruciating calf pain when walking.
- Conditions
- Peripheral Arterial Disease, Quality of Life, Quality of Care
- Trial name
- PORTRAIT (NCT01419080)
- Where
- 10 sites in United States
- Volunteers
- 797 people
- Sponsor
- Saint Luke's Health System
Peripheral Arterial Disease, Intermittent Claudication
Exercise Rehabilitation in Veterans With PAD
Peripheral artery disease (PAD) results in blockages of arteries (blood vessels) and decreased blood flow to the legs. This may cause difficulty or pain with walking or other activities that use leg muscles.
- Trial name
- NCT02607046
- Testing
- Exercise training, NMES
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Aortic Aneurysm, Aortic Aneurysm Abdominal
Prophylactic Suture Line Sealing With NE'X Glue R-eco in Cardiac and Vascular Surgery
This clinical study aims to evaluate the effectiveness and safety of using NE'X Glue R-eco to seal suture lines. The adhesive will be applied to reduce the risk of suture line bleeding in cardiac or vascular repair surgeries, a…
- Conditions
- Aortic Aneurysm, Aortic Aneurysm Abdominal, Valve Stenoses, Aortic, Valve Regurgitation, Mitral
- Trial name
- CLOSURE (NCT06918496)
- Testing
- Surgical placement of a prosthetic or biologic graft (patch), or an allograft for cardiac and (cardio)vascular repair.
- Where
- 2 sites in Belgium, Poland
- Volunteers
- 60 people
- Sponsor
- Grena Biomed Limited
Peripheral Arterial Disease
Clinical Trial Investigating the Combination Therapy With Luminor DCB and iVolution Stent in TASC C and D Femoropopliteal Lesions
The T.I.N.T.I.N. study investigates the safety and efficacy of the combination therapy with the Luminor drug coated balloon (DCB) and the iVolution stent in the treatment of TASC C and D femoropopliteal lesions.
- Trial name
- TINTIN (NCT03347383)
- Testing
- Combination therapy DCB + stent
- Where
- 9 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- ID3 Medical
Peripheral Arterial Disease
L-Citrulline in Peripheral Artery Disease
Some studies have reported improved vascular function with the supplementation of L-arginine in participants with cardiovascular disease (CVD).
- Trial name
- CIPER (NCT02521220)
- Testing
- L-citrulline
- Where
- 3 sites in Germany, Netherlands
- Volunteers
- 49 people
- Sponsor
- Maastricht University
Foot Ulcers, Arteriosclerosis Obliterans
HELP-Apheresis in Diabetic Ischemic Foot Treatment (H.A.D.I.F)
Diabetic foot (DF) is a common, severe and costly complication of diabetes. DF is underlied by neuropathy, atherosclerosis of distal arteries and infection, which result in tissue ulcers and necrosis.
- Conditions
- Foot Ulcers, Arteriosclerosis Obliterans, Diabetes Mellitus
- Trial name
- HADIF (NCT01518205)
- Testing
- LDL-apheresis
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Universita di Verona
Peripheral Arterial Disease
Carnosine for Peripheral Arterial Disease Patients
Oral supplementation of L-carnosine will increase muscle carnosine, stabilize HIF1-alpha promote angiogenesis, and thus improve the functioning of lower extremities in PAD patients.
- Trial name
- CAR-PAD (NCT05371145)
- Testing
- Carnosine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Shahid Baba
Peripheral Arterial Disease, Superficial Femoral Artery Stenosis
Shockwave IVL + DES
The objective of this clinical investigation is to evaluate, in a controlled setting, the 12 months safety and efficacy of the combination of Shockwave Intravascular Lithotripsy and a polymer coated Drug Eluting Stent device, for…
- Conditions
- Peripheral Arterial Disease, Superficial Femoral Artery Stenosis, Calcifications Vascular
- Trial name
- Shockwave DES (NCT05291247)
- Testing
- Peripheral lithotripsy system (Shockwave Medical)
- Where
- 6 sites in Germany
- Volunteers
- 50 people
- Sponsor
- Marc Bosiers, MD
Critical Lower Limb Ischemia
Allografts in Surgery of the Main Arteries
The study will examine the results of the use of biological materials (allogeneic arterial grafts, allogeneic venous graft, autologous vein, biological bovine decellularized graft) as a bypass grafts for reconstructive…
- Trial name
- NCT05455138
- Testing
- Arterial bypass grafting
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Ryazan State Medical University
Chronic Threatening Limb Ischemia
Oucomes of Endovascular Atherectomy in Femoropopliteal Arterial Disease
Peripheral artery disease (PAD) affects >200 millionadults worldwide and is amajor cause of morbidity ranging from exertional lower extremity pain to ischemic rest pain and ulcer formation.
- Trial name
- NCT07239089
- Testing
- Endovascular Atherectomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Peripheral Arterial Disease, Superficial Femoral Artery Stenosis
LegDeb2 Global Registry for Use of Legflow in Peripheral Arteries
LEGDEB2 is a Global Registry for the Treatment of Superficial Femoral and/or Popliteal or Below-The-Knee or Iliac Artery Lesions Using the Legflow Drug-Eluting Balloon
- Conditions
- Peripheral Arterial Disease, Superficial Femoral Artery Stenosis, Iliac Artery Stenosis, Arterial Occlusive Diseases
- Trial name
- LEGDEB2 (NCT04175197)
- Testing
- Drug Coated Balloon
- Where
- 7 sites in Italy, Mexico
- Volunteers
- 512 people
- Sponsor
- Federico II University
Peripheral Artery Disease
Community-based Exercise Following Revascularization for PAD
The primary goal of this clinical trial is to evaluate whether a community-based structured exercise therapy (CB-SET) intervention, which could be accessible and easily disseminated, adds benefit to peripheral artery disease…
- Trial name
- NCT04252950
- Testing
- CB-SET, Revascularization
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
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