Clinical trials: Peripheral Arterial Vascular Occlusion
Peripheral Arterial Disease
XPAD European Feasibility Study
A prospective, single arm, non-randomized European feasibility study to evaluate the safety and performance of the XPAD conduit in patients with peripheral arterial occlusive disease (PAOD), scheduled to undergo elective…
- Trial name
- NCT07716020
- Testing
- XPAD conduit
- Volunteers
- 15 people
- Sponsor
- Xeltis
Peripheral Arterial Disease
Safety and Feasibility of the Shockwave Lithoplasty® System for the Treatment of Peripheral Vascular Stenosis
To observe early safety and performance of the Shockwave Medical Lithoplasty® System (specifically, Lithoplasty® Catheters: 2.5 x 60mm, 2.75 x 60mm, 3.0 x 60mm, 3.25 x 60mm, and 3.5 x 60mm) in subjects to demonstrate that the…
- Trial name
- BTK (NCT02911623)
- Testing
- Shockwave Lithoplasty® System
- Where
- 4 sites in Austria, Germany and 1 more
- Volunteers
- 20 people
- Sponsor
- Shockwave Medical, Inc.
Angioplasty, Peripheral Arterial Disease
European All-comers' Multicentric Prospective REGISTRY on LUMINOR© Drug Eluting Balloon in the Superficial Femoral Artery and Popliteal Artery With 5 Years Follow-up.
The objective of this all-comers registry is to explore the safety, efficacy, and cost-efficiency of the LUMINOR© DEB in de-novo and restenotic-FP lesions.
- Conditions
- Angioplasty, Peripheral Arterial Disease, Drug-eluting Balloon, Femoral Artery
- Trial name
- LUMIFOLLOW (NCT04743180)
- Testing
- LUMINOR© Paclitaxel eluting balloon
- Where
- 15 sites in France
- Volunteers
- 500 people
- Sponsor
- iVascular S.L.U.
Artery Disease, Peripheral, Aortic Diseases
Relationship Between Morbimortality and Basal Activated Clotting Time (ACT) in Patients Undergoing Vascular Surgery
Check whether patients with higher comorbidity and risk of complication, estimated using the V (p) -POSSUM score, ACS NSQIP and the ASA classification, present higher baseline activated clotting time values.
- Conditions
- Artery Disease, Peripheral, Aortic Diseases, Carotid Artery Diseases, Other Disease
- Trial name
- NCT04703582
- Testing
- Activated clotting time
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Peripheral Arterial Occlusive Disease Fontaine Stage IIa
Acute Local Metabolomic Alterations in Blood and Muscle Tissue in Intermittent Claudication
The most common clinical presentation of lower extremity arterial disease is intermittent claudication. Current understanding of the pathophysiology of intermittent claudication, as well as its treatment options are limited.
- Trial name
- NCT05111379
- Where
- Estonia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Tartu
Peripheral Arterial Disease
Randomized Clinical Trial for Ewing Amputation in the VA
This study follows the Pilot Investigation of Ewing Amputation for Veterans with PAD Undergoing a Below Knee Amputation. The 2 year pilot feasibility phase has concluded recruitment and enrollment.
- Trial name
- NCT05437562
- Testing
- Ewing Below Knee Amputation, Standard Below Knee Amputation
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Peripheral Arterial Disease
Investigating a Model for Acute Ischemic Pain in Humans
The pathophysiology of acute ischemic pain is not well established. The aim of the present study was to investigate acute ischemic pain in humans with a view to establish a scientific model to perform future studies.
- Trial name
- NCT02192242
- Testing
- acute ischemic pain
- Where
- Germany
- Volunteers
- 11 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Claudication, Intermittent, Peripheral Artery Disease
The Effects of ATLAS Therapy on Nitric Oxide Bioavailability in Patients With Intermittent Claudication
This study will focus on people with claudication from peripheral arterial disease. The investigators are researching whether a multicomponent therapeutic can increase the production of Nitric Oxide in the blood and whether that…
- Conditions
- Claudication, Intermittent, Peripheral Artery Disease, Peripheral Vascular Diseases
- Trial name
- ATLAS (NCT04800692)
- Testing
- Tetrahydrobiopterin 10 mg/kg, Tetrahydrobiopterin 20 mg/kg, L-Ascorbate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Louis Messina
Chronic Kidney Disease Stage 3 and 4, Peripheral Artery Disease (PAD)
Exercise Activity to Improve Mobility in Patients With CKD and PAD
People affected by chronic kidney disease and concomitant diagnosed peripheral artery disease at intermediate stages, without contraindications to exercise therapy will be invited to participate in the study.
- Trial name
- EXACT-CKDPAD (NCT06621264)
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION, Control (Standard treatment)
- Where
- 3 sites in Italy
- Volunteers
- 124 people
- Sponsor
- University Hospital of Ferrara
Peripheral Arterial Disease
Safety and Effectiveness of Jetstream Atherectomy System (J-SUPREME)
The purpose of this study is to evaluate the safety and effectiveness of the Jetstream Atherectomy System for the treatment of Japanese patients with symptomatic occlusive atherosclerotic lesions in native superficial femoral…
- Trial name
- NCT02733653
- Testing
- Jetstream Atherectomy System
- Where
- 10 sites in Japan
- Volunteers
- 60 people
- Sponsor
- Boston Scientific Corporation
Critical Limb Ischemia
A Retrospective Analysis of Patients With Full Thickness Wounds in Limbs With Critical Ischemia
Once the patients are identified that have a full thickness wound on a limb clearly identified as having critical limb ischemia, these patients will be evaluated.
- Trial name
- NCT00760357
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Southwest Regional Wound Care Center
Peripheral Arterial Disease
In.Pact Flexion, Investigating the Performance of the In.Pact Admiral DEB for Popliteal Lesions
The objective of this study is to evaluate the performance of the In.Pact Admiral DEB for the treatment of popliteal lesions in comparison with literature results of stent treatment in popliteal lesions
- Trial name
- INPCTFLEXION (NCT02678065)
- Testing
- InPact Admiral DEB
- Where
- 4 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Flanders Medical Research Program
Peripheral Artery Disease
Improving Mobility in Peripheral Artery Disease Using an Ankle Foot Orthosis
This study will determine whether an ankle foot orthosis (AFO) improves walking performance in participants with PAD from its first use.
- Trial name
- NCT02902211
- Testing
- Ankle foot orthosis, Control/standard of care
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Hyperlipoproteinemia(a), Progressive Cardiovascular Disease
Randomized Controlled Trial of Lipid Apheresis in Patients With Elevated Lipoprotein(a)
Lipoprotein(a) [Lp(a)] is an independent risk factor for cardiovascular disease. Non-medical treatment measures (e.g. dietary therapy or weight loss) can hardly influence Lp(a) plasma concentrations.
- Trial name
- ELAILa (NCT01064934)
- Testing
- Lipid apheresis, Standard care
- Where
- Germany
- Sponsor
- Charite University, Berlin, Germany
Radial Artery Occlusion, Radial Artery Spasm
Radial Access Data in Vascular Interventions Registry
The RADIUS study is a prospective observational registry designed to collect real-world data regarding radial and ulnar artery access in percutaneous vascular interventions.
- Conditions
- Radial Artery Occlusion, Radial Artery Spasm, Vascular Access Complications, Coronary Artery Disease
- Trial name
- RADIUS (NCT07614386)
- Testing
- Radial and Ulnar Artery Access
- Where
- Turkey (Türkiye)
- Volunteers
- 20,000 people
- Sponsor
- Mersin Medicalpark Hastanesi
Critical Limb Ischemia (CLI)
LIFE-BTK Randomized Controlled Trial
The objective of this prospective, single-blinded, randomized controlled clinical investigation is to evaluate the safety and efficacy of the everolimus eluting Esprit BTK System for the planned treatment of narrowed…
- Trial name
- LIFE-BTK (NCT04227899)
- Testing
- Esprit BTK Device, Percutaneous Transluminal Angioplasty (PTA) Device
- Where
- 50 sites in United States, Australia and 4 more
- Volunteers
- 261 people
- Sponsor
- Abbott Medical Devices
Cardiovascular Diseases, Peripheral Vascular Diseases
Homocysteine and Progression of Atherosclerosis
In the first phase, to establish the relationship of progression of peripheral vascular disease (PVD) to plasma homocysteine. In the second phase, to conduct a randomized, controlled trial of folic acid treatment of plasma…
- Conditions
- Cardiovascular Diseases, Peripheral Vascular Diseases, Atherosclerosis, Cerebrovascular Disorders
- Trial name
- NCT00005338
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diabetic Foot, Critical Limb Ischemia
Umbilical Cord Mesenchymal Stem Cells Injection for Diabetic Foot
The purpose of this study is to determine whether umbilical cord Mesenchymal Stem Cells of treatment for diabetic foot is safe and effective in the management of diabetic foot ischemia, the therapeutic effect of stem cells is…
- Conditions
- Diabetic Foot, Critical Limb Ischemia, Mesenchymal Stem Cells, Umbilical Cord
- Trial name
- NCT01216865
- Testing
- umbilical cord mesenchymal stem cells, Standard Therapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Qingdao University
Atherosclerosis, Arteriosclerosis
BIOLUX P-II First-in-Man Study to Compare the Passeo-18 Lux DRB Against POBA in Infrapopliteal Arteries
A prospective, multicentric, randomized controlled trial to assess the safety and performance of the Passeo-18 Lux Paclitaxel releasing PTA balloon catheter versus the uncoated Passeo 18 PTA balloon catheter for the treatment of…
- Conditions
- Atherosclerosis, Arteriosclerosis, Vascular Disease, Peripheral Artery Disease
- Trial name
- BIOLUX P-II (NCT01867736)
- Testing
- Passeo-18 Lux DRB, Standard PTA (POBA)
- Where
- 6 sites in Austria, Belgium and 1 more
- Volunteers
- 72 people
- Sponsor
- Biotronik AG
Cardiovascular Diseases, Metabolic Disease
Vascular Lab Resource (VLR) Biorepository
This is a study of biomarkers obtained from prospectively collected subject samples and their correlation with cardiovascular and metabolic diseases.
- Conditions
- Cardiovascular Diseases, Metabolic Disease, Peripheral Artery Disease, Carotid Disease
- Trial name
- NCT05628948
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- The Cleveland Clinic
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