Clinical trials: Peripheral Blood Mononuclear Cell
Demyelinating Autoimmune Diseases, CNS
Epigenetic Evaluation of HAT/HDAC Activity in PBMC From Patients With Clinically Isolated Syndrome
The aim of the study is to compare the enzymatic activity of HATs and HDACs in peripheral blood mononuclear cell (PBMC) of patients with a clinically isolated syndrome (CIS group) and healthy controls (control group).
- Trial name
- EPIC (NCT02862301)
- Testing
- blood sample
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Immunologic Deficiency Syndrome, Leukemia
In Vitro Studies of Immunological and Stem Cell Function in Peripheral Blood Mononuclear Cells in Patients
Peripheral blood mononuclear cells (PBMC) will be collected from patients who have leukemia or lymphoma or other medical conditions involving altered lymphohematopoietic stem cell or immunological function.
- Conditions
- Immunologic Deficiency Syndrome, Leukemia, Lymphoma, Neoplasm
- Trial name
- NCT00001336
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Cancer Institute (NCI)
Burns
Allogenic Stem Cell Therapy in Patients With Acute Burn
Burn trauma,especially extensive ones, remains a life-threatening local and general inflammatory condition destroying the skin and underlying tissues, and resulting in serious sequelae.
- Trial name
- NCT01443689
- Testing
- human umbilical cord mesenchymal stem cells, human cord blood mononuclear cells and human umbilical cord mesenchymal stem cells, Conventional therapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Beike Bio-Technology Co., Ltd.
Acute Myeloid Leukemia
Venetoclax-containing Therapy Combined With Microtransplant for Newly Diagnosed AML
The purpose of this study is to evaluate whether HLA-mismatched donor G-CSF mobilized peripheral blood mononuclear cell (GPBMC) infusion with venetoclax-containing regimens (microtransplant, MST) could improve survival in adult…
- Trial name
- NCT07078591
- Testing
- Venetoclax, Azacitidine (AZA), Daunorubicin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Beijing 302 Hospital
Diabetic Foot Ulcer
Umbilical Cord Blood Mononuclear Cell Gel in the Treatment of Refractory Diabetic Foot Ulcer
Umbilical cord blood mononuclear cells (MNC) may improve the wound repair ability. This study aims to investigate the role of MNC in refractory diabetic foot ulcer by comparing the combination of PRP and MNC with PRP alone.
- Trial name
- DFU-MNC (NCT04689425)
- Testing
- Umbilical cord blood mononuclear cell gel（MNC）, The platelet rich plasma（PRP）
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University Third Hospital
Neurodegeneration, G-CSF
Neuroregenerative Potential of Intravenous G-CSF and Autologous Peripheral Blood Stem Cells
The current study describes a randomized, double-blind, cross-over study of intravenous G-CSF followed by infusion with autologous mobilized peripheral blood mononuclear cells (mPBMCs) in children with cerebral palsy (CP) to…
- Conditions
- Neurodegeneration, G-CSF, Peripheral Blood Mononuclear Cells, Cerebral Palsy
- Trial name
- NCT02983708
- Testing
- Peripheral blood mononuclear cells (mPBMC), G-CSF
- Volunteers
- 57 people
- Sponsor
- Hanyang University Seoul Hospital
Critical Limb Ischemia, Ischemia
HemaTrate™ in the Treatment of Critical Limb Ischemia
The primary objective of this study is to evaluate the performance of the HemaTrate™ Blood Filtration system in the treatment of critical limb ischemia.
- Trial name
- NCT03809494
- Testing
- HemaTrate™ Blood Filtration system, Saline
- Where
- 3 sites in United Kingdom
- Volunteers
- 2 people
- Sponsor
- Cook Research Incorporated
Peripheral Arterial Disease (PAD), Claudication, Intermittent
Expression of GLP1 Receptor on Peripheral Blood Mononuclear Cells in Advanced Peripheral Artery Disease: Paving the Way for GLP1R Agonists Treatment in Chronic Limb Threatening Ischemia
The goal of this observational study is to learn whether activation of the GLP-1 receptor could represent a therapeutic target by characterizing its expression and associated inflammatory mechanisms in patients with peripheral…
- Conditions
- Peripheral Arterial Disease (PAD), Claudication, Intermittent, Chronic Limb-Threatening Ischemia
- Trial name
- EXCEL-CLTI (NCT07340112)
- Testing
- Analysis of GLP-1 receptor expression
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Multiple Myeloma
Evaluation of the Spectra Optia® Mononuclear Cell Collection Procedure
The purpose of this investigation is to establish that hematopoetic stem cells collected on a new centrifugal blood separator, CaridianBCT's Spectra Optia Apheresis System, are able to reconstitute the hematopoetic systems of…
- Trial name
- NCT01292486
- Testing
- Spectra Optia Apheresis System
- Where
- 4 sites in United States
- Volunteers
- 32 people
- Sponsor
- Terumo BCT
Chronic Atrophic Gastritis
Clinical Study of Umbilical Cord Blood Mononuclear Cell Therapy for the Treatment of Chronic Atrophic Gastritis
To evaluate the efficacy and safety of umbilical cord blood mononuclear cells in the treatment of chronic atrophic gastritis.
- Trial name
- NCT05808010
- Testing
- Mononuclear cells, Weifuchun+Hydrotalcite/L-Glutamine and Sodium Gualenate Granules
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shandong Provincial Hospital
Healthy Subject
Collection of PBMCs From Healthy Subjects for the Development of Cellular Immunotherapy Product
Title: Collection of Peripheral Blood Mononuclear Cells (PBMCs) From Healthy Subjects for the Development of Cellular Immunotherapy Product Background: CAR-T therapies are being developed that utilize modified immune cells to…
- Trial name
- NCT04295096
- Testing
- Peripheral blood mononuclear cell apheresis
- Where
- China
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Jun Zhu
Cardiovascular Disease, Diabetes Type 2
Postprandial Inflammation and Fatty Acids
The main objective is to elucidate the acute effects of an oral intake of either saturated, monounsaturated or polyunsaturated fatty acids on peripheral blood mononuclear cells (PBMC) whole genome expression of obese and type 2…
- Conditions
- Cardiovascular Disease, Diabetes Type 2, Obesity
- Trial name
- PIFA (NCT00977262)
- Testing
- High saturated fat shake, High monounsaturated fat shake, High polyunsaturated fat shake
- Where
- 2 sites in Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Metastatic Melanoma
Study of Gene Modified Immune Cells in Patients With Advanced Melanoma
The purpose of this phase 2 study is to find the best way to give this new experimental regimen and determine if it can treat metastatic melanoma in humans.
- Trial name
- F5 (NCT00910650)
- Testing
- F5 TCR transgenic cells and MART-1 peptide pulsed dendritic cells, non-myeloablative conditioning chemotherapy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Inflammation
Proteomic Analysis of Mononuclear Cells After a High-Fat, High-Carbohydrate Meal With or Without Orange Juice
A high-fat, high-carbohydrate meal (HFHC) induces an increase in inflammation in peripheral-blood mononuclear cells in healthy subjects.
- Trial name
- NCT02587507
- Testing
- Orange juice, Water, Water with glucose
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Spinal Cord Contusion
Allogeneic Cord Blood Cells for Adults With Severe Acute Contusion Spinal Cord Injury
Study evaluates the safety and primary efficiency of systemic (i.v.) allogeneic human umbilical cord blood mononuclear cell infusions in patients with severe acute contusion spinal cord injury (ASIA A/B).
- Trial name
- NCT04331405
- Testing
- Human Allogeneic Umbilical Cord Blood Mononuclear Cells (hUCBMCs) systemic (i.v.) infusions
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Sklifosovsky Institute of Emergency Care
Hepatitis C, Chronic
Biliverdin Reductase A in Chronic Hepatitis C Virus Infection
In this project, the investigators aim to study the role of biliverdin reductase A (BLVRA) in HCV infected patients prior and during/after standard antiviral therapy in association with viral clearance, disease progression and…
- Trial name
- NCT01112033
- Where
- Czechia
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Chronic Migraine
Gene Expression of Endocannabinoid System in Episodic and Chronic Migraine Patients
Preclinical and clinical evidence suggests a role for the dysregulation of endocannabinoid system (ES) in migraine pain, particularly in subjects with chronic migraine.
- Trial name
- NCT04324710
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Cushing Syndrome
The Circadian Rhythm in CusHing SyndrOme in Active Phase and dUring RemiSsion (TheHOURS)
This is an observational, open, prospective multi-centre study designed to evaluate melatonin and cortisol circadian rhythm, immunological profile and anthropometric parameters in Cushing Syndrome patients during active Remission…
- Trial name
- TheHOURS (NCT03343470)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Roma La Sapienza
Fasting
Molecular Pathways Related to Short-term Fasting Response
This study will evaluate the effect of short-term fasting (36 hours) in gene expression in blood cells in healthy volunteers.
- Trial name
- NCT04259879
- Testing
- Fasting
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IMDEA Food
Knee Osteoarthritis
Intra Articular Injection of Peripheral Blood Mononuclear Cells for Knee Osteoarthritis
The goal of this Phase II/III, double-blinded, multicenter clinical trial is to assess the clinical efficacy of autologous peripheral blood mononuclear cells (PBMCs) in the management of knee osteoarthritis (KOA).
- Trial name
- PBMC-KOA (NCT07703280)
- Testing
- High-dose PCP-PBMCs injection, Solu-Medrol, Low-dose PCP-PBMCs injection
- Where
- 4 sites in Taiwan
- Volunteers
- 240 people
- Sponsor
- DuoGenic StemCells Corporation (DGSC)