Clinical trials: Peripheral Blood Mononuclear Cell
Complement Abnormality, Peripheral Blood Mononuclear Cells
The Role of Natural Killer, Complement and T-lymphocytes in COVID-19 Disease, a Prospective Monocentric Study
The current study is an open, non-randomized, monocentric, and interventional study. CoViD-19 patients will be recruited at UZ Brussel after informed consent is obtained.
- Conditions
- Complement Abnormality, Peripheral Blood Mononuclear Cells, Covid19
- Trial name
- TONIC (NCT05258643)
- Testing
- Blood analysis
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
COVID-19 Respiratory Infection
Expression of Toll-like Receptors 3 , 7 and 9 in Peripheral Blood Mononuclear Cells of COVID-19 Patients
The aim of the study is to assess the expression of TLR 3, 7, and 9 in the population of peripheral blood mononuclear cells (PBMC) and in B lymphocytes (CD19+), T lymphocytes (CD4+ and CD8+) using flow cytometry in relation to…
- Trial name
- NCT05089110
- Testing
- blood sample
- Volunteers
- 100 people
- Sponsor
- Assiut University
Peripheral Blood Mononuclear Cell
Peripheral Blood Mononuclear Cell Collection Protocol for UCART Cell Tumor Immunotherapy Study
Peripheral blood mononuclear cell collection protocol for tumor immunotherapy study of UCAR-T cells
- Trial name
- NCT04448509
- Testing
- Peripheral blood mononuclear cell apheresis
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- He Huang
Healthy
Postprandial Effects of Mixed Herbs and Spices on Pathways Associated With Glucose Homeostasis and Inflammation on PBMCs of Healthy Subjects
This study aims to investigate the effect of mixed of herbs and spices on gene expression of pathways associated with glucose homeostasis, oxidative stress, inflammation and its interrelation with circulating miRNA, in the…
- Trial name
- NCT02931643
- Testing
- High fat challenge breakfast, High fat challenge breakfast with mixed-spices
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Lund University
Physical Fitness, Mitochondrial Function, Bioenergetics
Effects of Acute Exercise in Fasting and Fed States in Individuals With Different Aerobic Fitness Levels
The aim of this study is to investigate the effects of aerobic fitness level, feeding status, and acute exercise on whole-body metabolic fuel utilization and mitochondrial function in peripheral blood mononuclear cells (PBMCs) in…
- Conditions
- Physical Fitness, Mitochondrial Function, Bioenergetics, Mitochondria, Energy Metabolism
- Trial name
- NCT07813403
- Testing
- Acute Moderate-Intensity Cycling Exercise, Ad Libitum Mixed Meal
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Chronic Hepatitis C
Peripheral Blood Mononuclear Cell (PBMC) Gene Expression in HCV Genotype 1 Patients
Our previous collaborative studies has developed a molecular diagnosis tool, which is characterized with a prediction model consisting single nucleotide polymorphisms (SNPs), for assessing the efficacy of interferon combined…
- Trial name
- PBMC (NCT00680173)
- Testing
- pegylated interferon alpha 2a and plus ribavirin
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Cell Function
In Vitro Study of Peripheral Blood Mononuclear Cell Function in Healthy Individuals and Patients
Peripheral blood mononuclear cells (PBMC) will be collected from healthy volunteers and patients who present with different diseases that involve or implicate the immune system dysregulation (HIV infection, autoimmune diseases…
- Trial name
- NCT00342485
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Vascular Disease, Vascular Disease Risk
Effect of Atorvastatin (Lipitor) on Gene Expression in People With Vascular Disease
This study will determine if the drug Atorvastatin (Lipitor) changes the genetic material found in blood cells of people with vascular (blood vessel) disease.
- Trial name
- NCT00293748
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Poor Graft Function
The Safety and Efficacy of Umbilical Cord Blood Mononuclear Cells in Patients With Secondary Poor Graft Function After Hematopoietic Stem Cell Transplantation
This study is conducted in a prospective, single-center clinical design and is divided into two stages: dose escalation and dose extension.
- Trial name
- NCT06792682
- Testing
- Dose escalation, Dose extension
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Atopic Dermatitis, Eczema Herpeticum
Interferon Responses in Eczema Herpeticum
Atopic dermatitis (AD) is a chronic skin disorder characterized by recurrent viral skin infections. A small subset of patients with AD suffer from disseminated viral infections, e.g., eczema herpeticum (ADEH+), after herpes…
- Conditions
- Atopic Dermatitis, Eczema Herpeticum, Herpes Simplex Infections, Eczema Vaccinatum
- Trial name
- ADRN-01 (NCT01429311)
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Stroke, Ischemic Stroke
Safety and Feasibility Study of Umbilical Cord Blood Mononuclear Cells Transplant to Treat Ischemic Stroke
The study is to assess the safety and possible efficacy of umbilical cord blood mononuclear cells (UCBMC) treatment of chronic ischemic stroke.
- Conditions
- Stroke, Ischemic Stroke, Brain Ischemia
- Trial name
- NCT01673932
- Testing
- UCBMC, surgery
- Where
- 2 sites in Hong Kong
- Volunteers
- 12 people
- Sponsor
- China Spinal Cord Injury Network
Spondylitis, Ankylosing
Analysis of the Peripheral Blood Mononuclear Cells of Patients With Ankylosing Spondylitis During Infliximab Treatment (Study P04465)(COMPLETED)
This is an open-label, controlled sub-study to the parent protocol (P04041, NCT00779935) to examine the expression profile of genes in patients in the active stage of ankylosing spondylitis (AS) compared to the healthy population…
- Trial name
- NCT00778869
- Testing
- Remicade
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Stage III Ovarian Carcinoma, Stage IV Ovarian Carcinoma
Autologous Dendritic Cells Loaded With Autologous Tumor Associated Antigens for Treatment of Advanced Epithelial Ovarian Carcinomas
This is a double-blind study in which approximately 99 study patients will be randomized in a 2:1 ratio to receive either AVOVA-1 or MC.
- Conditions
- Stage III Ovarian Carcinoma, Stage IV Ovarian Carcinoma, Fallopian Tube Carcinoma, Primary Peritoneal Carcinoma
- Trial name
- NCT02033616
- Testing
- AVOVA-1, MC
- Where
- 6 sites in United States
- Volunteers
- 99 people
- Sponsor
- Aivita Biomedical, Inc.
Glioma
Gene Expression, Immunological Status and Metabolome in Glioma Patients
Study on glioma patients treated with brain surgery is focusing on the analysis of their transcriptome expression profile measured in two immune cell populations, CD4+ T cells and CD56+ NK cells.
- Trial name
- NCT01525459
- Testing
- Glioma resection, Blood sampling
- Where
- 3 sites in Slovenia
- Volunteers
- 16 people
- Sponsor
- National Institute of Biology, Slovenia
Diabetic Foot, Critical Limb Ischemia
A Clinical Trial on Diabetic Foot Using Peripheral Blood Derived Stem Cells for Treating Critical Limb Ischemia
The purpose of this study is to determine whether the method (implanting stem cells derived from peripheral blood after G-CSF mobilization) of treatment is safe and effective in the management of diabetic foot ischemia, the…
- Conditions
- Diabetic Foot, Critical Limb Ischemia, Leg Ulcers
- Trial name
- NCT00922389
- Testing
- will receive G-CSF and peripheral blood derived mononuclear cells, G-CSF, Standard Therapy
- Where
- India
- Volunteers
- 36 people
- Sponsor
- Beike Biotech India Pvt.ltd
Obesity
Beta-glucan and Insulin Sensitivity in Obese Humans
Obesity is an important health problem of modern civilization. In Western societies, almost half of the adult population has problems with an increased body weight.
- Trial name
- NCT01393210
- Testing
- low calorie diet plus beta-glucan, low-calorie diet
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Marek Straczkowski
Cardiovascular Function, Gene Expression
Effect of a Polyphenol-rich Cocoa Extract on Peripheral Blood Mononuclear Cells Gene Expression
It has been evidenced that chocolate and cocoa consumption increase vasodilation and reduce blood pressure. However, the mechanisms implicated in these effects have not been elucidated yet.
- Trial name
- NCT01681394
- Testing
- Polyphenol-rich cocoa extract, Chocolate cream
- Where
- Spain
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Inflammatory Bowel Disease
Ex-vivo Modulatory Effect of Biological Drugs for Inflammatory Bowel Disease on the Mucosa and on Peripheral Blood Mononuclear Cells
To characterize circulating DC subsets from healthy controls and IBD patients and to assess, following an ex vivo challenge, the effect of anti-TNF (infliximab, adalimumab and golimumab), anti-p40 -IL-12/IL-23- (ustekinumab) and…
- Trial name
- NCT03043677
- Testing
- Ex-vivo stimulation of cells with infliximab, golimumab, adalimumab, vedolizumab and ustekinumab
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
ADHD, Immune System
Immunoprofilling of Peripheral Blood Mononuclear Cells in Children With Attention Deficit/Hyperactivity Disorder
The goal of this observational study is to learn about The immune cell landscape of peripheral blood mononuclear cells in children with ADHD compared to typically developing controls.
- Conditions
- ADHD, Immune System, Clinical Syndrome
- Trial name
- NCT06109337
- Testing
- drow blood
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Diabetes
Relation of White Blood Cell Function to Diabetes
Background: Patients who are pre-diabetic or have adult onset (type 2) diabetes have a significantly greater risk of developing heart, blood vessel, or kidney diseases.
- Trial name
- NCT00570154
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)