Clinical trials: Peripheral Blood Mononuclear Cell
Long COVID, Post-COVID-19 Condition
Mitochondrial Function in Peripheral Blood Mononuclear Cells, Muscle, and Skin of Long COVID Patients
Mitochondria are structures inside cells that are responsible for producing energy from nutrients through a series of steps, using oxygen.
- Trial name
- MitoLoCo (NCT07134673)
- Where
- Belgium
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Cancer
Histamine Receptor 2 Antagonists as Enhancers of Anti-Tumour Immunity
The immune response against tumors can be highly effective in preventing tumor development, growth and metastasis under certain circumstances.
- Trial name
- NCT03145012
- Testing
- Ranitidine
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Thromboangiitis Obliterans, Arteritis
Purified CD34+ Cells Versus Peripheral Blood Mononuclear Cells in Treatment of Critical Limb Ischemia
To compare the efficacy and cost-effectiveness between purified CD34+ cells and peripheral blood mononuclear cells in treatment of critical limb ischemia
- Conditions
- Thromboangiitis Obliterans, Arteritis, Peripheral Arterial Disease
- Trial name
- NCT02089828
- Testing
- autologous purified CD34+ cells, autologous peripheral blood mononuclear cells
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Zhongshan Hospital
Physical Fitness, Obesity
Exercise Changes to Peripheral Blood Mononuclear Cells in Children
The goal of this research is to determine how the peripheral immune system is altered by exercise and differences related to gender, pubertal status and health.
- Conditions
- Physical Fitness, Obesity, Child Development, Growth
- Trial name
- NCT00585403
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Recurrent Implantation Failure
hCG-activated PBMC-therapy in RIF Patients
Despite the many research done in the field of infertility and in vitro fertilization (IVF), more than half of the embryos transmitted in the IVF and intracytoplasmic sperm injection (ICSI) do not implant successfully.
- Trial name
- NCT03267797
- Testing
- Peripheral Blood Monouclear Cell, Phosphate Baffer Saline
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- SCARM Institute, Tabriz, Iran
Adult Solid Tumor
Study of SQZ-PBMC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors
This is a Phase 1 open-label, multicenter study of the safety and tolerability, immunogenic effects, antitumor activity, and pharmacodynamics of SQZ-PBMC-HPV as monotherapy and in combination with atezolizumab or other immune…
- Trial name
- NCT04084951
- Testing
- SQZ-PBMC-HPV, Atezolizumab, Ipilimumab
- Where
- 12 sites in United States, Canada and 1 more
- Volunteers
- 30 people
- Sponsor
- SQZ Biotechnologies
Crohn's Disease
PBMC (Peripheral Blood Mononuclear Cells) /Lymphocyte SPECT (Single Photon Emission Computerized Tomography) Imaging in Crohn's Disease
Using scintigraphic imaging including planar scintigraphy and SPECT, this study will evaluate the utility of two different ex vivo 99mTc-HMPAO labelled mononuclear cell populations in order to select the optimal methodology…
- Trial name
- NCT01051622
- Testing
- Labeling Ceretec
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pancreatic Cancer
Chemotherapy Compared to Biological Therapy in Treating Patients With Cancer of the Pancreas
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing.
- Trial name
- NCT00003780
- Testing
- tumor infiltrating lymphocyte therapy, gemcitabine hydrochloride
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Meyer Pharmaceuticals
Myelodysplastic Syndromes
Venetoclax-containing Therapy Combined With Microtransplant for Intermediate-risk and Higher MDS
This study aims to evaluate the safety and efficacy of a Venetoclax and hypomethylating agent-based regimen combined with infusion of HLA-mismatched donor G-CSF mobilized peripheral blood mononuclear cells (GPBMC) in patients…
- Trial name
- NCT07238686
- Testing
- Venetoclax, Azacitidine (AZA) or Decitabine (DAC), GPBMC infusion
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing 302 Hospital
Asthma
Non-Eosinophilic Biological Effects of IL-5
This study aims to investigate the role of IL-5 in suppressing anti-viral immune responses in bronchial epithelial cells (BECs) and in peripheral blood mononuclear cells (PBMCs) from 5 people with asthma.
- Trial name
- NCT06026202
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Imperial College London
Chronic Obstructive Pulmonary Disease
GR Defect in Peripheral Blood Mononuclear Cells in COPD
T.to investigate a possible mechanism of the glucocorticosteroid receptors (GR) defect in patients with severe COPD by studying the effect of dexamethasone (Dex) on GR- binding, interleukin production (IL-6/IL-8) and MKP-1…
- Trial name
- NCT00159237
- Testing
- blood test
- Where
- United Kingdom
- Sponsor
- Imperial College London
Alzheimer Disease, Lewy Body Disease
Immunohistochemical Study of Neurodegenerative Diseases
The subject uses cytof to analyze PBMC of sporadic AD and DLB, which is used to reveal the differences in immune characteristics of the two diseases at the single-cell level, build immune models for specific diseases, and define…
- Conditions
- Alzheimer Disease, Lewy Body Disease, Neurodegenerative Diseases
- Trial name
- NCT05518409
- Testing
- Detection of cytof in peripheral PBMC, Donepezil for patients with AD and DLB
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Sepsis
TRIM25 in Septic Patients
Sepsis is a life-threatening condition caused by the body's overwhelming response to infection, which can lead to organ damage and failure.
- Trial name
- NCT07320638
- Testing
- Gene and Inflammatory Marker Analysis in Sepsis
- Where
- China
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
HIV Infections
Valproic Acid and Its Effects on HIV Latent Reservoirs
The purpose of this study is to examine whether the co-administration of valproic acid (Epival®), with highly active antiretroviral therapy (HAART) can reduce the size of HIV latent reservoirs in infected CD4 cells.
- Trial name
- NCT00289952
- Testing
- Valproic Acid, HAART
- Where
- 6 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Jean-Pierre Routy
Non-small Cell Lung Cancer Stage III
Biomarkers of Stage III Locally Advanced Unresectable Non-small-cell Lung Cancer
This study aims to dynamically monitor the expression profile status of peripheral blood mononuclear cells (PBMC) and the changes in circulating tumor DNA (ctDNA) levels in patients with stage III locally advanced unresectable…
- Trial name
- NCT04749407
- Testing
- biomarker detection
- Where
- China
- Volunteers
- 50 people
- Sponsor
- First People's Hospital of Hangzhou
Infertility
Endometrium Immunomodulation by in Utero Administration of Peripheral Blood Mononuclear Cells
One of the most limiting factors in the field of assisted reproduction is implantation failure. A new approach to increase the chances of success involves the use of cells from the patient's blood, peripheral blood mononuclear…
- Trial name
- NCT04648566
- Testing
- Intrauterine administration of hCG-activated peripheral blood mononuclear cells, Intrauterine administration of sperm washing medium
- Where
- Canada
- Volunteers
- 423 people
- Sponsor
- Fertilys
Alzheimer Disease, Early-Onset
Examining Neuroinflammation in AlzHeimer's
Alzheimer disease (AD) is a neurodegenerative disorder with a poorly understood pathology. It is an irreversible progressive brain disease that slowly deteriorates memory, thinking and behavior.
- Trial name
- ENHANCE (NCT03548883)
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Stage IV Melanoma, Stage III Melanoma
Autologous Dendritic Cell-Tumor Cell Immunotherapy for Metastatic Melanoma
The purpose of this research is to evaluate the safety and effectiveness of tumor cell therapy. This research study is evaluating if a patient-specific experimental therapy for metastatic melanoma will lengthen survival with…
- Trial name
- NCT01875653
- Testing
- Autologous Dendritic Cell-Tumor Cell Immunotherapy (DC-TC), Autologous PBMCs in GM-CSF (MC)
- Where
- 18 sites in United States
- Volunteers
- 4 people
- Sponsor
- Lisata Therapeutics, Inc.
Pregnancy Complication
Influence of Preconceptional Obesity on the Myometrial Cells Differentiation Toward a Contractyl Phenotype
The purpose of this study is to improve the understanding of cellular mecanism involved in delivery disorders in obese women, first by characterizing the hyperplasia phenomenon of myometrail cells induced by inflammatory…
- Trial name
- ObeDi (NCT01762683)
- Testing
- Myometrium biopsy and blood samples
- Where
- 2 sites in France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Prediabetes, Type-2 Diabetes
Dietary Intervention Replacing Carbohydrate With Protein and Fat Has Greater Effect on Peripheral Blood Mononuclear Cell Metabolites Than on Plasma Metabolites in Patients With Prediabetes or Type-2 Diabetes
This study examined whether dietary-induced reductions in lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in peripheral blood mononuclear cells (PBMC) and plasma affected metabolic profiles in PBMCs and plasma.
- Trial name
- NCT02191644
- Testing
- Dietary intervention-refined rice, Dietary intervention-whole grains and legumes
- Where
- South Korea
- Volunteers
- 82 people
- Sponsor
- Yonsei University