Clinical trials: Peripheral Blood Mononuclear Cell
Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Autoimmune Diseases
Transcriptome Analysis of the Peripheral Blood in CIDP
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated disorder of peripheral nerves. Intravenous immunoglobulins (IVIg) are a first line therapy for CIDP.
- Conditions
- Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Autoimmune Diseases, Clarkson Syndrome, Muscular Autoimmune Disorders
- Trial name
- PHARMACOPID (NCT02404298)
- Testing
- IVIg
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Amyotrophic Lateral Sclerosis
Transplantation of Autologous Peripheral Blood Mononuclear Cells for Amyotrophic Lateral Sclerosis
To assess the safety of peripheral blood mononuclear cell transplantation into the subarachnoid space for the treatment of amyotrophic lateral sclerosis.
- Trial name
- NCT03085706
- Testing
- PBMC autotransplantation
- Where
- China
- Volunteers
- 14 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Kidney Transplantation
Clinical Trial With Donor Modified Immune Cells in Living Donor Kidney Transplantation
In this clinical trial the investigational medicinal product MIC is to be examined for its efficacy and safety in patients with living kidney transplantation.
- Trial name
- NCT05365672
- Testing
- MIC, Standard of Care
- Where
- 8 sites in Germany
- Volunteers
- 126 people
- Sponsor
- TolerogenixX GmbH
Spinal Cord Injury, Acute
Cord Blood Cells in Patients With Acute SCI
This is a prospective, single-blinded, single-center, randomized, comparative, interventional clinical study of systemic mononuclear multiple allogenic cord blood cells administration safety and efficiency in patients having…
- Trial name
- SUBSCI II (NCT05693181)
- Testing
- Multiple systemic (i.v.) administration of allogenic non-related group- and rhesus-compatible mononuclear cord blood cells, Control vehicle (sterile saline)
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Sklifosovsky Institute of Emergency Care
HIV, Immunodeficiencies
Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in People Living With and Without HIV
We are studying virologic and/or immunologic parameters of HIV infection and other infectious or non-infectious immune deficiency diseases in order to better understand the pathogenesis of HIV.
- Conditions
- HIV, Immunodeficiencies, Infectious Diseases
- Trial name
- NCT00001281
- Where
- 2 sites in United States
- Volunteers
- 2,419 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Red Blood Cell, Peripheral Blood Mononuclear Cell
Analysis of Proteome and Pathophysiological Characteristics of Human Blood Cells
The aim of this study is to investigate wether change in endothelial nitric oxid synthase of blood cells (erythrocytes and peripheral blood mononuclear cells (PBMC)) has an influence on development and progression of…
- Conditions
- Red Blood Cell, Peripheral Blood Mononuclear Cell, Endothelial NO-synthase
- Trial name
- NCT02272530
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Intermittent Claudication, PAD
Treatment of Intermittent Claudication by G-CSF-mobilized PB-MNC
This study will investigate the efficacy of G-CSF mobilized mononuclear cell injection of patients with PAD who presented with intermittent claudication.
- Conditions
- Intermittent Claudication, PAD, Atherosclerotic Ischemic Disease
- Trial name
- NCT03683628
- Testing
- PB-MNC therapy, No PB-MNC therapy
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
PAD, Critical Limb Ischemia
Treatment of No-option CLI by G-CSF-mobilized PB-MNC
This study will investigate the efficacy of G-CSF mobilized mononuclear cell injection of patients with PAD who presented with no-option CLI.
- Conditions
- PAD, Critical Limb Ischemia, Atherosclerotic Ischemic Disease
- Trial name
- NCT03686228
- Testing
- PB-MNC therapy, No-PB-MNC therapy
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Premature Ovarian Failure，
Stem Cell Therapy Combined Hormone Replacement Therapy in Patients With Premature Ovarian Failure
Premature ovarian failure (POF) refers the occurrence of amenorrhoea, elevated serum gonadotrophins and hypoestrogenism levels in female before the age of 40.
- Trial name
- NCT01742533
- Testing
- human umbilical cord mesenchymal stem cells, hUCMSCs and hCBMNCs, human cord blood mononuclear cells
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shenzhen Beike Bio-Technology Co., Ltd.
Hemodialysed Patients With Impaired Liver Enzymes
The Incidence of Occult Hepatitis C Virus Infection in Hemodialysed Patients With Liver Enzymes Disturbances
To assess the incidence of occult hepatitis C virus in hemodialysed patients with mild impairment of liver enzymes
- Trial name
- NCT01054664
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Meir Medical Center
Mitochondrial Function
Functional Mitochondrial Analysis PBMCs
The primary goal of this prospective, exploratory, longitudinal, single-centre, cohort study is to assess the stability of the mitochondrial flux in PBMCs over long-term cryopreservation.
- Trial name
- FMAP (NCT06498791)
- Testing
- Venipuncture, Questionnaire
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- VASCage GmbH
Prostate Cancer
GVAX in Advanced Prostate Cancer Patients Made Lymphopenic
Androgen (a male sex hormone) deprivation is the standard therapy for metastatic prostate cancer and results in regression or control of disease in 80-85% of patients.
- Trial name
- NCT00122005
- Testing
- GM-CSF gene transduced allogeneic vaccine GVAX
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Providence Health & Services
Osteoporosis
Exercise as an Modulator of Immunological Risk Factors for Osteoporosis
This is the second phase of a study designed to determine the immunological effects of long-term exercise on risk factors for ischemic heart disease (phase 1) and osteoporosis (phase 2).
- Trial name
- NCT02765945
- Testing
- Supervised exercise program
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- East Tennessee State University
Rheumatoid Arthritis
A Study to Evaluate the RNA Signature of Rheumatoid Arthritis From Synovium and Whole Blood
Rheumatoid arthritis is a systemic disease, it is not clear whether the gene expression profile exhibited by circulated peripheral blood cells and that expressed by the inflamed synovium mirror one another.
- Trial name
- NCT00781469
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- Imperial College London
ARDS (Acute Respiratory Distress Syndrome)
Lung Injury is One of the Primary Causes of Morbidity and Mortality in Critically Ill Patients. These Patients Will be Monitored for: 1) Immune Cell Activation 2) Blood-based Biomarkers. In Vitro Models Derived From These Samples Will be Treated With Novel Agent PIP-2 to Evaluate Its Efficacy.
Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) is a condition where high levels of inflammation damage the lung. This is a highly morbid condition with no specific pharmacologic therapies.
- Trial name
- ALI/ARDS (NCT07125079)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Pennsylvania
Crohn's Disease
Study of STA-5326 Mesylate in Patients With Moderate to Severe Crohn's Disease
STA-5326 is an oral experimental drug that has been shown to block the release of interleukin-12 from peripheral blood mononuclear cells.
- Trial name
- NCT00234741
- Testing
- STA-5326 mesylate
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Synta Pharmaceuticals Corp.
Collection of Peripheral Blood Mononuclear Cells by Means of Apheresis
A Study on the Collection of Peripheral Blood Mononuclear Cells From Healthy Volunteers for the Development of Allogeneic Cellular Immunotherapy Products
The objective of the study is to collect peripheral blood mononuclear cells (PBMC) from healthy volunteers for the research and development of allogeneic cellular immunotherapy products.
- Trial name
- NCT04027855
- Testing
- collection of peripheral blood mononuclear cells from healthy volunteers
- Where
- China
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Refractory Immune Effector Cell-related Hemocytopenia
A Randomized Controlled, Open, Single-center Clinical Study Evaluating the Efficacy and Safety of Umbilical Cord Blood Mononuclear Cells in Patients with Refractory Immune Effector Cell-related Hemocytopenia
The purpose of this study was to evaluate the safety and efficacy of umbilical cord blood mononuclear cell in the treatment of refractory immune effector cell-related hemocytopenia by observing the efficacy related factors and…
- Trial name
- NCT06729320
- Testing
- Umbilical cord blood mononuclear cells, Conventional hematopoietic recovery therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Beijing GoBroad Hospital
SCHIZOPHRENIA 1 (Disorder)
Effect of Fluvoxamine on Cognition, Behavior, Symptoms and mRNA and Protein Expression in Schizophrenia Patients
The purpose of this study is to determine effect of Fluvoxamine augmentation on cognitive function , aggressive behavior , clinical symptoms and mRNA (messenger ribonucleic acid) and protein expression in human peripheral…
- Trial name
- NCT01832285
- Testing
- fluvoxamine
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sha'ar Menashe Mental Health Center
Rheumatoid Arthritis
Oral CF101 Tablets Treatment in Patients With Rheumatoid Arthritis
This trial will test the hypothesis that the administration of CF101, a novel anti-inflammatory agent, to patients with rheumatoid arthritis and high A3AR expression at baseline will relieve signs and symptoms of the disease.
- Trial name
- NCT01034306
- Testing
- CF101
- Where
- 5 sites in Bulgaria, Israel
- Volunteers
- 79 people
- Sponsor
- Can-Fite BioPharma