Clinical trials: Peripheral Nerve Disorder
Radicular Pain, Adhesiolysis
Determinants of Clinical Outcome After Caudal Epidural Adhesiolysis for Chronic Lumbar Radicular Pain
Chronic lumbar radicular pain is a frequently encountered condition that can cause marked pain, limited physical function, and a substantial decline in quality of life.
- Conditions
- Radicular Pain, Adhesiolysis, Disc Disease Lumbar
- Trial name
- NCT07487935
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Mersin University
Neuroblastoma
Safety Study of Nifurtimox for Relapsed or Refractory Neuroblastoma
There is currently no curative treatment for children with relapsed/refractory neuroblastoma, and for these children the 5 year survival rate is <10%. As such, new therapeutic approaches are needed to treat these children.
- Trial name
- NCT00486564
- Testing
- Nifurtimox
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Vermont
Solid Tumor, Renal Cell Carcinoma (Kidney Cancer)
A Study of NDI 1150-101 in Patients With Solid Tumors
This study is to determine the maximum tolerated dose (MTD) and the recommended Phase 2 dose (RP2D) and to investigate the safety, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of NDI-101150 given as…
- Conditions
- Solid Tumor, Renal Cell Carcinoma (Kidney Cancer), Gastric and Gastroesophageal Junction (GEJ) Adenocarcinoma, Non-Small Cell Lung Cancer
- Trial name
- NCT05128487
- Testing
- NDI-101150, Pembrolizumab
- Where
- 19 sites in United States
- Volunteers
- 106 people
- Sponsor
- Nimbus Saturn, Inc.
Peripheral Neuropathy
Multimodal Ultrasound in Peripheral Neuropathy
This study will enforce the role of ultrasound in early diagnosis and screening on peripheral neuropathy in comparison with other modalities.
- Trial name
- NCT06711133
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
CHRONIC POST-TRAUMATIC NEUROPATHIC PAIN IN ANKLE AND FOOT
Pilot RCT of Efficacy of Perineural Local Anesthetics and Steroids for Chronic Post-traumatic Ankle and Foot Pain
Injections of local anesthetics (freezing) and steroids are often performed around injured nerves in individuals with nerve injury-related pain.
- Trial name
- PREPLANS (NCT02680548)
- Testing
- 0.9% saline, 0.25% bupivacaine hydrochloride injectable suspension USP, 4mg/cc methylprednisolone acetate injectable suspension USP
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University Health Network, Toronto
Neuropathic Pain
International Neuromodulation Registry
The design and execution of the International Neuromodulation Society (INS) registry has been developed with the objective of assessing the efficacy and safety of Spinal Cord Stimulation and other neuromodulation therapies using…
- Trial name
- NCT07354243
- Testing
- Neuromodulation therapies
- Volunteers
- 1,000 people
- Sponsor
- Poitiers University Hospital
Scapholunate Advanced Collapse (SLAC), Scapholunate Crystalline Advanced Collapse (SCAC)
The KinematX Midcarpal Total Wrist Arthroplasty Registry
The goal of this observational study is to learn about functional and patient reported outcomes in patient undergoing total wrist replacement with the KinematX total wrist replacement study.
- Conditions
- Scapholunate Advanced Collapse (SLAC), Scapholunate Crystalline Advanced Collapse (SCAC), Scaphoid, Trapezium, and Trapezoid Advanced Collapse (STTAC), Carpal Tunnel Syndrome (CTS)
- Trial name
- NCT05719935
- Testing
- KinematX total wrist arthroplasty system
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Extremity Medical
Sciatica
Topiramate in the Treatment of Sciatica
This study will test the effectiveness of topiramate to treat pain caused by lumbar radiculopathy, or sciatica. Sciatica results from damage to the lumbar nerve roots, typically causing back pain and sharp, shooting pain down one…
- Trial name
- NCT00011804
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Peripheral Neuropathy
Treatment Trial Using Low Level Laser Therapy (LLLT) for Treatment of Chemotherapy Induced Peripheral Neuropathy
The purpose of this research study is to determine if treatment with Low Level Laser Therapy (LLLT) is effective in treating the pain, numbness or tingling patients are experiencing following their chemotherapy.
- Trial name
- LLL (NCT01006408)
- Testing
- Low Level Laser
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Legacy Health System
Cervical Radiculopathy
Correlation Between Chronic Neck Pain and Shoulder Proprioception Among Patients With Cervical Radiculopathy
Is there correlation between cervical radiculopathy and shoulder proprioception or not?
- Trial name
- NCT04279340
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Yasmin Soliman Abdo Soliman
Carpal Tunnel Syndrome (CTS)
Very Early Outcomes in Endoscopic Versus Open Carpal Tunnel Release
We are looking at whether there is a difference in pain and function in the very early period when comparing carpal tunnel release performed by the endoscopic technique versus the open technique.
- Trial name
- NCT07364604
- Testing
- Carpal Tunnel Release
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- Stanford University
Sciatica, Low Back Pain
Effect of Muscle Energy Techniques on Functional Abilities in Patients With Discogenic Unilateral Sciatica
The purpose of the study to investigate the effect of muscle energy techniques on functional abilities of patients with chronic discogenic unilateral sciatica and to explain it from a physiological and functional point of view
- Trial name
- NCT04918238
- Testing
- Conventional program, Muscle energy technique
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Horus University
Cervicogenic Headache, Occipital Neuralgia
The MONARCH Case Series Study: SPRINT® Peripheral Nerve Stimulation for the Treatment of Head Pain
The purpose of this study is to learn if pain can be relieved by delivering small amounts of electricity (called "electrical stimulation") to the nerves at the top of the neck.
- Trial name
- NCT05491915
- Testing
- SPRINT Peripheral Nerve Stimulation (PNS) System
- Where
- 10 sites in United States
- Volunteers
- 50 people
- Sponsor
- SPR Therapeutics, Inc.
Neuroblastoma in Children, Neuroblastoma, Recurrent, Refractory
Expanded Access Protocol for the Use of SL-28 in the Treatment of Advanced Solid Tumors
This is an Expanded Access Program (EAP) that will give the participants access to the drug SL-28 before it is approved by the FDA.
- Conditions
- Neuroblastoma in Children, Neuroblastoma, Recurrent, Refractory, Advanced Cancer, Advanced Malignant Neoplasm
- Trial name
- NCT06872489
- Testing
- SL-28.
- Sponsor
- Second Life Therapeutics
Lumbar Spinal Stenosis, Lumbar Spondylolisthesis
Effectiveness and Safety of Korean Medicine for Low Back Pain or Sciatica Due to Lumbar Stenosis/Spondylolisthesis
A prospective observational study investigating the effectiveness and safety of integrative Korean medicine treatment in lumbar stenosis or spondylolisthesis patients with low back pain or sciatica at 3 locations of Jaseng…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Spondylolisthesis, Low Back Pain, Sciatica
- Trial name
- NCT03879447
- Testing
- Herbal medicine, Chuna manual medicine, Bee venom pharmacopuncture
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- Jaseng Medical Foundation
Diabetic Neuropathy
A Follow-On Trial to Assess the Long Term Safety and Efficacy of SPM 927 in Painful Distal Diabetic Neuropathy
Phase 2/3 open-label trial to assess the safety and tolerability of long-term treatment with lacosamide (SPM 927) in subjects with painful diabetic neuropathy.
- Trial name
- NCT00235443
- Testing
- lacosamide
- Where
- 84 sites in United States
- Volunteers
- 451 people
- Sponsor
- UCB Pharma
Low Back Pain, Sciatica
Integrated Supported Biopsychosocial Self-Management for Back Related Leg Pain
Guidelines advocate several complementary modalities as alternatives to drugs and other invasive treatments for chronic low back pain (LBP) conditions.
- Conditions
- Low Back Pain, Sciatica, Back Related Leg Pain, Pain, Chronic
- Trial name
- SUPPORT (NCT05022121)
- Testing
- Supported Biopsychosocial Self-Management (SBSM), Medical Care
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Diabetic Foot
Validation of Ipswich Touch Test for Diabetic Peripheral Neuropathy Screening in Primary Care
The goal of this observational study is to assess the accuracy of screening for diabetic peripheral neuropathy by comparing the Ipswich touch test with the 10-g monofilament test in patients diagnosed with type 2 diabetes.
- Trial name
- NCT06288555
- Testing
- Ipswich touch test
- Where
- Thailand
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Ponlawat Hanchana, MD
Carpal Tunnel Syndrome
Effectiveness of an Invasive Physical Therapy Protocol in Carpal Tunnel Syndrome: Randomized Controlled Clinical Trial
Carpal Tunnel Syndrome (CTS) is the most common peripheral neuropathy due to entrapment, caused by compression of the median nerve as it passes under the transverse carpal ligament at the wrist.
- Trial name
- NCT05527743
- Testing
- Invasive Physiotherapy
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Universitat Internacional de Catalunya
Carpal Tunnel, Transthyretin Amyloidosis
Concordance for Transthyretin Amyloidosis Between Synovial Biopsy and Anterior Carpal Ligament Biopsy
Transthyretin amyloidosis (ATTR) is an underdiagnosed condition that can present early as carpal tunnel syndrome, sometimes preceding cardiac involvement by several years.
- Trial name
- ATTR2026 (NCT07644325)
- Testing
- Annular ligament biopsy
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Clinique Saint Jean, France
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