Clinical trials: Peripheral Nerve Disorder
Foot Ulcer, Diabetic
Approaches to Foot Complication Prevention: A Survey of Diabetes Educators
The purpose of the survey is to assess the knowledge base, role in management, and resources available to diabetes educators regarding foot complication prevention within a variety of healthcare settings.
- Trial name
- NCT04400344
- Testing
- No intervention
- Where
- United States
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Podimetrics, Inc.
Pain
Update Prevalence of Chronic Pain in Hong Kong
Background Chronic pain is one of the major health problems among Western countries. It is also one of the most frequent reasons for seeking medical care. Chronic pain is also an important problem in Hong Kong.
- Trial name
- NCT01878877
- Where
- China
- Volunteers
- 1,570 people
- Sponsor
- The University of Hong Kong
Advanced Soft Tissue Sarcoma, Locally Advanced Angiosarcoma
Ribociclib and Doxorubicin in Treating Patients With Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by Surgery
This phase Ib trial studies the side effects and best dose of ribociclib when giving together with doxorubicin hydrochloride in treating patients with soft tissue sarcomas that has spread to other places or that cannot be removed…
- Conditions
- Advanced Soft Tissue Sarcoma, Locally Advanced Angiosarcoma, Locally Advanced Leiomyosarcoma, Locally Advanced Liposarcoma
- Trial name
- NCT03009201
- Testing
- Doxorubicin Hydrochloride, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- OHSU Knight Cancer Institute
Diabetic Foot Ulcer
Evaluating the Efficacy of Perinatal Membrane Allografts in Addition to the Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers.
The goal of this clinical trial is to learn if using perinatal tissue allografts improves healing of chronic, non-healing foot ulcers in diabetic patients.
- Trial name
- NCT06437028
- Testing
- Dual-layer perinatal tissue allograft, Three-layer fenestrated perinatal tissue allograft, Standard of care
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Samaritan Biologics
CMT, CMT (Charcot Marie Tooth Disease)
A Multi-omic Approach to the Identification of Novel Biomarkers in Early Charcot-Marie-Tooth 1A Disease (CMT1A)
The most common inherited neuropathy is Charcot-Marie-Tooth disease type 1A (CMT1A), caused by a duplication of the gene expressing PMP22.
- Conditions
- CMT, CMT (Charcot Marie Tooth Disease), CMT - Charcot-Marie-Tooth Disease, CMT1A
- Trial name
- CMT-MODs (NCT07476365)
- Where
- Germany
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Medical Center Goettingen
Cervical Radiculopathy
RCT of Multimodal Physiotherapy for Acute / Sub-acute Cervical Radiculopathy
Multimodal physiotherapy involving manual therapy and exercise has demonstrated a positive effect on pain and disability in sub-acute and chronic cervical radiculopathy (CR) but a research gap exists for optimal management in the…
- Trial name
- PACeR (NCT02449200)
- Testing
- Multimodal physiotherapy
- Where
- Ireland
- Volunteers
- 64 people
- Sponsor
- Royal College of Surgeons, Ireland
Optic Nerve Sheath Tumors, Benign
Multisession Radiosurgery for Optic Nerve Sheath Meningiomas
Traditional treatment options for optic nerve sheath meningiomas (ONSM) include observation, surgery and radiotherapy, but to date none of these has become the clear treatment of choice.
- Trial name
- ONSMsmSRS (NCT02594709)
- Testing
- Multisession Radiosurgery
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Diabetic Peripheral Neuropathy
A 6-Month Extension Study of VMDN-003-2 to Assess Engensis in Participants With Painful Diabetic Peripheral Neuropathy
To evaluate the durability of efficacy and long-term safety of intramuscular administration of Engensis or Placebo that was administered in the double-blind, randomized, VMDN-003-2 Placebo-controlled Phase 3 Study.
- Trial name
- REGAiN-1B (NCT04873232)
- Testing
- Engensis
- Where
- 16 sites in United States
- Volunteers
- 106 people
- Sponsor
- Helixmith Co., Ltd.
Sarcoma, Osteosarcoma
A Phase I Trial of T Cells Expressing an Anti-GD2 Chimeric Antigen Receptor in Children and Young Adults With GD2+ Solid Tumors
Background GD2 is a well-characterized tumor antigen in neuroblastoma, which is also expressed on osteosarcomas and some other sarcomas.
- Conditions
- Sarcoma, Osteosarcoma, Neuroblastoma, Melanoma
- Trial name
- NCT02107963
- Testing
- Anti-GD2-CAR engineered T cells, AP1903, Cyclophosphamide
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Diabetic Polyneuropathy
Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Diabetic Polyneuropathy (Stage 1 or 2)
To assess clinical efficacy and safety of long-term orally administered thioctic acid in the treatment of diabetic polyneuropathy.
- Trial name
- NATHAN1 (NCT00977483)
- Testing
- Thioctic Acid
- Where
- 38 sites in United States, Croatia and 7 more
- Volunteers
- 460 people
- Sponsor
- MEDA Pharma GmbH & Co. KG
Diabetic Peripheral Neuropathy
Effects of Vibration Therapy in Addition to Routine Physical Therapy in Patients With Diabetic Neuropathy
The study is aimed to determine the effects of sole-foot vibration therapy on pain intensity, static and dynamic balance, functional status and satisfaction to the intervention applied on patients with peripheral neuropathy due…
- Trial name
- NCT05580705
- Testing
- Routine Physical Therapy, Vibration Therapy
- Where
- Pakistan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Lahore
Morton's Neuroma
Study to Evaluate the Safety and Tolerability of CNTX-4975 in Subjects With Painful Intermetatarsal Neuroma (Morton's Neuroma)
The purpose of this study is to confirm that the local anesthetic applied to subjects with Morton's Neuroma satisfactorily mitigates procedure pain and ensures that post-procedure discomfort or pain will not result in bias or…
- Trial name
- NCT02550756
- Testing
- CTNX-4975
- Volunteers
- 11 people
- Sponsor
- Centrexion Therapeutics
Pain, Chronic Pain
Efficacy and Tolerability of Lidocaine Plaster for Treatment of Long-term Local Nerve Pain
The purpose of this trial is to investigate the efficacy and safety of lidocaine 5% medicated plaster in localized chronic post-operative neuropathic pain in comparison to placebo plaster.
- Conditions
- Pain, Chronic Pain, Neuropathic Pain, Postoperative Pain
- Trial name
- NCT01752322
- Testing
- Lidocaine 5% medicated plaster
- Where
- 42 sites in Austria, Belgium and 6 more
- Volunteers
- 444 people
- Sponsor
- Grünenthal GmbH
Painful Diabetic Peripheral Neuropathy (PDPN)
Cryoneurolysis for Painful Diabetic Neuropathy of the Foot
The study is a single-center, randomized, participant- and observer-masked, human-subjects, post-market clinical pilot study to investigate the use of ultrasound-guided percutaneous cryoneurolysis to treat diabetic neuropathy of…
- Trial name
- NCT06646731
- Testing
- cryoneurolysis
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Pain, Neuropathic, Epilepsy
Cancer in Patients With Gabapentin (GPRD)
High doses of gabapentin are associated with pancreatic acinar cell tumors in rats, but there has been no post marketing pancreatic carcinogenicity signal with gabapentin as reported by spontaneous reports in AERS or in the…
- Conditions
- Pain, Neuropathic, Epilepsy, Renal Pelvis Cancer, Pancreatic Cancer
- Trial name
- NCT01236053
- Testing
- Gabapentin prescriptions
- Volunteers
- 2,323,608 people
- Sponsor
- GlaxoSmithKline
Diabetes Mellitus, Painful Diabetic Neuropathy
The Development of Contextual Cognitive Behavioural Approach to PDN
Diabetes mellitus (DM) is highly prevalent, and a significant public health problem. Approximately 25-30% of all individuals with DM develop painful diabetic neuropathy (PDN).
- Trial name
- NCT03700528
- Testing
- Acceptance and Commitment Therapy (ACT)
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- King's College London
Peripheral Neuropathy
Long Term Outcome After Serial Lidocaine Infusion in Peripheral Neuropathic Pain
The purpose of this study to evaluated Long term outcome after serial Lidocaine infusion when compared with placebo in peripheral neuropathic pain patients in acute stage (less than 6 months) at 3 months after first time of…
- Trial name
- NCT02217267
- Testing
- Lidocaine
- Where
- Thailand
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Vestibular Schwannoma, Brain Metastases
Protocol for Evaluating a Planning Algorithm for Gamma Knife Radiosurgery
The process of developing Gamma Knife radiosurgery treatment plans is today very dependent on the level of human expertise resulting in a great heterogeneity of the intrinsic qualities of the treatment planning and the quality of…
- Conditions
- Vestibular Schwannoma, Brain Metastases, Para-optic Meningioma
- Trial name
- SPEED (NCT03520829)
- Testing
- Intuitive Plan
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Breast Cancer Patients, Chemotherapy Induced Peripheral Neuropathy (CIPN)
The Effect of Cold Salt Water Foot Bath on the Development Of Chemotherapy-Induced Peripheral Neuropathy
This prospective, randomised, controlled study was designed to evaluate the effectiveness of salt and unsalted cold water foot baths in preventing chemotherapy-induced peripheral neuropathy (CIPN) in patients receiving…
- Conditions
- Breast Cancer Patients, Chemotherapy Induced Peripheral Neuropathy (CIPN), Paclitaxel-induced Peripheral Neuropathy
- Trial name
- NCT06964802
- Testing
- Cold salt water foot bath, Cold water foot bath
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Tuba Eryiğit
Carpal Tunnel Syndrome, Tenosynovitis
Comparison of the Efficacy of Corticosteroid Injection and ESWT in Patients With CTS
In this study, the investigators aimed to demonstrate the efficacy of ESWT (extracorporeal shock wave therapy) and local corticosteroid injection in patients with carpal tunnel syndrome(CTS) compared to participants receiving…
- Trial name
- NCT03792945
- Testing
- local injection, extracorporeal shock wave therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Ahi Evran University Education and Research Hospital
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