Clinical trials: Peripheral Nerve Disorder
Lower Extremity Ischemia, Leg Ulcer
Safety and Efficacy of Autologous Bone Marrow Stem Cells for Lower Extremity Ischemia Treating
The purpose of this study is to determine whether autologous bone marrow-derived stem cells are effective in the treatment of lower extremity ischemia.
- Conditions
- Lower Extremity Ischemia, Leg Ulcer, Peripheral Vascular Disease, Diabetic Foot
- Trial name
- NCT01903044
- Testing
- BM-MNC injection
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Pontifícia Universidade Católica do Paraná
Painful Diabetic Peripheral Neuropathy
Efficacy and Safety of Low-Dose Duloxetine Plus Alpha-Lipoic Acid Versus Standard-Dose Duloxetine in Painful Diabetic Peripheral Neuropathy
This study will evaluate the efficacy and safety of low-dose duloxetine combined with alpha-lipoic acid compared with standard-dose duloxetine in adults with painful diabetic peripheral neuropathy.
- Trial name
- NCT07785544
- Testing
- Duloxetine, Alpha-Lipoic Acid
- Where
- Bangladesh
- Volunteers
- 170 people
- Sponsor
- Bangladesh Medical University
Leukemia, Myelodysplastic Syndromes
Genetic Study of Children With Soft Tissue Sarcoma or Rhabdomyosarcoma
RATIONALE: Determination of genetic markers for soft tissue sarcoma or rhabdomyosarcoma may help doctors identify patients who are at risk for therapy-related leukemia.
- Conditions
- Leukemia, Myelodysplastic Syndromes, Sarcoma
- Trial name
- NCT00003793
- Testing
- clonality analysis, microsatellite instability analysis, mutation analysis
- Where
- 96 sites in United States, Australia and 1 more
- Volunteers
- 294 people
- Sponsor
- Children's Oncology Group
Peripheric Neuropathy
Effect of Hilotherapy in the Management of Symptoms Related to Taxane-Associated Peripheral Neuropathy
In this randomized controlled study, it was aimed to determine the effect of hilotherapy on quality of life and comfort level in the management of symptoms related to taxane-associated peripheral neuropathy in patients with…
- Trial name
- NCT07345221
- Testing
- Hilotherapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Nuran Ayşen Pamir Aksoy
Charcot-Marie-Tooth Disease, Type IA
Determine the Safety and Dose of EN001 in Patients With Charcot-Marie-Tooth Disease (CMT) Type 1A
Open-label, Dose-escalation, Phase 1 Clinical Trial to Determine the Safety and Dose of EN001 in Patients with Charcot-Marie-Tooth disease (CMT) type 1A
- Trial name
- NCT05333406
- Testing
- EN001
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- ENCell
Diabetic Polyneuropathy
A Double-Blind, Placebo-Controlled Study of Fermented Deglycyrrhizinated Licorice Extract
This double-blind, placebo-controlled study evaluated the efficacy of oral α-amylase enzyme replacement therapy in treating early-stage diabetic polyneuropathy (DPN).
- Trial name
- NCT07148804
- Testing
- Fermented Deglycyrrhizinated Licorice, Non-fermented Deglycyrrhizinated Licorice
- Where
- Egypt
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Helwan University
Genetic and Inflammatory Polyneuropathies
Clinical, Electrophysiological and Genetic Characteristics of Hereditary and Inflammatory Polyneuropathies in France
To describe the clinical, electrophysiological, and genetic characteristics of patients with genetic and inflammatory polyneuropathies in France.
- Trial name
- POLYFRA (NCT07851844)
- Where
- 26 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neurofibromatosis 1
Trial to Evaluate the Safety of Lovastatin in Individuals With Neurofibromatosis Type I (NF1)
Neurofibromatosis type I (NF1) is a genetic disorder that affects approximately 1 in 3500 individuals. Half of people with NF1 inherit the condition from a parent, and half have a new occurrence of the condition.
- Trial name
- NF1 (NCT00352599)
- Testing
- Lovastatin
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, Los Angeles
Transthyretin Amyloidosis, Carpal Tunnel Syndrome
Transthyretin Cardiac Amyloidosis in Patients With Idiopathic Carpal Tunnel Syndrome Referred for Release Surgery
This study will determine the prevalence of transthyretin amyloidosis in pathology of the transverse carpal ligament and cardiac involvement using natriuretic peptides, electrocardiography and echocardiography in patients…
- Trial name
- PRATHYC (NCT04611204)
- Testing
- Descriptive cohort
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Toulouse
Chronic Inflammatory Demyelinating Polyneuropathy, Multifocal Motor Neuropathy
Effect of Resistance and Aerobic Exercise in CIDP or MMN
Resistance and aerobic exercise has been shown to be effective for maintenance of muscle strength in patients with neuromuscular diseases. Exercise in CIDP and MMN is sparsely described.
- Trial name
- NCT02121678
- Testing
- Resistance training, Aerobic training
- Where
- 2 sites in Denmark
- Volunteers
- 23 people
- Sponsor
- University of Aarhus
Diabetic Foot, Critical Limb Ischemia
Safety and Efficacy Study of Urokinase for the Treatment of Diabetic Foot Syndrome and Critical Limb Ischemia
In this randomized clinical trial (RCT) the investigators are trying to find out whether a low-dose therapy with daily short infusions of urokinase using 10 to 21 doses over a maximum of 30 days is capable of prolonging the…
- Trial name
- August2 (NCT01638585)
- Testing
- urokinase
- Where
- 18 sites in Germany
- Volunteers
- 34 people
- Sponsor
- GWT-TUD GmbH
Diabetic Neuropathies, Painful, Diabetic Neuropathy Peripheral
Posterior Tibial Nerve PRF for Diabetic Neuropathic Pain
This study aimed to evaluate the efficacy of ultrasound (US)-guided posterior tibial nerve pulsed radiofrequency (PTN PRF) in the treatment of painful diabetic peripheral neuropathy (DPNP) refractory to conservative treatments.
- Trial name
- NCT06463015
- Testing
- ultrasound-guided posterior tibial nerve pulsed radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Diskapi Teaching and Research Hospital
Lumbar Disc Herniation, Lumbar Radiculopathy
Effects of SNAGS With and Without Pilates in Lumbar Disc Bulge Patients
The aim of this study is to compare the effects of Sustained Natural Apophyseal Glides with and without Pilates on pain, range of motion and disability in patients with lumbar Disc Bulge.
- Trial name
- NCT06076408
- Testing
- SNAGS with Pilates, SNAGS
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Hodgkin Lymphoma
Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial)
This phase II Pediatric MATCH trial studies how well tazemetostat works in treating patients with brain tumors, solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that have come back (relapsed) or do not respond to…
- Conditions
- Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Hodgkin Lymphoma, Ann Arbor Stage III Non-Hodgkin Lymphoma, Ann Arbor Stage IV Hodgkin Lymphoma
- Trial name
- NCT03213665
- Testing
- Tazemetostat
- Where
- 117 sites in United States, Puerto Rico
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
Neurofibromatosis Type 1
Reading Disability in Children With NF1
A national, multicenter, randomized, transverse clinical trial, estimating the existence of phonological deficits in children with NF1 children compared with control children without NF1 with the same reading level.
- Trial name
- NCT02397967
- Testing
- Neuropsychological assessments
- Where
- 6 sites in France
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Stroke
Repetitive Nerve Stimulation to Improve Recovery After Stroke
Upper limb paresis is the most common type of post-stroke neurological impairment and a major cause of functional disability. Repetitive peripheral sensory stimulation (RPSS) is a novel strategy to improve upper limb motor…
- Trial name
- RESTORES (NCT03956407)
- Testing
- Suprathreshold repetitive peripheral sensory stimulation, Subthreshold repetitive sensory stimulation
- Where
- Brazil
- Volunteers
- 51 people
- Sponsor
- Hospital Israelita Albert Einstein
Diabetic Foot, Diabetic Neuropathies
Placenta Derived Stem Cells for Treating of Chronic Ulcers and Neuropathy
This is an initial dose escalation safety and exploratory efficacy study to treat two groups of subjects with critically sized diabetic wounds and diabetic neuropathy using placental-derived stem cells (PDSC) transplanted by…
- Conditions
- Diabetic Foot, Diabetic Neuropathies, Diabetic Foot Ulcer
- Trial name
- PDSC (NCT06373809)
- Testing
- Transplantation of Placenta Derived Stem Cells
- Where
- 2 sites in Nicaragua
- Volunteers
- 20 people
- Sponsor
- Michael H Carstens
Meralgia Paresthetica, Lateral Femoral Cutaneous Nerve Entrapment
HILT for Meralgia Paresthetica
This randomized controlled trial aims to investigate the efficacy of High-Intensity Laser Therapy (HILT) in the management of Meralgia Paresthetica (MP), a peripheral neuropathy causing pain, numbness, and tingling in the thigh…
- Trial name
- NCT05893732
- Testing
- High-Intensity Laser Therapy (HILT)
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Ahram Canadian University
Diabetic Neuropathies
Differences In The Severity Of Diabetic Neuropathy Based On Electromyography In Type 2 Diabetes Mellitus Patients With And Without Comorbidities
The goal of this clinical trial is to learn the differences severity level of diabetic neuropathy based on electromyelography in type II diabetic patient with and without comorbidities. The main questions of this study: 1.
- Trial name
- DISNEY-T2DM (NCT06573684)
- Testing
- Electromyography
- Where
- Indonesia
- Volunteers
- 78 people
- Sponsor
- Universitas Diponegoro
Breast Cancer, Ovarian Neoplasm
Omega-3 Fatty Acid in Treating Pain in Patients With Breast or Ovarian Cancer Receiving Paclitaxel
Paclitaxel, a widely used chemotherapeutic agent, is associated with several well-known side effects including neuropathy (weakness, numbness and pain) and generalized body aches.
- Conditions
- Breast Cancer, Ovarian Neoplasm, Pain
- Trial name
- NCT01821833
- Testing
- Omega-3 fatty acid, Paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- New Mexico Cancer Research Alliance
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