Clinical trials: Peripheral Nerve Disorder
Breast Cancer
Taxane Induced Peripheral Neuropathy in Chinese Patients With Breast Cancer
The purpose of this study is to collect clinical data, blood samples, and self reported symptoms of peripheral neuropathy from Chinese patients with breast cancer after treatment with taxanes.
- Trial name
- NCT04068090
- Testing
- Patient Questionnaires, Blood Collection
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Capsaicin, Ultaviolet B Light Burn
A Mechanistic Evaluation of the Nociceptive Desensitizing Properties of Topical Capsaicin
The aim of this project is to study the role of transient receptor potential (TRP-) channel V1 (TRPV1+) fibers in the development of cutaneous inflammation induced by epidermal Ultraviolet-B damage.
- Conditions
- Capsaicin, Ultaviolet B Light Burn, Neuropathic Pain, Lidocaine
- Trial name
- NCT03587220
- Testing
- Capsaicin Topical, Ultraviolet-B (UVB) irradiation, Histamine 1%
- Where
- Denmark
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Diabetes, Peripheral Neuropathy
Motor Learning in Gait in Subjects With Diabetic Peripheral Neuropathy
The purpose of this study is to determine whether individuals with diabetic peripheral neuropathy can learn to change the way they walk in order to reduce the pressures underneath the feet, which may lead to a reduced risk of…
- Trial name
- NCT00223782
- Testing
- Gait Training with Feedback, Gait Training with no feedback
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- US Department of Veterans Affairs
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Genetic Architecture of Chronic Inflammatory Demyelinating Polyradiculoneuropathy
The objective of this study is to characterize the genetic architecture of a large cohort of CIDP patients to evaluate whether specific alleles/haplotypes are implicated in the risk of CIDP, in its clinical and immunological…
- Trial name
- GEARCIDP (NCT06325878)
- Testing
- Genome-wide association study
- Where
- Italy
- Volunteers
- 3,500 people
- Sponsor
- Istituto Clinico Humanitas
Carpal Tunnel Syndrome, Compression Neuropathy
Acetyl-l-carnitine to Enhance Nerve Regeneration in Carpal Tunnel Syndrome
Study Hypothesis: Acetyl-l-carnitine increases nerve regeneration in patients with severe carpal tunnel syndrome. Carpal tunnel syndrome (CTS) is common, affecting almost 3% of the general population.
- Trial name
- NCT02141035
- Testing
- Acetyl-l-carnitine
- Where
- 3 sites in Canada
- Volunteers
- 20 people
- Sponsor
- University of Alberta
Sarcoma
Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma
RATIONALE: Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.
- Trial name
- NCT00740597
- Testing
- gene expression analysis, polymerase chain reaction, western blotting
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- City of Hope Medical Center
Carpal Tunnel Syndrome
Effects of Whole Wrist Versus Specific Carpal Bone Mobilization in the Patients of Carpel Tunnel Syndrome
The study was conducted to compare the effectiveness of Whole Wrist Mobilization versus Specific Carpal Bone Mobilization in reducing symptoms and improving function in patients with Carpal Tunnel Syndrome (CTS).
- Trial name
- NCT07724717
- Testing
- Specific Bone Mobilization, Whole Wrist Mobilization, Standardized Physiotherapy Treatment
- Where
- 2 sites in Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Peripheral Neuropathy, Cancer
L-carnosine Prophylactic Effect on Oxaliplatin Induced Peripheral Neuropathy in GIT Cancer Patients
This study evaluates the prophylactic effect of exogenous L-CARNOSINE in Oxaliplatin induced peripheral neuropathy, Thus half of the patients will receive L-CARNOSINE with Oxaliplatin and the other half will not receive…
- Trial name
- NCT02808624
- Testing
- L-CARNOSINE
- Where
- Egypt
- Volunteers
- 65 people
- Sponsor
- Cairo University
Dropfoot
Evaluation of Dual Channel vs. Single Channel FES for Dropfoot
Seventy (70) subjects put on the Ness L300 System, a FES device for ankle dorsiflexion for patients with foot drop. Stimulation will be given through two different electrodes: the QFE which is a single channel stimulation, and…
- Trial name
- NCT02494323
- Testing
- Functional Electrical Stimulation
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Bioness Neuromodulation
Diabetic Peripheral Neuropathy, Diabetic Neuropathy
Effect of Melatonin in Patients With Diabetic Peripheral Neuropathy
The aim of the current study is to measure the effect of melatonin as adjunct therapy on oxidative stress, inflammatory markers and clinical outcome in type 2 diabetic patients with diabetic peripheral neuropathy.
- Conditions
- Diabetic Peripheral Neuropathy, Diabetic Neuropathy, Diabetic Peripheral Neuropathy in Type 2 Diabetic Patients
- Trial name
- NCT07036796
- Testing
- Melatonin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Painful Diabetic Peripheral Neuropathy
Exploratory Study of MT-8554 in Subjects With Painful Diabetic Peripheral Neuropathy
The purpose of this study is to investigate the efficacy, safety, tolerability and pharmacokinetics of MT-8554, compared to placebo, in subjects with painful diabetic peripheral neuropathy.
- Trial name
- NCT05123196
- Testing
- MT-8554
- Where
- 33 sites in Japan
- Volunteers
- 156 people
- Sponsor
- Tanabe Pharma Corporation
Metastatic Chondrosarcoma, Locally Advanced Chondrosarcoma
Enasidenib in IDH2-Mutated Malignant Sinonasal and Skull Base Tumors
Background: Cancers of the nasal cavity or skull base are rare. They often are not diagnosed until they are at an advanced stage, and they often spread to other parts of the body.
- Conditions
- Metastatic Chondrosarcoma, Locally Advanced Chondrosarcoma, Metastatic Sinonasal Adenocarcinoma, Locally Advanced Sinonasal Adenocarcinoma
- Trial name
- NCT06176989
- Testing
- Enasidenib
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
Lumbosacral Radicular Pain
A Research Study to Characterize the Pharmacodynamics and Safety of Repeat Dose SP-102
This is an open-label, single-arm, repeat dose study to characterize the pharmacodynamics and safety/tolerability of SP-102 administered by epidural injection.
- Trial name
- NCT03613662
- Testing
- SP-102
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Semnur Pharmaceuticals, Inc.
Cancer
Vaccine Therapy in Treating Patients Who Have Undergone a Donor Stem Cell Transplant and Have Cytomegalovirus Infection That Has Not Responded to Therapy
RATIONALE: Vaccines may help the body build an effective immune response to kill cytomegalovirus infections. PURPOSE: This phase I trial is studying the side effects and best dose of vaccine therapy in treating patients who have…
- Trial name
- NCT00509691
- Testing
- cytomegalovirus pp65-specific cytotoxic T lymphocytes, polymerase chain reaction, diagnostic laboratory biomarker analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Louisville
Carpal Tunnel Syndrome
Assessment of Ultrasound Findings, Nerve Test Results, and Hand Function in Patients With Carpal Tunnel Syndrome
Carpal tunnel syndrome is one of the most common conditions caused by compression of a nerve at the wrist. It can lead to numbness, tingling, pain, weakness, and difficulty performing daily activities.
- Trial name
- NCT07752797
- Testing
- Ultrasonographic and Clinical Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 109 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Diabetic Peripheral Neuropathy
Comparison of Proprioceptive Neuromuscular Training and Sensory Re-education in Patients With Diabetic Peripheral Neuropathy
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus and is associated with sensory loss, impaired proprioception, balance deficits, and altered gait patterns, which significantly increase the risk…
- Trial name
- PNF-SR in DPN (NCT07380880)
- Testing
- Sensory Re-Education Program, Proprioceptive Neuromuscular Training
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Montiha Azeem
Neuroma
ALGRX 4975 in the Treatment of Patients With Morton's Neuroma
Subjects will have painful primary or post-operative intermetatarsal neuroma. Study drug or placebo will be injected into the space containing the neuroma.
- Trial name
- NCT00130962
- Testing
- ALGRX 4975
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- AlgoRx Pharmaceuticals
Peripheral Arterial Disease, Diabetic Foot
Efficacy and Safety of Intramuscular PDA-002 in Subjects With Diabetic Foot Ulcer With and Without PAD.
This is a Phase 2, multicenter, randomized, double-blind, placebo-controlled, dose-ranging study evaluating the efficacy and safety of intramuscular administration of human placenta-derived cells (PDA-002) in subjects with…
- Trial name
- DFU-002 (NCT02264288)
- Testing
- PDA-002
- Where
- 45 sites in United States
- Volunteers
- 159 people
- Sponsor
- Celularity Incorporated
Adult Angiosarcoma, Adult Desmoplastic Small Round Cell Tumor
Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma
This phase I trial is studying the side effects and best dose of cixutumumab given together with doxorubicin hydrochloride and to see how well they work in treating patients with unresectable, locally advanced, or metastatic soft…
- Conditions
- Adult Angiosarcoma, Adult Desmoplastic Small Round Cell Tumor, Adult Epithelioid Sarcoma, Adult Extraskeletal Myxoid Chondrosarcoma
- Trial name
- NCT00720174
- Testing
- Cixutumumab, Doxorubicin Hydrochloride, Laboratory Biomarker Analysis
- Where
- 13 sites in United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Vestibular Schwannoma, Vestibular Function Disorder
Role of Psychiatric Profile in Prehabituated Patients After Vestibular Schwannoma Surgery
The aim of this study is to assess effect of psychiatric profile on visual sensitivity and overall health status in patients who underwent surgery for vestibular schwannoma and were prehabituated by chemical vestibular ablation.
- Trial name
- NCT03638310
- Testing
- intratympanic application of gentamicin, microsurgical removal of vestibular schwannoma
- Where
- Czechia
- Volunteers
- 37 people
- Sponsor
- Charles University, Czech Republic
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