Clinical trials: Peripheral Nerve Disorder
Complex Regional Pain Syndrome
Treatment of Complex Regional Pain Syndrome
This study will investigate the feasibility of using repetitive transcranial magnetic stimulation (rTMS) and a sensorimotor training task to treat symptoms of pain in patients with complex regional pain syndrome (CRPS).
- Trial name
- NCT05197959
- Testing
- Repetitive transcranial magnetic stimulation, Sensorimotor training
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- McMaster University
Brain Tumor, Central Nervous System Tumor
High-Dose Chemotherapy Plus Autologous Stem Cell Transplantation Compared With Intermediate-Dose Chemotherapy Plus Autologous Stem Cell Transplantation With or Without Isotretinoin in Treating Young Patients With Recurrent High-Grade Gliomas
RATIONALE: Drugs used in chemotherapy, such as carboplatin, thiotepa, and etoposide, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00078988
- Testing
- filgrastim, carboplatin, etoposide
- Where
- 59 sites in United States, Australia and 1 more
- Volunteers
- 1 people
- Sponsor
- Children's Oncology Group
Polyneuropathies
Ultrasonography in Diagnosis of Polyneuropathy
The main goal of this trial is to establish recommendations for clinical practice that enhance the reliability, accessibility and convenience of sheer wave elastography as a routine diagnostic test for diverse peripheral…
- Trial name
- NCT06390527
- Volunteers
- 120 people
- Sponsor
- University Medical Centre Ljubljana
Urge Urinary Incontinence, Overactive Bladder (OAB)
Effect of Neuromodulation and Therapeutic Exercise in Urinary Incontinence
Urge urinary incontinence (UUI) is a component of the condition known as overactive bladder, a severe and debilitating chronic disorder affecting healthcare systems worldwide.
- Trial name
- UCV/INCONTINEN (NCT06783374)
- Testing
- Neuromodulation, Exercise, Exercise control group
- Where
- Spain
- Volunteers
- 63 people
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir
Diabetic Neuropathy, Painful
A Long-Term Study To Evaluate Safety And Efficacy Of Pregabalin For Pain Associated With Diabetic Peripheral Neuropathy
The purpose of this study is to assess the safety and efficacy of the long-term use of pregabalin at doses up to 600 mg/day in patients with painful diabetic peripheral neuropathy who have completed 13 weeks of dosing in Study…
- Trial name
- NCT00553280
- Testing
- pregabalin
- Where
- 27 sites in Japan
- Volunteers
- 123 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Neuropathic Pain
Brain Computer Interface and Virtual Reality (BCI-VR) for Pain Treatment
Pilot Interventional study with minimal risks and constraints, prospective, monocentric. Safety and Efficacity evaluation of a Novel Medical Device.
- Trial name
- GHOST (NCT03889353)
- Testing
- BCI sessions
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Nantes University Hospital
Diabetic Peripheral Neuropathy
Efficacy and Safety Study of Pregabalin in the Treatment of Pain on Walking in Patients With Diabetic Peripheral Neuropathy (DPN)
The intent of this study is to treat subjects with painful Diabetic Peripheral Neuropathy (DPN) who also have pain on walking and to determine whether or not pregabalin demonstrates improvement relative to placebo on the…
- Trial name
- NCT01474772
- Testing
- Pregabalin
- Where
- 45 sites in United States, Czechia and 2 more
- Volunteers
- 217 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Lumbar Radiculopathy, Pain, Intractable
Radiocontrast Media in the Pulsed Radiofrequency Treatment
Pulsed radiofrequency applied to the dorsal root ganglion (DRG) is an interventional treatment alternative in the treatment of lumbar radicular pain that does not respond to conservative methods.
- Trial name
- NCT04876469
- Testing
- Pulsed Radiofrequency treatment of the lumbar dorsal root ganglion
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sanliurfa Education and Research Hospital
Radiculopathy, Lumbosacral Region
Diagnostic Validity of the Neurodynamic or Orthopedic Tension Tests
The objective of the present study is to analyse the diagnostic validity of 8 neurodynamic and/or orthopedic tension tests using magnetic resonance imaging as the Gold Standard.
- Trial name
- NCT04485572
- Testing
- Straight Leg Raise test (SLR) and Bragard test (B), Fajersztajn test (F) and Sicard test (S), Passive Neck Flexion test (PNF)and Kernig test (K)
- Volunteers
- 1,887 people
- Sponsor
- University of Extremadura
Acute Pain
Effect of Remote Local Peripheral Nerve Cooling on Pain of Arterial Puncture
In this project, volunteers will be recruited to cool the superficial skin of the axillary brachial plexus away from the puncture point, resulting in local peripheral nerve cooling, and observe its impact on the pain of arterial…
- Trial name
- NCT06838572
- Testing
- Skin cooling to 20°C, Skin cooling to 15°C, Skin cooling to 8°C
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
PIK3CA-related Overgrowth Spectrum, CLOVES Syndrome
National Evaluation of Patients With PIK3CA-Related Overgrowth Spectrum (PROS)
Overgrowth syndromes are rare genetic disorders defined by tissue hypertrophy that can be either localized or generalized, affecting both latitudinal and longitudinal growth.
- Conditions
- PIK3CA-related Overgrowth Spectrum, CLOVES Syndrome, Klippel Trenaunay Syndrome, Megalencephaly
- Trial name
- COSY (NCT05563831)
- Testing
- national registry
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Pain, Osteoarthritis
Impact of Peripheral Nerve Blockade on Outcomes After Total Knee Replacement
Pain is common after knee replacement surgery and can impact a variety of patient outcomes. Peripheral nerve blocks provide improved pain control and may improve function.
- Trial name
- NCT02742961
- Testing
- Peripheral nerve block
- Where
- Canada
- Volunteers
- 178,214 people
- Sponsor
- Ottawa Hospital Research Institute
Neuropathy;Peripheral
Transcutaneous Pulsed Radiofrequency in Diabetic Polyneuropathy
Investigators want to investigate the efficacy of transcutaneous pulsed radiofrequency therapy in the treatment of diabetic peripheral neuropathy symptoms.
- Trial name
- NCT05480527
- Testing
- Transcutaneous pulsed radiofrequency current
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Diskapi Teaching and Research Hospital
Burn Scar Pain, Neuropathic Pain
Ultrasound Predictors of Persistent Burn Scar Pain After Blast and Drone-Related Injuries: A Prospective Cohort Study
Persistent burn scar pain is common after blast and drone-related injuries and may be driven by scar fibrosis, vascular activity, and peripheral nerve involvement within scar tissue.
- Conditions
- Burn Scar Pain, Neuropathic Pain, Combat-Related Burn Injury, Scar-Related Pain
- Trial name
- US-SCAR-PAIN (NCT07438769)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Lumbar Disc Herniation
Clinical Research on the Efficacy of Thread-embedding Acupuncture on Herniated Intervertebral Disc of Lumbar Spine
This clinical trial is designed to evaluate the efficacy and safety of thread-embedding acupuncture for treatment of lumbar herniated intervertebral disc (L-HIVD) by assessing pain, function, and quality of life.
- Trial name
- NCT03236753
- Testing
- Thread-embedding Acupuncture (TEA)
- Where
- 4 sites in South Korea
- Volunteers
- 70 people
- Sponsor
- Kyunghee University Medical Center
Neuralgia, Neuropathic Peripheral Pain
Efficacy of Valproate in Peripheral Neuropathic Pain
The purpose of this study is to determine whether valproate is effective and well tolerated in the treatment of neuropathic peripheral pain. The drug is administered by intravenous route followed by oral route during 4 weeks.
- Trial name
- NCT00221637
- Testing
- Sodium Valproate
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Bordeaux
Traumatic Brain Injury
Effects of Intranasal Nerve Growth Factor for Traumatic Brain Injury
Traumatic bain injury(TBI) remains a hidden epidemic involving individuals affected predominantly at a young age who in the most severe cases remain with permanent physical,psychological and cognitive deficits.This study will…
- Trial name
- NCT01212679
- Testing
- nerve growth factor, nomral saline
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Jinling Hospital, China
Urethral Stricture
Intraoperative Lidocaine or Dexmedetomidine for Postoperative Pain Modulation After Urethral Reconstruction.
The development of chronic postoperative pain (CPP) following surgery is influenced by several factors, among which the intensity of acute postoperative pain in the immediate perioperative period and mechanisms related to nerve…
- Trial name
- NCT07676942
- Testing
- Perioperative lidocaine infusion, Perioperative dexmedetomidine infusion
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Centre of Postgraduate Medical Education
Diabetic Neuropathy
FDGL Dose-Finding Study for Diabetic Neuropathy
This study investigates the optimal dose of fermented deglycyrrhizinated licorice (FDGL) that maximizes both safety and efficacy in managing diabetic neuropathy complications in adults.
- Trial name
- NCT07117942
- Testing
- Fermented Deglycyrrhizinated Licorice (FDGL)
- Where
- Egypt
- Volunteers
- 485 people
- Sponsor
- Helwan University
Lymphoma, Peripheral Neuropathy
Chemotherapy Induced Peripheral Neuropathy (CIPN) and Lymphoma Longitudinal Follow-up and Prognostic Factors
Vincristine-induced peripheral neuropathy, which is commonly a sensorimotor neuropathy, remains a major complication of lymphoma patients treated with R-CHOP.
- Trial name
- NeuroTox-L (NCT05378256)
- Testing
- Clinical scales of CIPN
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
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