Clinical trials: Peripheral Nerve Disorder
Piriformis Syndrome
Effects of MET and MFR on Piriformis Syndrome
The aim of this study is to comparatively evaluate the effects of two different manual therapy approaches, Muscle Energy Technique (MET) and Myofascial Release Technique (MFR), on pain threshold, muscle activation patterns, and…
- Trial name
- NCT07769203
- Testing
- Muscle Energy Technique, Myofascial Release Technique, Conventional Physical Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Igdir University
Peripheral Neuropathy
L-glutamine Supplementation to Alleviate Symptoms of Taxane-Induced Neuropathy in Patients With Breast Cancer
The purpose of the study is to determine whether daily, high-dose administration of l-glutamine can reduce numbness and tingling caused by a taxane chemotherapy in patients with breast cancer.
- Trial name
- NCT02215083
- Testing
- L-glutamine
- Where
- United States
- Sponsor
- Eastern Regional Medical Center
Diabetes Complications, type1diabetes
Early Detection of Long-term Diabetic Complications in Children and Adolescents With Type 1 Diabetes
Aims: To investigate early markers of long-term diabetic complications and the association to an extended glucose metabolic profile comprising glucose control (current and past), glucose variability and insulin sensitivity in…
- Conditions
- Diabetes Complications, type1diabetes, Children, Only, Diabetic Neuropathies
- Trial name
- NCT05159856
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Steno Diabetes Center Copenhagen
Polyneuropathies and Other Disorders of the Peripheral Nervous System, Chemotherapy Induced Neuropathic Pain
Trial of Quercetin in the Treatment and Prevention of Chemotherapy-induced Neuropathic Pain in Cancer Patients
The goal of this clinical research study is to learn about the effectiveness of quercetin in treating and preventing CINP. Researchers also want to learn if quercetin has an effect on participant's quality of life.
- Trial name
- NCT02989129
- Testing
- Questionnaires, Quercetin
- Sponsor
- M.D. Anderson Cancer Center
Advanced Solid Tumors
Phase I Trial of Oral PX-866
This study is being conducted to determine the safety and maximally tolerated dose of PX-866 when given orally on two different schedules: daily on days 1-5 and 8-12 of a 28 day cycle and daily on days 1-28 of a 28 day cycle.
- Trial name
- NCT00726583
- Testing
- PX-866
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Cascadian Therapeutics Inc.
Male Breast Cancer, Recurrent Adenoid Cystic Carcinoma of the Oral Cavity
Alvespimycin Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors
This phase I trial is studying the side effects and best dose of alvespimycin hydrochloride in treating patients with metastatic or unresectable solid tumors.
- Conditions
- Male Breast Cancer, Recurrent Adenoid Cystic Carcinoma of the Oral Cavity, Recurrent Basal Cell Carcinoma of the Lip, Recurrent Breast Cancer
- Trial name
- NCT00089362
- Testing
- alvespimycin hydrochloride, laboratory biomarker analysis, pharmacological study
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Carpal Tunnel Syndrome (CTS)
Radial Pressure Wave Therapy With or Without Parameter Modulation for Carpal Tunnel Syndrome.
This study aims to evaluate the clinical effects of radial pressure wave therapy in patients with a confirmed diagnosis of mild to moderate carpal tunnel syndrome.
- Trial name
- RPWT in CTS (NCT07070661)
- Testing
- Fixed-Dose Radial Pressure Wave Therapy., Modulated-Dose Radial Pressure Wave Therapy.
- Where
- Mexico
- Volunteers
- 44 people
- Sponsor
- Armando Tonatiuh Avila Garcia
Radiculopathy, Lumbar Disc Herniation
The Effect of Combination of Ultrasound and Flouroscopy Guidance in Caudal Epidural Injections
The primary purpose of this study is to asses the effect of caudal epidural injection guided by a combination of ultrasound and fluoroscopy on the duration of the procedure and the amount of radiation exposed during the…
- Conditions
- Radiculopathy, Lumbar Disc Herniation, Spinal Stenosis
- Trial name
- NCT05145842
- Testing
- floroscopy, ultrasound+fluoroscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Breast Cancer
Chemotherapy-Induced Peripheral Neuropathy - Additional Evaluation in Breast Cancer Survivors
The main goal of this trial is to identify the optimal cut-off score of a Scoring System to discriminate between mild chemotherapy-induced peripheral neuropathy (CIPN) and no CIPN in breast cancer survivors previously treated…
- Trial name
- NEURO-BREAC-02 (NCT07604441)
- Testing
- Symptom-based scoring system
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- University Hospital Schleswig-Holstein
Breast Cancer
Effectiveness of Cryotherapy Combined With Compression Therapy for Preventing Chemotherapy-induced Peripheral Neuropathy
This is a prospective, multi-center, randomized study designed to evaluate the clinical efficacy of cryotherapy combined with compression therapy in preventing albumin-paclitaxel induced peripheral neuropathy.
- Trial name
- NCT05341141
- Testing
- Frozen glove and sock, ddEC-ddT
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Peking University
Neuropathy, AIDS
Safety and Preliminary Evidence of Efficacy of Escalating Doses of Dimiracetam in AIDS Patients With Painful Neuropathy
One hundred consenting AIDS patients suffering from treatment induced painful neuropathy will be blindly randomize to Active and Placebo groups (ratio A/P = 3/2 and will receive increasing oral doses of dimiracetam starting from…
- Trial name
- NCT01135251
- Testing
- dimiracetam, sugar pill
- Where
- South Africa
- Volunteers
- 116 people
- Sponsor
- Neurotune AG
Pain, Chronic, Lumbar Radiculopathy
Study on the Use of Intraoperative Neurophysiological Monitoring in Spinal Cord Stimulator Trials
This is an observational pilot study. The spinal cord stimulator (SCS) procedure and neuromonitoring device is not under investigation. Neuromonitoring is typically performed on this patient population receiving SCS trials here.
- Conditions
- Pain, Chronic, Lumbar Radiculopathy, SCS
- Trial name
- SCS-Monitor (NCT05540756)
- Where
- United States
- Sponsor
- University of Chicago
Hereditary Spastic Paraplegia, Neurodegenerative Diseases
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)
The purpose of the HSP Sequencing Initiative is to better understand the role of genetics in hereditary spastic paraplegia (HSP) and related disorders.
- Conditions
- Hereditary Spastic Paraplegia, Neurodegenerative Diseases, Pediatric Disorder, Spasticity, Muscle
- Trial name
- NCT05354622
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Boston Children's Hospital
Transthyretin Amyloidosis, Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy
Biomarker for Transthyretin-Related Familial Amyloidotic Polyneuropathy (BioTRAP)
International, multicenter, observational, longitudinal study to identify biomarker/s for the development of a new MS-based biomarker for the early and sensitive diagnosis of Transthyretin-Related Familial Amyloidotic…
- Conditions
- Transthyretin Amyloidosis, Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy, Transthyretin Amyloid Cardiopathy
- Trial name
- BioTRAP (NCT02713880)
- Where
- 2 sites in Germany, India
- Sponsor
- CENTOGENE GmbH Rostock
Chemotherapy-induced Peripheral Neuropathy
A New Method for Identifying Sensory Changes in Painful Chemotherapy-induced Peripheral Neuropathy (CIPN)
The investigators propose that using the Diode Laser fiber type Selective Stimulator (DLss) in patients with chemotherapy-induced peripheral neuropathy (CIPN) will allow for the assessment of changes in small-fiber pain…
- Trial name
- NCT03687970
- Testing
- Brief Pain Inventory, Hospital Anxiety and Depression Scale, Neuropathic Pain Symptom Inventory
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Washington University School of Medicine
Spinal Cord Diseases, Spinal Cord Injuries
An Open-Label Long-Term Study Of Pregabalin For The Treatment Of Central Neuropathic Pain
The purpose of this study is to assess the safety of the long-term use of pregabalin at doses up to 600 mg/day in patients with central neuropathic pain (post spinal cord injury pain, post stroke pain, and multiple sclerosis…
- Conditions
- Spinal Cord Diseases, Spinal Cord Injuries, Neuralgia, Pain
- Trial name
- NCT01202227
- Testing
- pregabalin
- Where
- 26 sites in Japan
- Volunteers
- 104 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Posterior Cervical Spinal Surgery, Myelopathy Cervical
Cervical Orthosis Versus no Orthosis Following Multi-level Posterior Cervical Fusion
Use of cervical orthosis after instrumented posterior cervical spinal surgery is still widely practiced even though modern fusion techniques likely do not require additional stabilization from an external orthosis.
- Conditions
- Posterior Cervical Spinal Surgery, Myelopathy Cervical, Radiculopathy, Cervical, Spinal Stenosis Cervical
- Trial name
- NCT04308122
- Testing
- Cervical Orthosis (CO), No Orthosis
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Dr. Christopher Bailey
Cervical Radiculopathy
Effect of Manual Therapy on Sensory Features in Patients With Cervical Radiculopathy
Background \& Purpose: Cervical radiculopathy is a neurological disorder, which commonly results because of nerve compression. There are different types of physical therapy interventions that are used for cervical radiculopathy.
- Trial name
- NCT03328351
- Testing
- manual therapy, Superficial soft tissue massage
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 28 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Spinal Cord Injury + Peripheral Nerve Diseases
Assessment of Neuropathic Pain
Development of neuropathic pain is one of the most disabling sequels after spinal cord injury (SCI) and in peripheral nerve diseases.
- Trial name
- NCT02138344
- Where
- Switzerland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Chemotherapy-induced Peripheral Neuropathy (CIPN)
Efficacy of External Application of Rosemary Oil in Patients With Chemotherapy-Induced Peripheral Neuropathy: a Feasibility Study
Chemotherapy can cause sensory disorders in the hands and feet called peripheral neuropathy. Typical symptoms are pain, loss of sensation, tingling, numbness, and gait disturbances, which worsen patients' quality of life and…
- Trial name
- NCT05855044
- Testing
- Rosemary oil application
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
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