Clinical trials: Peripheral Nervous System Diseases
- Condition Peripheral Nervous System Diseases
- Funder type Industry (pharma, biotech, devices)
- Accepts healthy volunteers yes
Pain, Neuropathic, Neuropathic Pain
Effect of GSK1014802 on Electrical Hyperalgesia and Threshold Tracking in Healthy Subjects
This study is being conducted to assess the effects of GSK1014802 and a positive control, lidocaine, on tests of peripheral nerve excitability. This will be a double blind, placebo controlled, 4-period cross over study.
- Trial name
- NCT00964288
- Testing
- GSK1014802 low dose, Lidocaine, GSK1014802 high dose
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Biogen
Healthy Volunteers
A Study to Determine the Relative Bioavailability of Capsule and Tablet Formulations of GDC-0941 and the Effect of Food and Proton Pump Inhibition on GDC-0941 Tablet Pharmacokinetics in Healthy Volunteers
This is a Phase I, randomized, two-part, single-center pharmacokinetics (PK) study to assess the relative bioavailability of capsule and tablet formulations of GDC-0941 in the fasted state (Part 1) and to determine the effect of…
- Trial name
- NCT00999128
- Testing
- GDC-0941, rabeprazole
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Familial Amyloid Polyneuropathy (FAP)
Study of SOM0226 in Familial Amyloid Polyneuropathy
Clinical proof of concept study to evaluate SOM0226 efficacy in TTR Amyloidosis.
- Trial name
- NCT02191826
- Testing
- SOM0226
- Where
- Spain
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- SOM Innovation Biotech SA
Pain, Neuropathic Pain
Radicle Relief 2: A Study of Health and Wellness Products on Pain and Health Outcomes
A randomized, blinded, placebo-controlled study assessing the impact of health and wellness products on pain and other health outcomes
- Conditions
- Pain, Neuropathic Pain, Nociceptive Pain
- Trial name
- NCT05837923
- Testing
- Relief Active Study Product 1.1 Usage, Relief Active Study Product 1.2 Usage, Relief Active Study Product 2.1 Usage
- Where
- United States
- Volunteers
- 2,016 people, healthy volunteers welcome
- Sponsor
- Radicle Science
Herpes Zoster, Shingles
ZOSTAVAX™ (Zoster Vaccine Live) Long-term Effectiveness Study (V211-024)
This study will describe the impact of vaccination with ZOSTAVAX™ on the epidemiology of herpes zoster (HZ) in a cohort of vaccinated participants 50 years or age or older, compared to a cohort of unvaccinated participants.
- Trial name
- NCT01600079
- Testing
- ZOSTAVAX™
- Volunteers
- 1,505,647 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Alzheimer Disease
ADDIA Chronobiological Study
The present single center clinical chronobiological study on 24 subjects (12 patients with mild to moderate form of Alzheimer's disease and 12 Healthy subjects) aims at characterizing the ADDIA biomarkers: a) blood cell-based…
- Trial name
- NCT02973971
- Testing
- volumeric MRI
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Amoneta Diagnostics SAS
Neuropathic Pain
Safety, Tolerability and Pharmacokinetics of Single Ascending Doses of REL-1017 (d-Methadone)
This study evaluated the safety, tolerance, and pharmacokinetics (PK) of d-methadone in a limited dose range, in single administrations in humans.
- Trial name
- NCT03637361
- Testing
- REL-1017
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Relmada Therapeutics, Inc.
Neuropathic Pain
Evaluation of an ATP-Containing Parenteral Vitamin B Complex in Patients With Symptomatic Diabetic Polyneuropathy
Epinosine B Forte ampoule is an intramuscular injectable supplement containing adenosine triphosphate (ATP), Cocarboxylase (vitamin B1 derivative), vitamin B12, and nicotinamide (vitamin B3).
- Trial name
- NCT07296354
- Testing
- adenosine triphosphate, Vitamin B Complex
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Egyptian International Pharmaceutical Industries Co
Peripheral (Sensorimotor) Diabetic Polyneuropathy
To Assess the Bioequivalence of Test Oral Formulation of Alpha Lipoic Acid 600 mg HR Film Coated Tablets of Ilko Ilac San. Ve Tic. A.S. Versus Reference Thioctacid (Alpha Lipoic Acid) 600 mg HR Film Coated Tablets of Meda Pharma GmbH& CO .KG, Germany.
To assess the bioequivalence of test oral formulation of Alpha Lipoic acid 600 mg HR film coated tablets of Ilko Ilac San. Ve Tic. A.S.
- Trial name
- NCT04214665
- Testing
- Alpha Lipoic acid 600 mg HR film coated tablets
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ilko Ilac San. ve Tic. A.S.
Compartment Syndrome
Study of New Catheter & Pressure Monitor System to Help Prevent Compartment Syndrome From Developing in the Injured Leg
An investigation of a new catheter and pressure monitor system that may help to prevent a complication called compartment syndrome from developing in an injured leg.
- Trial name
- TS2 (NCT00681616)
- Testing
- Compartment Monitoring System (CMS), Compartment Monitoring System with Active Fluid Removal, Compartment Monitoring System without fluid removal
- Where
- 13 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Twin Star Medical, Inc.
Neuropathic Pain, Peripheral Neuropathy
Axon Therapy for Post-Traumatic Peripheral Neuropathic Pain Compared to Conventional Medical Management
Compare Axon Therapy using transcutaneous magnetic stimulation (tMS) against conventional medical management in treating post-traumatic peripheral neuropathic pain (PTPNP).
- Trial name
- NCT04795635
- Testing
- CMM + Axon Therapy
- Where
- 3 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- NeuraLace Medical, Inc.
Pain, Nociceptive Pain
Radicle Relief 1: A Study of Health and Wellness Products on Pain and Other Health Outcomes
A randomized, blinded, placebo-controlled study assessing the impact of health and wellness products on pain and other health outcomes
- Conditions
- Pain, Nociceptive Pain, Neuropathic Pain
- Trial name
- NCT05589935
- Testing
- Relief Study Product Usage
- Where
- United States
- Volunteers
- 457 people, healthy volunteers welcome
- Sponsor
- Radicle Science
Diabetic Neuropathy Peripheral
Study on Safety, Absorption and Metabolism of SYHA1402 Tablets in Healthy People
The trial used single-center, randomized, double-blind, placebo-controlled, single-dose study. The trial planned to enroll sixty-two healthy volunteers.
- Trial name
- NCT03988413
- Testing
- 25mg, 50mg, 100mg
- Where
- China
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Healthy Volunteer
Evaluating the Safety, Tolerability, and Pharmacokinetics of BIIB095 in Healthy Participants
The primary objective of the study is to evaluate the safety and tolerability of single- and multiple-ascending oral doses of BIIB095 in healthy participants.
- Trial name
- NCT03454126
- Testing
- BIIB095
- Where
- 2 sites in United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Biogen
Pain, Neuropathic, Pain, Inflammatory
Phase I Single Ascending Dose and Multiple Ascending Doses of Oral AFA-281 in Healthy Volunteers
Phase I Part 1 (single ascending dose): Double-blind dosing will occur in healthy volunteers in 4 cohorts of 8 subjects each. Six subjects in each cohort will be randomized to receive AFA-281 and 2 subjects will be randomized to…
- Trial name
- NCT05547503
- Testing
- AFA-281
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Afasci Inc
Neuropathic Pain
The Pharmacokinetics of GLA5PR Tablet According to the Renal Function
To evauate pharmacokinetics of GLA5PR tablet according to the renal function
- Trial name
- NCT03963362
- Testing
- GLA5PR tablet 75 mg, GLA5PR tablet 150 mg
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GL Pharm Tech Corporation
Diabetic Peripheral Neuropathy, Fibromyalgia
Pharmacokinetics of Two Formulation of Pregabalin
A Randomized, Single-Dose, Parallel-Group Study to Evaluate the Pharmacokinetic Profiles of Two Formulations of Pregabalin after Oral Administration in Healthy Volunteers under Fasting Conditions
- Conditions
- Diabetic Peripheral Neuropathy, Fibromyalgia, Partial Seizure Disorder
- Trial name
- NCT03712475
- Testing
- Pregabalin
- Where
- Taiwan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yung Shin Pharm. Ind. Co., Ltd.
Healthy
Study to Evaluate Safety, Tolerability and Pharmacokinetics of rhNGF Eye Drops in Healthy Volunteers
The primary objective of this study is to assess the safety and tolerability of single and multiple ascending doses of rhNGF when administered as eye drops in healthy subjects.
- Trial name
- NGF0112 (NCT01744704)
- Testing
- rhNGF 0.5 µg/mL Sentinel, rhNGF 5 µg/mL Sentinel, rhNGF 20 µg/mL Sentinel
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Dompé Farmaceutici S.p.A
Diabetic Neuropathies, Diabetic Neuropathy Peripheral
A Study Evaluating Drug-Drug Interaction (DDI) Between HSK16149 Capsules and Metformin Hydrochloride Tablets
This study is a single-center, open, single-arm study, conducted in healthy Chinese populations, and plans to enroll 22 healthy adult subjects (the ratio of either sex is not less than 1/3).
- Trial name
- NCT04841720
- Testing
- HSK16149, Metformin Hydrochloride tablet, HSK16149+Metformin（phase 3）
- Where
- China
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Postherpetic Neuralgia
New Topical Treatment for Continued Pain After Shingles
Shingles is an outbreak of rash or blisters on the skin that is caused by the same virus that causes chicken pox. Some people experience continued pain even after the shingles rash and blisters have healed; this pain is known as…
- Trial name
- NCT00566904
- Testing
- Epikeia coatings with aspirin, Epikeia coatings with lidocaine, Epikeia coatings alone
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Biomedical Development Corporation