Clinical trials: Peripheral Neuropathy Pain
Radiculopathy, Herniated Disk
Percutaneous Diskectomy SpineJet x Open Microdiskectomy in Treatment of Lumbar Radiculopathy
Approximately 300,000 patients undergo open surgical procedures to treat symptoms caused by disc herniation. Among the various surgical techniques practiced the percutaneous discectomy occupies its space since the first…
- Trial name
- PDOP_TLR (NCT01367860)
- Testing
- Open microdiscectomy, Percutaneous Diskectomy SpineJet
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Chronic Pain, Low Back Pain
High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System
Study designed to compare the conventional stimulation programming versus the high frequency stimulation programming of the spinal cord stimulator for subjects who already have a spinal cord stimulator.
- Conditions
- Chronic Pain, Low Back Pain, Radiculopathy, Complex Regional Pain Syndrome (CRPS)
- Trial name
- HFSCS (NCT02265848)
- Testing
- High frequency stimulation, Low frequency stimulation
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The Center for Clinical Research, Winston-Salem, NC
Pain, Neuropathic, Pain, Acute
Ice Immersion Using Virtual Reality & Augmented Reality
The purpose of this study is to evaluate the effectiveness of different technologies, Virtual Reality and Augmented Reality with modifications as passive content, active content, cognitive load modulation, and positive…
- Trial name
- NCT04196686
- Testing
- VR/AR, Ice Bath
- Where
- United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Stanford University
Carpal Tunnel Syndrome
Does a Different Local Anesthetic Improve Pain After Carpal Tunnel Release?
This study is being conducted to determine whether addition of a longer-acting local anesthetic to our current anesthetic protocol improves the post-operative pain after carpal tunnel release.
- Trial name
- NCT04833777
- Testing
- Local Anesthetics Lidocaine, Local Anesthetics Bupivacaine
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Complex Regional Pain Syndrome
Randomized Controlled Trial of Ketamine Infusion With Continuous Epidural Infusion for Treatment of Complex Regional Pain Syndrome
The purpose of this study is to determine whether epidural and ketamine infusions are effective in the treatment of Complex Regional Pain Syndrome (CRPS).
- Trial name
- NCT02094352
- Testing
- Ketamine Infusion + Epidural Infusion, Control Group + Epidural infusion, Ketamine Booster Infusion
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Spinal Cord Injuries, Neuropathic Pain
Capsaicin 8% Patch for Spinal Cord Injury Neuropathic Pain
A prospective case control study to determine the effectiveness and longevity of 8% capsaicin patch(es) in treating neuropathic pain in persons with spinal cord injury.
- Trial name
- Capsaicin (NCT02441660)
- Testing
- Capsaicin 8% Patch, Low Dose Capsaicin 0.025% Well Patch
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Chronic Low-Back Pain, Refractory Pain
Spinal Cord Stimulation vs. Medical Management for Low Back Pain (DISTINCT)
The objective of this study is to evaluate the efficacy of BurstDR dorsal column stimulation, compared with conventional medical management, in improving pain and back-related physical function in subjects suffering with chronic…
- Conditions
- Chronic Low-Back Pain, Refractory Pain, Neuropathic Pain
- Trial name
- NCT04479787
- Testing
- Spinal Cord Stimulation, Conventional Medical Management
- Where
- 30 sites in United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Devices
Neuropathic Pain, Pain
Optimized Programming in Spinal Cord Stimulation (SCS) System
The objective of this study is to evaluate extent, location, and perception of paresthesia as a function of anode/cathode configuration.
- Trial name
- OP (NCT00871819)
- Testing
- Precision Spinal Cord Stimulation (SCS)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Boston Scientific Corporation
Pudendal Nerve, Healthy Women
Pelvic Floor Shear-Wave Elastography in Healthy and Pudendal Neuralgia Women
This study will compare superficial pelvic floor shear-wave elastography between healthy women and women with pudendal neuralgia.
- Trial name
- ELANEP (NCT07458737)
- Testing
- Pelvic floor shear wave elastography, Pelvic Floor Impact Questionnaire-Short Form 7 (PFIQ-7), Female Sexual Distress Scale-Revised (FSDS-R)
- Where
- Slovakia
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Comenius University
Painful Peripheral Diabetic Neuropathy
Nociceptive Pain Fiber Response
This study is designed to evaluate the effectiveness of the Provant Therapy System in improving localized nerve growth and skin perfusion in subjects with painful peripheral diabetic neuropathy of the foot.
- Trial name
- NCT02696070
- Testing
- Provant Therapy System
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Regenesis Biomedical, Inc.
Migraines
A Study of LY2951742 in Healthy Volunteers
To evaluate the safety and tolerability of LY2951742 given as single or multiple subcutaneous injection in healthy male subjects
- Trial name
- NCT01337596
- Testing
- LY2951742
- Where
- Belgium
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Carpal Tunnel Syndrome, Susceptibility to
Non-surgical Intervention for Carpal Tunnel Syndrome
This randomized controlled trial graduate student research study will explore the effect of non-surgical intervention of the dorsal application of Kinesio Tape for carpal tunnel syndrome, and forearm wrist hand pain.
- Trial name
- NCT03360344
- Testing
- Kinesio 12 inch Tape, Kinesio 4 inch Tape, Cock up Splint and Lumbrical exercises
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Postoperative Pain, Carpal Tunnel Release
Pain Outcomes of Intra-operative IV Tylenol and/or IV Toradol for Carpal Tunnel and Distal Radius Fracture Surgeries
The purpose of this study is to determine the efficacy of intra-operative administration of IV tylenol and/or IV toradol in minimizing post-operative pain for carpal tunnel patients and distal radius fracture patients.
- Conditions
- Postoperative Pain, Carpal Tunnel Release, Distal Radius Fracture
- Trial name
- NCT02313675
- Testing
- Acetaminophen, Ketorolac Tromethamine, Saline
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- John Fowler
Low Back Pain, Sciatica
Integrated Supported Biopsychosocial Self-Management for Back Related Leg Pain
Guidelines advocate several complementary modalities as alternatives to drugs and other invasive treatments for chronic low back pain (LBP) conditions.
- Conditions
- Low Back Pain, Sciatica, Back Related Leg Pain, Pain, Chronic
- Trial name
- SUPPORT (NCT05022121)
- Testing
- Supported Biopsychosocial Self-Management (SBSM), Medical Care
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Nerve Block, Pain, Postoperative
Pudendal Nerve Block in Vaginal Surgery
The objective of this this randomized controlled study is to determine whether a pudendal nerve block at the time of vaginal surgery is associated with improved postoperative pain control and decrease opioid consumption compared…
- Conditions
- Nerve Block, Pain, Postoperative, Pelvic Floor Disorders, Pelvic Organ Prolapse
- Trial name
- NCT04198714
- Testing
- Pudendal block
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Diabetic Peripheral Neuropathy
Use of Topical Lidocaine to Reduce Pain in Patients With Diabetic Neuropathy
The purpose of this study is to see if an investigational drug known as the lidocaine 5% patch is safe and effective in reducing the symptoms of diabetic neuropathy, to examine how topical lidocaine affects the nerve endings, and…
- Trial name
- NCT01086150
- Testing
- Skin biopsy, Lidocaine 5% patches
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Restless Legs Syndrome, Neuropathic Pain
Spinal Cord Stimulation for Restless Legs Syndrome
The overall goal of this proposed study is to evaluate the underlying mechanisms of neural control of blood flow in the lower extremities in humans with restless leg syndrome (RLS).
- Trial name
- NCT03539081
- Testing
- Dual-energy X-ray absorptiometry Scan, Laboratory Measurements, Blood Flow Measurement
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Marshall Holland
Low Back Pain
Study to Evaluate the Effectiveness of Orthopedic Spinal Supports in the Treatment of Low Back Pain
The purpose of this study is to determine whether orthopedic spinal supports are effective in the treatment of low back pain.
- Trial name
- NCT00553540
- Testing
- Back supports
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cleveland Clinic Florida
Pain Disorders
Crossover, Single Dose Randomized, Bioequivalence of Ketoprofen Lysine Salt Immediate Release vs Oral Solution
Objectives: The objective of the study was to investigate the bioequivalence between two formulations containing ketoprofen lysine salt (KLS) when administered as single oral doses in two consecutive study periods to healthy male…
- Trial name
- NCT02350296
- Testing
- KSL 40 mg, OKi® 80 mg
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dompé Farmaceutici S.p.A
Neuropathic Pain
Effect of Eslicarbazepine Acetate on the Pharmacokinetics of Metformin in Healthy Volunteers
The primary objective was to investigate whether multiple-dose administration of eslicarbazepine acetate affects the pharmacokinetics of metformin.
- Trial name
- NCT00971295
- Testing
- Metformin, Eslicarbazepine acetate
- Where
- Portugal
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.