Clinical trials: Peripheral Neuropathy Pain
Neuropathic Pain, Chemotherapy-induced Peripheral Neuropathy (CIPN)
Efficacy of Spinal Cord Stimulation in Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and debilitating side effect of many cancer treatments. It affects 28 to 48% of patients receiving chemotherapy.
- Conditions
- Neuropathic Pain, Chemotherapy-induced Peripheral Neuropathy (CIPN), Cancer-related Pain
- Trial name
- CHEMOSTIM (NCT07579611)
- Testing
- Spinal cord stimulation (FAST mode)
- Where
- France
- Volunteers
- 68 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Painful Diabetic Neuropathy (PDN), Peripheral Neuropathy With Type 2 Diabetes
The Treatment of Painful Diabetic Neuropathy With Diet
The purpose of this clinical trial is to determine whether targeted nutritional changes can improve symptoms of painful diabetic neuropathy.
- Conditions
- Painful Diabetic Neuropathy (PDN), Peripheral Neuropathy With Type 2 Diabetes, Vegan Diet
- Trial name
- NCT07509671
- Testing
- Diet, Medical management
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- AdventHealth
Diabetic Peripheral Neuropathic Pain (DPN), Diabetic Neuropathies
Cannabidiol for the Treatment of Diabetic Peripheral Neuropathy: Pilot Study
The "Cannabidiol for the Treatment of Diabetic Peripheral Neuropathy: Pilot study (CBD-DPN1)" is a double-blinded, placebo-controlled, crossover pilot study evaluating the efficacy of Cannabidiol (CBD) and full-spectrum CBD…
- Trial name
- CBD-DPN1 (NCT07298408)
- Testing
- Cannabidiol (CBD) oral solution, Full-Spectrum CBD hemp extract oral solution
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Florida A&M University
Chemotherapy Induced Neuropathic Pain, Neuropathy Toxic
Prospective Exploratory Study of a Multiomic Blood Biomarker Panel to Predict Chemotherapy-Induced Peripheral Neuropathy (CIPN)
The goal of this prospective, multicenter, observational cohort study with longitudinal blood sampling and standardized neurological evaluation over 6 months is to identify biomarkers to predict the overall occurrence of chronic…
- Conditions
- Chemotherapy Induced Neuropathic Pain, Neuropathy Toxic, Taxane-induced Peripheral Neuropathy, Oxaliplatin Induced Peripheral Neuropathy in Cancer Patients
- Trial name
- PRECISE1 (NCT07511569)
- Testing
- longitudinal blood sampling and standardized neurological evaluation over 6 months
- Volunteers
- 192 people
- Sponsor
- Centre Hospitalier de Bligny
Diabetic Peripheral Neuropathy (DPN), Pain
Study on Serum Transcriptomics and Metabolomics in Patients With Diabetic Peripheral Neuropathy
This part of the study enrolled 30 sex- and age-matched healthy controls, 30 diabetic patients without peripheral neuropathy, and 30 patients with diabetic peripheral neuropathy (DPN).
- Trial name
- NCT07518433
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zhejiang Chinese Medical University
Chemotherapy Induced Peripheral Neuropathy (CIPN)
Intrathecal Ziconotide in Chemotherapy Induced Peripheral Neuropathy
The purpose of this observational, data collection, research is to evaluate if ziconotide, a commercially approved medication given by a FDA cleared intrathecal pump, for chronic pain is effective in the treatment of…
- Trial name
- NCT07499882
- Testing
- Ziconotide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Christian Hospital Northeast Northwest
Peripheral Neuralgia, Peripheral Neuropathy
Clinical Study of a Micro-Implantable Pulse Generator for the Treatment of Peripheral Neuropathic Pain (COMFORT 2)
This post market study is being conducted to document the comparative effectiveness and safety of peripheral nerve stimulation plus conventional medical management versus conventional medical management alone in the treatment of…
- Conditions
- Peripheral Neuralgia, Peripheral Neuropathy, Chronic Pain
- Trial name
- COMFORT 2 (NCT05870124)
- Testing
- Nalu Neurostimulation System for PNS, Conventional Medical Management
- Where
- 17 sites in United States
- Volunteers
- 185 people
- Sponsor
- Nalu Medical, Inc.
Diabetic Peripheral Neuropathy (DPN), Diabetic Peripheral Neuropathic Pain (DPNP)
Using Lymphovenous Bypass to Alleviate Diabetic Peripheral Neuropathy
Diabetes is a metabolic disease characterized by high blood sugar levels due to a lack of insulin. Long-term metabolic disorders can cause structural and functional changes in many organs, mainly affecting the vascular system…
- Conditions
- Diabetic Peripheral Neuropathy (DPN), Diabetic Peripheral Neuropathic Pain (DPNP), Diabetic Foot Ulcer
- Trial name
- LVB ease DPN (NCT07126197)
- Testing
- lymphovenous bypass at diseased foot dorsum
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
CRPS (Complex Regional Pain Syndromes), Radiculopathy
Intermittent Dosing of Dorsal Root Ganglion Stimulation as an Alternate Paradigm to Continuous Low-Frequency Therapy
This study seeks to evaluate the use of intermittent dosing as an alternative paradigm for patients with DRG stimulation in place for at least 1 year and minimum 50% pain relief in the targeted area.
- Conditions
- CRPS (Complex Regional Pain Syndromes), Radiculopathy, Peripheral Neuropathy
- Trial name
- NCT04909138
- Testing
- DRG stimulation 20 Hz 30/90, DRG stimulation 5 Hz 30/90
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rush University Medical Center
Chemotherapy-induced Peripheral Neuropathy (CIPN), Neuropathic Pain
Use of PEA and Scutellaria in Synergy With Therapeutic Exercise in Chemotherapy-induced Peripheral Neuropathy (CIPN): a Clinical Trial
This study aims to find out if taking specific dietary supplements (PEA and Scutellaria) along with therapeutic exercise can help reduce nerve pain and damage caused by chemotherapy.
- Trial name
- NCT07352514
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Palermo
Limb Ischemia, Low Back Pain
Comorbidity Screening and Referral by Prosthetists
Lower-limb amputation is associated with life-altering and life-limiting comorbidities. Currently, onus is on primary care providers to diagnose, educate, and refer patients for appropriate management.
- Conditions
- Limb Ischemia, Low Back Pain, Depression, Neuropathy;Peripheral
- Trial name
- NCT05410548
- Testing
- Standard-of-Care, Clinical Screening
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Delaware
Cancer, Neuropathy
Nutritional Supplement for Treating Chemotherapy Induced Neuropathy
Administration of a nutritional supplement containing palmitoyethanolamide, alpha lipoic acid, vitamin B12, vitamin B6 , vitamin B1, nicotinamide, magnesium, zinc, vitamin E, and superoxide of dismutase in individuals receiving…
- Conditions
- Cancer, Neuropathy, Chemotherapy Induced Pain Neuropathy, Chemotherapy-Induced Peripheral Neuropathy
- Trial name
- NCT07022938
- Testing
- Epineuron
- Where
- Greece
- Volunteers
- 71 people
- Sponsor
- Aristotle University Of Thessaloniki
Chemotherapy Induced Peripheral Neuropathy (CIPN), Neuropathic Pain
Evaluation of Effectiveness of Closed-loop Spinal Cord Stimulation (CL-SCS) Therapy for Treatment of Chemotherapy Induced Peripheral Neuropathy
The goal of this observational study is to learn about the effectiveness of closed-loop spinal cord stimulation (CL-SCS) therapy for treatment of painful chemotherapy induced peripheral neuropathy.
- Trial name
- CIPRESS (NCT07304401)
- Where
- 5 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- Rijnstate Hospital
Posttraumatic Peripheral Neuropathic Pain, Peripheral Neuropathy
DoD AtMS for Posttraumatic Peripheral Neuropathic Pain
The goal of this clinical trial is to learn if adaptative transcutaneous magnetic stimulation (AtMS) works to reduce pain caused by post-traumatic peripheral neuropathic pain (PTP-NP) within Veterans and/or active duty military…
- Conditions
- Posttraumatic Peripheral Neuropathic Pain, Peripheral Neuropathy, Peripheral Neuropathy Due to Surgical Trauma, Peripheral Neuropathy Due to Physical Trauma
- Trial name
- PTP-NP (NCT07301177)
- Testing
- Transcutaneous magnetic stimulation (tMS), Patient Machine Interface (PMI)
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Veterans Medical Research Foundation
Painful Diabetic Peripheral Neuropathy (PDPN)
Efficacy and Safety of the N0750 Compared to Monotherapies in the Treatment of Painful Diabetic Peripheral Neuropathy
A phase 3, prospective, adaptive, randomized, multicenter, double-blind, triple-masked, parallel clinical trial to evaluate the efficacy and safety of N0750 in relieving pain associated with painful diabetic peripheral neuropathy…
- Trial name
- ENFORCE (NCT06715462)
- Testing
- N0750, Cymbalta®, Lyrica®
- Where
- Brazil
- Sponsor
- Eurofarma Laboratorios S.A.
Diabetic Peripheral Neuropathy
Exercise Effects on Pain, Sleep and Depression in Diabetic Peripheral Neuropathy
It is known that the pain experienced by individuals with diabetic neuropathy negatively impacts sleep and quality of life, leading to numerous psychosocial problems such as anxiety and depression.
- Trial name
- NCT07291596
- Testing
- Ankle-Foot Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Amasya University
Peripheral Arterial Disease, Painful Diabetic Neuropathy
SCS for Patient With Painful Diabetic Neuropathy and Peripheral Arterial Disease
Peripheral arterial disease (PAD) affects over 230 million adults worldwide and is a highly morbid, costly, and disabling condition.
- Conditions
- Peripheral Arterial Disease, Painful Diabetic Neuropathy, Diabetes Mellitus, Type 2, Chronic Pain
- Trial name
- NCT06480786
- Testing
- Spinal cord stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Nebraska
Painful Diabetic Neuropathy, Diabetic Neuropathy, Painful
Phase 3 Gene Therapy for Painful Diabetic Neuropathy
The purpose of this study is to determine the safety and efficacy of bilateral intramuscular injections of VM202 versus placebo in the treatment of painful diabetic peripheral neuropathy.
- Trial name
- NCT02427464
- Testing
- Engensis (VM202)
- Where
- 25 sites in United States
- Volunteers
- 507 people
- Sponsor
- Helixmith Co., Ltd.
Xerosis Cutis, Neuropathic Pain Associated With Diabetic Peripheral Neuropathy
Effectiveness of CBD for Neuropathic Pain in Diabetic Foot Neuropathy
Evaluation of cannabidiol and urea 10%.
- Trial name
- NCT07162454
- Testing
- Group 1. Complete formula, Group 2. Cannabidiol and Urea 10% formula.
- Where
- Spain
- Volunteers
- 23 people
- Sponsor
- Universidad Complutense de Madrid
Diabetic Peripheral Neuropathic Pain, Chemotherapy-induced Peripheral Neuropathy
Real-World Pharmacological Treatment Pattern of Neuropathic Pain in China
The aim of this study is to investigate the pharmacological treatment pattern among patients with diabetic peripheral neuropathic pain (DPNP) and chemotherapy-induced peripheral neuropathy (CIPN) in China.
- Conditions
- Diabetic Peripheral Neuropathic Pain, Chemotherapy-induced Peripheral Neuropathy, Neuropathic Pain
- Trial name
- NCT06546202
- Testing
- No Drug
- Where
- 10 sites in China
- Volunteers
- 1,271 people
- Sponsor
- Daiichi Sankyo