Clinical trials: Peripheral Neuropathy Pain
Diabetic Peripheral Neuropathy, Painful Diabetic Neuropathy
Microvascular Dysfunction in Diabetic Peripheral Neuropathy
This study primarily seeks to evaluate dysfunction of small blood vessels and their linkage to dysfunction of nerves in people with Type 2 Diabetes.
- Trial name
- NCT05118217
- Testing
- This is a non-interventional study
- Volunteers
- 72 people
- Sponsor
- University of Plymouth
Nerve Entrapments, Pelvic Pain
Integration of Intraoperative Neuromonitoring Into Decompression Surgery
To describe a novel technique by integrating the intraoperative neurophysiological monitoring (IONM) into laparoscopy to protect pelvic nerves by continuously monitoring when they are at risk during surgery.
- Trial name
- NCT06009640
- Testing
- Intraoperative neurophysiological monitoring with Nicolet Endeavor IOM Machine
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Neuropathic Pain
Efficacy of Perioperative Pregabalin in Reducing the Incidence of Chronic Neuropathic Pain and Postthoracotomy Syndrome.
This study is designed to assess: 1. The impact of taking perioperative pregabalin on the incidence of chronic neuropathic pain and postthoracotomy syndrome at 3 months in patients who have undergone a thoracotomy with a thoracic…
- Trial name
- NCT00967135
- Testing
- Pregabalin
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Pelvic Pain Syndrome, Sacroiliac Disorder
Chronic Pelvic Pain in Females and Males
Pelvic pain is under-reported in healthy adults. Many patients with pelvic pain under-estimate the problem. Chronic pelvic pain can be managed properly, if diagnosed promptly.
- Conditions
- Pelvic Pain Syndrome, Sacroiliac Disorder, Piriformis Syndrome, Sacrococcygeal Disorder
- Trial name
- NCT06102733
- Testing
- Rehabilitation therapy
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Salem Anaesthesia Pain Clinic
Postoperative Pain, Neuropathic Pain
Impact of Pregabalin in Chronic Users vs. a Perioperative Limited Prescription on Oxycodone Requirement
Spinal surgery is associated with intense pain and associated to a history of preoperative chronic pain. Pregabalin is licensed to treat chronic neuropathic pain, particularly when high dose of opioid are required.
- Trial name
- PREGAB (NCT02866396)
- Testing
- Pregabalin, Naive patient
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Christophe Aveline, MD
Radiculopathy
Presentation of Lumbar Disc and Reduction of Symptoms
The trial aims to assess the hypothesis that presentation of the disc material to the patient following a lumbar microdiscectomy would positively influence the improvement in their leg and back symptoms.
- Trial name
- POLDAROS (NCT00440856)
- Testing
- Presentation of excised intervertebral disc fragments
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Carpal Tunnel Syndrome
Efficacy of Dry Needling With the Fascial Winding Technique in the Carpal Tunnel Syndrome
So far there are studies that report the benefits of physiotherapy treatment in carpal tunnel syndrome, but none on the treatment of dry needling.
- Trial name
- NCT03907956
- Testing
- Dry Needling with Fascial Winding Technique
- Where
- Spain
- Volunteers
- 86 people
- Sponsor
- Universitat Internacional de Catalunya
Diabetic Neuropathy, Painful
Randomized, Double-Blind, Multicenter, Placebo-Controlled Study Of Pregabalin For Pain Associated With Diabetic Peripheral Neuropathy
To evaluate the efficacy and safety of pregabalin at 300 mg/day and 600 mg/day (BID) in patients with painful diabetic peripheral neuropathy.
- Trial name
- NCT00553475
- Testing
- pregabalin
- Where
- 49 sites in Japan
- Volunteers
- 314 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Chronic Neuropathic Pain
Surgical Treatment of Chronic Neuropathic Pain
Observational registry study assessing the subject's pain history and the impact of surgery for the treatment of chronic neuropathic pain by comparing post-operative outcomes (pain level, pain medication usage, quality of life…
- Trial name
- Rethink Pain (NCT04287075)
- Testing
- Surgical Management of Neuroma
- Where
- 4 sites in United States
- Volunteers
- 8 people
- Sponsor
- Axogen Corporation
Chronic Pain
The Effectiveness of Continuous Ketamine Infusion (KONTINUE)
There are different treatment for chronic pain. One possible treatment is intravenous infusions of ketamine.
- Trial name
- KONTINUE (NCT06131970)
- Where
- Monaco
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Princesse Grace
Acute Sciatica
A Comparative Effectiveness Randomised Placebo Controlled Pilot Trial of the Management of Acute Lumbar Radicular Pain
Aim: In subjects with acute sciatica (≤ 4 weeks duration), this is a pilot comparative effectiveness study to evaluate feasibility and to determine final sample size for a future adequately powered randomised controlled trial of…
- Trial name
- SCIATICA (NCT03240783)
- Testing
- Betamethasone OR Dexamethasone Injectable, Normal Saline Flush, 0.9% Injectable Solution, Dexamethasone Oral Tablet
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- St George Hospital, Australia
Nerve Pain, Shoulder Pain
The Effect of Dexmedetomidine on Brachial Plexus Block for Shoulder Surgery
The purpose of this study is to determine whether a small dose of Dexmedetomidine, when given either intravenously or as part of the interscalene nerve block solution, prolongs pain relief following shoulder surgery compared to…
- Trial name
- DEX (NCT02225054)
- Testing
- Dexmedetomidine, Ropivacaine, Normal Saline
- Where
- Canada
- Volunteers
- 99 people
- Sponsor
- Women's College Hospital
Lumbosacral Radiculopathy, McKenzie Derangement Syndrome
Effect of Combined Lumbar Traction and Repetitive Back Extension Exercise on H-reflex in Lumbosacral Radiculopathy
The aim of the study is to investigate the effect of performing combined lumbar traction and repeated back extension exercise (McKenzie) on soleus H-reflex, pain, and disability in patients with lumbosacral radiculopathy.
- Trial name
- NCT06216288
- Testing
- Repeated back extension exercise (McKenzie), Mechanical traction
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Chronic Pain, Sciatica
NAPS: Non-awake Versus Awake Placement of Spinal Cord Stimulators
The primary objective is to demonstrate the safety and efficacy of a non-awake implantation method (EMG neuromonitoring) of a SCS paddle lead as compared to an awake implantation method (with local anesthesia and patient…
- Conditions
- Chronic Pain, Sciatica, Failed Back Surgery Syndrome
- Trial name
- NAPS (NCT02284542)
- Testing
- Awake, Non-Awake
- Where
- 4 sites in United States
- Volunteers
- 34 people
- Sponsor
- St. Luke's Hospital, Pennsylvania
Cervical Radiculopathy, Cervical Spondylosis
Effectiveness of Cervical Transforaminal Epidural Steroid Injection
Study Purpose: This study is intended to monitor outcomes for 1 year following cervical TFESI. Based on current clinic volume and enrollment rates into a current study of cervical epidural injections that is nearing completion…
- Conditions
- Cervical Radiculopathy, Cervical Spondylosis, Disk, Herniated
- Trial name
- NCT04544683
- Testing
- Cervical Transforaminal Epidural Injection with dexamethasone sodium phosphate
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Utah
Thoracic Outlet Syndrome
Treatment of Thoracic Outlet Syndrome (TOS) With Botox
The purpose of this study is: 1. To assess the effect of BOTOX injection to the scalene muscles on the severity of pain from TOS. 2. To assess the effect of BOTOX injection on numbness and tingling and quality of life.
- Trial name
- NCT00444886
- Testing
- Botulinum Toxin Type A injection (BOTOX)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Myasthenia Gravis, Guillain-Barre Syndrome
Neurology Inpatient Clinical Education Trial
The objective of this study is to compare the effectiveness of a personalized patient education program to the current hospital education and evaluate its impact using patient satisfaction scores.
- Conditions
- Myasthenia Gravis, Guillain-Barre Syndrome, Multiple Sclerosis, Seizures
- Trial name
- NCT03826056
- Testing
- Current standard discharge educational intervention, Personalized discharge educational intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Herniated Disk Lumbar
Return to Work After Early Intervention for Lumbar Disc Herniation Versus Usual Care
The most common cause of low back pain with radiculopathy among the working population is a Lumbar Disc Herniation (LDH). In general, the natural history of sciatica is favourable with spontaneous remission.
- Trial name
- WILD (NCT04657354)
- Testing
- Assessment
- Sponsor
- Spine Centre of Southern Denmark
Peripheral Nervous System Diseases, Pain
Study of NGX-4010 for the Treatment of Postherpetic Neuralgia
The purpose of the study is to assess the efficacy and safety of NGX-4010 applied for 60 minutes for the treatment of postherpetic neuralgia (PHN).
- Conditions
- Peripheral Nervous System Diseases, Pain, Neuralgia, Herpes Zoster
- Trial name
- NCT00115310
- Testing
- NGX-4010
- Volunteers
- 400 people
- Sponsor
- NeurogesX
Postherpetic Neuralgia
To Evaluate the Efficacy and Safety of SR419 in Patients With Postherpetic Neuralgia (PHN)
This is a Phase II, international multicenter, double-blind, placebo-controlled, crossover study to assess the efficacy of SR419 in PHN subjects.
- Trial name
- NCT05357677
- Testing
- SR419
- Where
- 13 sites in Australia, China
- Volunteers
- 83 people
- Sponsor
- Shanghai SIMR Biotechnology Co., Ltd.
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